Apoptotic cells anticancer drugs or radiation. Medical search. Frequent questions

In conclusion, the current investigation regarding anticancer effects of piperine against breast cancer revealed remarkable suppression of cancer cells. (ijpsonline.com)

With our recent discovery of the molecule HB-EGF in resistance pathways, we worked with collaborators in Japan to bring a new drug to the clinic that targets this specific pathway. (massgeneral.org)
State‑of‑the‑art research has indicated the retention of RUNX2 expression in a more invasive subtype of breast cancer, and in particular, triple‑negative breast cancer development and drug resistance are associated with estrogen receptor signaling pathways. (spandidos-publications.com)
In particular, we will discuss the modifications in intrinsic and extrinsic apoptotic pathways caused by proteins encoded by HPV early genes. (mdpi.com)
Lipids, amino acids, and nucleotides necessary for the biosynthesis of the daughter cells are mostly provided by intermediate metabolites of these pathways. (hindawi.com)
To prevent aberrant cell proliferation, these pathways are tightly regulated. (hindawi.com)
Ras proteins are membrane-bound small GTPases that act as molecular transducers, coupling cell surface receptors to intracellular effector pathways to regulate cellular processes such as cell proliferation, differentiation, migration, and apoptosis [ 3 ] [ 4 ] . (encyclopedia.pub)
Protein kinases are involved in signal transduction pathways linking growth factors, hormones and other cell regulation molecules to cell growth, survival and metabolism under both normal and pathological conditions. (justia.com)
Defects in apoptotic pathways can lead to cancer. (icbcongress.com)
Therefore, we aimed to demonstrate the potential anticancer effects of Sangju honey on human oral squamous cell carcinoma (OSCC), particularly focusing on epithelial-mesenchymal transition (EMT) and apoptotic and mitogen-activated protein kinase (MAPK) signaling pathways. (jcpjournal.org)
Western blot analysis was conducted to investigate protein expression related to EMT and apoptotic and MAPK signaling pathways. (jcpjournal.org)
In this chapter, we will focus on IL-21's biological effects and signaling pathways as well as discuss the potential implications and applications of IL-21 in leukemia cells. (intechopen.com)
Defects can occur at any point along these pathways, leading to malignant transformation of the affected cells, tumour metastasis and resistance to anticancer drugs. (biomedcentral.com)
The mechanisms of radioresistance are still poorly understood, despite it has been suggested that miRNAs play an important role in cell signaling pathways. (frontiersin.org)
Indeed, it has been shown that miRNAs play an important role in gene expression, mainly when associated with the monitoring of several cell and metabolic pathways, being also an essential component of the gene silencing machinery in most eukaryotic organisms ( 4 , 8 ). (frontiersin.org)
Molecular hydrogen appears to stimulate cellular death pathways in cancerous cells. (h2hubb.com)
Treatment with both H2 waters (HHW and NHW) increased the expression of p-AMPK, AIF and Caspase 3 (cell apoptosis pathways) in colon 26 cells. (h2hubb.com)
The levels of pAkt and pGSK3β (cell survival pathways), mainly expressed in neurons, were markedly up-regulated. (h2hubb.com)

Protein transport between the nuclear and the cytoplasmic compartment is a key factor for cell viability and proliferation. (massgeneral.org)
The combination of metformin with androgen biosynthesis/AR inhibitors results in caspase-independent apoptotic cell death in addition to inhibition of both cell proliferation and AR signaling. (renalandurologynews.com)
Cell proliferation involves the replication of all cellular contents with the required energy for this to happen. (hindawi.com)
This activation is necessary for both cell proliferation as well as glucose uptake and use. (hindawi.com)
For example, a subset of astrocytoma cells with ultra-long, thin, and highly dynamic membrane protrusions named tumor microtubes are able to extend in the surrounding tissue for tumor cell invasion, proliferation, and connection between tumor cells ( 11 ). (frontiersin.org)
At the same time, a subpopulation of highly tumorigenic glioma stem cells (GSCs) with high plasticity and self-renewal properties contribute to tumor malignancy through their sustained proliferation, invasion, stimulation of angiogenesis, suppression of anti-tumor immune responses and chemo-resistance ( 12 ). (frontiersin.org)
I mean, just check out the title given to one of the key studies on curcumin and myeloma (=published in "Blood" in 2003): "Curcumin (diferuloylmethane) down-regulates the constitutive activation of nuclear factor-kB and IkBa kinase in human multiple myeloma cells, leading to suppression of proliferation and induction of apoptosis. (healthblogs.org)
New antitumor strategies using drugs targeted to intracellular signaling involved in cell proliferation and survival, angiogenesis, and metastasis have become promising in recent years. (researchgate.net)
For example, temozolomide (TMZ), of use for glioblastoma (GBM) treatment, appears as capable of inducing autophagy partially inhibiting cancer cell proliferation. (nature.com)
Cell morphology studies were conducted to observe morphological changes, and the wound-healing assay was performed to evaluate the proliferation of honey-treated OSCC cells. (jcpjournal.org)
Sangju honey reduced cell viability, induced morphological changes, and significantly suppressed the proliferation and migration of Ca9-22 and YD-10B cells. (jcpjournal.org)
Sangju honey inhibits Ca9-22 and YD-10B cell proliferation by regulating EMT, inducing apoptosis, and suppressing the MAPK signaling pathway. (jcpjournal.org)
Cell proliferation was examined by MTT and cell count assays. (biomedcentral.com)
Cancer is the collective name for the group of diseases that results from aberrant cell growth and proliferation. (5dok.net)
These molecules are able to oxidize cellular macromolecules and DNA, potentially resulting in damage and mutations to proteins and genes that usually manage cell growth, proliferation or apoptosis. (5dok.net)
Its roles include regulation of proliferation, promotion of immune system and activation of apoptosis in B cells. (intechopen.com)
In these cells, IL-21 does not promote proliferation but enhances apoptosis and chemotaxis. (intechopen.com)
H2 has been shown to reduce the excessive expressions of MMP genes (MMP proteins are involved in multiple functions in cells, including cell proliferation, cartilage synthesis, apoptosis, angiogenesis, etc). (h2hubb.com)
A mutation in this gene resulting in reduced cell proliferation, and impaired cell motility and polarity, and has been identified in patients with primary microcephaly. (cancerindex.org)

