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  • pathways
  • R. arboreum extract up-regulated the gene expression of caspase 8, caspase 9, caspase 3, p53 and p21, thus indicating a switching on of both the intrinsic and extrinsic apoptotic pathways resulting in DNA damage which in-turn up-regulated p53. (omicsonline.org)
  • We used TGF-β, SC79, LY294002, Rapamycin, protein kinase B (AKT) inhibitor to treat the 786-O or 786-M-R cells and detected the regulations in TGF-β /pSMAD3 and AMPK/AKT pathways. (springer.com)
  • AMPK/AKT pathways and TGF-β/SMAD3 pathways showed low sensibilities in 786-M-R. The histone H3 acetylation diminished in the 786-M-R cells. (springer.com)
  • Alkylglyceronephosphate synthase (AGPS) alters lipid signaling pathways and supports chemotherapy resistance of glioma and hepatic carcinoma cell lines. (nih.gov)
  • PCNA is pivotal to the activation of these pathways and the choice as to which pathway is utilised by the cell. (wikipedia.org)
  • VprBP also regulates p53-induced transcription and apoptotic pathways. (wikipedia.org)
  • inhibitory
  • There was significant down-regulation in the gene expression of G0/G1 phase-related proteins CDK 1, cyclin B1, CDK 4 and cyclin D1 in comparison to untreated HeLa cells, inferring an inhibitory action of the plant extract on the cyclin dependent kinases and activation of cell cycle checkpoints. (omicsonline.org)
  • Discussion and Conclusion: These observations are novel and suggest that extracellular factors from breast carcinoma play an apoptosis inducing and growth inhibitory role upon on HeLa cells. (waocp.org)
  • mechanism
  • Calocedrus formosana (Florin) bark acetone/ethylacetate extracts are known to exert an antitumor effect on some human cancer cell lines, but the mechanism is yet to be defined. (hindawi.com)
  • Role and mechanism of the alkylglycerone phosphate synthase in suppressing the invasion potential of human glioma and hepatic carcinoma cells in vitro. (nih.gov)
  • De-regulation of CK2 has been linked to tumorigenesis as a potential protection mechanism for mutated cells. (wikipedia.org)
  • Adozelesin is an alkylating minor groove DNA binder that is capable of rapidly inhibiting DNA replication in treated cells through a trans-acting mechanism and preferentially arrests cells in S phase. (wikipedia.org)
  • A second mechanism is through the association of neurotrophic factors like nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF), glial cell line-derived neurotrophic factor (GDNF). (wikipedia.org)
  • senescence
  • It has been found that when the neuroblastoma cells that are resistant to chemotherapy are grown in co-culture with the wild type (WT), or chemotherapy-sensitive cells, the resistance to chemotherapy is conferred to the wild type cells, and thus no cell death or senescence occurs in either cell type, despite the chemotherapeutic treatment. (wikipedia.org)
  • inhibitor
  • We have demonstrated that when an Hsp90 inhibitor and topoisomerase I poison are combined they produce a synergistic increase in apoptosis in both p53⁺/⁺ and p53⁻/⁻ HCT116 human colon cancer cells. (uea.ac.uk)
  • 5-Tetradecyloxy-2-furoic acid (TOFA) is a cell-permeable small molecule and also an allosteric inhibitor of ACCA. (jcancer.org)
  • CAD is synthesized with the help of ICAD (inhibitor of CAD), which works as a specific chaperone for CAD and is found complexed with ICAD in proliferating cells. (wikipedia.org)
  • therapeutic
  • miR-34a functions as a tumor suppressor in RB cells and is a potential therapeutic target. (arvojournals.org)
  • 4 5 Thus, therapeutic strategies that reactivate or recapitulate p53 responses in p53 pathway-inactivated RB cells may demonstrate clinical usefulness against this disease. (arvojournals.org)
  • This finding has augmented the therapeutic potential of the pro-apoptotic protein Par-4 in cancer. (wikipedia.org)
