• Cancer, characterized by uncontrolled cell proliferation, is treated by chemotherapy and radiotherapy to induce apoptosis and kill cancerous cells. (news-medical.net)
  • New anticancer therapy strategies refer to the inhibition of CDK-cyclin complexes as an important target to prevent uncontrolled proliferation and induce apoptosis in cancer cells ( 2 ). (spandidos-publications.com)
  • Cancer cells exhibit an elevated apoptotic threshold and peptides that are able to induce apoptosis in tumor cells are increasingly seen as promising candidates for the development of new effective anticancer therapeutics. (eurogentec.com)
  • Recent basic and clinical research has revealed that hydrogen is an important physiological regulatory factor with antioxidant, anti-inflammatory and anti-apoptotic protective effects on cells and organs. (researchgate.net)
  • Therefore, the understanding of the diverse signalling molecules, signal recognition mechanisms and signal transduction pathways is fundamental for the insight into physiological and pathophysiological processes. (mdpi.com)
  • Synthetic peptides that can target the apoptotic signal transduction cascades and/or function as pro-apoptotic agents bearing pharmaceutical potential are being developed. (eurogentec.com)
  • In addition to being found in plants, IP6 is contained within almost all mammalian cells, where it is important in regulating vital cellular functions such as signal transduction, cell proliferation, and differentiation. (naturalnews.com)
  • According to Dr. Shamsuddin, when IP6 is administered it is rapidly taken into the cells and dephosphorylated to lower inositol phosphates, which further affect signal transduction pathways. (naturalnews.com)
  • It breaks up the DNA during apoptosis and promotes cell differentiation. (wikipedia.org)
  • Caspase-3 activation is a cell requirement during early stages of the skeletal myoblast differentiation. (wikipedia.org)
  • Caspase 3 is responsible for cellular differentiation, although it is unclear how this kind of protein can promote the cell apoptosis. (wikipedia.org)
  • Caspase signals resulting from the activation of nuclease CAD indicate that the cell differentiation is due to a CAD modification in chromatin structure. (wikipedia.org)
  • CAD leads to the initiation of the DNA strand breakage, which occurs during terminal differentiation of some cell, such as skeletal muscle cell. (wikipedia.org)
  • Targeting of p21 promoter is responsible for inducing cell differentiation, which is promoted by modifying the DNA nuclear microenvironment. (wikipedia.org)
  • The cell diversity is originated by cell differentiation, which has been attributed to the activation of specific transcription factors. (wikipedia.org)
  • It is thought to be involved in many physiological and pathophysiological processes, including antiaging mechanisms, differentiation and development, immunity, and elimination of microorganisms [ 9 - 13 ]. (ijpsonline.com)
  • The pleiotropic actions of TNF range from proliferative responses such as cell growth and differentiation. (uea.ac.uk)
  • Some extend regulated cell death can be considered an extreme form of cell differentiation that happens when cells fails to perform their normal intracellular routines. (hstalks.com)
  • The results of our preliminary study demonstrated that 6-OAP inhibits the proliferation of human MM cells by inducing the arrest of mitosis and inhibiting specific key pathways ( 5 ). (spandidos-publications.com)
  • Natural polyamines, putrescine, spermidine and spermine, play essential roles in the regulation of cell growth and proliferation. (spandidos-publications.com)
  • Processes involved in atherosclerosis include coagulation, inflammation, lipid metabolism, intimal injury, and smooth muscle cell proliferation (see the image below). (medscape.com)
  • To further investigate the molecular mechanism by which the extract promoted apoptosis and inhibited the proliferation of the AML cells used, apoptotic protein expression was determined through western blots. (nih.gov)
  • Our results showed that the treatment with A. cherimola ethanolic leaf extract exhibited an inhibitory effect on the proliferation of both cancer cell lines used in a dose- and time-dependent manner, with no toxic effects on normal mononuclear cells (MNCs) isolated from human bone marrow. (nih.gov)
  • Apoptotic cells can produce signals to instruct cells in their local environment, including ones that stimulate engulfment and proliferation. (elifesciences.org)
