Aquaporin 8 proteins glycerol aquaporin 3. Medical search. Frequent questions

The aquaporins (AQPs) are a family of transmembrane proteins forming water channels. (edu.sa)
Some AQPs (aquaglyceroporins) also exhibit glycerol and urea permeability. (edu.sa)
By RT-PCR on primary cell cultures, we found that up to 6 different AQPs (AQP1, 3, 5, 7, 9 and 10) may be selectively expressed in various cells from human skin. (edu.sa)
This review focuses on emerging topics encompassing the functional involvement of aquaporin channel proteins (AQPs) and membrane transport systems, also allowing permeation of NO and hydrogen peroxide, a major ROS, in oxidative stress physiology and pathophysiology. (hindawi.com)
This notion has been challenged by the discovery of new membrane transport functions, especially those exerted by aquaporins (AQPs), a family of membrane channel proteins widespread in nature [ 10 , 11 ]. (hindawi.com)
AQPs are essential membrane protein that operate Proscillaridin A as drinking water channels. (thekingsfoundation.org)
Nevertheless, this isn't a widely approved regulatory system for mammalian AQPs (8). (healthanddietblog.info)
From the 13 known AQPs in (-)-Epicatechin IC50 our body, AQP1 (16), AQP3 (17), and AQP5 (18) likewise have been proven to endure translocation towards the plasma membrane in response to hormonal activation of particular G protein-coupled receptors. (healthanddietblog.info)
Aquaporins (AQPs) are transmembrane water channels and some of them are permeable in addition to water to other small solutes including hydrogen peroxide. (bvsalud.org)
Aquaporins (AQPs) are water channel proteins that play a significant role in drought stress. (bvsalud.org)
Aquaporins (AQPs) are a family of transmembrane proteins present in all species that can be roughly divided into three subfamilies according to structure and function: 1) classical AQP, 2) aquaglyceroporin, and 3) superaquaporin. (bvsalud.org)
Various recent studies suggest that membrane channel proteins, named aquaporin (AQPs), by affecting stomatal conductance behavior could be involved in plant responses to stress conditions. (ac.ir)
The sunTIP7 gene is a member of AQPs protein that is included in different environmental stress such as drought stress. (ac.ir)
مطالعات متعدد اخیر نشان می-دهد که پروتئین-های کانال غشایی به نام Aquaporin (AQPs) با تأثیر بر رفتار هدایت روزنه می- توانند در پاسخ گیاهان به شرایط تنش نقش داشته باشند. (ac.ir)
2] "Aquaporins (AQPs) are water channels that facilitate transepithelial water transport across plasma membranes following an osmotic gradient [3]. (irosacea.org)
Aquaporins (AQPs) facilitate transport of water and small solutes across cell membranes and play an important role in different physiological processes in plants. (biomedcentral.com)
Phylogenetic analysis showed similar numbers of AQPs clustered in five distinct subfamilies including the plasma membrane intrinsic proteins (PIPs), the tonoplast intrinsic proteins (TIPs), the nodulin 26-like intrinsic proteins (NIPs), the small basic intrinsic proteins (SIPs), and the uncharacterized intrinsic proteins (XIPs). (biomedcentral.com)
Aquaporins (AQPs) are small (21-34 kD) integral membrane proteins, which form channels facilitating movement of water and other small solutes across the cell membrane. (biomedcentral.com)
In primitive land plants, two additional unique classes of AQPs, GlpF-like intrinsic protein (GIPs) and hybrid intrinsic proteins (HIPs) have been described and are presumed to have been lost in the course of evolution [ 12 ]. (biomedcentral.com)
History: Aquaporins (AQPs) users of a superfamily of transmembrane channel SP600125 proteins are ubiquitous in all domains of existence. (techuniq.com)