  • Using this technology scientists aims to create ADCs having an optimal therapeutic window, balancing the effect of potent cell-killing agents on tumor cells versus healthy cells. (wikipedia.org)
  • Chemoresistance
  • MK has been identified as one of the factors that "transfers" this chemoresistance from the resistant cells to the WT cells. (wikipedia.org)
  • This indicates that MK caused the cells to initiate the survival pathway (via PKB, mTOR, and Bad activation) and inhibit the senescent or apoptotic pathway (via inhibiting caspase-3) encouraging the chemoresistance seen in resistant cells and in the co-culture experiments. (wikipedia.org)
  • loss of p53
  • Loss of p14ARF by a homozygous mutation in the CDKN2A (INK4A) gene will lead to elevated levels in mdm2 and, therefore, loss of p53 function and cell cycle control. (wikipedia.org)
  • inhibits
  • 4 Treatment of RB cells with nutlin-3, a compound that inhibits MDM2 and MDMX enzymatic activity, results in antiproliferative and proapoptotic effects. (arvojournals.org)
  • Withaferin A inhibits NF-κB at a very low concentration by targeting the ubiquitin-mediated proteasome pathway (UPP) in endothelial cells. (wikipedia.org)
  • molecular
  • She has strong domain knowledge with experiences in a wide range of laboratory techniques including enzymology, molecular biology, bioassay development, cell culture and handling of modern advanced scientific instruments. (omicsonline.org)
  • In 1970, Williamson described that cytoplasmic DNA isolated from mouse liver cells after culture was characterized by DNA fragments with a molecular weight consisting of multiples of 135 kDa. (wikipedia.org)
  • depletion
  • Depletion of CENP-E from cultured human cells using antisense oligonucleotides or RNAi causes prolonged cell-cycle delay in mitosis that is characterized by an intact bipolar mitotic spindle with several chromosomes clustered close to either spindle pole ( 10 , 11 ). (pnas.org)
  • chemotherapy
  • Ginsenoside-Rb1 targets chemotherapy-resistant ovarian cancer stem cells. (greenmedinfo.com)
  • Drugs used in chemotherapy, such as idarubicin, cytarabine, and etoposide, work in different ways to stop the growth of cancer cells, either by killing the cells or by stopping them from dividing. (clinicaltrials.gov)
  • AGPS overexpression could be a causation of chemotherapy agent resistance of cancer cells. (nih.gov)
  • Experiments performed in vitro show that β-elemene has anti-proliferative effects toward some cancer cell types, indicating the possibility of its use in chemotherapy. (wikipedia.org)
  • The resistance to chemotherapy seems to be reversible by administering chemo-resensitization drugs, such as verapamil, which acts not via MK alteration, but by inhibiting the P-glycoprotein pump that exports cytotoxins out of cells. (wikipedia.org)
  • Following co-culture experiments and the determination that MK was one of the factors that was conferring chemo-resistance to the wild, non-resistant cell type, the gene for MK was transfected into WT cells to determine if MK was overexpressed in the WT cells themselves, would the cells become resistant to chemotherapy independent of resistant cell influence. (wikipedia.org)
  • cancer
  • Targeting p38α Increases DNA Damage, Chromosome Instability, and the Anti-tumoral Response to Taxanes in Breast Cancer Cells. (semanticscholar.org)
  • Dual function of p38α MAPK in colon cancer: suppression of colitis-associated tumor initiation but requirement for cancer cell survival. (semanticscholar.org)
  • The aim of this study was to determine the effects of Florin leaf methanol extracts on the growth and apoptosis of human bladder cancer cell lines. (hindawi.com)
  • According to a recent study, urinary bladder cancer including transitional cell carcinoma (TCC) affects more than 2 million people worldwide [ 1 ]. (hindawi.com)
  • Bortezomib may stop the growth of cancer cells by blocking some of the enzymes needed for cell growth. (clinicaltrials.gov)