It induced apoptosis, suppressed cell migration and invasion, blocked cell cycle and phosphatidylinositol 3-kinase/ protein kinase B signaling pathway. (ijpsonline.com)
the main pathway for cellular death is called the mitochondrial pathway, which is activated by a wide range of signals including radiation, cytotoxic drugs, cellular stress, and growth factor receptors and involves the release of proteins such as cytochrome c from mitochondrial membrane space. (icbcongress.com)
Finally, MAC was found to trigger apoptotic death pathway (based on expression levels of cleaved-caspase 3, Bax/Bcl-2 balance, p53 and p21). (biomedcentral.com)
This process induces tumor cell death in minutes by activating the apoptotic cell-death pathway. (knowledge-share.eu)
2006). Aloe-emodin induces apoptosis in T24 human bladder cancer cells through the p53 dependent apoptotic pathway. (herbshealthhappiness.com)
This article gives a comprehensive review of apoptosis, its mechanisms, how defects along the apoptotic pathway contribute to carcinogenesis and how apoptosis can be used as a vehicle of targeted treatment in cancer. (biomedcentral.com)

Findings from the Cusack Laboratory have shown that conventional anti-cancer therapies, such as radiation and chemotherapy, induce resistance mechanisms under the control of the gene transcription factor NF-kappaB. (massgeneral.org)
Our investigations are ongoing in biomarkers of resistance and potential new targets for therapeutic intervention in colorectal cancer, melanoma and Merkel cell carcinoma. (massgeneral.org)
The synthetic addition of a 2'-methoxyethyl on each nucleotide bookending the phosphorothioate backbone causes: An increased affinity for the RNA54 targeted gene sequence An increased resistance to digestive nucleases Decreased toxicity Increased tissue half-life by approximately seven days Decrease adverse side effects, enabling more potent concentrations Clusterin is upregulation in many tumours including prostate, breast, non-small cell lung, ovary and colorectal. (wikipedia.org)
This resistance is caused by the inhibition of the pro-apoptotic BLC2 gene, prevention of protein aggregation, and increased NF-KB. (wikipedia.org)
The recurrence and drug resistance of breast cancer are intractable due to the presence of breast cancer stem cells (BCSCs), which are adequate to initiate tumor formation and refractory to conventional remedies. (spandidos-publications.com)
The present review mainly focused on the latest updates on RUNX2 in BCSCs and their roles in breast cancer progression and drug resistance, providing insight that may aid the development of RUNX2‑based diagnostics and treatments for breast cancer in clinical practice. (spandidos-publications.com)
Taken together, these studies indicated the involvement of RUNX2 in BCSCs and its roles in breast cancer diagnosis and drug resistance, revealing its promising prospective clinical application and utility as an antitumor drug target in the future. (spandidos-publications.com)
Possible mechanisms for overcoming the resistance of HPV-infected tumor cells to anticancer drugs will be discussed. (mdpi.com)
In this paper, we describe the metabolic changes as well as the mechanisms of resistance to apoptosis occurring in cancer cells and cancer stem cells, underlying the connection between these two processes. (hindawi.com)
Resistance to anticancer agents and apoptosis results in cancer relapse and is associated with cancer mortality. (oaepublish.com)
Several mechanisms participate in the drug and apoptosis resistance phenotype in CSCs in various cancers. (oaepublish.com)
These emerging strategies may help target CSC-associated drug resistance and metastasis in clinical settings. (oaepublish.com)
This article will review the CSCs drug and apoptosis resistance mechanisms and how to target CSCs. (oaepublish.com)
Photothermal therapy may be a promising strategy for the treatment of GBM, as it allows the destruction of the tumor using heat as a non-chemical treatment for disease bypassing the GBM heterogeneity limitations, conventional drug resistance mechanisms and side effects on peripheral healthy tissues. (frontiersin.org)
Also, PKB is overexpressed in 15% of ovarian cancers, 12% of pancreatic cancers and 3% of breast cancers, and was shown to produce a survival signal that protects cells from apoptosis thus contributing to resistance to chemotherapy. (justia.com)
Such activity would result in increased cell death of tumor tissue where PKB is elevated, and in decreased resistance to chemotherapy agents. (justia.com)
Direct correlation between resistance to chemotherapy and activation of PKB was shown in several prostate cancer cell lines and in human tumorogenic tissues, and elevation of PKB levels in prostate tumor tissues, is clinically associated with HRPC (Yongde et al. (justia.com)
changes in the ability of apoptosis not only contribute to neoplasm enhancement but also lead to resistance to common cancer treatments such as radiation therapy or cytotoxic agents. (icbcongress.com)
one of the proposed mechanisms for resistance to cytotoxic and anti-neoplastic drugs is a change in the expression of the b-cell lymphoma-2 family, or bcl2. (icbcongress.com)
Autophagy may represent a mechanism of resistance to oxidative stress induced by chemotherapeutic drugs and may potentiate cancer cell survival to hypoxia and nutrient starvation due to the frequently defective tumor vascularization. (nature.com)
Its expression is associated with poor prognosis and chemotherapeutic/radiation resistance in various solid and hematopoietic tumors. (knowledge-share.eu)
Acquired drug resistance is an increasing challenge in treating cancer with chemotherapy. (emerginginvestigators.org)
Here, seeking to develop more efficient solar cells, the authors investigated photo-electrochemical (PEC) solar cells, specifically molybdenum diselenide (MoSe 2 ) based on its high resistance to corrosion. (emerginginvestigators.org)
Polymer drug conjugates, nano-based drug delivery systems can be utilized to protect normal body tissues from the adverse side effects of anticancer drugs and also to overcome drug resistance. (mdpi.com)