To understand the role of aquaglyceroporins in skin, we examined the relevance to human skin of the conclusion, from studies on mice, that skin AQP3 is only important for glycerol transport. (edu.sa)
2) the lifetime of various other aquaglyceroporins that use aquaporin-7 to ensure glycerol efflux and therefore a standard adiposity in human beings. (thekingsfoundation.org)
Glycerol and Drinking water permeability measurements using adipocytes and adipose membrane vesicles confirmed the current presence of working aquaglyceroporins. (thekingsfoundation.org)
The appearance of two aquaglyceroporins in individual adipose tissue is specially very important to the maintenance of regular or low glycerol items in the adipocyte, safeguarding individuals from obesity thus. (thekingsfoundation.org)
the aquaglyceroporins) are permeable to both drinking water and small nonionic molecules such as for example glycerol, urea, and ammonia (3, 4, 6). (healthanddietblog.info)
Aquaporins and aquaglyceroporins belong to the ancient superfamily of Major Intrinsic Proteins (MIPs) and facilitate passive transport of water and small solutes across membranes of various organisms [ 1 , 2 ]. (biomedcentral.com)

However, because water is a polar molecule this process of simple diffusion is relatively slow, and in tissues with high water permeability the majority of water passes through aquaporin. (wikipedia.org)
Aquaporin-10 silencing in FN1 individual differentiated adipocytes led to a 50% loss of glycerol and osmotic drinking water permeability. (thekingsfoundation.org)
[6] . Others have shown a similar change in paracellular permeability regulated by AQP5 in salivary glands, however in that system it was associated with alterations in claudin-7, claudin-3, and occludin [5] . (plos.org)

Biochimica et Biophysica Acta - Biomembranes , 1758 (8), 1034-1042. (edu.sa)
Biochimica et Biophysica Acta (BBA) - Biomembranes 2012, 1818 (3):839-850. (lu.se)

Water moves through cells in an organized way, most rapidly in tissues that have aquaporin water channels. (wikipedia.org)
AVI) pone.0054474.s002.avi (1.0M) GUID:?A9939A40-B32F-44EF-9990-5144610DE6C8 Abstract Background Glycerol outflow from adipocytes continues to be considered for ten years to become mediated by aquaporin-7, an aquaglyceroporin expressed in the adipose tissues highly. (thekingsfoundation.org)
Technique/Primary Findings -10 and Aquaporin-7 were portrayed in the white adipose tissues both at mRNA with protein level. (thekingsfoundation.org)
Immunofluorescence uncovered aquaporin-7 and -10 labelling in the individual adipose tissues both towards the plasma membrane also to a slim rim of cytoplasm of adipocytes. (thekingsfoundation.org)
Conclusions/Significance The full total outcomes indicate that aquaporin-7, from mice differently, exists in both capillary and adipocyte plasma membranes of individual adipose tissues. (thekingsfoundation.org)
Launch When working out and fasting, adipose tissues triglycerides are hydrolyzed into glycerol and free of charge essential fatty acids, and both items are released in to the bloodstream by different transportation systems [1], [2]. (thekingsfoundation.org)
AQP7 is certainly abundantly portrayed in mammal adipose tissues where represents the original pathway for glycerol transmembrane movement. (thekingsfoundation.org)
Dr. King's research focus early in his tenure was the biology of aquaporin water channel proteins in the respiratory tract as well as other tissues. (hopkinsmedicine.org)
Aquaporins in complex tissues: I. Developmental patterns in respiratory tract and glandular tissue of rat. (hopkinsmedicine.org)
Aquaporins in complex tissues: II. (hopkinsmedicine.org)
Bacteria of the genus Pseudomonas comprise a diverse group of microorganisms that can be isolated from different environments including fresh water, salt water, soil, internal tissues of plants, and food [ 8 ]. (biomedcentral.com)
Perilipin 5 (PLIN5) is a lipid-droplet-associated protein that coordinates intracellular lipolysis in highly oxidative tissues and is thought to regulate lipid metabolism in response to phosphorylation by protein kinase A (PKA). (uci.edu)

In conclusion, we suggest that in addition to glycerol, AQP3 may be important for water transport and hydration in human skin epidermis. (edu.sa)
Here, we report that aquaporin 3 (AQP3), a channel protein that mediates the transport of water/glycerol, was highly expressed in the epidermis and CD4+ T cells of both rosacea patients and experimental mice. (irosacea.org)
1] "Aquaporin 3 (AQP-3) is the protein product of the human AQP3 gene. (irosacea.org)
we previously demonstrated that aquaporin 3 (AQP3) is expressed in goblet cells and is positively correlated with GIM severity. (oncotarget.com)
However, the relationships of AQP3 with GIM classification and with other proteins, and their roles in the transition from GIM to gastric carcinoma (GC) remain unknown. (oncotarget.com)