  • Reductions in cellular proliferation were observed in both cell lines. (naturalnews.com)
  • In multicellular organisms, microvesicles and other EVs are found both in tissues (in the interstitial space between cells) and in many types of body fluids. (wikipedia.org)
  • Apoptosis is a mechanism of programmed cell death that occurs in multicellular organisms. (abcam.com)
  • The membrane of the endothelial microparticle contains receptors and other cell surface molecules which enable the identification of the endothelial origin of the microparticle, and allow it to be distinguished from microparticles from other cells, such as platelets. (wikipedia.org)
  • The "death receptors", which typically cause cell death by apoptosis, can be activated by ligands, such as TNF. (news-medical.net)
  • In conclusion, DA content was not responsible for the enhanced sensitivity of CATH.a cells to Mn toxicity, but oxidative stress was implicated as a probable mechanism of cytotoxicity. (cdc.gov)
  • The accumulation of cytosolic lipid globules and oxidative stress finally correlates with the apoptotic death of cells . (bvsalud.org)
  • Mitochondrial function or the ability to generate energy through OXPHOS (oxidative phosphorylation) is vital for cell homeostasis and its dysfunction has been linked to the pathogenesis of nearly all chronic diseases ( Pieczenik and Neustadt, 2007 ). (frontiersin.org)
  • In the present study, Mn toxicity was characterized in a human neuroblastoma (SK-N-SH) cell line and in a mouse catecholaminergic (CATH.a) cell line. (cdc.gov)
  • Mefloquine binding to human acyl-CoA binding protein leads to redox stress-mediated apoptotic death of human neuroblastoma cells. (bvsalud.org)
  • In this study, we show that mefloquine binds to and inactivates the human acyl-CoA binding protein ( hACBP ), potentially inducing redox stress in human neuroblastoma cells (IMR-32). (bvsalud.org)
  • These data show that di-GA exhibits three distinct anticancer activities: induction of apoptosis, cell-cycle arrest and disruption of cancer cell-induced lymphendothelial disintegration. (nature.com)
  • The mechanism of 6‑OAP cytotoxicity in all cell lines was associated with the induction of apoptosis with the presence of cleaved caspase‑3 and PARP. (spandidos-publications.com)
  • Strong induction of apoptosis in one compartment of the Drosophila wing disc causes apoptosis of cells in the other compartment, indicating that dying cells can release long-range death factors. (elifesciences.org)
  • A doubling of Bax expression was observed in endothelial cells, indicating the induction of apoptosis in this cell type. (uni-frankfurt.de)
  • Induction of apoptosis leads to characteristic cellular changes leading to death. (ijpsonline.com)
  • Endothelial microparticles are small vesicles that are released from endothelial cells and can be found circulating in the blood. (wikipedia.org)
  • UVA1 exposure stimulates endothelial cells to undergo neovascularization. (skintherapyletter.com)
  • Apoptosis of endothelial cells could be an initial manifestation leading to endothelial dysfunction and subsequent plaque development. (uni-frankfurt.de)
  • Microvesicles and exosomes are formed and released by two slightly different mechanisms. (wikipedia.org)
  • It further inhibited cell-cycle progression in the G1 phase by four different mechanisms: rapid downregulation of cyclin D1, induction of Chk2 with simultaneous downregulation of Cdc25A, induction of the Cdk-inhibitor p21 Cip/Waf and inhibition of ribonucleotide reductase activity resulting in reduced dCTP and dTTP levels. (nature.com)
  • MSCs can promote host tissue repair through several different mechanisms including donor cell engraftment, release of cell signaling factors, and the transfer of healthy organelles to the host. (frontiersin.org)
  • Exosomes are formed by invagination within a cell to create an intracellular vesicle called an endosome, or an endocytic vesicle. (wikipedia.org)
  • Cell death by necroptosis involves membrane breakage, which leaks intracellular molecules such as heat shock proteins. (news-medical.net)
  • CATH.a cells were significantly protected by the addition of 5 mM GSH (Mn EC50=200 M) and 10 mM N-acetyl cysteine (NAC) (Mn EC50=300 M), therefore, indirectly identifying intracellular ROS formation as a mechanism for Mn neurotoxicity. (cdc.gov)