Lab principal investigator James C. Cusack, MD , is co-inventor of the patent "Use of NF-kappaB inhibition in combination therapy for cancer," (United States patent 6,831,057), which describes the therapeutic strategy noted above and is now licensed to two pharmaceutical companies for novel drug development. (massgeneral.org)
ARV-SNEP could be potentially novel therapeutic approach for the treatment of drug-resistant melanoma. (nadph-oxidasesignaling.com)
10,11 Furthermore, despite its activity against cancer cells, CBD - alone or together with THC - appears to have a milder effect (or no effect at all) on normal cells in the same tissues or organ as the cancer itself, making it an attractive anti-cancer therapeutic. (dsm.com)
Secondly, the central nervous system (CNS) has a unique microenvironment and is protected by the blood-brain barrier (BBB), which limits the access of systemically delivered drugs to the brain reducing the therapeutic options available for GBM. (frontiersin.org)
One of most promising novel therapeutic approach to cancer therapy is the combination of anti-cancer drugs with calorie restriction. (unisalento.it)
Due to their nutritional value and therapeutic potential against malignant cells, several nutraceuticals have recently attracted a lot of fascination. (ijpbp.com)
The therapeutic efficacy of drugs is mediated by physical interaction with their cognate targets (mainly proteins). (nature.com)
The administration of anticancer drugs is one crucial approach that is employed for the treatment of cancer, although its therapeutic status is not presently satisfactory. (mdpi.com)
They transport therapeutic agents to the target cell/tissue. (mdpi.com)
This review article is based on the therapeutic outcomes of polymer-drug conjugates against breast and lung cancer. (mdpi.com)
One of the treatments applied in cancer is radiotherapy (RT), a therapeutic modality that uses ionizing radiation to induce damage in unwanted cells. (frontiersin.org)

CSCs represent a heterogeneous tumor cell population and lack specific cellular targets, which makes it a great challenge to target and eradicate them. (oaepublish.com)
There are hundreds of thousands published scientific reports showing that CBD and THC inhibit tumor cell growth. (fordating.club)

Metformin decreases AR and AR-V7 expression and induces apoptotic cell death," the researchers concluded. (renalandurologynews.com)
Curcumin induces apoptosis-independent death in oesophageal cancer cells. (healthblogs.org)
In addition, ERW induces apoptosis together with glutathione in human leukemia HL60 cells (Tsai et al. (h2hubb.com)

Dr. Cusack wrote the first clinical trial of combination chemotherapy with the drug bortezomib for solid organ malignancies, reported in the journal Cancer . (massgeneral.org)
It is also upregulated in response to standard cancer treatments including chemotherapy, androgen deprivation therapy, and radiation therapy. (wikipedia.org)
Cancer and cancer treatments, such as chemotherapy and radiation, can produce a number of side effects, including nausea and vomiting, loss of appetite and pain. (dsm.com)
While there are no studies to date that have confirmed CBD eases the side effects of cancer or cancer therapy, the molecule is understood to have some potential in modulating the most common and debilitating symptoms 15 Although largely based on THC, there are also already some cannabinoid-based drugs on the market prescribed to help relieve symptoms caused by chemotherapy. (dsm.com)
Nabilone for example - also known as Cesamet - is FDA-approved and licensed for treating severe sickness and nausea from chemotherapy, if other anti-sickness drugs are unable to control it. (dsm.com)
BC is both histopathologically as well as genetically heterogeneous, thus underlying mechanisms of developing BC still remains uncertain[ 3 ], which cause hurdles in BC diagnosis as well as treatment, owing to this conventional treatment for BC like surgery, radiation and chemotherapy does not hold good efficiency. (ijpsonline.com)
And let's not forget that our healthy cells are also affected in terrible ways by chemotherapy: some never recover. (healthblogs.org)
protect our healthy cells from the toxic effects of chemotherapy and 2. (healthblogs.org)
Despite advances in surgery, radiation, and chemotherapy, novel therapeutics are needed for head and neck cancer treatment. (aacrjournals.org)

likely involving the transcriptional activation of pro-apoptotic genes and their interaction with other proteins. (molcells.org)

Unlike necrosis, apoptosis produces cell fragments called apoptotic bodies that phagocytic cells are able to engulf and quickly removed before the contents of the cell can spill out onto surrounding cells and cause damage[ 3 ]. (biomedcentral.com)
Usually phagocytic cells engulf apoptotic cells before apoptotic bodies occur. (biomedcentral.com)

The mechanism of action for this antifungal activity is through the decrease of ergosterol synthesis, required for membrane integrity of fungal cells, via inhibition of the lanosterol 14 alpha-demethylase (14DM) catalyst. (ecancer.org)
HK2 is a glycolytic enzyme that contributes to the metabolism, growth and death inhibition of tumor cells. (knowledge-share.eu)
First, molecular hydrogen caused growth inhibition of human tongue carcinoma cells HSC-4 (cancerous) and human fibrosarcoma cells HT-1080 (cancerous) but did not compromise growth of normal human tongue epithelial-like cells DOK [ 14 ]. (h2hubb.com)
Neuronal differentiation and cell-cycle programs mediate response to BET-bromodomain inhibition in MYC-driven medulloblastoma. (cancerindex.org)

Most importantly, ARV showed promising cytotoXicity, anti-migration and apoptotic activity against vemurafenib-resistant melanoma cells. (nadph-oxidasesignaling.com)
C16-E4Y exhibited selective cytotoxicity toward cancer cells overexpressing the tyrosine kinase. (bvsalud.org)
Western blotting assay was implemented to check the levels of phosphatidylinositol 3-kinase and protein kinase B. Results revealed that piperine induced dose reliant cytotoxicity in MCF-7 human breast cancer cells. (ijpsonline.com)
Phase contrast microscopy evidenced some specific morphological modifications indicating apoptosis allied cytotoxicity of piperine like apoptotic bodies, condensed nucleus and membrane blabbing. (ijpsonline.com)
Using HeLa cells, they find MAT20 up-regulates expression of inflammation and cell cytotoxicity markers. (emerginginvestigators.org)

3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide assay was executed for determination of effects of piperine on breast cancer cell viability. (ijpsonline.com)
Ca9-22 and YD-10B human OSCC cells were treated with 0.25% or 0.5% Sangju honey, and the cell viability was examined using the Cell Counting Kit-8 assay. (jcpjournal.org)
Using a tetrazolium-based assay, the dose required to reduce cell viability by 50% (ED 50 ) was found to be ∼1.8 μmol/L in FaDu (human hypopharyngeal squamous cancer) and ∼2.6 μmol/L in C666-1 (human undifferentiated nasopharyngeal cancer) cells. (aacrjournals.org)
AE has notable anticancer effects and inhibits cell viability while stimulating the arrest of G2/M of the cell cycle. (herbshealthhappiness.com)