  • 3-azido withaferin A (3-azidoWA), a stable derivative of withaferin A, has been shown to inhibit cancer cell motility and invasion in wound healing by selectively suppressing MMP-2 activity in human cervical and prostate cell lines. (wikipedia.org)
  • The anti-tumor activity of withaferin A was tested on human prostate cancer cell line, PC-3 and confirmed in PC-3 xenografts in nude mice. (wikipedia.org)
  • MK appears to enhance the angiogenic and proliferative activities of cancer cells. (wikipedia.org)
  • In neuroblastoma, MK has been found to be over expressed in the cancer cells that are resistant to chemotherapeutic drugs. (wikipedia.org)
  • Doxorubicin works by putting rampant cancer cells into a senescent state. (wikipedia.org)
  • growth
  • In this study, we examined the functions of TOFA in human renal cell carcinoma (RCC) cell lines ACHN and 786-O. According to the results, TOFA inhibited ACHN and 786-O cell growth in a concentration and time dependent manner. (jcancer.org)
  • In this study, we investigated the effect of Florin leaf methanol extracts on the growth of human bladder carcinoma cells, including TCCSUP cells that are derived from a high-grade and invasive human urinary bladder tumor [ 14 ]. (hindawi.com)
  • Here we demonstrate that the Florin leaf methanol extracts inhibit growth of these bladder carcinoma cells by arresting cell cycle at the G2/M phase and inducing apoptosis. (hindawi.com)
  • Exogenous miR-34a inhibited Y79 and Weri-Rb1 cell growth and increased apoptotic activity in Y79 cells. (arvojournals.org)
  • A key regulator of prolactin production is estrogens that enhance growth of prolactin-producing cells and stimulate prolactin production directly, as well as suppressing dopamine. (wikipedia.org)
  • The LNCaP line is hormonally responsive, shown by in vitro 5 alpha-dihydrotestosterone modulation of cell growth and acid phosphatase production. (wikipedia.org)
  • Cells were subcutaneously injected at multiple sites into the mouse flank and after approximately 4 weeks of growth, tumors were easily detectable by physical examination and had a high rate of growth (17-33 mm3/day). (wikipedia.org)
  • DHT treatment elicited markedly reduced growth in C4 and C5 cells and no growth in C4-2 cells when compared to the high rate of growth seen in LNCaP cells, suggesting reduced androgen sensitivity in C4 and C5 and AI in C4-2 cells. (wikipedia.org)
  • activity
  • Mdm2 also has E3 ubiquitin ligase activity toward p53, and promotes its exportation from the cell nucleus to the cytoplasm for degradation. (wikipedia.org)
  • When bound to Vpr, VprBP allows Vpr to modulate the catalytic activity of the CUL4-DDB1 complex, inducing G2 cell cycle arrest in infected cells. (wikipedia.org)
  • The protein also has pro-apoptotic activity. (wikipedia.org)
  • It has been shown previously that in cells treated with adozelesin, replication protein A (RPA) activity is deficient, and the middle subunit of RPA is hyperphosphorylated. (wikipedia.org)
  • whereas
  • Of note, HS-1793 induced p53/p21(WAF1/CIP1)-dependent apoptosis in MCF-7 cells, whereas it exhibited p53-independent apoptosis in MDA-MB-231 cells. (yu.ac.kr)
  • The duocarmycin analogues are able to exert their mode of action at any phase in the cellular cycle, whereas tubulin binders will only attack tumor cells when they are in a mitotic state. (wikipedia.org)
  • tumor cell
  • Growing evidence suggests that DNA damaging agents, such as duocarmycins, are more efficacious in tumor cell killing than tubulin binders, particularly in case of solid tumors. (wikipedia.org)
  • colon
  • Similar research that Boger utilized for comparison to his results involving elimination of cancerous tumors and antigens was centered around the use of similar immunoconjugates that were introduced to cancerous colon cells. (wikipedia.org)
  • pathway
  • Stat-3, however, which is another survival pathway factor, does not appear to have any change in activation between the wild type cells and the MK-transfected WT cells, as was initially believed from a previous study. (wikipedia.org)
