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  • ischemic
  • Acute cerebral ischemic reperfusion injury (CIRI), a hotspot for clinical research, is a pathophysiologic phenomenon commonly encountered in the field of emergency medicine, especially during the perioperative periods. (hindawi.com)
  • Damage
  • In a rabbit model, the administration of ascorbate aggravates damage, likely through the abrogation of the endogenous enzymatic antioxidant response triggered by short episodes of ischemia [ 10 ]. (hindawi.com)
  • Methods
  • Animal experiments focus on understanding the mechanism behind IRI and try to find methods to minimize IRI either before, during or after ischemia. (biomedcentral.com)
  • Factors
  • Apoptotic homeostasis can be disrupted by various extracellular factors generated by physiopathological conditions. (rupress.org)
  • dopamine
  • Simultaneous treatment with BDM suppressed contractility without affecting [Ca 2+ ] i and did not reduce dopamine-stimulated apoptotic markers. (ahajournals.org)
  • significantly
  • During storage of the transplant, the temperature is reduced to approximately 4 °C. During this cold ischemia period, metabolism is significantly reduced which allows for prolonged preservation of the organ until transplantation. (biomedcentral.com)
  • outcome
  • STUDIES in laboratory animals have shown that anesthetic agents reduce infarct size and improve neurologic outcome after transient focal and incomplete hemispheric ischemia. (asahq.org)
  • These grafts are associated with an increased sensitivity to IRI and decreased graft outcome due to prolonged ischemia and donor comorbidity. (biomedcentral.com)
  • studies
  • Several studies have depicted that, induction of HO-1 expression interferes with the progression of a number of hepatic pathophysiological conditions including ischemia/ reperfusion (I/R) injury, liver inflammation, hepatic fibrosis and hepatitis [ 4 ]. (hindawi.com)