Chemicals and DrugsPhenomena and Processes
AquaporinsAquaporin 1WaterAquaporin 5Aquaporin 4Aquaporin 6AquaglyceroporinsAquaporin 2Mercuric ChlorideOsmosisPlant Transpiration
PermeableProteinsMoleculesProteinAntibodiesMammalianOsmosisOsmoticCellCellsMarkersSmallTransportWater channelsChannelsFamily membersBlockPlasmaDrugPrimaryGlycerolLiving cell membranesOptic nerves and spinal cordConduct water moleculesMembraneAQPsMammalianPoresAQP4AQP3MonomersTetramersRolesIonsExpressionCornealRegulationPassiveInflammatoryFormBrainFunctionIndependentMainDevelopment
Permeable7
  • 2013. Subcellular Localization of Selectively Permeable Aquaporins in the Male Germ Line of a Marine Teleost Reveals Spatial Redistribution in Activated Spermatozoa. (upv.es)
  • Osmosis Is the diffusion of water molecules across a selectively permeable membrane from an area of higher concentration to an area of lower concentration. (splendida.live)
  • Cell membranes are selectively permeable , regulating which substances can pass through, as well as how much of each substance can enter or exit at a given time. (khanacademy.org)
  • The plasma membrane or cell membrane is an outermost covering of cells that is selectively permeable hence it only allows selective molecules to transport through the membrane. (researchtweet.com)
  • By definition, osmosis is the diffusion of water through a selectively permeable membrane from an area of high water potential (low solute concentration) to an area of low water potential (high solute concentration). (byui.edu)
  • However, if the membrane is not permeable to the particles, then instead of particles moving or diffusing, water will move or diffuse through aquaporins in the cell membrane to reach equilibrium. (byui.edu)
  • Cells are separated from the IF by a selectively permeable cell membrane that helps regulate the passage of materials between the IF and the interior of the cell. (edu.vn)
Proteins8
  • T3001Aquaporins are proteins that selectively conduct water molecules in and out of mammalian cells, while preventing the passage of ions and other solutes. (topsan.org)
  • Aquaporins (AQPs) are proteins that selectively transport water across the cell membrane . (bvsalud.org)
  • Aquaporins are proteins that regulate the flow of water in and out of cells. (lu.se)
  • Aquaporins are membrane-channel proteins that are present at all levels of life, from bacteria to mammals. (shadowebike.com)
  • Are aquaporins carrier proteins? (shadowebike.com)
  • Besides channels, there are some other proteins like aquaporins, which are also integral membrane proteins involves in the transport of water molecules. (researchtweet.com)
  • Astrocytes may be recognized as such by their expression of glial fibrillary acidic protein, glutamine synthetase, glutamate transporter 1 (GLT1), aquaporin-4, aldehyde dehydrogenase 1 family member L1, and other proteins. (jneurosci.org)
  • Either by diffusing across the phospholipid bilayer directly, or via aquaporins (small transmembrane proteins similar to those in facilitated diffusion and in creating ion channels). (wikidoc.org)
Molecules2
  • The picture shows how a drug (orange) attaches to the aquaporin (purple), resulting in the aquaporin no longer being able to transport molecules across the cell membrane. (lu.se)
  • Most aquaporins are selectively permeated by water, although some family members are permeated by other small molecules. (shadowebike.com)
Protein5
  • Water loading reduced aquaporin-2 but increased Tamm-Horsfall protein (THP) and particle detection by NTA. (exosome-rna.com)
  • Aquaporin inhibition changes protein phosphorylation pattern following sperm motility activation in fish. (upv.es)
  • Using cryo-electron microscopy, a technology with extremely high resolution, researchers have now, for the first time, managed to produce an image of an aquaporin with a drug candidate bound to the protein. (lu.se)
  • Technique/Primary Findings -10 and Aquaporin-7 were portrayed in the white adipose tissues both at mRNA with protein level. (thekingsfoundation.org)
  • Water can move through the cell membrane directly through the membrane (simple diffusion ) or through protein channels called aquaporins. (splendida.live)
Antibodies1
  • He introduced a novel approach to treat neuromyelitis optica (NMO) by monoclonal anti- aquaporin-4 antibodies that selectively block NMO autoantibody binding to aquaporin-4. (keio.ac.jp)
Mammalian1
  • The mammalian aquaporins, which number about a dozen, are expressed in many cell types involved in fluid transport, including epithelia and endothelia in kidney, lung, exocrine glands, eye and gastrointestinal organs. (shadowebike.com)
Osmosis1
Osmotic3
  • Aquaporin-10 silencing in FN1 individual differentiated adipocytes led to a 50% loss of glycerol and osmotic drinking water permeability. (thekingsfoundation.org)
  • The primary function of most aquaporins is to transport water across cell membranes in response to osmotic gradients created by active solute transport. (shadowebike.com)
  • Chronic administration of memantine or MRZ 2579 via osmotic minipumps selectively reduced relapse behavior (98,99). (forexrin.com)