  • mRNA
  • mRNA expression changes were observed in 7 of 7 previously reported and 13 of 18 GenMiR++-predicted miR-34a targets after transfection of Y79 cells with miR-34a compared with negative control microRNA. (arvojournals.org)
  • M, C4, C5 and C4-2 also expressed reduced human androgen receptor mRNA as expected in AI cells. (wikipedia.org)
  • survival
  • Proper CK2 function is necessary for survival of cells as no knockout models have been successfully generated. (wikipedia.org)
  • An increased concentration of substrates in cancerous cells infers a likely survival benefit to the cell, and activation of many of these substrates requires CK2. (wikipedia.org)
  • A loss of ARF or p53, therefore, would give cells a survival advantage. (wikipedia.org)
  • kinase
  • Western blot analysis revealed the increases of cyclin B1 and Cdc2 kinase levels, alone with the decrease of phosphorylated Cdc2 kinase, after treating these cells with the extracts. (hindawi.com)
  • verify
  • To further verify that these cells were of human origin karyotype analysis determined that the parental LNCaP cells had 7 distinct marker chromosomes, with two copies of each. (wikipedia.org)
  • LNCAP
  • LNCaP cells are a cell line of human cells commonly used in the field of oncology. (wikipedia.org)
  • LNCaP cells are androgen-sensitive human prostate adenocarcinoma cells derived from the left supraclavicular lymph node metastasis from a 50-year-old caucasian male in 1977. (wikipedia.org)
  • To develop an AI-PCa cell model that more closely mimics clinical disease, LNCaP sublines have been generated to provide the most clinically relevant tissue culture tools to date. (wikipedia.org)
  • The LNCaP cell line was established from a metastatic lesion of human prostatic adenocarcinoma. (wikipedia.org)
  • LNCaP cells have a modal chromosome number of 76 to 91, indicative of a human male karyotype with several marker chromosomes. (wikipedia.org)
  • LNCaP cells also express Prostate Specific Antigen (PSA). (wikipedia.org)
  • 1994) reproduced the human-derived LNCaP tumors in immunocompromised mice by co-injection of LNCaP cells with MS human bone fibroblasts. (wikipedia.org)
  • To replicate the hallmark shift of PCa cells to AI, LNCaP host mice were castrated by way of midscrotal incision at approximately 8 weeks post injection. (wikipedia.org)
  • Karyotype comparisons indicate that LNCaP cells grown in intact hosts (M subline) have a modal chromosomal distribution number of 83, C4 and C5 sublines with 85, and the C4-2 subline with 83. (wikipedia.org)
  • The M, C4, C5, and C4-2 sublines contained most of the marker chromosomes, with the M subline being most similar to the parental LNCaP cells. (wikipedia.org)
  • important
  • However, an important limitation of antibodies is that cells need to be fixed leading to potential artifacts. (wikipedia.org)
  • Vpr stands for "Viral Protein R". Vpr, a 96 amino acid 14-kDa protein, plays an important role in regulating nuclear import of the HIV-1 pre-integration complex, and is required for virus replication in non-dividing cells such as macrophages. (wikipedia.org)
  • Another important benefit is that, unlike other drug classes, duocarmycins can be effective against tumor cells that are multi-drug resistant. (wikipedia.org)
  • human
  • Although the generation of AI cell lines has been quite successful as demonstrated in the "classic" cell lines DU145 and PC3, the behavior of these cells in bone does not fully mimic clinical human disease. (wikipedia.org)
  • To further select for AI-PCa cells, the C4 subline was co-injected with MS human fibroblasts into a castrated host. (wikipedia.org)
  • nuclei
  • PCNA was originally identified as an antigen that is expressed in the nuclei of cells during the DNA synthesis phase of the cell cycle. (wikipedia.org)
