• Aquaporin 3 (AQP-3) is the protein product of the human AQP3 gene. (wikipedia.org)
  • Accordingly, we analyzed the prognostic impact of AQP3 expression and polymorphisms in a number of patients with early breast cancer (EBC). (dsmc.or.kr)
  • Materials and Methods: AQP3 expression was investigated on the basis of the immunohistochemistry of tissue microarray specimens from 447 EBC patients who underwent surgery between 2003 and 2008. (dsmc.or.kr)
  • the staining score was defined as sum of these scores used to categorize the AQP3 expression as negative (0 through 2), weak (3 through 5) or strong (6 or more). (dsmc.or.kr)
  • Results: A total of 180 (40.3%) patients were identified as AQP3-positive (staining score >2), including 86 (19.2%) cases of strong expression (stating score >5). (dsmc.or.kr)
  • In a univariate analysis, AQP3 expression was significantly associated with survival for the patients with HER2-over-expressing EBC. (dsmc.or.kr)
  • Meanwhile, none of selected AQP3 polymorphisms were related to AQP3 expression in tumor tissue or survival in the current study. (dsmc.or.kr)
  • Conclusion: AQP3 expression in tumor tissue may be considered as a potential prognostic marker in patients with HER2-over-expressing EBC after curative surgery. (dsmc.or.kr)
  • Background Aquaporin 3 (AQP3) and Cellular-mesenchymal to epithelial transition factor (c-Met) are both overexpressed in human breast cancer and highly related to proliferation and migration. (scite.ai)
  • Methods We used immunohistochemistry to determine the expression of AQP3 and c-Met in breast cancer tissue specimens and analysed whether there was any correlation between the two molecules. (scite.ai)
  • Real-time quantitative polymerase chain reaction and Western blotting were used to detect AQP3 expression in MCF-7 and MDA-MB-231 cells after human hepatocyte growth factor (hHGF) treatment and/or transfection with c-Met silencing small interfering (si)RNA. (scite.ai)
  • Studies have shown that hHGF can increase c-Met phosphorylation, and we discovered that the hHGF-induced increase in AQP3 expression was dose dependent. (scite.ai)
  • However, after reducing c-Met expression with c-Met-specific siRNA, AQP3 expression decreased accordingly. (scite.ai)
  • Conclusions Our study indicated that AQP3 expression was regulated by c-Met in human breast cancer. (scite.ai)
  • Aquaporin-3 (AQP3) is a membrane protein that contributes to the water homeostasis of the epidermis, and decreased AQP3 expression following ultraviolet (UV)-irradiation of the skin is associated with reduced skin moisture. (kyobobook.co.kr)
  • No previous study has examined whether the skin-moisturizing effect of MELs might act through the modulation of AQP3 expression. (kyobobook.co.kr)
  • Our results revealed that UVA irradiation decreases AQP3 expression at the protein and messenger RNA (mRNA) levels, but that MEL treatment significantly ameliorated these effects. (kyobobook.co.kr)
  • which acts as a potent transcription factor for AQP3 expression. (kyobobook.co.kr)
  • Collectively, our findings suggest that MELs can be used as a potential ingredient that modulates AQP3 expression to improve skin moisturization following UVA irradiation-induced damage. (kyobobook.co.kr)
  • 수분통로단백질인 aquaporin 3 (AQP3)은 백반증, 건선 등 다양한 피부 관련 질병의 발현에 중요한 역할을 한다. (e-ajbc.org)
  • Aquaporin 3 (AQP3) plays an important role in the expression of various skin-related diseases such as vitiligo and psoriasis. (e-ajbc.org)
  • In a matrix-grown Madin-Darby canine kidney cyst model, AQP3 expression promoted cyst enlargement and was associated with increased expression of hypoxia-inducible factor 1-α and glucose transporter 1 and increased glucose uptake. (bvsalud.org)
  • Aquaporin-3 (AQP3), a transporter of water, glycerol and H2O2, is expressed in basolateral membranes of principal cells in kidney collecting duct. (bvsalud.org)
  • Following IR, AQP3 deletion inhibited activation of mitogen-activated protein kinase (MAPK) signaling and produced an increase in the ratios of Bax/Bcl-2, cleaved caspase-3/caspase-3 and p-p53/p53. (bvsalud.org)
  • Studies in transfected MDCK cells showed that AQP3 expression attenuated reduced cell viability following hypoxia-reoxygenation, with reduced apoptosis and increased MAPK signaling. (bvsalud.org)
  • Here, we show that signal transduction by H2O2 depends on entry into the cell by transit through aquaporin-3 (AQP3), a plasma membrane H2O2-conducting channel. (bvsalud.org)
