Aqp1 human aquaporin 3. Medical search. Frequent questions

1. Distribution of aquaporin water channels AQP1 and AQP5 in the ductal system of the human pancreas. (nih.gov)
5. Tear secretion by lacrimal glands in transgenic mice lacking water channels AQP1, AQP3, AQP4 and AQP5. (nih.gov)
18. Decreased expression of AQP1 and AQP5 in acute injured lungs in rats. (nih.gov)
Subsequent studies have highlighted the functional significance of AQPs, particularly AQP1 and AQP5 in lung pathophysiology and diseases, including but not limited to chronic and acute lung injury, chronic obstructive pulmonary disease (COPD), other inflammatory lung conditions, and lung cancer. (nih.gov)
Description: This is Competitive Enzyme-linked immunosorbent assay for detection of Human Aquaporin 5 (AQP5) in serum, plasma, saliva, tissue homogenates, cell lysates and other biological fluids. (fslregister.nl)
Description: Enzyme-linked immunosorbent assay based on the Competitive Inhibition method for detection of Human Aquaporin 5 (AQP5) in samples from serum, plasma, saliva, tissue homogenates, cell lysates and other biological fluids with no significant corss-reactivity with analogues from other species. (fslregister.nl)
Description: A sandwich quantitative ELISA assay kit for detection of Human Aquaporin 5 (AQP5) in samples from tissue homogenates, cell lysates or other biological fluids. (fslregister.nl)
Finally, we use the physiological pHS and pHi data--collected with different pHS electrode diameters, different distances of the pHS electrode from the membrane, and different mutants of AQP1 and AQP5--to inform and validate the model. (nih.gov)
Our study aimed to determine whether the altered expression of biomarkers linked to corneal injuries, such as the edema-regulating proteins aquaporin-1 and aquaporin-5 (AQP1 and AQP5), occurred following primary blast exposure. (molvis.org)
Corneas obtained from the euthanized blast-exposed and control rabbits were processed for quantitative PCR and western blot to quantify mRNA and the protein expression of AQP1 and AQP5. (molvis.org)
Immunohistochemical analysis was conducted to determine the cellular localization of AQP1 and AQP5. (molvis.org)
mRNA levels of AQP1 and AQP5 increased in the whole cornea lysates of blast-exposed rabbits relative to those of the controls. (molvis.org)
Western blot analyses of whole cornea lysates revealed that the expression levels of AQP1 and AQP5 were approximately 2- and 1.5-fold higher, respectively, in blast-exposed rabbits compared to controls. (molvis.org)
Primary blast exposure resulted in edema-related changes in the cornea manifested by the altered expression of the edema-regulating proteins AQP1 and AQP5 with blast overpressure-specific impulses. (molvis.org)

AQP-4 belongs to the aquaporin family of integral membrane proteins that conduct water through the cell membrane. (wikipedia.org)
In part because of Dr. Agre's work, interest in the aquaporin family of related proteins was rekindled throughout the world, and hundreds of related proteins have been recognized in vertebrates and invertebrates, plants, and unicellular organisms. (medscape.com)
Aquaporins (AQPs) are membrane proteins responsible for transporting water, some gases and small solutes such as CO2 and glycerol. (iyte.edu.tr)
According to our findings, tested aquaporin proteins may play roles in T cell activation, differentiation, and apoptosis. (iyte.edu.tr)
Aquaporins (AQPs) aka water channels are a family of conserved transmembrane proteins (~30 kDa monomers) expressed in various organ systems. (nih.gov)
In January 22 Proceedings of the National Academy of Sciences, Landon King and colleagues from Johns Hopkins School of Medicine, Baltimore, show that aquaporins (AQP) are proteins that control the vascular permeability in the lung, and have a role in human pulmonary physiology.King et al. (the-scientist.com)
Thirteen homologous proteins exist in humans. (nih.gov)
Aquaporin proteins significantly increase water permeability across tissues and cell membranes. (arizona.edu)
Available experimental evidence indicates the presence of several ion channel and transporter proteins in ZG membranes (aquaporins, vacuolar-type H + -ATPase, zinc influx transporter SLC30A2). (pancreapedia.org)
Aquaporins (AQPs), a family of membrane channel proteins involved in many body functions, are emerging among the targets of bioactive phytochemicals in imparting their beneficial actions. (frontiersin.org)
This review provides an update on the involvement of Aquaporins (AQPs), a family of membrane channel proteins with important role in many body functions, in the beneficial effects imparted by food polyphenols and herbal phytocompounds, both in health and disease. (frontiersin.org)
Aquaporins (AQPs) are channel proteins largely expressed in living organisms mediating the transport of water and some anaelectrolytes across biological membranes ( Agre, 2004 ). (frontiersin.org)

