This review focuses on emerging topics encompassing the functional involvement of aquaporin channel proteins (AQPs) and membrane transport systems, also allowing permeation of NO and hydrogen peroxide, a major ROS, in oxidative stress physiology and pathophysiology. (hindawi.com)
This notion has been challenged by the discovery of new membrane transport functions, especially those exerted by aquaporins (AQPs), a family of membrane channel proteins widespread in nature [ 10 , 11 ]. (hindawi.com)
2] "Aquaporins (AQPs) are water channels that facilitate transepithelial water transport across plasma membranes following an osmotic gradient [3]. (irosacea.org)
Juan Fuentes ABSTRACT Aquaporins (AQPs) are specific transmembrane water channels with an important function in water homeostasis. (silverchair.com)
Background/Aim: Recent studies have revealed aquaporins (AQPs) as targets for novel anti-tumor therapy since they are likely to play a role in carcinogenesis, tumor progression and invasion. (dsmc.or.kr)
Aquaporins (AQPs) are a large family of integral membrane water transport channel proteins that facilitate the transport of water through the cell membrane. (nsjbio.com)
AQP72
Glycerol efflux from adipocytes takes place via a particular glycerol route that is one of the aquaporin (AQP) family members, known as AQP7 [2], [3]. (thekingsfoundation.org)
Although most aquaporins are only permeable to water, AQP3, AQP7, AQP9 and one of the two AQP10 transcripts are also permeable to urea and glycerol. (nsjbio.com)
Membrane3
Immunofluorescence uncovered aquaporin-7 and -10 labelling in the individual adipose tissues both towards the plasma membrane also to a slim rim of cytoplasm of adipocytes. (thekingsfoundation.org)
Individual cultured differentiated Proscillaridin A adipocytes demonstrated an aquaporin-7 and -10 labelling generally in the cytoplasm and in the lipid droplets with insulin reinforcing the lipid droplets staining and isoproterenol inducing its translocation towards the plasma membrane area. (thekingsfoundation.org)
This gene encodes a member of the aquaporin family of intrinsic membrane proteins that function as water-selective channels in the plasma membranes of many cells. (antibodies-online.com)
Facilitate transepithelial water1
Steffen S. Madsen SUMMARY Aquaporins may facilitate transepithelial water absorption in the intestine of seawater (SW)-acclimated fish. (silverchair.com)
AQP44
IHC staining of FFPE human small intestine with Aquaporin 4 antibody (clone AQP4/3324). (nsjbio.com)
SDS-PAGE analysis of purified, BSA-free Aquaporin 4 antibody (clone AQP4/3324) as confirmation of integrity and purity. (nsjbio.com)
Analysis of HuProt(TM) microarray containing more than 19,000 full-length human proteins using Aquaporin 4 antibody (clone AQP4/3324). (nsjbio.com)
In skeletal muscle, AQP4 (Aquaporin 4, also known as mercurial insensitive water channel), localizes to the sarcolemma of fast-twitch muscle fibers. (nsjbio.com)
Glycerol4
Here, we report that aquaporin 3 (AQP3), a channel protein that mediates the transport of water/glycerol, was highly expressed in the epidermis and CD4+ T cells of both rosacea patients and experimental mice. (irosacea.org)
AVI) pone.0054474.s002.avi (1.0M) GUID:?A9939A40-B32F-44EF-9990-5144610DE6C8 Abstract Background Glycerol outflow from adipocytes continues to be considered for ten years to become mediated by aquaporin-7, an aquaglyceroporin expressed in the adipose tissues highly. (thekingsfoundation.org)
Aquaporin 3 (AQP-3) is the protein product of the human AQP3 gene. (wikipedia.org)
It works synergistically with glycerin as it up-regulates Aquaporin 3 (AQP3), an important transmembrane protein that transports our beloved friend glycerin, along with its' hydrating groupie water molecules that surround it, into the cell. (incidecoder.com)
Technique/Primary Findings -10 and Aquaporin-7 were portrayed in the white adipose tissues both at mRNA with protein level. (thekingsfoundation.org)
The encoded protein is the predominant aquaporin found in brain. (antibodies-online.com)
A portion of amino acids 254-323 from the human protein was used as the immunogen for the Aquaporin 4 antibody. (nsjbio.com)
Steve F. Perry ABSTRACT The present study tested the hypothesis that zebrafish ( Danio rerio ) aquaporin -1a1 (AQP1a1) serves as a multi-functional channel for the transfer of the small gaseous molecules, CO 2 and ammonia, as well as water. (silverchair.com)
Tumor2
Meanwhile, none of selected AQP3 polymorphisms were related to AQP3 expression in tumor tissue or survival in the current study. (dsmc.or.kr)
Conclusion: AQP3 expression in tumor tissue may be considered as a potential prognostic marker in patients with HER2-over-expressing EBC after curative surgery. (dsmc.or.kr)
Monoclonal1
The results were compared with those obtained from the group receiving anti-AQP3 monoclonal antibodies. (kiev.ua)
AQP102
TIF) pone.0054474.s001.tif (361K) GUID:?8B48F563-BB0C-40F3-A790-0C68C8A51508 Movie S1: Subcellular localization of aquaporin-10 (AQP10) in individual cultured differentiated adipocytes after insulin excitement. (thekingsfoundation.org)
