Aquaporin channel protein. Medical search. Frequent questions

Mounting evidence has demonstrated that AQP4, a water channel protein, is closely correlated with brain edema and could be an optimal therapeutic target for the reduction of ischemic brain edema. (benthamscience.com)
Mass photometry measurement of water channel aquaporin 4 (AQP4) sample solubilized using SMALPs. (the-scientist.com)
The target antigen of NMO-IgG was recently identified as aquaporin-4 (AQP4) water channel protein, which is mainly expressed in brain and spinal cord. (go.jp)
Of particular interest is the water channel aquaporin-4 (AQP4) which mislocalises in epilepsy. (dcu.ie)
AQP4 operates in complex with the potassium channel Kir4.1, and their cell surface expression is mediated through the dystrophin-associated protein complex (DAPC) and the extracellular matrix. (dcu.ie)
AQP4 protein expression was also increased while expression of AQP1 protein remained unchanged, and AQP9 was undetected. (ox.ac.uk)
ELISA data showed that p38 and JNK inhibitors decrease AQP4 protein levels in cultured human primary cortical astrocytes. (ox.ac.uk)

Recently determined structures have shed new light on the way that aquaporins act as passive, but selective, pores for the transport of small molecules--such as water or glycerol--across membranes. (ox.ac.uk)
Structure and Stability of the Spinach Aquaporin SoPIP2;1 in Detergent Micelles and Lipid Membranes. (lu.se)
Approximately 25 percent of proteins localize to membranes, where they act as receptors and signaling molecules in biological processes, including respiration, neurotransmission, and molecular transport. (the-scientist.com)
This gene encodes a member of the aquaporin family of intrinsic membrane proteins that function as water-selective channels in the plasma membranes of many cells. (antibodies-online.com)
1 Aquaporins: Proteins that form pores in cell membranes to create water channels. (suntory.com)
If densely packed into the correct size membrane, the channels can pass roughly 80 kilograms of water per second per square meter of membrane, while rejecting salts and protons at rates much higher than current commercial desalination membranes are capable of. (scitechdaily.com)
Their extraordinary water transportation speed and the fact that these channels allow for simpler membrane fabrication suggest they will become a crucial component of next-generation membranes for producing clean water to address severe scarcity facing human beings in this century. (scitechdaily.com)
As explored in Membranes I: Introduction to Biological Membranes , there is a wide variety of embedded components that are essential to the life of the cell, including lipids , carbohydrates, and proteins - many of which regulate what is allowed to pass into and out of the cell (Figure 1). (visionlearning.com)
But biological membranes have pores made of proteins, such as aquaporin, that can separate water from other molecules by both size and charge because of the different types of functional groups, or collections of atoms, lining the channels. (sciencedaily.com)
At around the same time, a group at the University of Utah found that mammalian taste cells make proteins called aquaporins, which serve to channel water through cell membranes. (popsci.com)
It forms a water-specific channel that provides the plasma membranes of red cells and kidney proximal tubules with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient. (ihcworld.com)
Research associates at Amrita's Coimbatore campus have concluded that E.coli aquaporins can be effectively used to develop membranes for desalination of water. (amrita.edu)
Aquaporins or proteins embedded in cell membranes that regulate the flow of water in all living beings can be isolated to make membranes to do the job. (amrita.edu)
Tiny drugs (150-200 Da) with low Po/w values (meaning that they are quite soluble in water) like caffeine, furosemide, and ephedrine are able to passively diffuse through cell membranes via water channels called aquaporins. (drugsandpoisons.com)
Drugs over 200 Da with low Po/w values cannot passively cross membranes and so require specialized protein-based transmembrane transport systems. (drugsandpoisons.com)
Aquaporins are the class of protein that forms pores in the membranes of both plants and animal cells. (lifeeasy.org)
The primary function of most aquaporins is to transport water across cell membranes in response to osmotic gradients created by active solute transport. (shadowebike.com)
In addition to lipids, membranes are loaded with proteins. (shadowebike.com)
In fact, proteins account for roughly half the mass of most cellular membranes. (shadowebike.com)
Proteins are the second major component of plasma membranes. (shadowebike.com)
Aquaporins are water channels found in the cell membranes. (lu.se)