The goal of this study is to detect the expression level of AQP1, AQP3, and AQP4 in activated and apoptotic T cells. (iyte.edu.tr)
Bu çalışmanın amacı, AQP1, AQP3 ve AQP4 proteinlerinin aktive edilmiş ve apoptotik T hücrelerindeki ekspresyon seviyelerini saptamaktır. (iyte.edu.tr)

Aquaporin-4, also known as AQP-4, is a water channel protein encoded by the AQP4 gene in humans. (wikipedia.org)
In the CNS, AQP4 is the most prevalent aquaporin channel, specifically located at the perimicrovessel astrocyte foot processes, glia limitans, and ependyma. (wikipedia.org)
The assembly of AQP4 monomers into tetramers is similar to other aquaporin channels. (wikipedia.org)
Additionally, AQP4 can also be located in epithelial cells of many organs throughout the human body, such as the kidney, intestine, salivary glands, sensory organs, and skeletal muscles. (wikipedia.org)
Recently, a group of patients have been described who have an NMO spectrum disorder (NMOsd) and who are seronegative for AQP4 antibodies but positive for IgG aquaporin-1 (AQP1) or myelin oligodendrocyte glycoprotein (MOG) antibodies. (nih.gov)
and if point mutations in the gDNA of AQP4 , AQP1 and MOG genes could be associated with the etiology of NMOsd. (nih.gov)

Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Rat Aquaporin 2, Collecting Duct (AQP2) in samples from tissue homogenates, cell lysates and other biological fluids with no significant corss-reactivity with analogues from other species. (lscwarsaw.com)

Found throughout nature, aquaporin water channels confer high water permeability to cell membranes. (nih.gov)
6. Coexpression of AQP1 with the SGLT1 increased the water permeability more than 10-fold and steady state isotonic transport was achieved after less than 2 s of sugar activation. (ku.dk)
We have also studied gas permeability of membrane- embedded tetrameric aquaporin (AQP) water channels, revealing how these membrane channels mediate permeation of gases--via the four monomeric pores and the central pore--with different degrees of selectivity. (nih.gov)

We found a significance between increased expression level of AQP1, 3, and 4 in activated T cells as well as decreased expression level of each three AQPs in apoptotic T cell populations. (iyte.edu.tr)
Of the 13 AQPs (AQP0 through AQP12) in the human body, four (AQPs 1, 3, 4, and 5) are expressed in the respiratory system. (nih.gov)

Investigators from Johns Hopkins University School of Medicine in Baltimore, Maryland, and the International Blood Group Referencing Laboratory in Bristol, United Kingdom, later identified the Colton antigens as residing in an extracellular location of the AQP1 protein. (medscape.com)

Notably, Dr. Agre learned from the atlas of human genetic linkages that the Colton blood group was located on the short arm of human chromosome 7, [ 7 ] the same site as the gene encoding AQP1. (medscape.com)
Identification of the Colton blood group antigen on the extracellular domain of AQP1 allowed identification of rare individuals who are AQP1-null and manifest a subclinical form of nephrogenic diabetes insipidus. (nih.gov)
aquaporin 1 (Colton blood group) [S. (gsea-msigdb.org)
En los humanos, los polimorfismos de esta proteína dan lugar al antígeno del grupo sanguíneo Colton. (bvsalud.org)
In humans polymorphisms of this protein result in the Colton blood group antigen. (bvsalud.org)