  • In response to injury, AQP3-depleted colonic epithelial cells showed defective lamellipodia, focal adhesions, and repair after wounding, along with impaired H2O2 responses after exposure to the intestinal pathogen Citrobacter rodentium Correspondingly, AQP3-/- mice showed impaired healing of superficial wounds in the colon and impaired mucosal innate immune responses against C. rodentium infection, manifested by reduced crypt hyperplasia, reduced epithelial expression of IL-6 and TNF-α, and impaired bacterial clearance. (bvsalud.org)
  • We have previously provided molecular evidence of expression of aquaporin 3 (AQP3) in normal human urothelium and in UBC of various stages. (sagepub.com)
  • However, only aquaporin-3 (AQP3), a member of the aquaporin family, showed significantly higher levels in the CBD-treated group than in the control group at both the mRNA and protein levels. (layv.co)
  • In addition, it is possible that increased expression of AQP3, which plays an important role in skin water retention, is a contributor to the mechanism. (layv.co)
  • Background/Aim: Recent studies have revealed aquaporins (AQPs) as targets for novel anti-tumor therapy since they are likely to play a role in carcinogenesis, tumor progression and invasion. (dsmc.or.kr)
  • The aquaporins (AQPs) are a family of transmembrane proteins forming water channels. (edu.sa)
  • In the present work, we examined the overall expression of AQPs in cells from human skin and we reviewed data on the functional role of AQPs in skin, particularly in the epidermis. (edu.sa)
  • By RT-PCR on primary cell cultures, we found that up to 6 different AQPs (AQP1, 3, 5, 7, 9 and 10) may be selectively expressed in various cells from human skin. (edu.sa)
  • This review focuses on emerging topics encompassing the functional involvement of aquaporin channel proteins (AQPs) and membrane transport systems, also allowing permeation of NO and hydrogen peroxide, a major ROS, in oxidative stress physiology and pathophysiology. (hindawi.com)
  • This notion has been challenged by the discovery of new membrane transport functions, especially those exerted by aquaporins (AQPs), a family of membrane channel proteins widespread in nature [ 10 , 11 ]. (hindawi.com)
  • One of the main traits underlying salt tolerance is the presence of aquaporins (AQPs), a family of proteins that facilitate the movement of water across cell membranes. (botany.one)
  • Choroid plexus epithelial cells (CPECs) secrete most of the CSF through poorly understood mechanisms that involve aquaporins (AQPs) and various solute transport proteins like the Na+-K+-2Cl- cotransporter 1 (NKCC1). (wright.edu)
  • Because of their relatively high transcript expression the present work addresses the cellular and subcellular location of AQPs 4, 7 and 9 proteins in CPECs and EP cells, using immunolabeling with validated antibodies and confocal immunofluorescence. (wright.edu)
  • Aquaporins (AQPs) facilitate transport of water and small solutes across cell membranes and play an important role in different physiological processes in plants. (biomedcentral.com)
  • The present study reports the identification and structural and expression analysis of the AQPs found in the diploid progenitor genomes of A. hypogea i.e. (biomedcentral.com)
  • The global expression profile of AQPs in A. hypogea revealed a similar pattern of AQP expression regardless of the subfamilies or the genomes. (biomedcentral.com)
  • The tissue-specific expression of AQPs suggests an important role in the development and function of the respective organs. (biomedcentral.com)
  • Aquaporins (AQPs) are small (21-34 kD) integral membrane proteins, which form channels facilitating movement of water and other small solutes across the cell membrane. (biomedcentral.com)
  • Aquaporin-5 (AQP5) is a water-specific channel located on the apical membrane of epithelial cells in several sites in mammals, including corneal and pancreatic epithelium, secretory cells in salivary and lacrimal glands, and airway submucosal glands, bronchial epithelium and type I pneumocytes of the respiratory tract. (plos.org)
  • Takata K, Matsuzaki T, Tajika Y. Aquaporins: water channel proteins of the cell membrane. (benthamscience.com)
  • All-trans-retinoic acid regulates aquaporin-3 expression and related cellular membrane permeability in the human amniotic environment. (igred.fr)
  • The expression of AQP1 in the basolateral membrane is a subject of debate. (wright.edu)
  • its expression in the basolateral membrane of mouse CPECs is undetectable. (wright.edu)
  • 2) AQP 7 expression was found to be restricted to the apical membrane of CPECs and EPCs. (wright.edu)
  • Molecular Membrane Biology 2013, 30 (3):246-260. (lu.se)
  • 114(3): 568-573, 2017 01 17. (bvsalud.org)