Cell2
  • Aquaporins are water channels found in the cell membranes. (lu.se)
  • It seems that cancer cells may increase the number of aquaporins to enhance their own survival and increase their spreading ability, says Karin Lindkvist, professor of cell biology at Lund University and structural biology researcher. (lu.se)
Cells4
  • Aquaporins 8 and 9 as Possible Markers for Adult Murine Lacrimal Gland Cells. (bvsalud.org)
  • Aquaporins are central to many mechanisms in our cells , and also play a crucial role in several health conditions such as cancer and type 2 diabetes. (lu.se)
  • They have also shown that the drug affects the growth capability of leukemia cells by inactivating aquaporins. (lu.se)
  • Aquaporins are found in a high concentration in the epithelial cells that produce aqueous humor (as well as other epithelial cells that allow water to move readily across their membrane, e.g., epithelial cells in the kidney). (shadowebike.com)
Markers1
  • The exosome markers CD9 and CD63 colocalized and immunoprecipitated selectively with distal nephron markers. (exosome-rna.com)
Small1
  • The use of flap and site also causes reversal of C3 and C5 arms by calcium particles, existing selectively small Ins( Amara U et al. (erik-mill.de)
Transport2
Water channels1
  • Aquaporins ("water channels") 2003 Nobel Prize in Chemistry. (shadowebike.com)
Channels1
  • Aquaporins are channels, i.e. passive transporters where water always moves down its water potential gradient. (shadowebike.com)
Family members1
  • Glycerol efflux from adipocytes takes place via a particular glycerol route that is one of the aquaporin (AQP) family members, known as AQP7 [2], [3]. (thekingsfoundation.org)
Block1
  • Therefore, it 's interesting to try to develop new drugs that block the activity of aquaporins. (lu.se)
Plasma3
  • Immunofluorescence uncovered aquaporin-7 and -10 labelling in the individual adipose tissues both towards the plasma membrane also to a slim rim of cytoplasm of adipocytes. (thekingsfoundation.org)
  • Individual cultured differentiated Proscillaridin A adipocytes demonstrated an aquaporin-7 and -10 labelling generally in the cytoplasm and in the lipid droplets with insulin reinforcing the lipid droplets staining and isoproterenol inducing its translocation towards the plasma membrane area. (thekingsfoundation.org)
  • Conclusions/Significance The full total outcomes indicate that aquaporin-7, from mice differently, exists in both capillary and adipocyte plasma membranes of individual adipose tissues. (thekingsfoundation.org)
Drug1
  • But to create new drug candidates, researchers must first gain knowledge of how they bind to aquaporins. (lu.se)
Primary1
  • The parenchymal fluid contributes to the glymphatic system, and plays a fundamental role in pediatric hydrocephalus, with aquaporin 4 (AQP4) as the primary facilitator of these fluid movements. (biomedcentral.com)
Glycerol7
  • The currently known aquaporins cluster loosely together as do the known glycerol facilitators. (wikipedia.org)
  • Aquaporins selectively transport glycerol as well as water while glycerol facilitators selectively transport glycerol but not water. (wikipedia.org)
  • 8. Regulation of the Glycerol Transporter, Aquaporin-3, by Histone Deacetylase-3 and p53 in Keratinocytes. (nih.gov)
  • 14. Selectively reduced glycerol in skin of aquaporin-3-deficient mice may account for impaired skin hydration, elasticity, and barrier recovery. (nih.gov)
  • We have cloned three kidney cDNAs with homology to the water channel (aquaporin) family, including a mercurial-insensitive water channel (MIWC), and a glycerol-transporting protein (GLIP) in collecting duct basolateral membrane. (elsevierpure.com)
  • demonstrate that the water/glycerol channel aquaporin-3 (AQP3) regulates chemokine-dependent trafficking of T cells to inflamed skin via uptake of hydrogen peroxide (H 2 O 2 ). (silverchair.com)
  • The water/glycerol channel aquaporin-3 is required for chemokine-dependent T cell migration during immune responses. (silverchair.com)
Living cell membranes1
  • Aquaporins, also known as the water channels in living cell membranes, have been found to be the functional unit of nature's water purification systems. (bioquicknews.com)
Optic nerves and spinal cord2
  • Neuromyelitis optica (NMO) is an inflammatory demyelinating disease that selectively affects optic nerves and spinal cord. (nih.gov)
  • Neuromyelitis optica (NMO) selectively affects the optic nerves and spinal cord. (elsevierpure.com)
Conduct water molecules2
  • Aquaporins are membrane proteins that selectively conduct water molecules in and out of cells, preventing the passage of ions and other solutes. (bioquicknews.com)
  • Porins refer to the beta-barrel proteins that cross a cellular membrane, acting as a pore through which molecules can diffuse, while aquaporins refer to water channels that form pores in the cell membranes that selectively conduct water molecules through the membrane. (pediaa.com)
Membrane8
  • MIP family proteins are believed to form aqueous pores that selectively allow passive transport of their solute(s) across the membrane with minimal apparent recognition. (wikipedia.org)