  • Autophagy, the type II cell death, is a physiological mechanism involving degradation of intracellular damaged proteins and organelles into membrane vacuoles. (ijpsonline.com)
  • 1976. Intracellular effects of chronic arsenic administration on renal proximal tubule cells. (cdc.gov)
  • Yet, ferroptosis also occurs in non-transformed tissues as demonstrated by this study, thus implicating this cell death pathway in the development of a wide range of pathological conditions. (sciencedaily.com)
  • These results demonstrate that at least some neuronal and astrocytic death in HIV infection occurs by apoptosis. (nih.gov)
  • This occurs frequently in animal development: in human fetuses, for example, cells in the hand are directed to die to remove webbing between the fingers. (elifesciences.org)
  • Myofiber atrophy occurs with aging and in many diseases but the underlying mechanisms are incompletely understood. (sdbonline.org)
  • In contrast, the mechanism of the type of occupational asthma that occurs without latency after high-level exposure to irritants remains undetermined. (cdc.gov)
  • Purvalanol, a novel cyclin-dependent kinase inhibitor, is referred to as a strong apoptotic inducer which causes cell cycle arrest in various cancer cells such as prostate, breast and colon cancer cell lines. (spandidos-publications.com)
  • Moreover, inhibitor of PI3K/AKT signaling pathway could inhibit paraptosis-like cell death induced by 125 I seeds radiation. (hindawi.com)
  • And paraptosis is also insensitive to apoptotic and autophagic inhibitor [ 10 ]. (hindawi.com)
  • Pertoft H. and Fries E. (1995) Inter-a-inhibitor is required for the formation of the hyaluronan-containing coat on fibroblasts and mesothelial cells. (lu.se)
  • Therefore, the aim of the present study was to investigate the apoptotic effect of 6-OAP against human myeloma cells. (spandidos-publications.com)
  • Further work is now needed to investigate the exact molecular mechanisms behind the activation of p63. (elifesciences.org)
  • Here we use single cell RNA sequencing to investigate cellular interactions in TGCT.A total of 18,788 single cells from three TGCT and two Giant Cell Tumor of Bone (GCTB) samples underwent singe cell RNAseq. (stanfordchildrens.org)
  • NK-cell lineages all of which are further incidence of leukaemia and lymphoma, and radiodiagnosis physician (for imag- classified as distinct entities including it is important to investigate whether ing). (who.int)
  • Although purvalanol-induced cell cycle arrest and apoptotic cell death were demonstrated in prostate ( 5 ), breast ( 6 ) and colon cancer cells ( 7 ), the exact molecular mechanism of purvanol-induced apoptosis has not been elucidated yet. (spandidos-publications.com)
  • Many roads lead to CASM: Diverse stimuli of noncanonical autophagy share a unifying molecular mechanism. (babraham.ac.uk)
  • Resveratrol's anti-cancer capability has attracted widespread attention, but its molecular mechanism has not been systematically explained. (mdpi.com)
  • Though initially dismissed as cellular debris, microvesicles may reflect the antigenic content of the cell of origin and have a role in cell signaling. (wikipedia.org)
  • Microvesicle budding takes place at unique locations on the cell membrane that are enriched with specific lipids and proteins reflecting their cellular origin. (wikipedia.org)
  • By developing novel tools and harnessing the power of metabolomics, proteomics and functional genomics, our lab will define 1) how the lysosome communicates with other cellular compartments to fulfill the metabolic demands of the cell under various metabolic states, 2) and how its dysfunction leads to rare and common human diseases. (stanford.edu)
  • Activation follows a spring-loaded mechanism not requiring further translation of other cellular factors in oocytes and is associated with unfolding of the inhibitory structure that blocks the tetramerization interface. (elifesciences.org)
  • created 'undead' cells in which one of these proteins was turned on, but other downstream proteins (that are responsible for the cellular execution phase of apoptosis) had been turned off: these cells were undergoing apoptosis, but could not complete the process and die. (elifesciences.org)
  • We will also cover how cellular stress and alterations in metabolism influence the cellular death programs such as apoptosis, necroptosis, ferroptosis and others. (celldeath-apoptosis.org)
  • Autophagy and apoptosis are two forms of programmed cell death, which are essential for cellular homeostasis. (ijpsonline.com)
