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  • coronary heart d
  • Our mouse model repository maintains hundreds of mouse models to accelerate research in coronary heart disease (including, atherosclerosis, ischemic/reperfusion injury and myocardial infarction), hypertension, hypertrophy and heart failure, and other heart abnormalities. (jax.org)
  • Cardiovascular diseases (principally coronary heart disease and stroke) together account for more than 150 000 deaths a year in the United Kingdom. (bmj.com)
  • At the University of Liverpool, Professor Critchley developed a coronary heart disease (CHD) mortality model, (IMPACT with Professor Simon Capewell), which has since been widely replicated and refined. (sgul.ac.uk)
  • Professor Critchley was appointed as a postdoctoral research fellow at the University of Liverpool in 2000, where she developed methodological expertise in coronary heart disease modelling, and in systematic reviews methodology. (sgul.ac.uk)
  • diseases
  • Here, we review several recent advances in the fields of genetic and tissue engineering that have made it possible to model aspects of these diseases in vitro , and we discuss the potential applications of these technologies to drug discovery and personalized medicine. (frontiersin.org)
  • The association between air pollution and respiratory 1 , 2 , 3 , 4 , 5 , 6 , 7 , 8 and cardiovascular diseases 2 , 9 is a subject of study, and the global concern about the quality of air has been increasing. (scielo.br)
  • Objective of this study was to develop and validate a fuzzy linguistic model for prediction of hospitalization due to respiratory diseases. (scielosp.org)
  • Decision Support Systems for Cardiovascular Diseases Based on Data Mining and Fuzzy Modelling. (igi-global.com)
  • sEH inhibition is a well established approach in cardiovascular, renal, and inflammatory diseases in murine models, but its contribution in type 2 diabetes mellitus remains to be established. (pnas.org)
  • She has broad interests in cardiovascular and diabetes epidemiology, and in exploring the public health implications of associations between chronic and infectious diseases (tuberculosis and diabetes). (sgul.ac.uk)
  • clinical
  • In this article, Bonnett and colleagues provide a guide to presenting clinical prediction models so that they can be implemented in practice, if appropriate. (bmj.com)
  • 6 7 Although the TRIPOD statement highlights the importance of the presentation of models, relatively little information or practical guidance exists on how to actually present a prediction model for use after development-for example, to aid implementation in clinical settings, if appropriate. (bmj.com)
  • Substantial heterogeneity in predictor and outcome definitions was observed between models, and important clinical and methodological information were often missing. (bmj.com)
  • Thus, identification of therapeutic approaches to simultaneously treat or prevent diabetes and atherosclerosis would be of high scientific merit and clinical benefit. (jci.org)
  • cardiac
  • The simplified models can also act as a bridge to identifying more sophisticated cardiac models, by providing an initial set of patient specific parameters that can reveal trends and interactions in the data over time. (ac.be)
  • Our model includes a cardiac center-of-mass regression module which allows for an automatic shape prior registration. (springer.com)
  • Genetic
  • Recent advances in stem cell technologies, genetic engineering, and tissue engineering have the potential to revolutionize our ability to model and study heart failure in vitro . (frontiersin.org)
  • In a type 1 diabetes model, genetic and pharmacological inhibition of sEH results in increased insulin secretion and attenuation of hyperglycemia ( 18 ). (pnas.org)
  • focuses
  • Dr. Peterson's recent research focuses on measuring and modeling human, organ, and/or cell performance, including exposures to various physical stimuli and the subsequent biological responses. (schweitzer-online.de)
  • inflammation
  • We will conduct several animal studies, to continue work on our general hypothesis that pre-existing inflammation and old age are important priming factors to sensitize the host for subsequent pulmonary and cardiovascular effects of inhaled ultrafine particles. (epa.gov)
  • Stress-induced damage, computed using a remaining life approach, stimulates inflammation (production of matrix degrading factors and growth stimuli). (tcd.ie)
  • Particulate
  • We constructed a fuzzy model for prediction of hospitalizations due to pneumonia, bronchitis, bronchiolitis and asthma second exposure to fine particulate matter (PM 2.5 ) in residents of Volta Redonda, RJ, in 2012. (scielosp.org)
  • diagnosis
  • The transparent reporting of a multivariable prediction model for individual prognosis or diagnosis (TRIPOD) statement provides guidance on key information for authors to report when developing or validating prediction models. (bmj.com)
  • homeostasis
  • The two branches of the autonomic nervous system (ANS), the sympathetic and vagal subsystems, cooperate to maintain homeostasis in the cardiovascular (CV) system, namely the continuous controlled movement of blood through the whole organism to transport nutrients to organ tissues - to every cell of the organism ( Guyton and Hall, 2006 ). (frontiersin.org)
  • humans
  • The advent of brain imaging has been useful in specifying more clearly the neural involvement in hypertension and providing a possible bridge between behavioral and self-report information in humans and the mechanistic observations in animal models. (biomedsearch.com)
  • The mechanobiological parameters of the model were estimated by calibrating the model response to the results of a balloon angioplasty study in humans. (tcd.ie)
  • methodological