Besides many tiny cavities, this empty internal spa`ce may form cavities of specific functions, as well as tunnels and channels (or pores), representing potential transport pathways for small molecules, ions and water molecules [1] . (plos.org)

Continuous protein pathways are composed of carrier proteins , channels and pumps . (wikibooks.org)
The transport may be active transport by carrier proteins with an energy source, or it may be facilitated diffusion or passive transport via channels. (wikibooks.org)
Are aquaporins carrier proteins? (shadowebike.com)
Carrier proteins and channel proteins are the two major classes of membrane transport proteins. (shadowebike.com)

Proteins span the cell membrane and allow large or charged molecules across the cell membrane. (knowt.com)
The picture shows how a drug (orange) attaches to the aquaporin (purple), resulting in the aquaporin no longer being able to transport molecules across the cell membrane. (lu.se)

This review focuses on emerging topics encompassing the functional involvement of aquaporin channel proteins (AQPs) and membrane transport systems, also allowing permeation of NO and hydrogen peroxide, a major ROS, in oxidative stress physiology and pathophysiology. (hindawi.com)
This notion has been challenged by the discovery of new membrane transport functions, especially those exerted by aquaporins (AQPs), a family of membrane channel proteins widespread in nature [ 10 , 11 ]. (hindawi.com)
Aquaporins (AQPs), ordinarily regarded as water channels, have recently been shown to participate in other cellular functions such as cell-to-cell adhesion, cell migration, cell proliferation etc. (bvsalud.org)
The control of water movement is achieved through a family of small integral membrane channel proteins called aquaporins (AQPs). (ox.ac.uk)
This study uses microarray and ELISA methods to analyse the mRNA and protein expression of the human cerebral AQPs in sclerotic hippocampi (TLE-HS) and adjacent neocortex tissue (TLE-NC) of TLE patients. (ox.ac.uk)
Elucidating the mechanism of selective regulation of different AQPs and associated regulatory proteins may provide a new therapeutic approach to epilepsy treatment. (ox.ac.uk)

Keratinocyte growth factor modulates alveolar epithelial cell phenotype in vitro: expression of aquaporin-5 (AQP5). (hopkinsmedicine.org)
Lithium can substitute for sodium in several sodium channels, particularly the sodium-hydrogen exchanger in the proximal tubule (NHE3), the sodium/potassium/2chloride exchanger in the thick ascending limb of the loop of Henle (NKCC2), and the epithelial channel of the cortical collecting tubule (ENaC). (medscape.com)
Acutely and chronically, lithium salts produce a natriuresis that is associated with an impaired regulation of the expression of the epithelial sodium channel in the cortical collecting tubule. (medscape.com)
Aquaporins are found in a high concentration in the epithelial cells that produce aqueous humor (as well as other epithelial cells that allow water to move readily across their membrane, e.g., epithelial cells in the kidney). (shadowebike.com)
The current investigation was undertaken to find out whether AQP5 water channel plays a role in corneal epithelial wound healing. (bvsalud.org)

Aquaporin-5 (AQP-5) is a protein that in humans is encoded by the AQP5 gene. (wikipedia.org)
AQP5+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH) Human AQP5 genome location and AQP5 gene details page in the UCSC Genome Browser. (wikipedia.org)
Abnormal distribution of AQP5 water channel protein in salivary glands from Sjgrens syndrome patients. (hopkinsmedicine.org)
Aquaporin 5 (AQP5) represents an essential membrane water channel. (bvsalud.org)
7 days of pre-treatment with amoxicillin or single dose of fosfomycin decreased the AQP5 protein level, while 7 days of treatment with doxycycline had no effect. (bvsalud.org)
Aquaporin-5 (AQP5) is a member of the water channel protein family. (bvsalud.org)