Custirsen acts as an anti-cancer drug by binding to the mRNA initiation site of the clusterin gene, reducing clusterin protein plasma concentrations. (wikipedia.org)
The anti-apoptotic activity of clusterin in aiding tumour growth is due to interactions with protein complexes. (wikipedia.org)
a) Anticancer activity of a novel class of compound - Bromodomain and EXtra-Terminal motif (BET) protein de- grader in sensitive and vemurafenib-resistant melanoma (b) Preformulation studies and formulation develop- ment. (nadph-oxidasesignaling.com)
Given that protein aggregates in liver cells are closely linked to alcoholic liver disease, these findings suggest that quercetin could be a useful treatment for patients with this condition. (qualitycounts.com)
Molecular 'switch' reverses chronic inflammation and aging - Science Daily, 2/6/20 - 'By studying mice and immune cells called macrophages, the team found that a protein called SIRT2 is responsible for deacetylating the NLRP3 inflammasome. (qualitycounts.com)
In drug discovery, efficient screening of protein-drug interactions (PDIs) is hampered by the limitations of current biophysical approaches. (nature.com)
Using this YaxAB nanopore, we demonstrate label-free, single-molecule detection of interactions between the anticancer Bcl-xL protein and small-molecule drugs as well as the Bak-BH3 peptide. (nature.com)
Although protein-protein interactions (PPIs) are promising targets, drugging them is one of the key challenges in drug discovery 19 . (nature.com)
The present invention provides inhibitors of protein kinases comprising a molecule having at least a first moiety competent for penetration of the molecule into cells, and a second moiety for having a protein kinase inhibiting effect within the cells. (justia.com)
The complex molecules are preferably peptide conjugates having improved cell-permeability, serum stability and kinase selectivity compared to known protein kinase inhibitors. (justia.com)
The present invention relates to cell permeable, stable conjugates comprising a cell-permeability enhancement moiety and a peptide or peptidomimetic, as selective inhibitors of protein kinases, to pharmaceutical compositions containing them, as well as to processes for the preparation and use of such complex molecules. (justia.com)
PKB is an anti-apoptotic protein kinase whose activity is strongly elevated in human malignancies. (justia.com)
This kinase is a catalytic subunit of the protein kinase complex that is important for cell cycle G1 phase progression and G1/S transition. (cancerindex.org)

The evidence for these anticancer effects, in vitro , in vivo , and clinical are summarised, and the putative mechanisms of their action outlined. (ecancer.org)
There are a number of pre-clinical in-vitro and in-vivo studies that suggest cannabinoids - including CBD and THC - have anti-cancer activity in a wide variety of cancer types, including a role in cancer cell death and blocking cancer cell growth. (dsm.com)
Sulforaphane suppresses the growth of triple-negative breast cancer stem-like cells in vitro and in vivo. (ijpbp.com)
An image depicting head and neck squamous cell carcinoma in vitro can be seen below. (medscape.com)
Head and neck squamous cell carcinoma in vitro (cell culture). (medscape.com)

Self-assembled C16-E4pY induced endoplasmic reticulum stress that caused apoptotic cell death. (bvsalud.org)
however, neither drug induced cell death. (renalandurologynews.com)
When safe and gross cytoreduction is achieved, residual infiltrating GBM cells undetectable by advanced imaging techniques still remain in the peritumoral area leading to disease progression and inevitable patient's death ( 7 , 8 ). (frontiersin.org)
Here we show that nutrient deprivation can consistently enhance the sensitivity of tumor cells to cell death induction by CDDP, also of those malignancies particularly resistant to any treatment, such as oncogenic BRAF melanomas. (unisalento.it)
Mechanistic studies revealed that the combined therapy induced cell death is characterized by ROS accumulation and ATF4 in the absence of ER-stress. (unisalento.it)
Apoptosis is a process of programed cell death. (biomedcentral.com)
of it, let's have a quick look at "apoptosis," which means " programmed cell death. (healthblogs.org)
Cancer cells are able to mutate and protect themselves from death in various ways. (healthblogs.org)
when the anta-apoptotic members of the bl2 family increase, it can inhibit apoptosis and cell death. (icbcongress.com)
On one hand, autophagy allows cancer cell to survive in unfavorable environmental conditions, on the other hand, once internal energy resources are exhausted, it leads to cell death. (nature.com)
Death of GSCs was apparently due to the iron dependent form of programmed cell death characterized by the accumulation of lipid peroxides called ferroptosis. (nature.com)
Cell death through apoptosis leads to rapid and selective clearing of tumor cells without eliciting inflammation, and avoiding potential toxic effects caused by the inflammatory process. (knowledge-share.eu)
Cancer is the result of aberrant regulation of growth and death in cells. (5dok.net)
Aloe vera also contains a substance known as 1,8-dihydroxy-3-[hydroxymethyl]-anthraquinone (or simply AE), which has been proven to induce cell death among T24 cells (human bladder cancer cell line). (herbshealthhappiness.com)
Cell death, particularly apoptosis, is probably one of the most widely-studied subjects among cell biologists. (biomedcentral.com)
In cancer, there is a loss of balance between cell division and cell death and cells that should have died did not receive the signals to do so. (biomedcentral.com)
It is used, in contrast to necrosis, to describe the situation in which a cell actively pursues a course toward death upon receiving certain stimuli [ 7 ]. (biomedcentral.com)
Morphological alterations of apoptotic cell death that concern both the nucleus and the cytoplasm are remarkably similar across cell types and species [ 11 , 12 ]. (biomedcentral.com)
Usually several hours are required from the initiation of cell death to the final cellular fragmentation. (biomedcentral.com)
Shortening telomeres can cause cell apoptosis (cell death). (h2hubb.com)
HS (hydrogen-rich saline) significantly reduced neuronal apoptosis (cell death) and improved neurological function at 24 hours after SAH (subarachnoid hemorrhage). (h2hubb.com)