  • Researchers concluded that IP6 decreased cellular growth of these cells by pro-apoptotic mechanisms. (naturalnews.com)
  • Anti-cell death is a technique adopted by multi-cellular organisms as a defensive and developmental mechanism (Franklin-Tong and Gourlay, pg 390). (essaywriter.org)
  • Retinal ganglion cell death was induced by acute optic nerve crush in wild-type and Sigmar1 −/− mice. (molvis.org)
  • Our data indicated faster retinal ganglion cell death in Sigmar1 −/− than in wild-type mice under the stresses caused by optic nerve crush, providing direct evidence for a role of the σR1 in alleviating retinal degeneration. (molvis.org)
  • Fifteen micromoles of purvalanol induced a reduction in cell viability by 20 and 35% within 24 and 48 h, respectively. (spandidos-publications.com)
  • The number of live RGCs was then counted using a cell viability assay. (molvis.org)
  • The anti-proliferative effect of A. cherimola ethanolic leaf extract was evaluated via cell viability assay. (nih.gov)
  • Embryo morphology al ows options, the discovery of cell-free DNA in the evaluation of its growth, viability, and biological fluids has led to major advances in implantation capacity. (who.int)
  • Co-labeling studies identified the cells as neurons, reactive astrocytes, and, rarely, the multinucleated giant cells of HIV encephalitis. (nih.gov)
  • Additionally, we hypothesize that apoptotic death of reactive astrocytes may be a normal mechanism whereby the brain removes an excess number of astrocytes that have proliferated after certain types of brain injury. (nih.gov)
  • We were able to use this signal chain for pharmacological intervention and consequently to protect cells and tissues. (sciencedaily.com)
  • The scope of the special issue is to summarize and enlarge the knowledge in signalling processes and networks in diverse cells and tissues. (mdpi.com)
  • The tissues of developing organisms can be shaped by apoptosis, a form of regulated cell killing. (elifesciences.org)
  • ER alerts a self-protective mechanism that is called ER stress during nutrient deprivation, pathogen infection, alterations in redox status, intraluminal Ca 2+ levels and folding defective protein conditions ( 9 ). (spandidos-publications.com)
  • In this study, by comparing the activity of normal cell lines and cancer cell lines after treating with resveratrol, it was found that resveratrol has more significant cytotoxicity in cancer cell lines. (mdpi.com)
  • In vitro , talazoparib caused cytotoxicity in cancer cell lines that harboured defects in DNA repair genes, including BRCA1 and BRCA2. (drugbank.com)
  • We describe here an approach for quantification of radiation-induced cell death in vivo using the transparent embryo of the zebrafish, Danio rerio , as a model vertebrate system. (bioone.org)
  • We investigated the in vivo relationship between the incidence of apoptotic cell death and left ventricular function serially from the beginning of hypertension to decompensated heart failure in Dahl salt-sensitive rats. (portlandpress.com)
  • What we found was beyond our expectations: the two drugs acted in a synergistic manner and efficiently reduced tumor growth in vitro as well as in vivo, using cell- and patient-derived xenograft models of TNBC," says Jean-Jacques Lebrun. (futurity.org)
  • What we found was beyond our expectations: the two drugs acted in a synergistic manner and efficiently reduced tumor growth in vitro as well as in vivo, using cell- and patient-derived xenograft models of TNBC," says Lebrun, who is also a professor in the McGill department of medicine. (futurity.org)
  • Employing in vitro cell culture of inherited mitochondrial disease and an in vivo animal experimental model of low-grade inflammation (high fat feeding), we show human-derived MSCs to alter mitochondrial function. (frontiersin.org)
  • This review explores evolving knowledge of the immunopathogenic mechanisms, pharmacogenomic associations, in vivo and ex vivo diagnostics for causality assessment, and medication cross-reactivity data related to SCAR syndromes. (medscape.com)
  • [ 4 ] The aim of this article is to provide a complementary review of emerging immunopathogenic mechanisms, established pharmacogenomic associations, in vivo and ex vivo causality assessment tools and medication cross-reactivity data related to SCAR syndromes. (medscape.com)