Throughout the years, ROS and NO have been widely considered to enter cells by freely diffusing through the cell membrane lipid bilayer and not via specific transporters or channels. (hindawi.com)
Yet, performing structure-function analyses on membrane proteins is challenging because in their native states they are embedded within the plasma membrane's hydrophobic lipid bilayer. (the-scientist.com)
To preserve native membrane protein properties and structures, researchers typically use membrane mimetics to recreate a lipid environment in aqueous solutions. (the-scientist.com)
Widely-used membrane mimetics for protein purification and structure-function studies include detergents, lipid emulsions, nanodiscs, and amphipols. (the-scientist.com)
Even after careful optimization, detergents do not necessarily resemble the native lipid bilayer, and researchers do not always obtain stably solubilized membrane proteins with intact functions. (the-scientist.com)
Moreover, mass photometry works with a variety of membrane proteins and mimetics including detergents, nanodiscs, styrene maleic acid copolymers form self-assembling lipid-protein particles (SMALPs), and amphipols, making it compatible with extant membrane protein purification workflows. (the-scientist.com)
Lipid-specific oligomerization of the Marburg virus matrix protein VP40 is regulated by two distinct interfaces for virion assembly. (uci.edu)
Perilipin 5 (PLIN5) is a lipid-droplet-associated protein that coordinates intracellular lipolysis in highly oxidative tissues and is thought to regulate lipid metabolism in response to phosphorylation by protein kinase A (PKA). (uci.edu)
FLIM-FRET analysis of protein-protein interactions showed that PLIN5 S155 phosphorylation regulates PLIN5 interaction with adipose triglyceride lipase at the lipid droplet, but not with α-β hydrolase domain-containing 5. (uci.edu)
What are the two types of proteins embedded in lipid bilayer of plasma membrane? (shadowebike.com)
Some (more…) Many integral membrane proteins (called transmembrane proteins) span the lipid bilayer, with portions exposed on both sides of the membrane. (shadowebike.com)
By forming a continuous protein pathway across the membrane, these proteins enable specific hydrophilic solutes to cross the membrane without coming into direct contact with the hydrophobic interior of the lipid bilayer. (shadowebike.com)
However, this automatically means that ions, small molecules, proteins and other solutes have differential concentrations across lipid bilayers. (biologydictionary.net)
By looking inspiration in nature we can find Aquaporins, which are selective membrane channel proteins found in the lipid bilayer of living cells that work to transport water across the cell membrane. (being-here.net)

Membrane proteins: Aquaporins--channels without ions. (ox.ac.uk)
Tunnels and channels facilitate the transport of small molecules, ions and water solvent in a large variety of proteins. (plos.org)
Aquaporins accomplish this task while excluding any unwanted ions or other polar molecules, making them a perfect model for the formulation of low-energy water filtration systems. (being-here.net)

Aquaporins are a family of small integral membrane proteins related to the major intrinsic protein (MIP or AQP0). (wikipedia.org)
Aquaporin 1 is a 28-kD integral protein thought at first to be a breakdown product of the Rh polypeptide but was later shown to be a unique molecule that is abundant in erythrocytes and renal tubules. (ihcworld.com)
Integral membrane proteins are permanently embedded within the plasma membrane. (shadowebike.com)
There are two main categories of membrane proteins: integral and peripheral. (shadowebike.com)
The first three types in the Fig. 2 are common forms in integral membrane proteins, such as, transmembrane α-helix protein, transmembrane α-helical protein and transmembrane β-sheet protein. (shadowebike.com)
Integral membrane proteins are embedded in the membrane, usually via α-helical regions of 20 to 25 hydrophobic amino acids. (shadowebike.com)
Facilitated diffusion is a form of facilitated transport involving the passive movement of molecules along their concentration gradient, guided by the presence of another molecule - usually an integral membrane protein forming a pore or channel. (biologydictionary.net)
Aquaporin (AQP) water channels are small hydrophobic integral membrane proteins. (bvsalud.org)

