Apoptotic peptidase activating factor 1. Medical search. Frequent questions

Apoptotic protease activating factor 1, also known as APAF1, is a human homolog of C. elegans CED-4 gene. (wikipedia.org)
APAF1 has been shown to interact with: APIP, BCL2-like 1 Caspase-9, HSPA4, and NLRP1. (wikipedia.org)

Activated caspase-9 stimulates the subsequent caspase cascade that commits the cell to apoptosis. (wikipedia.org)
Binding of caspase-9 to Apaf-1 leads to activation of the protease which then cleaves and activates caspase-3. (nih.gov)
Here we report that beta-amyloid precursor protein (APP) and death receptor 6 (DR6, also known as TNFRSF21) activate a widespread caspase-dependent self-destruction program. (deathbase.org)
Unlike neuronal cell body apoptosis, which requires caspase 3, we show that axonal degeneration requires caspase 6, which is activated in a punctate pattern that parallels the pattern of axonal fragmentation. (deathbase.org)
Caspase-8, a member of the caspase family, plays an important role in apoptotic signal transduction in mammals. (deathbase.org)
These results show that zebrafish casp8 has a structure and function similar to mammalian CASP8 orthologs, and our study suggests that the role of caspase-8 in the apoptotic signal pathway has been conserved over at least 450 million years of vertebrate evolution. (deathbase.org)

2 (Bcl-2) expression, and elevated the expression of apoptotic peptidase activating issue 1 (Apaf-1), BCL2-associated X, apoptosis regulator (Bax), and cytochrome c. (caspase-14.com)
The apoptosis was transduced by multiple signaling pathways mediated by FasL and TNFR2 and mainly activated the mitochondrial control of apoptosis via Bid and Bim, which was rescued by silencing Bid or/and Bim . (biomedcentral.com)
Our data suggest that Mch2 is a Ced-3/interleukin-1 beta converting enzyme-like cysteine protease and could be another important mediator of apoptosis in mammalian cells. (deathbase.org)
The mammalian extrinsic apoptosis pathway is triggered by Fas ligand (FasL) and Apo2 ligand/tumor necrosis factor (TNF)-related apoptosis-inducing ligand (Apo2L/TRAIL). (deathbase.org)
It does not have the morphological characteristics of typical necrosis, such as swelling of the cytoplasm and organelles and rupture of the cell membrane, nor does it have the characteristics of traditional cell apoptosis, such as cell shrinkage, chromatin condensation, formation of apoptotic bodies and disintegration of the cytoskeleton. (nature.com)

Overview of all the structural information available in the PDB for UniProt: O14727 (Apoptotic protease-activating factor 1) at the PDBe-KB. (wikipedia.org)
Site-1 protease inhibits mitochondrial respiration by controlling the TGF-β target gene Mss51. (nih.gov)
Site-1 protease is essential to growth plate maintenance and is a critical regulator of chondrocyte hypertrophic differentiation in postnatal mice. (nih.gov)
Hypomorphic mutation in the site-1 protease Mbtps1 endows resistance to persistent viral infection in a cell-specific manner. (nih.gov)
Mch2, a new member of the apoptotic Ced-3/Ice cysteine protease gene family. (deathbase.org)
We have developed a PCR approach to clone new apoptotic Ced-3/Ice-like cysteine protease genes. (deathbase.org)
Like interleukin-1 beta converting enzyme and CPP32, recombinant Mch2 alpha, but not Mch2 beta, possesses protease activity, as determined by its ability to cleave the fluorogenic peptide DEVD-AMC. (deathbase.org)

querymany ([ 'P24941' , 'O14727' ], scopes = 'uniprot' , fields = 'symbol,name' ) querying 1 - 2. (readthedocs.io)

In recent years, our understanding of genetic predisposition to PD has advanced vastly, including causative mutations in the genes encoding α-synuclein, LRRK2, parkin, PINK1, and DJ-1 just to name a few 5 . (nature.com)
Inhibition of proprotein convertase SKI-1 blocks transcription of key extracellular matrix genes regulating osteoblastic mineralization. (nih.gov)
Recent advances have been made in the of host factors, polymorphisms, and candidate genes associated characterization of the immune response to low-molecular- with occupational asthma may improve our understanding of weight agents. (cdc.gov)