  • In vivo and in organized cells, and proper symmetry are healthy individuals, macrophages can characteristics of higher-quality embryos, which phagocytize DNA that has been passively point to healthy development and higher rates of released into the blood from apoptotic or necrotic implantation. (who.int)
  • Cyclin-dependent kinases (CDKs), are members of the serine-threonine protein kinase family and are responsible for taking control of cell cycle regulation in eukaryotic cells. (spandidos-publications.com)
  • Additionally, this discussion expands its mandate by analyzing the function and regulation of anti-cell death in plant development. (essaywriter.org)
  • Drs. Kim Vanderlinden and Ivana Vucenik describe what is presently known about how IP6 works to help normalize the rate of cell division, normalize cell physiology, enhance Natural Killer (NK) cells, increase tumor suppressor P53 gene activity, inhibit inflammation, and inhibit angiogenesis. (naturalnews.com)
  • Purvalanol is a purine-derived CDKI that binds with a high selectivity and competitively to the ATP binding side of CDK1/2 and leads to G2/M cell cycle arrest ( 4 ). (spandidos-publications.com)
  • Although the conventional activities of p53 such as cell cycle arrest, senescence, and apoptosis are well accepted as the major checkpoints in stress responses, accumulating evidence implicates the importance of other tumor suppression mechanisms. (nature.com)
  • Is p53-dependent ferroptosis sufficient for tumor suppression in the absence of cell cycle arrest, senescence, and apoptosis? (nature.com)
  • To date, various mechanisms have been suggested to explain the powerful tumor-suppressive effect of p53, including the induction of cell cycle arrest, senescence, and apoptosis. (nature.com)
  • In addition, time-dependent cleavage of PARP was also detected in U266 and MM.1S cells. (spandidos-publications.com)
  • Western blot analysis revealed a Bax/Bcl2 dependent mechanism of apoptosis, as well as PARP cleavage, confirming the apoptotic results observed previously. (nih.gov)
  • A246015] Inhibition of PARP in cancer cells with BRCA mutations leads to genomic instability and apoptotic cell death. (drugbank.com)
  • In the beginning, UPR has protective effect, but in prolonged ER stress UPR triggers apoptotic cell death. (helsinki.fi)
  • Our aims are to identify and understand mechanisms regulating breast cancer cell death and how inflammatory signaling can be induced and influence breast cancer progression. (lu.se)
  • We have discovered that Smac mimetics can induce long-term changes in the breast cancer cell phenotype which includes inflammatory signaling. (lu.se)
  • The current study evaluates the anti-cancer and anti-proliferative properties of Annona cherimola ethanolic leaf extract (AELE) on Acute Myeloid Leukemia (AML) cell lines cultured in vitro (Monomac-1 and KG-1). (nih.gov)
  • They hypothesized that IP6 would inhibit the cell growth rate of Barrett's adenocarcinoma in vitro. (naturalnews.com)
  • They hypothesized that IP6 would significantly inhibit cell growth of cutaneous melanoma in vitro. (naturalnews.com)
  • They hypothesized that IP6 would significantly inhibit cell growth and increase the apoptotic rate of pancreatic cancer in vitro. (naturalnews.com)
  • Among these unconventional activities, an iron-dependent form of non-apoptotic cell death, termed ferroptosis, attracts great interest. (nature.com)
  • Ferroptosis is an iron dependent form of cell death, that is triggered by the discoordination of iron, lipids, and thiols. (cdc.gov)
  • In cells stimulated to undergo ferroptosis we identified PE-truncated species with sn-2 truncations ranging from 5 to 9 carbons. (cdc.gov)
  • Our results indicate that several dozens of proteins for each cell type, are PE-lipoxidated in HT-22, MLE, and H9c2 cells and M2 macrophages after they were induced to undergo ferroptosis. (cdc.gov)
  • Paraptosis is a kind of caspase-independent programmed cell death and is characterized by distinct cytoplasmic vacuolization derived from swelling endoplasmic reticulum and/or mitochondria. (hindawi.com)
  • Apoptosis is a distinct form of programmed cell death in which cells activate an intrinsic suicide program to self-destruct. (elifesciences.org)
  • Apoptosis is a distinct form of cell death that has been under intensive investigations in the past few years. (uni-frankfurt.de)