  • 2017). By activating the antioxidant defense system, Astaxanthin r egulates anti-inflammatory gene expression and inhibits the progression of inflammation (Ahmed et al. (loaskin.com)
  • Li XJ, Xiang Y, Ma B and Qi XQ: Effects of acetazolamide combined with or without NaHCO 3 on suppressing neoplasm growth, metastasis and aquaporin-1 (AQP1) protein expression. (spandidos-publications.com)
  • Caspase 3, CD44, Akt/ mTOR, and p38/STAT3 protein expression levels were measured by Western blotting. (fabad.org.tr)
  • Association Between the Single Nucleotide Polymorphism and the Level of Aquaporin-4 Protein Expression in Han and Minority Chinese with Inflammatory Demyelinating Diseases of the Central Nervous System. (cdc.gov)
  • The developmental gradient in monocot leaves has been exploited to uncover leaf developmental gene expression programs and chloroplast biogenesis processes. (biomedcentral.com)
  • This allows us to generate the first biologically-informed gene expression map of this leaf, with the entire developmental gradient from meristematic to fully differentiated cells captured. (biomedcentral.com)
  • Using a network reconstruction algorithm, we predict that known chloroplast gene expression regulators are differentially involved across those developmental stages. (biomedcentral.com)
  • Konkuk Research Team demonstrates Agerarin stimulates circadian CLOCK-mediated aquaporin-3 gene expression in. (konkuk.ac.kr)
  • To identify human PPARs-responsive genes, we established tetracycline-regulated human hepatoblastoma cell lines that can be induced to express each human PPAR and investigated the gene expression profiles of these cells. (biomedcentral.com)
  • Interestingly, it was noted that while ligand-activated PPARδ induced target gene expression, unliganded PPARδ repressed these genes. (biomedcentral.com)
  • Retinol works through these receptors, upturning in gene expression, which increases collagen Type I, III, and IV production and aquaporin -3. (ewalibeauty.com)
  • Berry intake changes hepatic gene expression and DNA methylation patterns associated with high-fat diet. (lu.se)
  • It has been shown that astaxanthin treatment inhibits the inflammatory effects of UV radiation by decreasing UV-induced reactive nitrogen species production, inflammatory cytokine expression, and apoptosis (cell death) in the epidermis ( Yoshihisa et al. (loaskin.com)
  • Consistent with this relatively high divergence among the subtype-specific ligand binding domains, differential activation of PPARs by endogenous and exogenous compounds may account for the specific biological activity of the three PPAR subtypes [ 2 , 3 ]. (biomedcentral.com)
  • Expression and localization of aquaporins 3 and 7 in bull spermatozoa and their relevance to sperm motility after cryopreservation. (researchmap.jp)
  • Analysis of the expression profile of CRH-POMC system genes in vitiligo skin biopsies. (igib.res.in)
  • The real-time RT-PCR was used to verify the altered expression of selected genes by PPARs and we found that these genes were induced to express in the same pattern as detected in the microarray analyses. (biomedcentral.com)
  • The authors conclude by recommending the GhPIP1;1 and GhTIP2;1 aquaporins located on the plasma and vacuolar membranes, respectively, as reliable markers for identification of cotton genotypes tolerant to salt stress. (botany.one)
  • Structure and Stability of the Spinach Aquaporin SoPIP2;1 in Detergent Micelles and Lipid Membranes. (lu.se)
  • Oxidative stress-induced calreticulin expression and translocation: new insights into the destruction of melanocytes. (igib.res.in)
  • Expression and function of aquaporins in human skin: Is aquaporin-3 just a glycerol transporter? (edu.sa)
  • Dive into the research topics of 'Expression and function of aquaporins in human skin: Is aquaporin-3 just a glycerol transporter? (edu.sa)
  • Aquaporin-9 Protein Is the Primary Route of Hepatocyte Glycerol Uptake for Glycerol Gluconeogenesis in Mice. (lu.se)
  • Aquaporins are multifunctional water and solute transporters highly divergent in living organisms. (benthamscience.com)
  • Structural mechanism of plant aquaporin gating. (lu.se)
  • Real-time quantitative PCR (qPCR) was used to validate the lncRNA expression level. (researchsquare.com)
  • Purification and characterization of two protein kinases acting on the aquaporin SoPIP2;1. (lu.se)
  • Igarashi H, Huber VJ, Tsujita M, Nakada T. Pretreatment with a novel aquaporin 4 inhibitor, TGN-020, significantly reduces ischemic cerebral edema. (benthamscience.com)
  • Suberoylanilide hydroxamic acid (SAHA) (a HDAC inhibitor) increases expression of aquaporin-3 in normal skin cells (keratinocytes). (wikipedia.org)