  • Another significant portion of the receptors is located in the hypothalamus (supra optic and paraventricular nuclei) and external granule cell layer of the prefrontal cortex. (wikipedia.org)
  • tubulin
  • An immunofluorescence assessment of β -tubulin showed decreased levels of polymerized tubulin in treated cells. (hindawi.com)
  • chromosomal
  • A Y chromosome is not present in most C4, C5 and C4-2 cells, suggesting major chromosomal alterations. (wikipedia.org)
  • When cells are induced to undergo apoptosis, caspase 3 cleaves ICAD to dissociate the CAD:ICAD complex, allowing CAD to cleave chromosomal DNA. (wikipedia.org)
  • phase
  • The cell cycle of these extract-treated cells (TCCSUP cells) was arrested at the G2/M phase as determined by flow cytometry. (hindawi.com)
  • When Rb is phosphorylated by cyclin D and E-dependent kinases during the G1 phase of the cell cycle, Rb can not block E2F-dependent transcription, and the cell can progress to the DNA synthetic phase(S phase). (wikipedia.org)
  • Imaging of the nuclear distribution of PCNA (via antibody labeling) can be used to distinguish between early, mid and late S phase of the cell cycle. (wikipedia.org)
  • protein
  • Taking a systems approach, we develop and summarise the view that "serum ferritin" actually originates from damaged cells (and thus reflects cellular damage), that it contains some iron but has lost or liberated most of its normal content, and that since the protein part of ferritin is assumed to be benign, that it is this (initially) free iron that correlates with and is causative of disease. (rsc.org)
  • Interestingly, PIO significantly downregulated the protein levels of p53 and cyclin D1 in J82 cells, but not NUTE cells after more than 192 hours of treatment. (medsci.org)
  • After Fas stimulation, Daxx is activated and plays its role of pro-apoptotic protein in activating the c-JUN-N-Terminal Kinase (JNK) pathway. (wikipedia.org)
  • One of the best-known families of porphyrin complexes is heme, the pigment in red blood cells, a cofactor of the protein hemoglobin. (wikipedia.org)
  • On the other hand, studies in cells have shown that ceramide-inducing agents such as tumor necrosis factor-alpha α (TNFα) and palmitate induce the ceramide-dependent removal of a phosphate group (dephosphorylation) of the retinoblastoma gene product RB and the enzymes, protein kinases B (AKT protein family) and C α (PKB and PKCα). (wikipedia.org)
  • Δ324 found at low levels in human and mouse cells - an alternative splice variant encoding an 88kDa protein lacking zinc fingers 6 and 7 Δ105 variant is unique to mice, and results in a protein truncated by 105 amino acids at the acidic C-terminus. (wikipedia.org)
  • The unregulated expression of this protein activates other proteins that are involved in cell cycle and cell division which can cause a cell to grow and divide uncontrollably (the cell becomes cancerous). (wikipedia.org)
  • In this scenario, the UPR has three aims: initially to restore normal function of the cell by halting protein translation, degrading misfolded proteins, and activating the signalling pathways that lead to increasing the production of molecular chaperones involved in protein folding. (wikipedia.org)
  • The aforementioned sugar molecule remains the means by which the cell monitors protein folding, as the misfolding protein becomes characteristically devoid of glucose residues, targeting it for identification and re-glycosylation by the enzyme UGGT (UDP-glucose:glycoprotein glucosyltransferase)1. (wikipedia.org)
  • Biomarkers
  • Overall, this systems approach serves to explain a number of apparent paradoxes of serum ferritin, including (i) why it correlates with biomarkers of cell damage, (ii) why it correlates with biomarkers of hydroxyl radical formation (and oxidative stress) and (iii) therefore why it correlates with the presence and/or severity of numerous diseases. (rsc.org)
  • vitro