  • These findings indicated that Solanum nigrum extract induced cell death in MDA-MB-468 cells by two distinct mechanisms, apoptosis and autophagy, and these findings further suggest a possibility that this extract could be used to treat triple negative breast cancer. (ijpsonline.com)
  • 6‑O‑angeloylplenolin (6‑OAP) is a sesquiterpene lactone agent that has been previously demonstrated to inhibit the growth of multiple myeloma (MM) cells through mitotic arrest with accumulated cyclin B1. (spandidos-publications.com)
  • cDNA hydridization array analysis with two differing Mn concentrations and time points, identified no noteworthy mRNA inductions of genes associated with programmed cell death. (cdc.gov)
  • The expression levels of autophagy-related genes, Lc3 and Beclin1 increased in cells treated with 1.5 mg/ml of Solanum nigrum extract. (ijpsonline.com)
  • DEAF-1 activates the expression of Mtk and Drs promoter-luciferase fusion genes in S2 cells. (sdbonline.org)
  • Cells can die in different ways by using precise and highly regulated mechanisms of cell demolition, in which multiple genes evolutionarily conserved participate. (hstalks.com)
  • Therefore, there is need for fundamental distinction between the different types and functions of genes that are involved in anti-cell death in plants. (essaywriter.org)
  • The main aim of this paper is to review the pathways that lead to cell death in plants with a purpose of identifying the anti-cell death genes. (essaywriter.org)
  • At the end of the discussion, significant insights will be developed to paint a picture of the emerging trends in plant development with respect to the topical research on anti-cell death genes. (essaywriter.org)
  • The dominant discovery in these experiments indicates that there is a heterologous expression of certain genes in plants that can regulate cell death. (essaywriter.org)
  • Apoptosis is associated with nuclear disintegration, followed by removal of the cell by macrophages. (news-medical.net)
  • A major component of cells in Tenosynovial Giant Cell Tumor (TGCT) consists of bystander macrophages responding to CSF1 that is overproduced by a small number of neoplastic cells with a chromosomal translocation involving the CSF1 gene. (stanfordchildrens.org)
  • View our webinar focusing on the pathways of necroptotic cell death. (abcam.com)
  • Once activated, p53 coordinates multiple downstream pathways, thereby maintaining the homeostasis of the host cell or organism (if the stress is mild, transient, and repairable) or eliminating damaged cells (if the stress is acute, prolonged, and difficult to resist). (nature.com)
  • Many signalling pathways were elucidated in cell-free systems or in intact cells. (uni-frankfurt.de)
  • By integrating these findings, we propose an updated and unifying mechanism for noncanonical autophagy, centered on ATG16L1 and V-ATPase. (babraham.ac.uk)
  • [ 2 ] These findings, coupled with ototoxicity associated with later development of other aminoglycosides, led to a great deal of clinical and basic scientific research into the etiology and mechanisms of ototoxicity. (medscape.com)
  • Immunofluorescence and immunohistochemistry for a range of markers was used to validate and extend the scRNAseq findings.Two recurrent neoplastic cell populations were identified in TGCT that are highly similar to non-neoplastic synoviocytes. (stanfordchildrens.org)
  • CHRNA5 expression research findings from the laboratory to CHRNA5 was among the markers with in bronchial cel s modulates cell the population. (who.int)
  • These findings suggest that inter- the apoptotic destruction of lymphocytes and dendritic ventions aimed at reducing the extent of immune cell apop- tosis could improve outcomes for a variety of severe cells could have a particularly adverse effect on disease human infections, including those caused by emerging outcome. (cdc.gov)
  • Endothelial microparticles have been found to prevent apoptosis in recipient cells by inhibiting the p38 pathway via inactivating mitogen-activated protein kinase (MKP)-1. (wikipedia.org)
  • We found that 125 I seeds radiation activated PI3K/AKT signaling pathway and could trigger paraptosis-like cell death. (hindawi.com)
  • Our data suggest that 125 I seeds radiation can induce paraptosis-like cell death via PI3K/AKT signaling pathway. (hindawi.com)
  • Eiger is produced in apoptotic cells and, through activation of the c-Jun N-terminal kinase (JNK) pathway, is able to propagate the initial apoptotic stimulus. (elifesciences.org)
  • found that the JNK pathway activated apoptosis in anterior cells. (elifesciences.org)
