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  • precursor
  • Arachidonic acid may serve as an intracellular second messenger in many cell types, as well as precursor for biologically active molecules such as the eicosanoids (a family of oxygenated metabolites that may act as second messengers or as local mediators), and anandamide (an endogenous cannabinoid substance). (alibris.com)
  • secretion
  • Preincubation of resident peritoneal macrophages with 10-100 ng/ml LPS for 60 min resulted in the cells becoming primed for enhanced (three-to eightfold higher) arachidonic acid (20:4) secretion in response to a variety of triggers. (rupress.org)
  • Our previous data suggested that lipoxygenation of endogenously released arachidonic acid (AA) is a critical step in stimulus-secretion coupling in the pancreatic beta cell. (diabetesjournals.org)
  • However, the unstable intermediate 12-hydroperoxyei-cosatetraenoic acid (12-HPETE), and positional isomers of 12-HPETE, potentiated glucose-induced insulin secretion. (diabetesjournals.org)
  • membrane
  • Arachidonic acid is stored within the cell membrane, and is responsible for signaling adaptive changes in the response to muscle damage and related stimuli. (steroid.com)
  • liver
  • Arachidonic acid is a polyunsaturated fatty acid present in the phospholipids (especially phosphatidylethanolamine , phosphatidylcholine , and phosphatidylinositides ) of membranes of the body's cells , and is abundant in the brain , muscles , and liver . (wikipedia.org)
  • intermediate
  • In addition to being involved in cellular signaling as a lipid second messenger involved in the regulation of signaling enzymes, such as PLC -γ, PLC-δ, and PKC -α, -β, and -γ isoforms, arachidonic acid is a key inflammatory intermediate and can also act as a vasodilator . (wikipedia.org)
  • yield
  • The Nterm-phos hydrolyzes phosphate monoesters, such as lipid phosphates, to yield alcohols and phosphoric acid (reaction 2). (wikipedia.org)
  • commonly
  • Arachidonic acid is most commonly used by bodybuilders and weight-trained athletes in sports where enhanced anaerobic (short, rapid burst) performance is required. (steroid.com)
  • little
  • NG-Monomethyl-L-arginine and nitro-L-arginine, compounds that inhibit the nitric oxide-like endothelium-derived relaxing factor, had little or no effect on arachidonic acid-induced relaxations. (ahajournals.org)