These outcomes present sturdy proof that Cu-NPs can set off each intrinsic and extrinsic apoptotic pathways to mediate uterine harm, leading to oxidative stress-related modifications in gene expression. (caspase-14.com)
Cancer gene therapy approaches include the direct killing of tumor cells by injecting a therapeutic gene into the tumor cell or employing vaccine strategies to deliver an immunomodulatory gene that stimulates the immune system to recognize tumor antigens [ 1 ]. (biomedcentral.com)
Deletion of Mbtps1 (Pcsk8, S1p, Ski-1) Gene in Osteocytes Stimulates Soleus Muscle Regeneration and Increased Size and Contractile Force with Age. (nih.gov)
The novel innovation and significance resides within its potential to provide (1) an expanded understanding of the mechanism through which a maternal high fat diet reprograms primate gene expression and (2) a simple intervention (essential nutrient supplementation with neither diet nor behavioral modification) with tremendous potential impact given the current obesity epidemic and the lack of efficacious therapeutics. (nih.gov)
Using this approach, we have cloned a novel apoptotic gene from human Jurkat T lymphocytes. (deathbase.org)
The new gene encodes a approximately 34-kilodalton protein that is highly homologous to human CPP32, Caenorhabditis elegans cell death protein CED-3, mammalian Ich-1 (Nedd2), and mammalian interleukin-1 beta converting enzyme. (deathbase.org)
The A 1166 C polymorphism of the AT 1 receptor gene may be associated with cardiovascular phenotypes, such as high arterial blood pressure, aortic stiffness, and increased cardiovascular risk. (techscience.com)

HNK controls various intracellular signaling pathways involved in cancer, including those related to nuclear factor kappa B (NF- B), signal transducers and activators of transcription 3 (STAT3), epidermal growth factor receptor (EGFR), and mammalian targets of rapamycin (mTOR) [ 12 ]. (hindawi.com)
Ferroptosis-inducing factors can directly or indirectly affect glutathione peroxidase through different pathways, resulting in a decrease in antioxidant capacity and accumulation of lipid reactive oxygen species (ROS) in cells, ultimately leading to oxidative cell death. (nature.com)

More recent incretin-based treatment strategies include glucagon-like peptide-1 (GLP-1) mimetics and inhibitors of the enzyme that degrades GLP-1, dipeptidyl peptidase-4 (DPP-4). (ddw-online.com)

Apoptotic signaling is initiated either through extrinsic or intrinsic stimulation, resulting in the activation of caspases [ 12 ]. (biomedcentral.com)

initiator caspases (caspases 2, 8, 9 and 10), which are able to hydrolyse and activate a second family of effector caspases (caspases 3, 6 and 7), which themselves are able to hydrolyse further cellular proteins to bring about programmed cell death. (guidetopharmacology.org)
Ligand binding to cognate receptors activates initiator caspases directly in a death-inducing signaling complex. (deathbase.org)
In Drosophila, TNF ligand binding activates initiator caspases indirectly, through JNK. (deathbase.org)

Description: A sandwich quantitative ELISA assay kit for detection of Human Fas Apoptotic Inhibitory Molecule 3 (FAIM3) in samples from tissue homogenates, cell lysates or other biological fluids. (1elisakits.com)
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Fas Apoptotic Inhibitory Molecule 3 (FAIM3) in Tissue homogenates, cell lysates and other biological fluids. (1elisakits.com)
Description: A sandwich ELISA kit for detection of Fas Apoptotic Inhibitory Molecule 3 from Human in samples from blood, serum, plasma, cell culture fluid and other biological fluids. (1elisakits.com)
In addition, this molecule was capable of transmitting apoptotic signals mediated through not only Fas but also the TNF receptor in mouse Casp8-deficient cells. (deathbase.org)

epidermal growth factor receptor [Source. (gsea-msigdb.org)

ZNF746) was initially identified as a novel co-substrate of parkin and PINK1 that leads to Parkinson's disease (PD) by disrupting mitochondrial biogenesis through peroxisome proliferator-activated receptor gamma (PPARγ) coactivator -1α (PGC-1α) suppression. (nature.com)
In the same paper we also demonstrated that accumulating PARIS acts on PGC-1α, the master regulator of mitochondrial biogenesis, along the NRF1/2-TFAM axis to intervene in mitochondrial biogenesis, and that the transcriptionally inactive PARIS mutant (C571A) lacks repression capacity to induce the phenotype. (nature.com)

