• In the search for agents from tropical medicinal plants to treat these two neglected tropical diseases, serially extracted petroleum ether, dichloromethane and methanol extracts of the leaves of Monodora crispata and Monodora brevipes , and eleven aporphines alkaloids isolated from the dried powdered leaves of the two plants were evaluated against Leishmania donovani promastigotes and Trypanosoma brucei brucei trypomastigotes. (omicsonline.org)
  • In order to understand the structural tolerance of the aporphine core required for 5-HT 2A antagonism an exhaustive Structure Activity Relationship (SAR) study was designed.Accordingly, a diverse library of nantenine analogues was synthesized and evaluated for affinity at the 5-HT 2A receptor. (cuny.edu)
  • Based on results of these studies, it is concluded that the interaction of C3 halogenated aporphine analogues with Phe339/Phe340 residues might be responsible for their enhanced affinity. (cuny.edu)
  • These are analogues of Aporphines, where a nitrogen atom replaces the carbon atom at position 1, and a keto group at C7. (hmdb.ca)
  • The relative concentration of alkaloids and phenolics in boldo leaves and their activity suggest that free-radical scavenging effect is mainly due to catechin and flavonoids and that antioxidant effect is mainly related with the catechin content The high catechin content of boldo leaves and its bioactivity suggest that quality control of Boldo folium has to combine the analysis of catechin as well as their characteristic aporphine alkaloids. (worldwidescience.org)
  • 1976). „Aporphines. (wikipedia.org)
  • Cotzias GC, Papavasiliou PS, Tolosa ES, Mendez JS, Bell-Midura M (1976) Treatment of Parkinson's disease with aporphines. (springer.com)
  • Se evaluó en laboratorio la actividad insecticida de polvo y extractos líquidos etanólicos y hexánicos del boldo ( Peumus boldus Molina sobre S. zeamais y T. castaneum. (worldwidescience.org)
  • Aporphines have been explored as antioxidants, anti-tuberculosis, antimicrobial and anticancer agents. (cuny.edu)
  • Finally, a novel series of flexible tris-(phenylalkyl)amines were synthesized and evaluated to test the importance of a rigid aporphine core as well as incorporation of N-phenylalkyl substituents. (cuny.edu)