Aquaporin-1 and aquaporin-9 gene variations in sudden infant death syndrome. (cdc.gov)
The expression of the mRNA of the hepatic lipase was significantly reduced in CRF animals with the ratio between it and that of house keeping gene G3DPH being 15 +/-3% compared to 40 +/- 1.3% in normal, 44+/-2.9% CRF-PTX, 44 +/- 5.4% in CRF-V, and 39 +/- 3.9% in normal-V rats. (jci.org)
For example, animal model gene knockout (KO) or inhibition of coagulation factor XI (FXI), 1 , 2 FXII, 3 , 4 glycoprotein VI (GPVI), 5-8 water channel aquaporin-1 (AQP1), 9 or protein kinase C alpha 10 show no significant bleeding defects but markedly affect arterial thrombosis. (ashpublications.org)
Gene and protein expression levels of KDR and AQP1 were detected by reverse transcription-polymerase chain reaction and western blot analysis. (geneticsmr.com)
Cetuximab in combination with afatinib synergistically inhibited the growth and migration of cells and downregulated the gene and protein expression of KDR and AQP1, indicating that a combination of cetuximab and afatinib is a potential strategy for lung cancer therapy. (geneticsmr.com)
And it is precisely for this reason that scientists have been looking for THE language gene , which is responsible for giving humans what other animals do not have, in other words speech. (chromosomewalk.ch)
AQP1: This gene codes for a protein - aquaporin - that acts as a channel for ferrying water molecules throughout our body. (chromosomewalk.ch)
Because the gene page contains a lot of information, it takes on average 3-5 seconds to load. (uth.edu)

Description: A sandwich ELISA kit for detection of Aquaporin 2, Collecting Duct from Rat in samples from blood, serum, plasma, cell culture fluid and other biological fluids. (lscwarsaw.com)
Description: A quantitative ELISA kit for measuring Human in samples from biological fluids. (lscwarsaw.com)
Description: Quantitativecompetitive ELISA kit for measuring Human Lactoferrin, LTF/LF in samples from breastmilk. (lscwarsaw.com)

The model rests on the high resolution X-ray structure of the homologous bacterial glycerol transporter GlpF, electron crystallographic data at 3.8 A resolution and a multiple sequence alignment of the aquaporin superfamily. (nih.gov)
Water and glycerol permeation through the glycerol channel GlpF and the aquaporin family. (nih.gov)

13. Expression and subcellular localization of the AQP8 and AQP1 water channels in the mouse gall-bladder epithelium. (nih.gov)

Other performances that aquaporin-4 is involved in are synaptic plasticity, astrocyte migration, regulation of extracellular space volume, and the homeostasis of potassium. (wikipedia.org)
Ocular tissues, including the trabecular meshwork (TM) and retinal pigment epithelium (RPE), are especially reliant on aquaporin mediated water movement for ocular homeostasis. (arizona.edu)
The role and regulation of AQP1 as it relates to homeostasis in different ocular tissues is not well understood. (arizona.edu)
I hypothesized that ocular tissues respond to external mechanical and molecular cues by altering AQP1 expression and function in order to regulate ocular fluid movement and maintain homeostasis.To test how AQP1 function is altered in response to external cues in order to maintain tissue-specific homeostasis, I addressed the following two aims. (arizona.edu)
The first aim was directed at determining how mechanical strain, an external stimulus that routinely affects TM function, influences AQP1 expression and TM homeostasis. (arizona.edu)

Western Blot was performed to identify expression of AQP 1, 3 and 4. (iyte.edu.tr)
AQP1, 3 ve 4 proteinlerinin ekspresyonunu belirlemek için western blot yapılmıştır. (iyte.edu.tr)
Primary cultures of human TM were subjected to static and cyclic stretch and then analyzed for changes in AQP1 expression by western blot and cell damage by activity of lactate dehydrogense (LDH) in conditioned media. (arizona.edu)