Many isoforms of aquaporin have been identified in mammals, designated AQP0through AQP10. (nsjbio.com)
Proteins1
However, the relationships of AQP3 with GIM classification and with other proteins, and their roles in the transition from GIM to gastric carcinoma (GC) remain unknown. (oncotarget.com)
Membranes1
Conclusions/Significance The full total outcomes indicate that aquaporin-7, from mice differently, exists in both capillary and adipocyte plasma membranes of individual adipose tissues. (thekingsfoundation.org)
Immunohistochemistry2
GIM classification was determined via HID-AB staining, and AQP3, CD24, LGR5 and Ki67 expression were determined by immunohistochemistry. (oncotarget.com)
Materials and Methods: AQP3 expression was investigated on the basis of the immunohistochemistry of tissue microarray specimens from 447 EBC patients who underwent surgery between 2003 and 2008. (dsmc.or.kr)
Mice1
Impaired stratum corneum hydration in mice lacking epidermal water channel aquaporin-3. (kiev.ua)
Findings1
Our findings reveal that AQP3-mediated activation of NF-κB in keratinocytes and activation of STAT3 in CD4+ T cells acted synergistically and contributed to the inflammation in rosacea. (irosacea.org)
Skin's2
This moisturizer uses a high-concentration of ceramides to better replenish your skin's natural barrier and aquaporins to help generate and lock in moisture. (incidecoder.com)
Ceramide-3 replenishes the skin's natural moisture barrier to prevent moisture loss due to evaporation. (eucerin.ca)
Keratinocytes1
Suberoylanilide hydroxamic acid (SAHA) (a HDAC inhibitor) increases expression of aquaporin-3 in normal skin cells (keratinocytes). (wikipedia.org)
Glycerin1
To put it more simply - AQP3 makes sure that glycerin and water are well distributed in the outer layer of the skin and thus the skin is well-hydrated. (incidecoder.com)
Psoriasis2
Aquaporin 3 levels are often lower in psoriasis than in healthy skin. (wikipedia.org)
Aquaporin 3 (AQP3) plays an important role in the expression of various skin-related diseases such as vitiligo and psoriasis. (e-ajbc.org)
Targets1
Aquaporins: important but elusive drug targets. (kiev.ua)
The effect of carbon monoxide's donor CORM-2 on erythrocyte aquaporins. (kiev.ua)
Mechanism3
We aim to explore the regulatory mechanism of AQP3 and the function of AQP3 on the skin. (e-ajbc.org)
We summarize the distribution of AQP3 in skin and the regulatory mechanism of AQP3, then point out the function of AQP3 on the skin and the development trend of AQP3 as a new target in the field of cosmetic research. (e-ajbc.org)
CrossRef Ikarashi N, Aburada T, Kon R, Sugiyama K. Water control mechanism of byakkokaninjinto and its active components via aquaporins. (kiev.ua)
Expression5
AQP3 expression showed significant correlation to type III GIM. (oncotarget.com)
Accordingly, we analyzed the prognostic impact of AQP3 expression and polymorphisms in a number of patients with early breast cancer (EBC). (dsmc.or.kr)
the staining score was defined as sum of these scores used to categorize the AQP3 expression as negative (0 through 2), weak (3 through 5) or strong (6 or more). (dsmc.or.kr)
Results: A total of 180 (40.3%) patients were identified as AQP3-positive (staining score >2), including 86 (19.2%) cases of strong expression (stating score >5). (dsmc.or.kr)
In a univariate analysis, AQP3 expression was significantly associated with survival for the patients with HER2-over-expressing EBC. (dsmc.or.kr)
Widely1
Aquaporins are widely distributed and it is not uncommon for more than one type of AQP to be present in the same cell. (nsjbio.com)
Channel1
We investigated the metabolism of mouse isolated heart under the influence of tricarbonyldichlorothenium (II)- dimer (CORM-2 and 2,3-4,5-bis-O-isopropylidene-βD-fructopyranose sulfamate (topiramate) as potential blockers of aquaporine channel (AQP3) of cardiac myocytes. (kiev.ua)
Skin2
S. Tanaka SUMMARY The ventral pelvic skin of the tree frog Hyla japonica expresses two kinds of arginine vasotocin (AVT)-stimulated aquaporins (AQP-h2 and AQP-h3), which affect the capacity of the frog's skin to absorb water. (silverchair.com)
Aquaporin-3 in the epidermis: more than skin deep. (kiev.ua)
we previously demonstrated that aquaporin 3 (AQP3) is expressed in goblet cells and is positively correlated with GIM severity. (oncotarget.com)
Function1
A. S. Verkman SUMMARY There is considerable potential for translating knowledge of aquaporin structure, function and physiology to the clinic. (silverchair.com)
Is your rosacea social media group a registered 501 c 3 non profit? (irosacea.org)
Type1
So far, it is well recognized that a multistep process is involved in the progression from normal gastric mucosa to intestinal-type GC, including chronic gastritis, chronic atrophic gastritis, intestinal metaplasia, dysplasia and invasive carcinoma, which was originally proposed by Correa [ 2 , 3 ]. (oncotarget.com)