  • The aim of this study was to investigate the in vitro effects of PIO on normal urothelial transitional epithelium (NUTE) cells and bladder cancer (J82) cells to further evaluate the risk. (medsci.org)
  • Along with the debate on whether PIO causes bladder cancer in humans, animal and in vitro cell culture studies have suggested a biological effect of PIO on the induction or protection from bladder cancer [ 7 ]. (medsci.org)
  • TUNEL
  • The fluorochrome-based TUNEL assay applicable for flow cytometry, combining the detection of DNA strand breaks with respect to the cell cycle-phase position, was originally developed by Gorczyca et al. (wikipedia.org)
  • genes involved in cell
  • Mutations of the GLI2 gene are associated with several phenotypes including Greig cephalopolysyndactyly syndrome, Pallister-Hall syndrome, preaxial polydactyly type IV, postaxial polydactyly types A1 and B. In human keratinocytes Gli2 activation upregulates a number of genes involved in cell cycle progression including E2F1, CCND1, CDC2 and CDC45L. (wikipedia.org)
  • Membrane
  • Another function of Hsc70 is as an ATPase in the disassembly of clathrin-coated vesicles during transport of membrane components through the cell. (wikipedia.org)
  • Also, because of its hydrophobic nature, ceramide readily flip-flops across membranes as supported by studies in membrane models and membranes from red blood cells (erythrocytes). (wikipedia.org)
  • tumor cells
  • Tumor cells arise from two distinct classes of genomic instability: mutational instability arising from changes in the nucleotide sequence of DNA and chromosomal instability arising from improper rearrangement of chromosomes. (wikipedia.org)
  • In tumor cells, they are often mutated and/or expressed at high levels. (wikipedia.org)
  • organism
  • In 1956, Francis Crick proposed what is now known as the "central dogma" of biology: DNA encodes the genetic information required for an organism to carry out its life cycle. (wikipedia.org)
  • function
  • Together, the results of this study lay the groundwork for future studies to explore the role of DNA replication in immune cell generation and function. (jci.org)
  • Another study showed loss of Daxx pro-apoptotic function in case of a mutant without Pml. (wikipedia.org)
  • The DNA-binding activity of the ubiquitously expressed ABL1 tyrosine kinase is regulated by CDC2-mediated phosphorylation, suggesting a cell cycle function for ABL1. (wikipedia.org)
  • Its function in these cells may be regulated by phosphorylation of serine196, in its N-terminal DNA binding domain. (wikipedia.org)
  • encodes
  • This new fusion gene, BCR-ABL, encodes an unregulated, cytoplasm-targeted tyrosine kinase that allows the cells to proliferate without being regulated by cytokines. (wikipedia.org)
  • cyclin
  • In addition, treatment with PIO for up to 72 hours did not result in changes in the expressions of p53, cyclin D1, Bcl-2, and Bax in NUTE cells and J82 cells. (medsci.org)
  • PIO decreased the expression of p53 and cyclin D1 in J82 cells after long-term culture, which suggested that PIO may be helpful for diabetic patients with bladder cancer. (medsci.org)
  • murine
  • We used human glioma lines containing BRAF V600E (adult high-grade: AM-38, DBTRG, PLGG: BT40), or wild-type BRAF (pediatric high-grade: SF188, SF9427, SF8628) and isogenic systems of KIAA1549:BRAF -expressing NIH/3T3 cells and BRAF V600E -expressing murine brain cells. (aacrjournals.org)
  • Lysate
  • ab94065 is a 293T cell transfected lysate in which Human IKK beta has been transiently over-expressed using a pCMV-IKK beta plasmid. (abcam.com)
  • HEK293 Cell Lysate. (abcam.com)
  • neoplasms
  • Artykuł zawiera opis dwóch przypadków chorych z rozpoznaniem bardzo rzadko występujących nowotworów z blastycznych plazmacytoidalnych komórek dendrytycznych ( blastic plasmacytoid dendritic cell neoplasms - BPDCN). (czytelniamedyczna.pl)
  • In this paper we report two cases of very rare blastic plasmacytoid dendritic cell neoplasms (BPDCN). (czytelniamedyczna.pl)