The biological importance of activation targets of Nanog, Oct4, SOX-2, and c-Myc in CSCs, which are more frequently overexpressed in poorly differentiated tumors than in well-differentiated tumors, has been shown by correlating signature characteristics of these cells and poor survival [ 3 ] . (oaepublish.com)
Taken together, our results present the YaxAB nanopore as a robust platform for label-free, ultrasensitive, single-molecule detection of PDIs, opening up a possibility for low-cost, highly efficient drug discovery against diverse drug targets. (nature.com)
the mitochondrial anticancer targets are called mitokan, which by selective accumulation in the mitochondria and damage to the mitochondrial membrane, leads to increased ros and apoptosis. (icbcongress.com)
Endocr Metab Immune Disord Drug Targets. (tocotrienolresearch.org)

For example, the potential of CBD in breast cancer has been studied for many years, showing consistent and effective pro-apoptotic and anti-proliferative activity in many different breast cancer cells and mouse models. (dsm.com)
Its anti-proliferative qualities mean that it can prevent cancer cells from reproducing. (fordating.club)

As metastasis requires coordination of multiple cells in the tumor microenvironment, their findings that HF-1 augments cytokine expression such as VEGF & TGF-B show that HF-1 has potential application to therapeutics. (emerginginvestigators.org)
It is designed to treat micrometastatic disease (or breast cancer cells that have escaped the breast and regional lymph nodes but which have not yet had an established identifiable metastasis). (medscape.com)

Another consequence of aging is the accumulation of so-called senescent cells, normal cells that stop dividing, contribute to tissue aging and secrete substances like cytokines that induce inflammation. (qualitycounts.com)
Continuous exposure of HDM201 led to induction of p21 and delayed accumulation of apoptotic cells. (bace-signal.com)

Itraconazole, a common triazole anti-fungal drug in widespread clinical use, has evidence of clinical activity that is of interest in oncology. (ecancer.org)

In addition, we show that autophagy is not involved in the enhanced sensitivity of melanoma cells to combined CDDP/EBSS-induced apoptosis. (unisalento.it)

29% of melanomas are driven by mutations in N-Ras, while H-Ras mutations appears mutated in 5% of head and neck squamous cell carcinoma and 6% of bladder cancers [ 11 ] . (encyclopedia.pub)

Reported molecular self-assemblies are triggered by hydrolysis of well-designed molecules inside or outside cancer cells. (bvsalud.org)
Here, we report the in situ synthesis of a self-assembling molecule using a tyrosine kinase overexpressed in cancer cells. (bvsalud.org)
Phosphorylation of C16-E4Y promoted self-assembly to form nanofibers in cancer cells. (bvsalud.org)
These results show that an enzyme overexpressed in cancer cells is available for intracellular synthesis of an antitumor self-assembling drug that is cell-selective. (bvsalud.org)
In contrast, metformin inhibited AR, AR-V7, and PSA expression in a dose-dependent manner and induced apoptosis in prostate cancer cells. (renalandurologynews.com)
As well as acting on cancer cells directly, it has been suggested that CBD affects the tumor environment too by stopping the development of blood cells that feed the cancer, preventing its ability to spread and reducing inflammation. (dsm.com)
However, cancer cells overcome these controls, in particular by acquiring genetic mutations leading to the activation of oncogenes (pten, myc) or loss of tumor suppressors (p53) [ 1 ]. (hindawi.com)
In contrast to normal cells, most cancer cells predominantly produce energy by a high rate of glycolysis followed by lactate fermentation, even in the presence of oxygen, a less efficient metabolism compared to a low rate of glycolysis followed by mitochondrial oxidation of pyruvate [ 2 ]. (hindawi.com)
In contrast, cancer cells shift their metabolism toward lactate production even in the presence of oxygen [ 4 ], partly through genetic modifications that stabilize the transcription factor Hypoxia Inducible Factor (HIF) involved in the adaptation of the cells to hypoxia, under nonhypoxic conditions as well as generating an adaptive response to the hypoxic microenvironment (Figure 1 ). (hindawi.com)
Metabolic adaptations of cancer cells. (hindawi.com)
Glucose and glutamine are the 2 major substrates used by cancer cells. (hindawi.com)
Clonogenic assay was implemented for checking the effect of piperine on clonogenic potency of breast cancer cells. (ijpsonline.com)
I have received many messages from excited blog readers and MM list friends sending me links to different news reports on a recent study showing that curcumin kills esophageal cancer cells. (healthblogs.org)
All of these studies show that curcumin kills different types of cancer cells …not just esophageal, but also myeloma, prostate (etc. etc. etc.) cells. (healthblogs.org)
The problem, of course, is how best to deliver an irresistible but lethal package of curcumin right to the doorstep of our cancer cells. (healthblogs.org)
But the normal apoptotic process doesn't apply to cancer cells. (healthblogs.org)
Conventional medicine uses harmful chemicals and radiation to stop the partying of cancer cells. (healthblogs.org)
Cancer cells eventually become resistant to these chemical attacks, with obvious consequences. (healthblogs.org)
Hi all Cancer cells need iron for tumor growth Take out the iron and your natural cancer killer cells can then do their thing. (healthblogs.org)
Pharmacologic ascorbic acid concentrations selectively kill cancer cells: action as a pro-drug to deliver hydrogen peroxide to tissues. (ijpbp.com)
The body generates roughly 10,000 cancer cells every day. (cancertutor.com)
7 ) Vitamin D3 deficiency is one of the most common factors contributing for the ability of these cancer cells to proliferate and invade new tissue. (cancertutor.com)
early studies have shown differences between mitochondria of normal cells and cancer cells. (icbcongress.com)
Hence, thanks to this complex mechanism, autophagy can provide energy supply to the cell and can represent a key cytoprotection mechanism allowing cell survival in unfavorable microenvironmental conditions such as those often found by cancer cells 7 . (nature.com)
Precis: Pulsed high doses versus sustained low doses of the p53-MDM2 inhibitor HDM201 elicit a pro-apoptotic response from wild-type p53 cancer cells, offering guidance to current clinical trials with this and other drugs that exploit the activity of p53. (bace-signal.com)
Cancer cells are known to exhibit significantly elevated ROS levels. (5dok.net)
regardless, cancer cells regulate their ROS levels rigorously as high levels may also be toxic to them. (5dok.net)
the prodrug approach may be truly selective because it requires the aberrant high ROS levels in cancer cells to activate it. (5dok.net)
Some herbs may act as "immunomodulators" - stimulating the immune system to fight against cancer cells. (herbshealthhappiness.com)
as an agent that has been shown to be toxic to cancer cells may also be toxic to healthy cells. (herbshealthhappiness.com)
Some herbs (such as Milk thistle) have been found by studies to act selectively against cancer cells and this is considered a highly desired quality. (herbshealthhappiness.com)
In this study, the authors demonstrate that the use of an herbal formulation, consisting of turmeric and green tea, alongside a traditional chemotherapeutic drug, 5-fluorouracil (FU) significantly decreases the level of cytokines produced in breast cancer cells when compared to the levels produced when exposed solely to the chemo drug. (emerginginvestigators.org)
The authors use HF-1, an herbal formation, on bone marrow derived cells as well as breast cancer cells to assess HF-1's ability to prevent tumorigenesis. (emerginginvestigators.org)
with tumor-associated antigens, the DCs induce antigen-specific cytotoxic T lymphocytes (CTLs), which assault cancer cells. (opioid-receptors.com)
H2 appears to shorten telomeres in cancer cells. (h2hubb.com)
ERW [hydrogen water] causes telomere shortening in cancer cells and suppresses tumor angiogenesis by scavenging intracellular ROS and suppressing the gene expression and secretion of vascular endothelial growth factor. (h2hubb.com)