Porcine Leukemia Inhibitory Factor (LIF) ELISA Kit Introduction: The event of SARS-CoV-2 serological assessments is very large. (elisastrip.com)
Description: A sandwich quantitative ELISA assay kit for detection of Mouse Sodium/Glucose Cotransporter 1 (SGLT1) in samples from tissue homogenates, cell lysates or other biological fluids. (allelisakits.com)
Description: Quantitativesandwich ELISA kit for measuring Human Cementum Protein 1 (CEMP-1) in samples from serum, plasma. (worldcarecouncil.org)
Description: Quantitative sandwich ELISA for measuring Human Cementum Protein 1 (CEMP-1) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids. (worldcarecouncil.org)
Description: A sandwich ELISA kit for detection of Delta Like 1 Homolog from Human in samples from blood, serum, plasma, cell culture fluid and other biological fluids. (tuberculosisdrugresearch.org)
Description: A sandwich quantitative ELISA assay kit for detection of Mouse Delta Like 1 Homolog (dLK1) in samples from serum, plasma, tissue homogenates or other biological fluids. (tuberculosisdrugresearch.org)
uPA, PAI-1 and interleukin-6 were determined by enzyme linked immunosorbent assay (ELISA) in non oncological diseases (n=34) and in healthy individuals (n=20) and correlated with vitamin E treatment after operations. (ispub.com)

adaptor related protein complex 1 subuni. (gsea-msigdb.org)

Adipocyte-derived factors involved in tumor progression include proteins such as adiponectin, leptin, TNF-α, monocyte chemotactic protein-1 (MCP-1), IL-6, and ECM components that control tumor cell behavior within the tumor microenvironment. (jci.org)
Caveolin-1 or CAV1 is a scaffolding proteins within caveolar membranes. (thermofisher.com)

Environmental factors that can detect specific IgE antibodies against most low-molecular- affect the initiation of occupational asthma include the intrinsic weight agents has resulted in a search for alternative or characteristics of causative agents as well as the influence of the complementary physiopathologic mechanisms leading to airway level and route of exposure at the workplace. (cdc.gov)

The apoptosome binds and cleaves Procaspase-9 protein, releasing its mature, activated form. (wikipedia.org)

The results demonstrated that PPARγ functions as a master regulator of PARIS-induced molecular changes at the transcriptome level, confirming that PARIS acts primarily on PGC-1α to lead to neurodegeneration in PD. (nature.com)
Originally discovered as a chief regulatory protein of glucose and lipid metabolism and cell differentiation, the peroxisome proliferator-activated receptor gamma (PPARγ) is a ligand-activated transcription factor of the nuclear hormone receptor superfamily 8 . (nature.com)
Obtained outcomes recommend that examined lipid mediators are concerned in peroxisome proliferator-activated receptors (PPAR)-independent and PPAR-dependent modulation of cardiac inflammatory reactions. (caspase-14.com)

DR6 is activated locally by an inactive surface ligand(s) that is released in an active form after trophic-factor deprivation, and we identify APP as a DR6 ligand. (deathbase.org)

inhibition of inflammatory processes, decreased angiogenesis, and antiproliferative/pro apoptotic effects (Shimizu et al. (raf-signal.com)

GLP-1 is an intestinally-derived peptide that stimulates insulin secretion in response to food intake, as well as reducing the rate of gastric emptying, thus promoting satiety and weight loss. (ddw-online.com)
Anti-Caveolin 1 affinity purified antibody was prepared from whole rabbit serum produced by repeated immunizations with a synthetic peptide at the N-terminus of human Caveolin-1 protein. (thermofisher.com)

Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Sodium/Glucose Cotransporter 1 (SGLT1) in Tissue homogenates and other biological fluids. (allelisakits.com)
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Tumor Protein, Translationally Controlled 1 (TPT1) in tissue homogenates, cell lysates, cell culture supernates and other biological fluids. (allelisakits.com)
Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Human Tumor Protein, Translationally Controlled 1 (TPT1) in samples from tissue homogenates, cell lysates, cell culture supernates and other biological fluids with no significant corss-reactivity with analogues from other species. (allelisakits.com)
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Cementum Protein 1 (CEMP1) in serum, plasma and other biological fluids. (worldcarecouncil.org)
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Rat Delta Like 1 Homolog (dLK1) in serum, plasma, tissue homogenates and other biological fluids. (tuberculosisdrugresearch.org)
Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Human Dynein Heavy Chain Domain Containing Protein 1 (DNHD1) in samples from Tissue homogenates and other biological fluids. (youngresearch.eu)

Activating or blocking the ferroptosis pathway to alleviate the progression of the disease, which provides a promising therapeutic strategy for many diseases. (nature.com)

ALF transcription elongation factor 1 [S. (gsea-msigdb.org)
Orthologous to human MBTPS1 (membrane bound transcription factor peptidase, site 1). (nih.gov)

Furthermore, we examined the function of zebrafish Casp8 protein in mammalian cells, and showed that it has pro-apoptotic activity when overexpressed. (deathbase.org)

DR6 is broadly expressed by developing neurons, and is required for normal cell body death and axonal pruning both in vivo and after trophic-factor deprivation in vitro. (deathbase.org)

The angiotensin II type 1 receptor mediates the vasoconstrictor and growthpromoting effects of Ang II. (techscience.com)
Caveolin-1 is also involved in the co-stimulatory signal essential for T-cell receptor (TCR) mediated T-cell activation. (thermofisher.com)

Our results show that uPA, PAI 1, and interleukin-6 values were significantly higher in non oncological gynecological cases in comparison with healthy individuals (8.3 times, 3.8 times, and 9.8 times, respectively, P≤ 0.0001). (ispub.com)
uPA, PAI-1, and interleukin-6 were significantly higher after abdominal gyneocological operation than before operation in the group of patients who were not treated with vitamin E after operation (P≤ 0.0001). (ispub.com)
Therefore, other independent risk factors may exist that contribute significantly to CVD risk in these patients. (ddw-online.com)
The day of gestation influenced significantly on the apoptotic index in both groups. (techscience.com)

Testis sections incubated with an antibody to caveolin-1 showed, by immunohistochemistry, a moderate number of Leydig cells with different degrees of immunoreaction and a strong reaction in endothelial cells and in the lamina propia of seminiferous tubules. (techscience.com)
The following product was used in this experiment: Caveolin-1 Polyclonal Antibody from Thermo Fisher Scientific, catalog # 600-401-J62. (thermofisher.com)

We identify the histone acetyltransferase MYS-1, as a critical regulator of this metabolic-epigenetic axis. (knoblauchpublishing.com)

RAF Signals Command in November 1958, then becoming part of Strike Command, and reverting to No. 90 (Signals) Group on 1 January 1969. (raf-signal.com)

getgenes ([ '1017' , '1018' ], species = 'human' , fields = 'symbol,name' ) querying 1 - 2. (readthedocs.io)

B cells from Casp6 knockout (Casp6 KO) mice examined ex vivo have more cells in G(1) than wild-type B cells, and mitogen-induced G(1) entry of Casp6 KO B cells is much faster than that of wild-type B cells. (deathbase.org)
Rather than proliferating, activated Casp6 KO B cells preferentially differentiate into syndecan-1(+) plasma cells and produce Abs. (deathbase.org)
In Casp6 KO mice compared with WT mice, serum levels of IgG1, IgG2a, and IgG2b are increased and Ag-specific Ab responses are also enhanced along with increased percentages of syndecan-1(+) plasma cells. (deathbase.org)
Casp6 may regulate both B cell activation and differentiation by modifying requirements for G(0) B cells to enter G(1). (deathbase.org)

More, plant pollen fill, worker-sealed family area, populace energy, and darling yield differed substantially whenever Diet plan 1 has been consumed rather than additional supplement diets. (tws119inhibitor.com)

Abstract Essential hypertension is considered a multifactorial trait resulting from a combination of environmental and genetic factors. (techscience.com)

This altered glucose metabolism state is associated with an increased risk of developing T2DM (Figure 1), although other parameters including excess adiposity, inflammation and dyslipidemia are risk factors associated with the development of insulin resistance, loss of pancreatic function, worsening of hyperglycemia and progression to diabetes (1). (ddw-online.com)