  • The usefulness of most of the models remains unclear owing to methodological shortcomings, incomplete presentation, and lack of external validation and model impact studies. (bmj.com)
  • left ventricle
  • For validation a comparison is done between the optimized parameters for a baseline model, which uses the direct measurements of the left ventricle pressure and volume, and the optimized parameters from the approximated driver function. (canterbury.ac.nz)
  • prediction model
  • When choosing the format to present a prediction model, researchers should carefully consider the intended users, settings, and timing of use. (bmj.com)
  • Rather than developing yet another similar CVD risk prediction model, in this era of large datasets, future research should focus on externally validating and comparing head-to-head promising CVD risk models that already exist, on tailoring or even combining these models to local settings, and investigating whether these models can be extended by addition of new predictors. (bmj.com)
  • Furthermore
  • Furthermore, the fuzzy model is very simple and involves low computational costs, an implementation making possible. (scielosp.org)
  • risk
  • The main outcomes are first-time cardiovascular events and consequent deaths, as well as total consequence costs, which combine medical expenditures and productivity costs associated with cardiovascular events and risk factors. (cdc.gov)
  • Causal influences move down and to the right, ending with 2 outcomes: 1) first-time cardiovascular events and consequent deaths and 2) costs associated with these events and with the identified risk factors. (cdc.gov)
  • Prediction models are also known as risk scores, prognostic indices, or prognostic scores. (bmj.com)
  • Eligibility criteria for study selection Studies describing the development or external validation of a multivariable model for predicting CVD risk in the general population. (bmj.com)
  • The prediction horizon was not specified for 49 models (13%), and for 92 (25%) crucial information was missing to enable the model to be used for individual risk prediction. (bmj.com)
  • Over the past two decades, numerous prediction models have been developed, which mathematically combine multiple predictors to estimate the risk of developing CVD-for example, the Framingham, 3 4 5 SCORE, 6 and QRISK 7 8 9 models. (bmj.com)
  • Conclusions Any intervention that achieved even a modest population-wide reduction in any major cardiovascular risk factor would produce a net cost saving to the NHS, as well as improving health. (bmj.com)
  • Development
  • Results 9965 references were screened, of which 212 articles were included in the review, describing the development of 363 prediction models and 473 external validations. (bmj.com)
  • In conclusion, the paper shows that the arterial tissue response to mechanical stimulation can be predicted using a stochastic cell modeling approach, and that the simulation captures features of restenosis development observed with real stents. (tcd.ie)
  • dietary
  • Modeling studies suggest that a small reduction in dietary sodium would result in a sizable general population health benefit. (springer.com)
  • Legislation or other measures to reduce dietary salt intake by 3 g/day (current mean intake approximately 8.5 g/day) would prevent approximately 30 000 cardiovascular events, with savings worth at least £40m a year. (bmj.com)
  • diabetes
  • Pharmacologic approaches to diabetes management may have direct or indirect antiinflammatory effects, the latter potentially attributable to an improved metabolic state. (jci.org)
  • mortality
  • She was first author on several UK publications using the model, and led initial work looking at a middle income setting in Beijing where CHD mortality was rising. (sgul.ac.uk)
  • Medical
  • 1 A large number of prediction models are published in the medical literature each year, 2 and most are developed using a regression framework such as logistic and Cox regression ( box 1 ). (bmj.com)
  • obesity
  • In addition, cytochrome P450 2C (CYP2C) expression is decreased and sEH expression is increased in obese Zucker rats, a commonly used animal model of obesity and insulin resistance ( 18 ). (pnas.org)
  • study
  • This study models the probability of incompatibility versus compatibility for binary or unordered multistate phylogenetic characters, by treating the allocation of taxa to character states as a classical occupancy problem in probability. (biomedsearch.com)
  • exposures
  • We expect to be able to extend the use of our animal models to exposures of ambient ultrafine particles and organic ultrafine carbonaceous particles. (epa.gov)
  • inputs
  • The model has 4 inputs, each with 2 membership functions generating 16 rules, and the output with 5 pertinence functions, based on the Mamdani's method, to estimate the association between the pollutants and the number of hospitalizations. (scielo.br)
  • The model contains two inputs, PM 2.5 and temperature, with three membership functions for each input, and an output with three membership functions for admissions, which were obtained from DATASUS. (scielosp.org)
  • thus
  • The parameters do not significantly change between the two approaches thus showing that the patient specific approach to identifying the driver function is valid, and has potential clinically. (canterbury.ac.nz)
  • human
  • His team is now trying to translate this finding by doing ROS therapy and gene replacement therapy in animal models of Barth syndrome to see if anything could potentially help human patients. (ecnmag.com)
  • computational
  • To build a fuzzy computational model to estimate the number of hospitalizations of children aged up to 10 years due to respiratory conditions based on pollutants and climatic factors in the city of São José do Rio Preto, Brazil. (scielo.br)