Genetic defects involving aquaporin genes have been associated with several human diseases including nephrogenic diabetes insipidus and neuromyelitis optica. (wikipedia.org)
The isolate showed several genes that are associated with resistance to environmental stresses, such as genes encoding heat/cold shock proteins, antioxidant enzymes, carbon starvation proteins, proteins that control osmotic balance and biofilm formation. (biomedcentral.com)

Phylogenetic analysis of plant MIP sequences revealed four major subfamilies: the plasma membrane intrinsic proteins (PIPs), tonoplast intrinsic proteins (TIPs), nodulin 26-like intrinsic proteins (NIPs) and small and basic intrinsic proteins (SIPs). (biomedcentral.com)

Aquaporins selectively conduct water molecules in and out of the cell, while preventing the passage of ions and other solutes. (wikipedia.org)
The major intrinsic proteins (MIPs) facilitate the transport of water and neutral solutes across the lipid bilayers. (biomedcentral.com)

Aquaporins are transmembrane proteins that form water channels to allow water to be actively transported across the cell membrane. (charlottetilbury.com)

Aquaporins, also called water channels, are channel proteins from a larger family of major intrinsic proteins that form pores in the membrane of biological cells, mainly facilitating transport of water between cells. (wikipedia.org)
Annotation of Selaginella moellendorffii major intrinsic proteins and the evolution of the protein family in terrestrial plants. (lu.se)
Phylogeny of major intrinsic proteins. (lu.se)

Increasing gene dosage greatly enhances recombinant expression of aquaporins in Pichia pastoris. (lu.se)
Unexpected complexity of the Aquaporin gene family in the moss Physcomitrella patens. (lu.se)
Direct rules by AQP gene manifestation and/or AQP proteins degradation may be accomplished over a period level from hours to times (9, 10). (healthanddietblog.info)
After cell sorting, the gene expressions of membrane proteins in early and late erythropoiesis precursors and in nonerythroid cells were characterized using microarray analysis. (biomedcentral.com)
Among characterized gene candidates, aquaporin 0 (AQP0) expressed as a surface protein in early- and late-stage erythropoiesis precursors and was not expressed on nonerythroid cells. (biomedcentral.com)
As we all know, genomics and proteomics explore life activities at the gene and protein levels respectively, but in fact many life activities in cells occur at the metabolite level, such as cell signal release, energy transfer and intercellular communication, etc. are all affected by metabolites regulation. (creative-proteomics.com)
The corresponding gene, AtWRINKLED1 ( AtWRI1, At3g54320), encodes a protein with two APETALA2-ethylene responsive element-binding protein (AP2/EREBP) motifs that is a signature for plant-specific transcription factors involved in a wide range of developmental processes [ 5 , 6 ]. (biomedcentral.com)

One study examined the roles of aquaporin 3 and aquaporin 10, which are water/glycerol channel proteins located in the epidermis, and concluded that overexpression of these channels may play a role. (medscape.com)

Plasma membrane intrinsic proteins (PIPs), tonoplast intrinsic proteins (TIPs), Nod26-like intrinsic protein (NIPs) and small and basic intrinsic proteins (SIPs) are subfamilies of plant MIPs. (biomedcentral.com)

The cell membranes of a variety of different bacteria, fungi, animal and plant cells contain aquaporins through which water can flow more rapidly into and out of the cell than by diffusing through the phospholipid bilayer. (wikipedia.org)
However the first report of protein-mediated water transport through membranes was by Gheorghe Benga and others in 1986, prior to Agre's first publication on the topic. (wikipedia.org)
Structure and Stability of the Spinach Aquaporin SoPIP2;1 in Detergent Micelles and Lipid Membranes. (lu.se)
To maintain optimal water levels, Aquaporin water channels facilitate the movement of large amounts of water, transporting it through cell membranes and plasma membranes to ensure our cells have plenty of water, helping to prevent water loss. (charlottetilbury.com)
During vesiculation, bioactive lipids and receptors re- main associated with vesicle membranes, and cytosolic proteins and nucleic acids are contained within the vesicles [11]. (unicyte.ch)
These two levels serve degraded by a phosphorylation including at least 6 membranes in a such tail that both leaves the 2' disorder ubiquitination and adducts the 3' heart to the 5' cell. (evakoch.com)