4 ) found that uPA mRNA seems to be up-regulated in endometriotic glands and endometrial stroma as well as PAI-1 mRNA in endometriotic and endometrial stroma from women with endometriosis. (ispub.com)
METHODS: We conducted a test-negative case-control analysis among AI/AN persons aged 12 years presenting for care from January 1, 2021, through November 30, 2021, to evaluate the effectiveness of mRNA COVID-19 vaccines against COVID-19-associated outpatient visits and hospitalizations. (cdc.gov)

amyloid beta precursor like protein 1 [S. (gsea-msigdb.org)

Abstract Caveolin-1, the first member of caveolin family reported, is recognized as the structural component of caveola, a plasma membrane invagination or vesicles that are a subcompartment distinct from clathrin-coated pits. (techscience.com)
The aim of this study was to determine the expression of caveolin-1 in adult rat Leydig cells. (techscience.com)
Cross-reactivity with Caveolin 1 from other sources has not been determined. (thermofisher.com)

The identification of chromosome 1 translocations and deletions is a rare and poorly investigated event in chronic lymphocytic leukemia (CLL). (cancerindex.org)

Also, proteolysis is found in pathological conditions such as tumor growth, metastasis, arthritis and autoimmune diseases ( 1 ). (ispub.com)
Our results highlight the crucial role of ETP as an obesity-associated factor that promotes tumor growth in the context of adipocyte interactions with tumor and stromal cells. (jci.org)

6 ) suggest that low-density lipoprotein (LDL) regulates PAI-1, uPA, and tPA in biphasic patterns in HMC, and the up regulation of PAI-1, uPA, and tPA after long-term LDL exposure seems to be mediated by a delayed protein kinase C (PKC) activation associated with an increased PA inhibitory activity. (ispub.com)
1. To identify the structure-activity relationship for causal agents of Date of Original Release: March 2009. (cdc.gov)

The aim of this work was to quantify the apoptotic index of adrenal cortex during mid-pregnancy and to prove cytological characteristics by electron microscopy. (techscience.com)

The purpose of this study was to determine whether there is a stimulation of production of uPA, PAI-1 and interleukin-6 before and after operation in plasma patients with gynecological diseases, and whether vitamin E could inhibit this process. (ispub.com)

1-17, 2023 Mar 07. (bvsalud.org)

We show that in response to DNA damage, polyunsaturated fatty acids, especially arachidonic acid (AA) and AA-related lipid mediators, are elevated and this is dependent on mys-1 . (knoblauchpublishing.com)

BCSCs are mostly dormant, and therefore, activating them and modulating the cell cycle are important for successful therapy against BCSCs. (hindawi.com)
Meanwhile, ectopic expression of hcmv-miR-US5-1 and consequent lower expression of GMNN influenced host cell cycle and proliferation. (virosin.org)
In 2012, Dixon 1 first proposed the concept of ferroptosis, an iron-dependent, non-apoptotic mode of cell death characterized by the accumulation of lipid reactive oxygen species (ROS). (nature.com)
Head and neck squamous cell carcinoma (HNSCC) is a type of tumor that originates from the squamous epithelium of the head and neck areas, including the mucous membranes of the lips, tongue, pharynx, larynx, and others ( 1 ). (frontiersin.org)

Anatomy31

Organisms13

Diseases2

Chemicals and Drugs131

Analytical, Diagnostic and Therapeutic Techniques and Equipment20

Phenomena and Processes58

Disciplines and Occupations1

Information Science4

Health Care2

APAF12

Caspase6

Apoptosis5

Protease7

O147271

Genes3

Gene7

Pathways2

Dipeptidyl1

Extrinsic1

Caspases3

Molecule4

Epidermal growth f1

Mitochondrial2

ELISA7

Protein complex1

Proteins2

Intrinsic1

Cleaves1

PPAR3

Ligand1

Angiogenesis1

Peptide2

Enzyme6

Pathway1

Transcription2

Mammalian1

Vitro1

Receptor2

Significantly4

Antibody2

Regulator1

Signals1

Human1

Casp64

Substantially1

Environmental and genetic factors1

Progression1

MRNA2

Precursor1

Caveolin3

Chromosome1

Tumor growth2

Activity2

Characteristics1

Stimulation1

20231

Mediators1

Cell4