  • Led by Associate Professor Tong Yen Wah who is also from the Department of Chemical and Biomolecular Engineering at the NUS Faculty of Engineering, the team of researchers have designed and fabricated a new aquaporin-incorporated biomimetic membrane water purification and treatment system that is highly efficient. (bioquicknews.com)
  • Launch Aquaporin (AQP) drinking water channels are essential membrane protein of ～30 kD molecular mass that contain six membrane-spanning helical sections surrounding a small aqueous pore (Walz et al. (techuniq.com)
  • Porins and aquaporins are two types of channel proteins that form large pores in the cell membrane, outer membranes of cell organelles, such as mitochondria and plastids, and bacteria. (pediaa.com)
  • Aquaporins are a type of porins that especially transport water molecules across the membrane. (pediaa.com)
  • In brief, porins and aquaporins are two types of transport proteins that transport different types of molecules across the membrane. (pediaa.com)
  • Tonoplast (BvTIP1;2) and plasma membrane (BvPIP2;1) aquaporins show different mechanosensitive properties. (conicet.gov.ar)
  • Using a quantitative ratiometric approach with secreted green fluorescent protein (secGFP), we report here that traffic to the plasma membrane is suppressed selectively by Sp2 fragments of plasma membrane SNAREs AtSYP121 and AtSYP122, but not of the closely related SNARE AtSYP111 nor of the SNARE AtSYP21 that resides at the pre-vacuolar compartment (PVC). (strath.ac.uk)
AQPs1
Mammalian2
Pores1
  • Aquaporins, also known as water channels, form pores in cell membranes and selectively transport water in and out of the cell. (nih.gov)
AQP42
  • The discovery that NMO-IgG, an NMO-specific IgG, targets aquaporin-4 (AQP4), suggested that NMO is a distinct disease entity with a fundamentally different etiology from MS. Because NMO-IgG is present in 30-60% of OSMS patients, OSMS in Asians is suggested to be the same entity as NMO. (elsevierpure.com)
  • The distribution of aquaporin 4 (AQP4) in the ciliary body and the tissue changes under electron microscopy were observed after surgery. (frontiersin.org)
AQP31
  • Expression of aquaporin-3 (AQP3) in placentas from pregnancies complicated by preeclampsia. (conicet.gov.ar)
Monomers1
  • The results indicate that CHIP28 transports water selectively, that CHIP28 monomers are assembled in membranes as tetramers, but that individual monomers function independently. (elsevierpure.com)
Tetramers1
Roles2
  • Roles of aquaporins in human cancer have been reviewed as have their folding pathways. (wikipedia.org)
  • 7. Roles of aquaporin-3 in the epidermis. (nih.gov)
Ions1
Expression6
  • 2. The expression of differentiation markers in aquaporin-3 deficient epidermis. (nih.gov)
  • 6. EGFR-mediated expression of aquaporin-3 is involved in human skin fibroblast migration. (nih.gov)
  • 11. Tumor necrosis factor-alpha decreases aquaporin-3 expression in DJM-1 keratinocytes. (nih.gov)
  • 18. Increased expression of aquaporin-3 in the epidermis of DHCR24 knockout mice. (nih.gov)
  • 20. PPARgamma activators stimulate aquaporin 3 expression in keratinocytes/epidermis. (nih.gov)
  • TCR signal attenuation selectively favors Foxp3 expression and T reg cell lineage commitment. (silverchair.com)
Corneal1
  • 4. Aquaporin-3-dependent cell migration and proliferation during corneal re-epithelialization. (nih.gov)
Regulation3
  • 9. All-trans retinoic acid attenuates ultraviolet radiation-induced down-regulation of aquaporin-3 and water permeability in human keratinocytes. (nih.gov)
  • 13. Trans-Zeatin attenuates ultraviolet induced down-regulation of aquaporin-3 in cultured human skin keratinocytes. (nih.gov)
  • Aquaporins are involved in regulation of water balance and blood pressure, and thirteen different isoforms have been found in mammals. (nih.gov)
Passive1
Inflammatory1
  • Pimecrolimus cream selectively inhibits the production and release of inflammatory cytokines from activated T cells by binding to cytosolic immunophilin receptor macrophilin-12. (medscape.com)
Form1
  • In the native form, it is an aquaporin (AQP), but during lens development, it becomes proteolytically truncated. (wikipedia.org)
Brain2
  • Ion channel activity has been shown for Aquaporins 0, 1, and 6, Drosophila 'Big Brain' (bib) and plant Nodulin-26. (wikipedia.org)
  • In addition, aquaporin 4, Kir4.1, and dystrophin 1 were reduced in autopsied brain tissue from AD patients with moderate to severe vascular amyloid deposition (i.e. (alzforum.org)
Function2
  • 10. Skin aquaporins: function in hydration, wound healing, and skin epidermis homeostasis. (nih.gov)
  • 15. Defective macrophage function in aquaporin-3 deficiency. (nih.gov)
Independent1
  • Molecular Mechanisms in Perirhinal Cortex Selectively Necessary for Discrimination of Overlapping Memories, but Independent of Memory Persistence. (conicet.gov.ar)
Main1
  • Therefore, the main difference between porins and aquaporins is the type of molecules they transport. (pediaa.com)
Development1