Affinity tags can reduce merohedral twinning of membrane protein crystals. (lu.se)
Multi-pass membrane protein. (cusabio.com)
Examples of function annotation using dissectHMMER, including the function discovery of an uncharacterized membrane protein Q9K8K1_BACHD (WP_010899149.1) as a lactose/H+ symporter, are presented. (beds.ac.uk)

The 3' replication has freely activated by RNase Z surface, a mature binding in receptors( reviewed in Maraia and Lamichhane 2011). (evakoch.com)

Annotation transfer for function and structure within the sequence homology concept essentially requires protein sequence similarity for the secondary structural blocks forming the fold of a protein. (beds.ac.uk)
The sequence homology concept [ 1 - 3 ] is collectively founded upon the inductive reasoning that a homologous protein group (as an antecedent) shares a high level of sequence similarity (as a consequent) [ 4 - 8 ]. (beds.ac.uk)

2016, 8(3), 681-704. (molquest.com)

Structural mechanism of plant aquaporin gating. (lu.se)
The key arguments for carbon-based life are the ubiquity of organic (carbon-containing) compounds in the universe and the ability of carbon to form stable compounds with many elements, thus creating the wide variety of structural, catalytic, and informational macromolecules (very large molecules, such as DNA and proteins) that make up Earth life. (nationalacademies.org)
Implicitly, this refers to a high level of similarity among comparable structural elements across the sequences so that a common structural fold among these homologs is maintained which, in turn, governs the general biological function of this homologous protein family. (beds.ac.uk)
MARV assembles and buds from the host cell plasma where MARV matrix protein (mVP40) dimers associate with anionic lipids at the plasma membrane inner leaflet and undergo a dynamic and extensive self-oligomerization into the structural matrix layer. (uci.edu)

Vol. 1758, No. 8. (edu.sa)
Biochim Biophys Acta 2006, 1758 (8):1157-1164. (lu.se)

Purification and characterization of two protein kinases acting on the aquaporin SoPIP2;1. (lu.se)

Aquaporins are multifunctional water and solute transporters highly divergent in living organisms. (benthamscience.com)

TIF) pone.0054474.s001.tif (361K) GUID:?8B48F563-BB0C-40F3-A790-0C68C8A51508 Movie S1: Subcellular localization of aquaporin-10 (AQP10) in individual cultured differentiated adipocytes after insulin excitement. (thekingsfoundation.org)
Subcellular localization prediction of predicted BoGST proteins was performed using Protcomp 9.0 from Softberry [96]. (molquest.com)

Two hydrophobic loops contain conserved asparagine-proline-alanine ("NPA motif") which form a barrel surrounding a central pore-like region that contains additional protein density. (wikipedia.org)
Also known as water channels, aquaporins are integral membrane pore proteins. (wikipedia.org)
Using artifcial sweat containing bovine serum albumin as a model protein, we performed experiments under fowing conditions to demonstrate that pore clogging results from the aggregation of proteins by aluminium polycations at specifc location in the sweat pore. (espci.fr)

Expression and function of aquaporins in human skin: Is aquaporin-3 just a glycerol transporter? (edu.sa)
Dive into the research topics of 'Expression and function of aquaporins in human skin: Is aquaporin-3 just a glycerol transporter? (edu.sa)
Transporter that facilitates the transmembrane diffusion of water, dihydroxyacetone, glycerol and H(2)O(2). (cusabio.com)

It was not until 1992 that the first aquaporin, 'aquaporin-1' (originally known as CHIP 28), was reported by Peter Agre, of Johns Hopkins University. (wikipedia.org)

The main aim of our research is to understand the molecular details and physiological roles of the multitude of water channel-like proteins present in plants and animals. (lu.se)
Molecular Membrane Biology 2013, 30 (3):246-260. (lu.se)
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors. (novusbio.com)
Major Conclusions: As(OH)3 and Sb(OH)3 behave as inorganic molecular mimics of glycerol a property that allows their passage through AQP channels. (techuniq.com)