  • Cancer-associated pathway interfering peptides found naturally have been synthetically produced for use in cancer models to induce cell death through apoptotic and non-apoptotic mechanisms. (eurogentec.com)
  • While BRCA-dependent homologous recombination can repair DSBs in normal cells, this repair pathway is defective in cells with BRCA1/2 mutations, such as certain tumour cells. (drugbank.com)
  • High expression of GFPT2 in the neoplastic cells is associated with activation of the YAP1/TAZ pathway. (stanfordchildrens.org)
  • HCT 116 colon cancer cells were exposed to purvalanol, which activated ER stress via upregulation of PERK, IRE1α gene expression, eIF-2α phosphorylation and ATF-6 cleavage at early time-points in the HCT 116 colon cancer cells. (spandidos-publications.com)
  • Understanding the association between Cell-free DNA levels in embryo CM and the quality of embryo cleavage could help improve the quality of IVF techniques. (who.int)
  • This prospective study was conducted with 96 spent CM from patients undergoing IVF cycle, in order to determine relationships of Cell-free DNA levels in embryo CM with embryo cleavage quality on day 3. (who.int)
  • Microvesicles play a role in intercellular communication and can transport molecules such as mRNA, miRNA, and proteins between cells. (wikipedia.org)
  • The endothelial microparticles in some of these disease states have been shown to have arrays of cell surface molecules reflecting a state of endothelial dysfunction. (wikipedia.org)
  • Necroptosis falls somewhere in the middle, with several molecules and processes that can trigger, modulate, and effect necroptosis in cells. (news-medical.net)
  • These neoantigens , which are peptides are processed and presented to the T cells in association with MHC molecules to elicit an immune response against the underlying cancer. (eurogentec.com)
  • Cell permeable peptides (CPP) such as TAT, or antennapedia, conjugated to anti-cancer drugs are under evaluation for their ability to penetrate and deliver anti-tumor molecules into cancer cells. (eurogentec.com)
  • We specifically study Smac mimetics, small molecules mimicking the effect of the pro-apoptotic protein Smac. (lu.se)
  • An introductionto the mechanisms of apoptotic cell death and apoptosis assays and markers. (abcam.com)
  • Finally, apoptotic markers of Mn-induced cell death were investigated. (cdc.gov)
  • the location and absence of cell-specific markers suggested a glial origin for the labeled cells. (nih.gov)
  • She received her PhD from UCSF, where she investigated the cell biology and biochemistry of membrane trafficking in the laboratory of Dr. Peter Walter. (stanford.edu)
  • Visit the Tumor Cell Biology groups research portal via this link. (lu.se)
  • The protein then switches to an active form when DNA damage is detected to trigger the process of cell self-destruction. (elifesciences.org)
  • Enhanced immunity and antioxidant properties also contribute to tumor cell destruction. (naturalnews.com)
  • Cell death refers to a series of events that culminate in the organized and controlled destruction of the cell. (essaywriter.org)
  • Furthermore, di-GA inhibited the generation of lymphendothelial gaps by cancer cell spheroid-secreted lipoxygenase metabolites. (nature.com)
  • In the present study, our aim was to determine the time-dependent, ER-mediated apoptotic and autophagy induction of purvalanol in HCT 116 colon cancer cells. (spandidos-publications.com)
  • Olomoucine, roscovitine and purvalanol are examples of CDK inhibitors (CDKIs) designed and investigated for their apoptotic potential on cancer cells ( 3 ). (spandidos-publications.com)
  • Increased levels of polyamines in cells are considered to be involved in cancer progression. (spandidos-publications.com)
  • The irradiation and chemotherapy drugs that are used to destroy cancer cells also damage healthy cells. (elifesciences.org)
  • Many studies on the cancer-killing activity of 125 I seeds radiation mainly focused on its ability to trigger apoptosis, which is the most well-known and dominant type of cell death induced by radiation. (hindawi.com)
  • Colorectal cancer remains one of the most common causes of cancer-related deaths worldwide [ 1 ]. (hindawi.com)
  • We found besides apoptosis that 125 I seed radiation killed colorectal cancer cell via inducing paraptosis. (hindawi.com)
  • We further focused our interest on the molecular mechanisms that underlie 125 I seeds radiation-induced paraptosis on colorectal cancer cells. (hindawi.com)
