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  • GABA
  • Most of the critical peptides involved in the regulation of energy homeostasis have been colocalized with the inhibitory transmitter GABA in the arcuate nucleus. (labome.org)
  • There was no electrophysiological evidence for functional expression of P2X4 receptors on AgRP-NPY neuron somata, but instead, we found clear evidence for functional presynaptic P2X4 receptor-mediated responses in terminals of AgRP-NPY neurons onto two of their postsynaptic targets (Arc POMC and paraventricular nucleus neurons), where ATP dramatically facilitated GABA release. (nih.gov)
  • brain
  • The hypothalamic arcuate nucleus in the brain acts like the information hub of energy balance, receiving information both from peripheral organs involved in energy storage or release, and receiving axonal information from other regions of the brain that also play important roles in CNS regulation of energy homeostasis, and sending out efferent information that regulates food intake and utilization. (labome.org)
  • P2X4 Receptor Reporter Mice: Sparse Brain Expression and Feeding-Related Presynaptic Facilitation in the Arcuate Nucleus. (nih.gov)
  • We report the distribution of tdTomato-expressing cells throughout the brain and particularly strong expression in the hypothalamic arcuate nucleus. (nih.gov)
  • Since the arcuate nucleus (ARC) shows a less restrictive blood-brain barrier, expresses GRs, and projects to the PVN, we investigated whether the ARC can detect and produce fast adjustments of circulating Cort. (eneuro.org)
  • This fast control may be an alternative mechanism used by circulating hormones and metabolites to communicate with control centers in the brain via the arcuate nucleus for fast feedback. (eneuro.org)
  • POMC
  • Proopiomelanocortin (POMC) is a precursor polypeptide that is cleaved into MSH and β-endorphin and expressed in the arcuate nucleus. (wikipedia.org)
  • To test the hypothesis that arcuate glutamate cells regulate the activity of anorexigenic proopiomelanocortin (POMC) neurons, we will record from POMC neurons while stimulating local glutamate cells with the excitatory microdrop method to activate cell bodies but not axons of passage. (labome.org)
  • We investigated the expression of proopioimelanocortin (POMC) mRNA in the arcuate nucleus of Sprague-Dawley (SD) rats after administering capsaicin, hypothesizing that administering capsaicin activates the central opioid system. (psychiatryinvestigation.org)
  • rats
  • In the present study, we show that microcuts effectively removing SCN-arcuate nucleus (ARC) interconnectivity in Wistar rats result in a loss of rhythmicity in locomotor activity, corticosterone levels, and body temperature in constant dark (DD) conditions. (eneuro.org)
  • density
  • A-C) Representative immunolabelling (upper panels) and quantification (lower panels) of the number of kisspeptin- immunoreactive neurons in the RP3V (A) and fiber density in the RP3V (B) and arcuate nucleus (C) in wild type mice. (thefreedictionary.com)
  • levels
  • Here, we demonstrate that the arcuate nucleus rapidly senses circulating corticosterone levels and thus adjusts the endocrine adrenal output via the preautonomic neurons in the PVN. (eneuro.org)
  • cell
  • A second set of experiments, using whole cell patch clamp recording in hypothalamic slices, addresses the question of "What active or passive membrane characteristics make the glutamate neurons unique", compared with the GABAergic neurons of the arcuate nucleus that have received substantial attention. (labome.org)
  • different
  • Two nuclei may have the same atomic number but different mass numbers, thus constituting different forms, or isotopes isotope , in chemistry and physics, one of two or more atoms having the same atomic number but differing in atomic weight and mass number. (thefreedictionary.com)