Aquaporin-9 Protein Is the Primary Route of Hepatocyte Glycerol Uptake for Glycerol Gluconeogenesis in Mice. (lu.se)

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. (cusabio.com)
The stargazin-related protein γ7 interacts with the mRNA-binding protein heterogeneous nuclear ribonucleoprotein A2 and regulates the stability of specific mRNAs, including Cav2. (google.cl)

Keratinocyte growth factor modulates alveolar epithelial cell phenotype in vitro: expression of aquaporin-5 (AQP5). (hopkinsmedicine.org)

Transcriptional regulation of aquaporins in accessions of Arabidopsis in response to drought stress. (lu.se)
The effects of the loss of TIP1;1 and TIP1;2 aquaporins in Arabidopsis thaliana. (lu.se)

In 1990, Verkman's experiments demonstrated functional expression of water channels, indicating that water channels are effectively proteins. (wikipedia.org)
Aquaporin-1 water channel protein in lung: ontogeny, steroid-induced expression, and distribution in rat. (hopkinsmedicine.org)
Expression of Aquaporin-1 water channel protein in mouse erythro-leukemia cells: genetic regulation of corticosteroid and chemical induction. (hopkinsmedicine.org)
Genomic organization and developmental expression of aquaporin-5 in lung. (hopkinsmedicine.org)
Based on the differential expression levels of cell-surface molecules during erythropoiesis, flow cytometry analysis is a useful tool for analyzing the erythropoiesis process [ 8 ]. (biomedcentral.com)

Protein structure evaluation showed a hydrophilic aromatic/arginine (ar/R) selectivity filter (SF) in PIPs whereas other subfamilies mostly contained a hydrophobic ar/R SF. (biomedcentral.com)

Glycerol efflux from adipocytes takes place via a particular glycerol route that is one of the aquaporin (AQP) family members, known as AQP7 [2], [3]. (thekingsfoundation.org)

Triglycerides are lipid compounds composed of a glycerol esterified to 3 fatty acid chains of varying length and composition. (medscape.com)

BMC Plant Biology 2008, 8 (1):45. (lu.se)

He was elected to the American Society for Clinical Investigation in 2006 for work on aquaporin water channels. (hopkinsmedicine.org)
Water is kept out of cells by lipid bilayers, and so, it relies on Aquaporin water channels to act as an open gateway that allows entry into our cells. (charlottetilbury.com)

In turn, fold conservation implies the conservation of a sequence pattern of hydrophilic/hydrophobic and size-restricted residues within the protein family. (beds.ac.uk)
MIPs in plants are abundant and constitute a large and highly divergent protein family. (biomedcentral.com)
The high-resolution structures of several members of MIP family have been determined and are available in the Protein Data Bank (PDB) [ 15 ]. (biomedcentral.com)
DEC-205 (CD205), a member of the macrophage mannose receptor protein family, is the prototypic endocytic receptor of dendritic cells, whose ligands include phosphorothioated cytosine-guanosine (CpG) oligonucleotides, a motif often seen in bacterial or viral DNA. (uci.edu)
Here we describe the 3.2 Å cryo-EM structure of human DEC-205, thereby illuminating the structure of the mannose receptor protein family. (uci.edu)

Interestingly, however, results suggested that impaired glycerol, rather than water transport was responsible for this phenotype. (edu.sa)
The most common type of Aquaporin in the skin is Aquaporin-3 which is known to help transport water from the skin's surface into skin cells. (charlottetilbury.com)
however, scientists learnt more about Aquaporin and water transport after recognising its ability to regulate the flow of water. (charlottetilbury.com)

Furthermore, against the backdrop that the number of well-studied proteins continues to grow at a slow rate, it necessitates for a search methodology to dive deeper into the sequence similarity space to connect the unknown sequences to the well-studied ones, albeit more distant, for biological function postulations. (beds.ac.uk)

and would depend on calmodulin activation and phosphorylation of AQP1 at two threonine residues by proteins kinase C. This immediate mechanism offers a rationale for the adjustments in drinking water transportation that are needed in response to continuously changing local mobile drinking water availability. (healthanddietblog.info)
The very best studied exemplory case of this is actually the legislation of AQP2 translocation in individual kidney cells, which would depend on vasopressin-mediated activation of proteins kinase A with the G protein-coupled receptor, vasopressin V2 receptor (15). (healthanddietblog.info)
We recently confirmed that elevated translocation of AQP1 is certainly triggered upon this speedy timescale by hypotonic stimulus in a particular proteins kinase C (PKC)- and microtubule-dependent way (19). (healthanddietblog.info)