Water permeation across biological membranes: mechanism and dynamics of aquaporin-1 and GlpF. (nih.gov)
Fraternal twins: AQP1 and GlpF. (nih.gov)
Twelve mammalian aquaporin homologues have been separated by Dr. Agre and collaborators into 2 subsets: aquaporins (AqpZ) and aquaglyceroporins (GlpF). (medscape.com)

Furthermore, in vivo thrombus formation after FeCl3 injury to carotid arteries was also markedly suppressed in AQP1-null mice, but hemostasis after tail bleeding remained normal. (jci.org)

11. Functional requirement of aquaporin-5 in plasma membranes of sweat glands. (nih.gov)
We conclude that AQP1 is a major regulator of the platelet procoagulant response, able to modulate coagulation after injury or pathologic stimuli without affecting other platelet functional responses or normal hemostasis. (jci.org)
The functional Aquaporin 1 -783G/C-polymorphism is associated with survival in patients with glioblastoma multiforme. (cdc.gov)

15. Aquaporin 1 water channel is overexpressed in the plasma membranes of pancreatic ducts in patients with autoimmune pancreatitis. (nih.gov)
Red cell membranes isolated from individuals with autosomal recessive HS have only 40-50% of the normal amount of spectrin (relative to band protein 3). (medscape.com)
The result could be unprecedented insight into the pathways and mechanisms of gas transport across membranes, which would be invaluable for understanding both normal human physiology and pathogenesis of numerous diseases. (nih.gov)

9. Expression of aquaporins in the rat ocular tissue. (nih.gov)
The combined studies indicate tissue specific AQP1 regulation may offer new avenues to target water movement in treatment of ocular pathologies. (arizona.edu)
Recently, great efforts have been made to design protocols for obtaining ocular cells from human stem cells to model diseases or for regenerative purposes. (biomedcentral.com)

0.05, n = 3). (arizona.edu)
0.05) and increase in active caspase-3 expression，but no difference was found in PNAS-2 expression. (shsmu.edu.cn)

Improved geometry and enhanced stability in molecular dynamics simulations demonstrate a significant improvement of the aquaporin-1 structure. (nih.gov)
Dr. Agre, with many other collaborators using many modalities, was able to make a 3-dimensional model of the molecular structure of aquaporin. (medscape.com)
Biochemical analysis of the Rhesus blood group antigen led to the serendipitous discovery of AQP1, the first molecular water channel. (nih.gov)
First, it acts as a molecular water pump: for each 2 Na+ and 1 sugar molecule 264 water molecules were cotransported in the human SGLT1 (hSGLT1), 424 for the rabbit SGLT1 (rSGLT1). (ku.dk)

The detection of IgG aquaporin-4 antibodies in the serum of patients with Neuromyelitis optica (NMO) has dramatically improved the diagnosis of this disease and its distinction from multiple sclerosis. (nih.gov)
Increased detection of early RCC lesions in many patients is due to the widespread use of computed tomography (CT) and magnetic resonance imaging (MRI), and the 5-year survival rate for early RCC detection is as good as 93% [ 2 ] [ 3 ] . (encyclopedia.pub)

7. Identification and localization of aquaporin water channels in human salivary glands. (nih.gov)

The extent of AQP1 immunostaining (AQP1-IS) increased in the epithelial cell layer after blast exposure. (molvis.org)

20. Uroguanylin and guanylate cyclase C in the human pancreas: expression and mutuality of ligand/receptor localization as indicators of intercellular paracrine signaling pathways. (nih.gov)
Here we describe the 3.2 Å cryo-EM structure of human DEC-205, thereby illuminating the structure of the mannose receptor protein family. (uci.edu)
The expression of genes well known to be estrogen regulated, such as progesterone receptor, intestinal calcium-binding protein, and complement component 3, is not affected by consumption of the soy/alfalfa-based diet when assessed by microarray or quantitative reverse transcriptase-polymerase chain reaction analysis. (nih.gov)
I treated primary cultures of human RPE with either atrial natriuretic peptide (ANP) or 8-bromo-cyclic guanosine monophosphate (8-Br-cGMP) in the presence or absence of Anantin (ANP-receptor inhibitor) or H-8 (Protein Kinase G inhibitor). (arizona.edu)
download The Post Utopian Imagination: American Culture in 3 genes the activation of from( 50) with receptor to window, written by the Small cell transfer vitamin. (familie-vos.de)
In this study, we examined the effect of cetuximab (epidermal growth factor receptor monoclonal antibody) combined with afatinib (epidermal growth factor receptorand human epidermal growth factor receptor 2 tyrosine kinase irreversible inhibitor) on the apoptosis of A549 cells and on kinase domain receptor (KDR) and aquaporin 1 (AQP1) expression in A549 cells. (geneticsmr.com)

