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  • membrane
  • Aquaporins contain two tandem repeats, each containing three membrane-spanning domains and a pore-forming loop with the signature motif Asn-Pro-Ala (NPA). (ebi.ac.uk)
  • degradation
  • Hypercalcemia induces targeted autophagic degradation of aquaporin-2 at the onset of nephrogenic diabetes insipidus. (au.dk)
  • 2001
  • They are involved in (1) nephrogenic diabetes insipidus, (2) brain water balance and hearing and (3) salivary secretion ( Li and Verkman, 2001 ). (tcdb.org)
  • osmotic
  • After axonal transport to the posterior pituitary, AVP is stored in vesicles and released in response to an increase in plasma osmotic pressure and sodium concentration ( 3 ). (pnas.org)
  • sodium
  • The aim of present study was to investigate whether DHFZT could relieve pulmonary and intestinal injury by regulating aquaporins after SAP induced by sodium taurocholate in rats. (biomedcentral.com)
  • rats
  • Twenty-four rats were randomly divided into 3 groups: sham group ( n = 8), model group (SAP, n = 8), DHFZT group (SAP with DHFZT treatment, n = 8). (biomedcentral.com)
  • form
  • In the native form, it is an aquaporin, but during lens development, it becomes proteolytically truncated. (tcdb.org)
  • highly
  • Aquaporins are characterized by presence of highly conserved asparagine proline alanine (NPA) boxes that are important for the formation of a water-permeating pore. (acris-antibodies.com)
  • death
  • Aquaporin 9 changes in pyramidal cells before and is expressed in astrocytes after delayed neuronal death in the ischemic hippocampal CA1 region of the gerbil. (ebi.ac.uk)
  • shown
  • Ion channel activity has been shown for Aquaporins 0, 1, and 6, Drosophila Big Brain and plant Nodulin-26 ( Yool and Campbell, 2012 ). (tcdb.org)