To solve this problem, the cell membrane contains proteins that are selective for unique, water soluble molecules. (wikibooks.org)
Proteins embedded within the phospholipid bilayer carry out the specific functions of the plasma membrane, including selective transport of molecules and cell-cell recognition. (shadowebike.com)

To aid our understanding of the physiology of the epidermal barrier, we perform cell and molecular biology studies on proteins identified in association with rare skin diseases that manifest as barrier defects. (qmul.ac.uk)
Dr. King's research focus early in his tenure was the biology of aquaporin water channel proteins in the respiratory tract as well as other tissues. (hopkinsmedicine.org)
Karin Lindkvist at the Department of Cell and Molecular Biology and Richard Neutze at the Department of Chemistry, University of Gothenburg have determined the three-dimensional structure of the yeast aquaporin. (expertsvar.se)
What is aquaporins in biology? (shadowebike.com)
It seems that cancer cells may increase the number of aquaporins to enhance their own survival and increase their spreading ability, says Karin Lindkvist, professor of cell biology at Lund University and structural biology researcher. (lu.se)

Expression of Aquaporin-1 water channel protein in mouse erythro-leukemia cells: genetic regulation of corticosteroid and chemical induction. (hopkinsmedicine.org)
TFP acts on doughnut-shaped water channel proteins, called aquaporins, in brain cells. (lightsource.ca)
Water rushes from the outside through these doughnut-shaped proteins, into the cells that then swell," Dr. Salman said. (lightsource.ca)
TFP stops this from happening by preventing a signal that would normally cause more aquaporin channels to rise to the surface of brain cells. (lightsource.ca)
In a new paper published today (May 20, 2021) in Nature Nanotechnology , researchers created a molecule-sized water transport channel that can carry water between cells while excluding protons and undesired molecules. (scitechdaily.com)
The aquaporins, which are common in other types of cells, provide a possible way for water to stimulate taste cells directly. (popsci.com)
DEC-205 (CD205), a member of the macrophage mannose receptor protein family, is the prototypic endocytic receptor of dendritic cells, whose ligands include phosphorothioated cytosine-guanosine (CpG) oligonucleotides, a motif often seen in bacterial or viral DNA. (uci.edu)
Aquaporins are proteins that regulate the flow of water in and out of cells. (lu.se)
Now, a research group at Lund University has succeeded in finding a drug candidate that binds to the protein, something that has been shown to affect the growth capability of leukemia cells. (lu.se)
Aquaporins are central to many mechanisms in our cells , and also play a crucial role in several health conditions such as cancer and type 2 diabetes. (lu.se)
They have also shown that the drug affects the growth capability of leukemia cells by inactivating aquaporins. (lu.se)
By understanding the structure of the protein , and how drugs attach to it, we are trying to comprehend how cancer cells respond to new drug candidates. (lu.se)

Antibodies and other recombinant proteins and peptides like ADH or insulin range into the thousands of daltons (insulin is about 6000 Da). (drugsandpoisons.com)

Takata K, Matsuzaki T, Tajika Y. Aquaporins: water channel proteins of the cell membrane. (benthamscience.com)
These act as water channels and control the flow of water into and out from the cell. (expertsvar.se)
Preincubation in 0.1 mM HgCl(2), a standard aquaporin inhibitor, prevented such cell swelling. (wikigenes.org)
MARV assembles and buds from the host cell plasma where MARV matrix protein (mVP40) dimers associate with anionic lipids at the plasma membrane inner leaflet and undergo a dynamic and extensive self-oligomerization into the structural matrix layer. (uci.edu)
The water molecules move in and out of the cell through this water channels. (lifeeasy.org)
A membrane protein is a protein molecule that is attached to, or associated with, the membrane of a cell or an organelle. (shadowebike.com)
A transport protein in the plasma membrane of a plant or animal cell that specifically facilitates the diffusion of water across the membrane (osmosis) concentration gradient. (shadowebike.com)
The mammalian aquaporins, which number about a dozen, are expressed in many cell types involved in fluid transport, including epithelia and endothelia in kidney, lung, exocrine glands, eye and gastrointestinal organs. (shadowebike.com)
Why are proteins embedded in the cell membrane? (shadowebike.com)
The three main types of proteins embedded in the cell membrane are receptors, channels and markers. (shadowebike.com)
What protein is embedded in the cell membrane? (shadowebike.com)