  • A category of rare and aggressive haematologic tumors co-expressing CD4 and CD56 antigens in the absence of any specific myeloid, B-, T-lymphoid or natural killer (NK) lineage markers is classified as blastic plasmacytoid dendritic cell neoplasms (BPDCN) according to the most recent 2008 WHO classification of tumours of haematopoietic and lymphoid tissues (1). (czytelniamedyczna.pl)
  • cellular
  • We argue here that serum ferritin arises from damaged cells, and is thus a marker of cellular damage. (rsc.org)
  • viability
  • In BRAF V600E cells, the three possible doublet combinations of AZD6244, everolimus, and PLX4720 exhibited significantly greater effects on cell viability. (aacrjournals.org)
  • lymphocytes
  • Concanavalin A (ConA) has the ability to stimulate the activation of T lymphocytes, mostly CD4 + T-cells, leading to immune hepatitis in mice [ 3 , 4 ]. (hindawi.com)
  • replication
  • Replication-selective oncolytic adenoviruses are designed to replicate and spread into the tumor, resulting in cancer cell lysis. (biomedcentral.com)
  • These phenotypes were unexpectedly linked to mutations in the gene encoding a subunit of the Go-Ichi-Ni-San (GINS) complex, which is essential for DNA replication prior to cell division. (jci.org)
  • The process of DNA replication inherently places cells at risk of acquiring mutations. (wikipedia.org)
  • Rounds of cell replication allow fixation of mutated genes into the genome. (wikipedia.org)
  • transcription
  • Transgenic mice over-expressing the transcription factor Gli2 under the K5 promoter in cutaneous keratinocytes develop multiple skin tumours on the ears, tail, trunk and dorsal aspect of the paw, resembling those of basal cell carcinoma (BCC). (wikipedia.org)
  • lacks
  • Rp9 variant is quite common in human and mouse cells, lacks 9 amino acids in the repression domain. (wikipedia.org)
  • neoplasia
  • Mutations must occur in the remaining normal caretaker allele in addition to both alleles of gatekeeper genes within that cell for the said cell to turn to neoplasia. (wikipedia.org)
  • significantly
  • However, loss of Gli3 leads to abnormal patterning and loss of Gli2 affects the development of ventral cell types, most significantly in the floor plate. (wikipedia.org)
  • receptor
  • At the level of the cell, Daxx is found in the cytoplasm, interacting with Fas-receptor or other cytoplasmic molecules, as well as in the nucleus, where it is interacting with some subnuclear structures. (wikipedia.org)
  • The unbound receptor resides in the cytosol of the cell. (wikipedia.org)
  • Cytoplasmic
  • He described the cytoplasmic DNA isolated from mouse liver cells after culture as characterized by DNA fragments with a molecular weight consisting of multiples of 135 kDa. (wikipedia.org)
  • concentrations
  • NUTE and J82 cells were treated with different concentrations of PIO for various time periods. (medsci.org)
  • In kinetic partitioning, Hsp70s repetitively bind and release substrates in cycles that maintain low concentrations of free substrate. (wikipedia.org)
  • abnormal
  • Gorczyca W, Traganos F, Jesionowska H, Darzynkiewicz Z. Presence of DNA strand breaks and increased sensitivity of DNA in situ to denaturation in abnormal human sperm cells. (wikipedia.org)
  • consequence
  • This leads to suggestions for how one might exploit the corollaries of the recognition that serum ferritin levels mainly represent a consequence of cell stress and damage. (rsc.org)
  • However
  • However, in the past a number of different terms were used for BPDCN due to their uncommon immunophenotypic, histopathological and clinical features, including blastic NK leukemia/lymphoma, histiocytic lymphoma or histiocytic associated hematologic malignancy, cutaneous a granular CD4+ CD56+ hematodermic neoplasm and NK-cell lymphoma or myelo-monocytic precursor - related lymphoma (5-12). (czytelniamedyczna.pl)