The replication and activator of known role existing mediates teamed at Mitochondrial tissues through cells that are dysplasia and pathway, Glycosyltransferases to transfer circulating cis-cisternae and human processing( indexed in Matallanas et al, 2011). (familie-vos.de)

AQP1 relates reconstituted on both the different and active download of common cAMP and strongly is cell through the activation and precisely into the strand. (familie-vos.de)

However, aquaporin expression involved in activation, proliferation, and differentiation as well as apoptosis of T cells are not well known yet. (iyte.edu.tr)
Objective To observe specific binding ability of anti-PNAS-2 single chain antibody with PNAS-2 antigen and its effects on apoptosis of human leukemic U937 cells. (shsmu.edu.cn)

2014), and of the anti-aquaporin-1 antibodies in neuromyelitis optica (J. Tzartos et al. (neurodiagnostics.gr)

Aquaporins in lung health and disease: Emerging roles, regulation, and clinical implications. (nih.gov)
Aquaporin-1 water channel protein in lung: ontogeny, steroid-induced expression, and distribution in rat. (jci.org)

In this study we found that remnant chymase, by proteolyzing human serum and human aortic intimal fluid, prevents these two physiologic fluids from effectively inducing cholesterol efflux from cultured macrophage foam cells. (jci.org)

3. The role of aquaporin water channels in fluid secretion by the exocrine pancreas. (nih.gov)
10. Guanylin in the human pancreas: a novel luminocrine regulatory pathway of electrolyte secretion via cGMP and CFTR in the ductal system. (nih.gov)
However, deletion of AQP1 had minimal effects on collagen-induced platelet granule secretion, aggregation, or membrane ballooning. (jci.org)

Recently they have also contributed to the discovery of the third autoantigen in MG, the LRΡ4, and have discovered a new autoantigen for neuromyelitis optica, the aquaporin-1 . (neurodiagnostics.gr)

NIEHS research uses state-of-the-art science and technology to investigate the interplay between environmental exposures, human biology, genetics, and common diseases to help prevent disease and improve human health. (nih.gov)
Much of their research has been on the development of new diagnostics for neuroimmune diseases (illustrated in recent publications and in 2 of their 3 patents). (neurodiagnostics.gr)
Hence, a large number of biologically active phytocompounds of foods have been isolated, characterized, and eventually modified representing a natural source of novel molecules to prevent, delay or cure several human diseases. (frontiersin.org)

7. The data suggest that SGLT1 has three roles in isotonic water transport: it cotransports water directly, it supplies a passive pathway for osmotic water transport, and it generates an osmotic driving force that can be employed by other pathways, for example aquaporins. (ku.dk)
In termination to complex infancy, pathways of all 3 post-synaptic HAT reactions have required known to bring regions( Glozak et al. (evakoch.com)

16. Downregulation of aquaporins 1 and 5 in nasal gland by osmotic stress in ducklings, Anas platyrhynchos: implications for the production of hypertonic fluid. (nih.gov)
Even though bulk fluid movement is paracellular through the TM and transcellular through the RPE, both express aquaporin-1 (AQP1). (arizona.edu)
Analysis of LDH release with respect to AQP1 expression revealed an inverse linear relationship (rÂ² = 0.7780).The second aim was directed at characterizing signaling mechanisms responsible for regulating fluid transport in RPE, previously shown to be dependent upon AQP1. (arizona.edu)
Inhibition of these effects was successful with Anantin treatment but not with application of H-8.The data presented demonstrate a novel role of protection for AQP1 in TM, and also expand upon cGMP dependent regulation of RPE fluid transport. (arizona.edu)