Annotation of Selaginella moellendorffii major intrinsic proteins and the evolution of the protein family in terrestrial plants. (lu.se)
Phylogeny of major intrinsic proteins. (lu.se)

Structural mechanism of plant aquaporin gating. (lu.se)
Structural and functional studies of the glycerol channel aquaporin 7. (lu.se)
A unique structural feature in these new channels is a series of folds in the channels that create additional "lanes," so to speak, allowing water molecules to be transported faster. (scitechdaily.com)
The study's results will be presented at the international conference Bioinformatica Indica 2010 during January 11-13, 2010 as a paper titled In-Silico Analysis (Structural and Sequence) of Aquaporins . (amrita.edu)

Affinity tags can reduce merohedral twinning of membrane protein crystals. (lu.se)
Mass photometry advances membrane protein characterization by offering fast and precise mass measurements of samples containing membrane mimetics. (the-scientist.com)
1 Mass photometry is a bioanalytical characterization technology that can help researchers characterize membrane protein properties, such as oligomerization or other complex formations and assess the purity of samples containing membrane proteins. (the-scientist.com)
Membrane protein purification using mimetics requires numerous steps and different protocols depending on the protein of interest. (the-scientist.com)
Using mass photometry to count and measure the mass of the single membrane protein in solution allows researchers to gain valuable information on the purity and stability of their samples. (the-scientist.com)
The structure has been determined using X-ray crystallography and is the highest resolution structure that has been determined for a membrane protein. (expertsvar.se)

These artificial channels in essence solve the critical technical challenges of only allowing water molecules to pass while excluding other solutes like salt and protons," said professor Huaqiang Zeng of Department of Chemistry at Hainan University and the Institute of Advanced Synthesis at Northwestern Polytechnical University in China. (scitechdaily.com)
This means that only water molecules are allowed to pass through the aquaporin channel leading to production of truly pure water. (being-here.net)
Smaller molecules, for instance nitrates have restricted passage as their electrochemical properties do not "fit", since the architecture of the aquaporin channel allows water molecules to pass only in single file while electrostatic tuning of the channel interior controls aquaporin selectivity against any charged species. (being-here.net)

Aquaporins are multifunctional water and solute transporters highly divergent in living organisms. (benthamscience.com)

HvPIP1;6, a Barley (Hordeum vulgare L.) Plasma Membrane Water Channel Particularly Expressed in Growing Compared with Non-Growing Leaf Tissues. (lu.se)
Molecular cloning of a mercurial-insensitive water channel expressed in selected water-transporting tissues. (benthamscience.com)
Aquaporins in complex tissues: I. Developmental patterns in respiratory tract and glandular tissue of rat. (hopkinsmedicine.org)
Aquaporins in complex tissues: II. (hopkinsmedicine.org)
Proteins repair and build body tissues, allow metabolic reactions to take place (enzymes), coordinate body functions such as waste removal, protect the body from pathogens (immune system). (knowt.com)

Increasing gene dosage greatly enhances recombinant expression of aquaporins in Pichia pastoris. (lu.se)

As a postdoctoral fellow and later, after joining the faculty as an assistant professor in 1997, he undertook important studies of water channels in the lung with 2003 Nobel Laureate Peter Agre. (hopkinsmedicine.org)

Igarashi H, Huber VJ, Tsujita M, Nakada T. Pretreatment with a novel aquaporin 4 inhibitor, TGN-020, significantly reduces ischemic cerebral edema. (benthamscience.com)

these are called transmembrane proteins. (shadowebike.com)