The 2003 Nobel Prize in Chemistry was awarded jointly to Peter Agre for the discovery of aquaporins and Roderick MacKinnon for his work on the structure and mechanism of potassium channels. (wikipedia.org)

ELAC1 has been in the use and may as define as an RNase Z. In pyrophosphates subfamilies are transcribed from coupling tubules in the function by a two receptor chromatin that appears ultraviolet from protein threatening( reviewed in Popow et al. (evakoch.com)

Within this research, we combined laser (-)-Epicatechin IC50 beam scanning confocal microscopy of chimeras of AQP1 with green fluorescent proteins (AQP1-GFP), calcium mineral imaging, and mutagenesis to determine that AQP1 translocation underpins the rules of cellular drinking water flow, as assessed by adjustments in cell quantity. (healthanddietblog.info)

Identification of selective inhibitors of the potassium channel Kv1.1-1.2(3) by high-throughput virtual screening and automated patch clamp. (mpg.de)

Abnormal distribution of AQP5 water channel protein in salivary glands from Sjgrens syndrome patients. (hopkinsmedicine.org)
Aquaporin-5 (AQP5) is a water-specific channel located on the apical surface of airway epithelial cells. (plos.org)
Aquaporin-5 (AQP5) is a water-specific channel located on the apical membrane of epithelial cells in several sites in mammals, including corneal and pancreatic epithelium, secretory cells in salivary and lacrimal glands, and airway submucosal glands, bronchial epithelium and type I pneumocytes of the respiratory tract. (plos.org)
In both studies, mechanisms by which AQP5 altered these proteins were not further elucidated. (plos.org)

Overexpression of a plasma membrane aquaporin in transgenic tobacco improves plant vigor under favorable growth conditions but not under drought or salt stress. (ac.ir)

Because aquaporins are usually always open and are prevalent in just about every cell type, this leads to a misconception that water readily passes through the cell membrane down its concentration gradient. (wikipedia.org)
Plant and Cell Physiology 2007, 48 (8):1132-1147. (lu.se)
Takata K, Matsuzaki T, Tajika Y. Aquaporins: water channel proteins of the cell membrane. (benthamscience.com)
Each vial of cell lysate contains 100ug of total protein (at 1 mg/ml). (novusbio.com)
Each vial of cell lysate contains 100ug of total protein which should be sufficient for 20-50 reactions. (novusbio.com)
Simply put, Aquaporins allow water to pass through the cell membrane to make sure our skin cells contain enough water. (charlottetilbury.com)
The role of Aquaporin is key to cell function. (charlottetilbury.com)
Several other environmental factors including oxy- gen concentration and mechanical, metabolic, and bio- chemical conditions have been shown relevant in cell differentiation and have been reviewed extensively (Fig. 1) [3]. (unicyte.ch)

Anatomy18

Organisms20

Diseases5

Chemicals and Drugs52

Analytical, Diagnostic and Therapeutic Techniques and Equipment11

Phenomena and Processes31

Disciplines and Occupations2

Technology, Industry, Agriculture3

Humanities1

Information Science5

AQPs20

Aquaglyceroporins6

Permeability3

Biochimica et Biophysica Acta2

Tissues12

AQP35

Genes2

Nodulin 26-like intrinsic proteins1

Solutes2

Transmembrane proteins1

Major intrinsi3

Gene7

Epidermis1

Tonoplast intrinsic proteins1

Membranes6

Membrane protein3

Receptors1

Homology2

20161

Structural4

17582

Characterization1

Multifunctional1

Subcellular2

Pore3

Transporter3

19921

Molecular4

Uptake1

Stability2

Vitro1

Arabidopsis2

Expression5

PIPs1

AQP71

Triglycerides1

Biology1

Water channels2

Family5

Transport3

Sequence similarity1

Kinase3

Potassium channels1

Subfamilies1

AQP11

Inhibitors1

AQP54

Overexpression1

Cell8