Besides the renal collecting duct cells, AQP1 also is found in secretory glands, brain, and other organs. (medscape.com)

the airway wall thickness did not change in AQP1-null subjects. (the-scientist.com)

They thus are to urinary adenine via the BRAF-MEK phosphatidylinositol-3,4,5-trisphosphate regulation. (familie-vos.de)

Public, especially the youth, about the and Physiology of Human the use of exogenous testosterone can help to boost it up again. (htdig.org)

6. Differential expression of aquaporin-3 and aquaporin-5 in pancreatic ductal adenocarcinoma. (nih.gov)
8. Expression and immunolocalization of aquaporin water channels in rat exocrine pancreas. (nih.gov)
14. Expression and immunolocalization of water-channel aquaporins in the rat and mouse mammary gland. (nih.gov)
The results show AQP1 expression and LDH release significantly increased with static stretch. (arizona.edu)
Expression of PNAS-2 and active caspase-3 was detected by Western blotting. (shsmu.edu.cn)

[ 3 ] Aquaporin, the protein that channels water in and out of cells, was overlooked initially when the protein sequences of the Rh protein molecule were being identified in Dr. Agre's lab because it was initially thought to be a breakdown product of the Rh polypeptide. (medscape.com)
The mechanism involves an AQP1-mediated rapid membrane stretching during procoagulant spreading but not ballooning, leading to calcium entry through mechanosensitive cation channels and a full procoagulant response. (jci.org)
collectively trained from the bodies, SMAC channels to IAP radiation elements budding them from Caspase: disorder humans activating the second effects. (familie-vos.de)

We hypothesized that water entry was mediated by the water channel aquaporin-1 (AQP1) and aimed to determine its role in the platelet procoagulant response and thrombosis. (jci.org)
Aquaporin-1( AQP1) in the thin thioredoxin and the promoting FBW7)-mediated talin of Henle is other for particularly 90 part of platelet( tightly understood from group steps of AQP1). (familie-vos.de)

Isotonic transport by the Na+-glucose cotransporter SGLT1 from humans and rabbit. (ku.dk)
both the human and the rabbit clones were tested. (ku.dk)

The aquaporin-4 tetramers accumulate to transform into orthogonal arrays of particle (OAPs) in the cell plasma membrane. (wikipedia.org)
Until now, it has been shown that AQP1, 3 and 5 expressed in both B and T lymphocytes of mice, regulate cell volume. (iyte.edu.tr)

Aquaporins have been implicated in certain types of renal disease and conditions that deal with mechanisms for water balance, such as sweating and thirst. (medscape.com)

Chymase in granules released from degranulated rat serosal mast cells, i.e., in granule remnants, proteolyzes human high density lipoprotein3 (HDL3), and so reduces its ability to induce cholesterol efflux from macrophage foam cells in vitro. (jci.org)

Aquaporin is present in many cells of the body. (medscape.com)
Peripheral Blood Mononuclear Cells (PBMCs) were isolated from Human peripheral blood drawn from healthy donors by ficoll density gradient Centrifugation method. (iyte.edu.tr)
Here, the generation of more advanced in vitro multiocular organoids from human induced pluripotent stem cells (hiPSCs) is demonstrated. (biomedcentral.com)
The conjunctiva covers the sclera and is composed of 3-5 layers of epithelium with superficial scattered goblet cells that produce important mucins for the tear film. (biomedcentral.com)
Degranulated mast cells are present in human fatty streaks. (jci.org)

Common variable immunodeficiency (CVID) is a heterogeneous group of disorders characterized by hypogammaglobulinaemia, defective specific antibody production and an increased susceptibility to recurrent and chronic infections [1-3]. (micrornainhibitors.com)

Anatomy6

Organisms2

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Phenomena and Processes10

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AQP514

Proteins12

AQP32

AQP46

AQP21

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Johns Hopkins1

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ELISA Kit3

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AQP81

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Western blot3

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0.052

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