It has been shown that cancerous cells have a higher expression of MMP genes leading to tumor invasion and tumor angiogenesis. (h2hubb.com)

There are many factors and variables that contribute to the pathogenesis of cancers such as oxidative stress, DNA damage and mutation, ionizing radiations, carcinogenic chemicals, and so much more. (h2hubb.com)

Ideally, a drug that inhibits PKB should cause both cell cycle arrest and promote apoptosis. (justia.com)

In normal cells, glucose participates in cellular energy production through glycolysis as well as through its complete catabolism via the tricarboxylic acid (TCA) cycle and oxidative phosphorylation (OXPHOS). (hindawi.com)
This is actually a normal cellular process: cells are born, live for a while, do what they are supposed to do, then begin shrinking and eventually break up into fragments and die. (healthblogs.org)
the mitochondria are the main site for oxidative and synthesis (atp) phosphorylation, and provides approximately 95% of cellular energy and is called the cell s energy home. (icbcongress.com)
This is the multihit theory of tumorigenesis, in which a series of multiple triggering events in the genetic and cellular makeup of a cell ultimately cause cancer. (medscape.com)

This revealed increased expression of B-cell lymphoma 2 associated X and reduced expression of B-cell lymphoma 2, indicating apoptosis induction by piperine. (ijpsonline.com)
Antitumor therapies targeted to reduce the induction, recruitment, or suppressive activities of the immune cells have been investigated. (researchgate.net)
Okamoto (12,13) reported that a relatively low dose of 5-FU led to the enhancement of anticancer immunity mediated from the induction of helper T-cell type-1 cytokines (such as interferon- and interleukin-12) and natural-killer cell activity in individuals with oral malignancy. (opioid-receptors.com)

To avoid elimination by this mechanism, human papillomaviruses (HPV) have developed several mechanisms that enable the cells they infect to elude both extrinsic and intrinsic apoptosis. (mdpi.com)
In this manuscript, we review the current literature regarding how HPV-infected cells avoid apoptosis and the molecular mechanisms involved in these events. (mdpi.com)
Studying such mechanisms not only provides mechanistic insights into these cells that are unresponsive to drugs, but may lead to the development of targeted and effective therapeutics to eradicate CSCs. (oaepublish.com)
The signaling mechanisms of IL-21 in different cell types have been identified. (intechopen.com)
However, we know less about the biological effects of IL-21 and its signaling mechanisms in leukemia cells and monocytes. (intechopen.com)
Moreover, further preclinical studies are warranted to explore the molecular mechanisms of these agents in treatment of cancer and their possible potential to overcome chemoresistance of tumor cells. (ac.ir)
Here, we aim to provide an overview on the mechanisms of miRNA biogenesis and to discuss the functional impact of miRNAs on PCa under radiation response. (frontiersin.org)
[ 6 ] These events lead the cancer cell to escape normal cell growth and control mechanisms, to avoid system control mechanisms (ie, immunologic surveillance), and to establish a nutrient supply. (medscape.com)

The drug was increasingly administered in six dose cohorts of 40 mg, 80 mg, 160 mg, 320 mg, 480 mg, and 640 mg. (wikipedia.org)
Cell migration as well as cell invasive ability of MCF-7 cells was reduced to minimum by the application of piperine in dose dependent-manner. (ijpsonline.com)
High dose pharmaceutical drugs interact and inhibit Vitamin D conversion. (cancertutor.com)
The main goal of RT consists in delivering a precise dose of radiation in a target volume, such as tumor, promoting the tumor cells eradication with as minimal damage as possible in surrounding normal tissues ( 13 ). (frontiersin.org)
Earlier studies suggested that certain chemotherapeutic providers, including gemcitabine, 5-fluoro-uracil (5-FU) and a metronomic dose of cyclophosphamide, as well as irradiation, may activate the sponsor immunity or inhibit suppressors of sponsor responses, such as regulatory T cells (Tregs) and myeloid-derived suppressor cells, enhancing the Rabbit Polyclonal to ERI1 effect of malignancy immunotherapy (9-11). (opioid-receptors.com)

BET inhibitors (BETi especially JQ1) gained a lot of interest in last decade due to its promising anticancer eﬃcacy in number of preclinical cancer models including hematologic malig- nancies and solid tumors (Delmore et al. (nadph-oxidasesignaling.com)
Here we investigated the effect Cisplatin (CDDP), one of the most potent chemotherapeutic agent used to treat tumors, in association with fasting in wild type and mutated BRAF(V600E) melanoma cell lines. (unisalento.it)
Maintaining a steady supply of Vitamin D for the synthesis of GcMAF is a powerful strategy to inhibit tumors relating to prostate cancer cell growth. (cancertutor.com)
This patent protects peptides with anticancer activity capable of targeting the enzyme hexokinase 2 (HK2) in different types of tumors. (knowledge-share.eu)
The peptides identified in this patent belong to Activatable Cell Penetrating Peptides (ACPPs) family, designed to selectively target the HK2 in tumors maximizing their efficacy while limiting off-target side effects in healthy tissues. (knowledge-share.eu)
Treatment of drug/radiation resistant tumors that over-express HK2. (knowledge-share.eu)