  • AQP4 expression in CPECs is debatable. (wright.edu)
  • Preliminary study on the association of AQP4 promoter polymorphism with anti-aquaporin-4 antibody positivity in southern Han Chinese patients with idiopathic demyelinating disorders of central nervous system. (cdc.gov)
  • The mRNA expression profile of cytokines connected to the regulation of melanocyte functioning in vitiligo skin biopsy samples and peripheral blood mononuclear cells. (igib.res.in)
  • Therefore, in the present study, we performed lncRNA and mRNA microarray analyses to explore the lncRNA and mRNA expression profile in response to oligohydramnios in pregnant women. (researchsquare.com)
  • Unexpected complexity of the Aquaporin gene family in the moss Physcomitrella patens. (lu.se)
  • In the kidney, aquaproin-3 is unresponsive to the antidiuretic hormone vasopressin, unlike aquaporin-2. (wikipedia.org)
  • Water is also be transported from the luminal side of cells into the vasculature by aquaporin 3. (drugbank.com)
  • Compared to control-treated cells, CD44 (3.2- fold) and p-STAT3 (2.44-fold) protein expressions were upregulated in PEITC-treated cells. (fabad.org.tr)
  • Studies have shown that astaxanthin can decrease the damage incurred from photogaging by suppressing cell damage caused by free radicals and inhibiting the expression of MMPs in different cells (Kishimoto et al. (loaskin.com)
  • [6] . Others have shown a similar change in paracellular permeability regulated by AQP5 in salivary glands, however in that system it was associated with alterations in claudin-7, claudin-3, and occludin [5] . (plos.org)
  • Role of aquaporin-4 in cerebral edema and stroke. (benthamscience.com)
  • Vella J, Zammit C, Di Giovanni G, Muscat R, Valentino M. The central role of aquaporins in the pathophysiology of ischemic stroke. (benthamscience.com)
  • The purpose of this study is to study expression level and possible role of lncRNAs in oligohydramnios. (researchsquare.com)
  • The expression of α-smooth muscle actin (α-SMA), collagen I, transforming growth factor-β1 (TGF-β1) and Smad2 were measured by western blotting. (spandidos-publications.com)
  • The expression of α-SMA, collagen I, TGF-β1 and p-Smad2 in the TAC group was higher than those in the sham group. (spandidos-publications.com)
  • Acetazolamide also reduced the expression of α-SMA, collagen I, TGF-β1 and p-Smad2 in the TAC mice. (spandidos-publications.com)
  • Correlation of increased MYG1 expression and its promoter polymorphism with disease progression and higher susceptibility in vitiligo patients. (igib.res.in)
  • Aquaporin-4-autoimmunity in patients with systemic lupus erythematosus: A predominantly population-based study. (cdc.gov)
  • The expression of each introduced PPAR gene was investigated using the various concentrations of doxycycline in the culture media. (biomedcentral.com)
  • We found that the expression of each PPAR subtype was tightly controlled by the concentration of doxycycline in these established cell lines. (biomedcentral.com)
  • Aquaporin 3 levels are often lower in psoriasis than in healthy skin. (wikipedia.org)
  • 3 ] found that 74% of T2DM patients had one or more skin problems, with the highest amount being dry skin (47%), followed by infection (10%), diabetic foot (5%), hair loss, and diabetic dermopathy (4%), respectively. (hindawi.com)
  • A collaborative 3-year research project is being conducted on lands administered by the U.S. Fish and Wildlife Service, the National Park Service, and other federal lands, and on state, local, and private lands along the Atlantic and Mississippi flyways. (cdc.gov)
  • Consistent down regulation of AQP expression was found in salt tolerant genotypes, i.e. those that were able to maintain photosynthetic rates under salt stress. (botany.one)
  • In addition, basal expression levels of tight junction protein-1 encoding ZO1 were lower in R91W;Nrl −/− than in wt retinas. (nature.com)
  • Recent studies indicate that aquaporin 3 is overexpressed in many types of malignancies such as melanoma and primary effusion lymphomas as well as cancers of the lung, colon, stomach, esophagus, mouth, liver, and pancreatic duct. (wikipedia.org)
  • Previous studies reported aquaporin (AQP)-3 expression in cysts derived from collecting ducts in ADPKD. (bvsalud.org)
  • Aquaporin 3 Expression Loss in Urothelial Carcinoma: Association with Tumor Invasion Depth, but not with Grading? (sagepub.com)
  • The effects of the loss of TIP1;1 and TIP1;2 aquaporins in Arabidopsis thaliana. (lu.se)
  • The volume of amniotic fluid varies at different stages of pregnancy [ 2 , 3 ], and the average amniotic fluid volume is 400 mL at term [ 4 ]. (researchsquare.com)