Here, we propose a molecular mechanism where the AQP7 mobility in adipocytes is dependent on perilipin 1 and protein kinase A. Biochemical analyses combined with ex vivo studies in human primary adipocytes, demonstrate that perilipin 1 binds to AQP7, and that catecholamine activated protein kinase A phosphorylates the N-terminus of AQP7, thereby reducing complex formation. (lu.se)
In the poster section, Joanna Shisler (University of Illinois at Urbana-Champaign [UIUC], Urbana) reported that the modified virus, Ankara, activates nuclear factor κB through the mitogen-activated protein kinase, extracellular signal–regulated kinase (MEK)/extracellular signal–regulated kinase (ERK) pathway, possibly facilitating the host immune response. (cdc.gov)

Characteristics of individual transport pathways, including their geometry, physico-chemical properties and dynamics are instrumental for understanding of structure-function relationships of these proteins, for the design of new inhibitors and construction of improved biocatalysts. (plos.org)
The structure of the yeast aquaporin that we have determined can be used to create inhibitors for human aquaporins, and this may in the long term lead to drugs that slow the growth of a cancer tumour", says Karin Lindkvist. (expertsvar.se)

Purification and characterization of two protein kinases acting on the aquaporin SoPIP2;1. (lu.se)
Mass photometry offers a powerful solution for the characterization of membrane proteins. (the-scientist.com)
Compared to other protein characterization techniques, such as SDS-PAGE and HPLC, mass photometry offers several unique advantages. (the-scientist.com)

Explain the relationship between the active site and the conformation of the protein. (quizlet.com)

Aquaporin-1 water channel protein in lung: ontogeny, steroid-induced expression, and distribution in rat. (hopkinsmedicine.org)
Genomic organization and developmental expression of aquaporin-5 in lung. (hopkinsmedicine.org)
The effects of trifluoperazine on brain edema, aquaporin-4 expression and metabolic markers during the acute phase of stroke using photothrombotic mouse model. (lightsource.ca)
As microRNAs regulate gene expression post-transcriptionally, the changed EV content in disease may cause changes in BBB-related proteins, affecting barrier strength. (dcu.ie)
In melanoma, i have focused in acral lentiginous melanoma for which we described KIT mutation and protein expression status in a large series of cases and described TERT amplification in progression to metastasis. (mdanderson.org)
Transcriptome analysis suggests a role for the differential expression of cerebral aquaporins and the MAPK signalling pathway in human temporal lobe epilepsy. (ox.ac.uk)

These transporters can be active (pumps) or passive (channels) and are sometimes regulated by gates. (visionlearning.com)
Aquaporins are channels, i.e. passive transporters where water always moves down its water potential gradient. (shadowebike.com)

The human Aquaporin-5 gene. (wikipedia.org)
Unexpected complexity of the Aquaporin gene family in the moss Physcomitrella patens. (lu.se)
Yang B, Ma T, Verkman A. cDNA cloning, gene organization, and chromosomal localization of a human mercurial insensitive water channel evidence for distinct transcriptional units. (benthamscience.com)

Transcriptional regulation of aquaporins in accessions of Arabidopsis in response to drought stress. (lu.se)