Figure 1 shows how the Ca 2+ /cAMP signaling interaction could be pharmacologically modulated by the combined use of the Ca 2+ channel blockers (CCB) and drugs that promote the increase of [cAMP] c (cAMP-enhancer compounds). (researchgate.net)
Hence, there is still a need for alternative and well-tolerated compounds that exhibit antineoplastic effects in sarcoma cells. (spandidos-publications.com)
The focus of this review is on illuminating the anticancer attributes found in a variety of nutraceuticals, such as polyphenols, flavonoids, carotenoids, and other bioactive compounds. (ijpbp.com)
These bioactive compounds are capable of killing cancerous cells without damaging normal cells. (ijpbp.com)
Anticancer effect of antimalarial artemisinin compounds. (ijpbp.com)
Diverse BH3-mimetic compounds have been identified for anticancer drug discovery. (nature.com)

some drugs are designed to disturb the respiratory tract and permeability of the mitochondrial membrane, which increases the levels of ros and regulates the expression of the gene in mitochondria. (icbcongress.com)
the mitochondrial penetrating peptides (mpp) are unique tools for accessing the cell and delivering bioactive cargo to the mitochondria. (icbcongress.com)

Adjuvant treatment for breast cancer involves radiation therapy and a variety of chemotherapeutic and biologic agents. (medscape.com)

Cell-selective killing using molecular self-assemblies is an emerging concept for cancer therapy. (bvsalud.org)
Because of its mutated aggressive genetics, this cell has a selective growth advantage over its neighbors. (medscape.com)

However, the ability of HPV-infected cells to resist apoptotic signals renders such therapies ineffective. (mdpi.com)

Activation of PAR2 can reduce the radiated U87 cell apoptosis via modulating the expression of p53. (biomedcentral.com)
While the activation of CB2 and TRPV1 receptors were seen in MDA-MB-231 cells, the effect was partial. (fordating.club)

Researchers found a statistically significant increase in the apoptotic index in prostatectomy specimens. (wikipedia.org)

PTOX prevents cell growth via polymerization of tubulin, leading to cell cycle arrest and suppression of the formation of the mitotic-spindles microtubules. (ac.ir)

The chromatin further condenses until it breaks up inside a cell with an intact membrane, a feature described as karyorrhexis [ 15 ]. (biomedcentral.com)
Cancer is characterized by uncontrolled growth and division of a cell, with extension beyond the normally limiting basement membrane and through the boundaries of normal cells. (medscape.com)

Of note, other studies have also indicated the involvement of RUNX2 in breast cancer stem cells (BCSCs) and breast cancer progression ( 22 , 23 ). (spandidos-publications.com)

Substantial data have provided convincing evidence establishing that human cancers emerge from cancer stem cells (CSCs), which display self-renewal and are resistant to anticancer drugs, radiation, and apoptosis, and express enhanced epithelial to mesenchymal progression. (oaepublish.com)
In contrast, the ED 50 values were much higher in untransformed cells, specifically at ∼8.8 μmol/L in GM05757 (primary normal human fibroblast), ∼8.9 μmol/L in HNEpC (primary normal human nasal epithelial), and ∼19.6 μmol/L in NIH/3T3 (mouse embryonic fibroblast) cells. (aacrjournals.org)

This is the very ﬁrst paper investigating a PROTAC class of molecule for the treatment of drug resistant cancer, preformulation and formulation studies. (nadph-oxidasesignaling.com)
A successful therapy must therefore eliminate these cells known to be highly resistant to apoptosis. (hindawi.com)

Clinical trials have shown that patients with prostate, lung, and basal cell carcinoma have benefited from treatment with itraconazole, and there are additional reports of activity in leukaemia, ovarian, breast, and pancreatic cancers. (ecancer.org)
Since cancer stem cells have been hypothesized to play a role in refractory/relapsing cancers, in the present work we investigated if autophagy could represent a constitutive cytoprotection mechanism for glioblastoma stem-like cells (GSCs) and if the modulation of autophagic process could affect GBM growth and survival. (nature.com)
In December 2013, Hoffmann-La Roche, manufacturer of capecitabine (Xeloda), an oral agent for the treatment of breast and colorectal cancers, reported that in rare cases, patients using the drug may develop potentially fatal cutaneous disease, such as Stevens-Johnson syndrome or toxic epidermal necrolysis. (medscape.com)

The therapy of choice involves surgical resection with a wide margin of healthy tissue, usually followed by radiation treatment in order to decrease local recurrence ( 2 , 3 ). (spandidos-publications.com)
In conclusion, this review sheds light on the emerging insights into nutraceuticals' anticancer properties and their potential as valuable components of integrative cancer therapy. (ijpbp.com)
Taking proanthocyanidin, a chemical found in grape seed extract, does not reduce breast tissue hardness, pain, or tenderness in people treated with radiation therapy for breast cancer. (medlineplus.gov)
Early stage, organ-confined, prostate cancer is often managed with surgery or radiation therapy until the patient dies from unrelated causes. (justia.com)
Hence, it represents an important target for anticancer therapy. (nature.com)
Patients still deal with cancer itself, as well as radiation therapy. (fordating.club)
They also reported that DC therapy in combination free base inhibitor database with an oral fluoropyrimidine, S-1, enhanced sponsor immune reactions and elicited a designated anticancer effect, as compared to DCs only in tumor-bearing mice (14), and that DC vaccine combined with gemcitabine and/or S-1 probably prolonged the survival of individuals with advanced pancreatic malignancy (15). (opioid-receptors.com)

Therefore, the current investigation was designed to unveil the anticancer effects of piperine molecule against human breast carcinoma. (ijpsonline.com)
Distinctive nanopore event distributions observed in the two-dimensional (ΔI/I o -versus-I N ) plot illustrate the ability of the YaxAB nanopore to discriminate individual small-molecule drugs bound to Bcl-xL from non-binders. (nature.com)

Although the recent Food and Drug Administration (FDA) approval of the first Ras G12C inhibitor is an important milestone, only a small percentage of patients will benefit from it. (encyclopedia.pub)
free base inhibitor database Thus far, the DC-based vaccine has had some success, as sipuleucel-T (Dendreon Co., Seattle, WA, USA) was authorized as the 1st anticancer vaccine by the US Food and Drug Administration in 2010 2010 (5). (opioid-receptors.com)

To monitor morphology of cancerous breast cells, phase contrast microscopy was performed after piperine exposure. (ijpsonline.com)
Specifically, cancerous cells are characterized by an enhanced rate of growth, loss of function and the potential to invade healthy tissue. (5dok.net)

Typically, rapidly proliferating tumor cells have glycolytic rates up to 200 times higher than those of their normal tissue of origin, even in the presence of oxygen [ 3 ]. (hindawi.com)
The results showed that U87 cells and human glioma tissue expressed PAR2. (biomedcentral.com)
Inefficient penetration of cancer drugs into the interior of the three-dimensional (3D) tumor tissue limits drugs' delivery. (emerginginvestigators.org)

Within the scope of this trial, we investigated the effects of the natural pine bark extract pycnogenol on human fibrosarcoma cells. (spandidos-publications.com)

For instance, a recent study by our group reported the facilitating effect of RUNX2 during aggressiveness and chemoresistance of TNBC cells via activating MMP1, which was significantly associated with poor prognosis ( 21 ). (spandidos-publications.com)

To date, RUNX2 has been involved in diverse physiological processes, including osteogenic differentiation of mesenchymal stem/stromal cells, chondrocyte hypertrophy, immunomodulation, vascular invasion and endothelial cell migration via modulating a variety of signaling cascades (e.g. (spandidos-publications.com)
In addition to its importance as a biological phenomenon, defective apoptotic processes have been implicated in an extensive variety of diseases. (biomedcentral.com)

We have examined the role of Fam60a, a gene highly expressed in embryonic stem cells, in mouse development. (bvsalud.org)

This hydrolysis can occur in cancer and normal cells because of the abundance of water in living systems. (bvsalud.org)
In normal cells, the fate of pyruvate depends on many factors, one of which is oxygen availability. (hindawi.com)
Increased efficiency in drug delivery would allow lower concentrations of drugs to be used, minimizing damage to normal cells. (emerginginvestigators.org)
however, it does not compromise the growth of normal cells. (h2hubb.com)
and prevents cell apoptosis in normal cells. (h2hubb.com)

This study aims to investigate the role of protease activated receptor-2 (PAR2) in regulation the apoptosis process in glioma cells. (biomedcentral.com)
Since defective of apoptosis plays a crucial role in the pathogenesis of cancer, we hypothesized that PAR2 might be involved in the regulation of glioma cell apoptosis. (biomedcentral.com)
However in all cases for cancer to develop, the cells have to acquire mutations that allow growth--‐regulation bypass and apoptosis evasion, both of which are normally under strict supervision. (5dok.net)
As main findings, 23 miRNAs were already identified as being involved in genetic regulation of PCa cell response to RT. (frontiersin.org)

Therefore, technological innovation is required to overcome current limitations and accelerate drug discovery in the pharmaceutical industry. (nature.com)

Based on scientific research, molecular hydrogen appears to have promising anticancer effects. (h2hubb.com)
Molecular hydrogen in numerous studies has demonstrated an anti-apoptotic effect in health or injured cells. (h2hubb.com)

Additionally, based on the properties summarised previously, it is proposed that itraconazole may synergise with a range of other drugs to enhance the anti-cancer effect, and some of these possible combinations are presented in the supplementary materials accompanying this paper. (ecancer.org)
increase the murderous anti-cancer effect of chemo drugs. (healthblogs.org)

Metformin, a widely used oral anti-diabetic drug, enhanced the anti-prostate cancer activity of abiraterone and enzalutamide. (renalandurologynews.com)
Metformin, a widely used oral anti-diabetic drug, enhanced the anti-prostate cancer activity of abiraterone and enzalutamide, a study presented at the American Association for Cancer Research (AACR) Annual Meeting 2016 has shown. (renalandurologynews.com)
In addition, autophagy interpheres with cell cycle progression, de facto exerting a cytostatic activity. (nature.com)

however these treatments have limited efficacy and induce significant toxic effects on healthy cells. (unisalento.it)
The good herb: Buckwheat liquor helps cells clean house - Science Daily, 8/16/21 - 'When the researchers looked more closely at specific components of tartary buckwheat extract, they found that one component, quercetin, had the same effects as the extract. (qualitycounts.com)
The anticancer drugs are limited pharmacologically, resulting from the serious side effects, which could be life-threatening. (mdpi.com)
Stinging Nettle Common in Europe and North America, stinging nettle possesses unique abilities that rival those of conventional hormone modulating drugs without negative side effects. (erictecce.com)

Anatomy20

Organisms6

Diseases20

Chemicals and Drugs110

Analytical, Diagnostic and Therapeutic Techniques and Equipment43

Phenomena and Processes57

Disciplines and Occupations6

Technology, Industry, Agriculture4

Information Science5

Health Care12

Regarding anticancer effects1

Pathways17

Proliferation19

Pathway6

Resistance24

Therapeutic11

Tumor cell2

Induces3

Chemotherapy9

Proteins1

Phagocytic cells2

Inhibition4

CytotoXicity5

Viability4

Protein13

Vitro5

Death21

Targets4

Anti-proliferative2

Metastasis2

Accumulation2

Oncology1

Melanoma cells1

Squamous cell carc1

Cancer cells36

Genes1

Oxidative stress1

Inhibits1

Cellular4

Induction3

Mechanisms8

Dose5

Tumors6

Compounds6

Mitochondrial2

Chemotherapeutic1

Selective2

Signals1

Activation2

Prostatectomy1

Arrest1

Membrane2

Breast cancer stem1

Epithelial2

Resistant2

Cancers3

Therapy7

Molecule2

Inhibitor2

Cancerous2

Tissue3

Human fibrosarcoma cells1

Associated with poor prognosis1

Processes2

Gene1

Normal cells5

Regulation4

Overcome1

Molecular2

Effect2

Activity3

Effects4