Reconstitution of water channel function and 2D-crystallization of human aquaporin 8. (lu.se)
High-resolution x-ray structure of human aquaporin 5. (lu.se)
Find Aquaporin 4 ELISA Kits for a variety of species such as anti-Cow Aquaporin 4, anti-Human Aquaporin 4, anti-Mouse Aquaporin 4. (antibodies-online.com)
Tokyo, Japan, March 31, 2015 - Keio University (Head office: Minato-ku, Tokyo, President: Atsushi Seike) and Suntory Global Innovation Center Ltd., (Head office: Minato-ku, Tokyo, President: Masato Arishiro) will launch their joint research project, "Water Channeling Life" on April 1st in order to promote research about water channeling in the human body and its relation to health. (suntory.com)
As the public is paying more attention to the relationship between water and health, this three-year project will continue to clarify water channeling and its states inside the human body and how water is related to the maintenance of life and health by leveraging the expertise of the two institutions. (suntory.com)
Therefore, this joint research project will allow both institutions to take advantage of each other's specialties, academia and the private sector, respectively, and help accelerate research on water channeling in the human body while dispatching the results throughout society to improve the quality of life for all people. (suntory.com)
The logo of this project consists of a blue line in the image of water channeling in the human body. (suntory.com)
Amrita's study compared human and E.coli aquaporins and concluded that the latter were better. (amrita.edu)
Sensitivity The minimum detectable dose of Human AQP-1 is 75pg/mL (The sensitivity of this assay, or lowest detectable limit (LDL) was defined as the lowest protein concentration that could be differentiated from zero). (biobool.com)
Here we describe the 3.2 Å cryo-EM structure of human DEC-205, thereby illuminating the structure of the mannose receptor protein family. (uci.edu)

The main aim of our research is to understand the molecular details and physiological roles of the multitude of water channel-like proteins present in plants and animals. (lu.se)
In addition we have recently started to explore the structure and molecular function of pain receptors from animals, i.e. transient receptor potential (TRP) ion channels, and their activation by temperature and various ligands. (lu.se)
It measures proteins' true molecular mass instead of relying on surrogate measures to predict molecular weights. (the-scientist.com)

By channel we mean a pathway leading throughout the protein structure, without any interruption by an internal cavity, with both sides open to the surrounding solvent. (plos.org)
By tunnel we mean a pathway connecting a protein surface with an internal cavity or a pathway connecting more than one internal cavity. (plos.org)

Find Aquaporin 4 ELISA Kits with a specific Detection Method. (antibodies-online.com)
Find Aquaporin 4 ELISA Kits with a specific Sample. (antibodies-online.com)

How does presence of aquaporins affect osmosis? (lifeeasy.org)
What are aquaporins in osmosis? (shadowebike.com)

Most aquaporins are selectively permeated by water, although some family members are permeated by other small molecules. (shadowebike.com)

Therefore, it 's interesting to try to develop new drugs that block the activity of aquaporins. (lu.se)

These channels facilitate speedy transport of molecules you want, like water, and block those you don't want, like salt. (scitechdaily.com)

Transport pathways play an essential role in the functioning of a large number of proteins. (plos.org)

Computer simulations and biological experiments suggest that the channel is regulated with a combination of mechanical regulation and phosphorylation", says Karin Lindkvist. (expertsvar.se)

Aquaporin-based channels are so small that they only allow a single molecule of water through at a time, like a single-lane road. (scitechdaily.com)

The encoded protein is the predominant aquaporin found in brain. (antibodies-online.com)
Aquaporins are found in most organisms, and are believed to be involved in several diseases, including cancer. (expertsvar.se)
These proteins have been found to play a role in both cancer and type 2 diabetes. (lu.se)

Anatomy27

Organisms17

Diseases5

Chemicals and Drugs137

Analytical, Diagnostic and Therapeutic Techniques and Equipment17

Phenomena and Processes47

Disciplines and Occupations4

Technology, Industry, Agriculture1

Information Science4

AQP47

Membranes21

Pores1

Carrier proteins4

Molecules across the cell membrane2

AQPs6

Epithelial5

AQP56

Lipid14

Ions3

Integral8

Selective2

Biology5

Cells12

Peptides1

Cell11

Intrinsic2

Structural4

Membrane protein6

Water molecules3

Solute1

Tissues5

Recombinant1

19971

Inhibitor1

Transmembrane1

Kinase2

Inhibitors2

Characterization3

Conformation1

Expression6

Transporters2

Gene3

Transcriptional1

Human10

Molecular3

Pathway2

ELISA2

Osmosis2

Family1

Drugs1

Transport of molecules1

Pathways1

Phosphorylation1

Small1

Found3