  • Resveratrol could play a toxic role through inducing apoptosis of the cancer cell in a time- and concentration-dependent manner. (mdpi.com)
  • Cancer is one of the leading causes of death globally with more than 100 different cancer types reported, owing to a vast genetic heterogeneity in cancer states. (eurogentec.com)
  • Tumor derived, tumor associated antigens (TAA) or homing peptides are used as targets for the development of cancer vaccines (such as NY-ESO-1 peptide vaccine) as they illicit an immune response against cells containing the cancer antigen. (eurogentec.com)
  • More recently, tumor specific antigens or tumor specific neoantigens (TSNA) that arise from tumor cell mutations are being identified in a large number of cancer patients. (eurogentec.com)
  • Although significant progress has been made in systemic treatments, pancreatic cancer (PC) still remains the fourth leading cause of cancer-related deaths in the United States with an estimated 42,470 new cases and 35,240 deaths in 2009 ( 1 ). (aacrjournals.org)
  • Breast cancer cells were treated with varying concentrations (1 to 5 mg/ml) of Solanum nigrum extract for 24 and 48 h. (ijpsonline.com)
  • One of the hallmarks of breast cancer is resistance of tumor cells to cell death. (ijpsonline.com)
  • Therefore, remedies based on the induction of programmed cell death attracted greater attention for cancer treatment [ 8 ]. (ijpsonline.com)
  • As previous known, the more differentiated the malignant cells, the less aggressive and dangerous is the cancer. (naturalnews.com)
  • Breast cancer is the leading cause of cancer death in women around the world, responsible for 1,700 deaths every day. (futurity.org)
  • Chemotherapy treatment can even enrich these tumors in cancer stem cells and be detrimental to the patient, as we have shown in a previous study," says Jean-Jacques Lebrun, senior scientist in the Cancer Research Program at the Research Institute of McGill University Health Centre (RI-MUHC) and principal investigator of the study. (futurity.org)
  • Macropinocytosis is a natural mechanism that cancer cells use for their own advantage, to grow bigger and faster," explains Dai. (futurity.org)
  • En plus de son rôle éminent dans le développement, l'apoptose est fréquemment liée à de nombreuses pathologies : dans le cancer, les mécanismes physiologiques de l'apoptose se trouvent souvent perturbés, permettant ainsi une croissance rapide de la tumeur, alors que dans le cas des maladies neurodégénératives il y a au contraire sur activation de l'apoptose. (crcl.fr)
  • For example, excessive inhibition by which tissue remodeling takes place during normal of apoptosis is an underlying mechanism of cancer, while growth and development and the physiologic mechanism an inappropriate increase is seen in some neurodegenera- by which labile cell populations such as gastrointestinal tive diseases and other conditions. (cdc.gov)
  • Apoptosis is a cell self-destruct process that removes toxic and/or useless cells during mammalian development and other life processes. (wikipedia.org)
  • An alternative infectious processes and may contribute to high case fatal- approach attempts to identify mechanisms shared by most ity rates by impairing adaptive immune function. (cdc.gov)
  • have performed a range of biochemical, biophysical and cell culture experiments to study how p63 is kept in its inactive form in the oocytes of mice. (elifesciences.org)
  • To characterize molecular and biochemical mechanisms of hypersensitive reaction (HR) in plants, a tobacco suspension culture of BY -2 was treated with the proteinaceous HR elicitor harpin from several pathovars of Pseudomonas syringae. (fao.org)
  • MSC co-culture with skin fibroblasts from mitochondrial disease patients rescued aberrant mitochondrial morphology from a fission state to a more fused appearance indicating an effect of MSC co-culture on host cell mitochondrial network formation. (frontiersin.org)
  • First author and Humboldt fellow at the HMGU, Dr. Jose Pedro Friedmann Angeli sums it up as follows: "Our data show that we can use pharmacological approaches to stop this form of regulated cell death. (sciencedaily.com)
  • A 438079 hydrochloride is a competitive P2X 7 receptor antagonist (pIC 50 = 6.9 for the inhibition of Ca 2+ influx in the human recombinant P2X 7 cell line). (tocris.com)
  • This leads to the competitive inhibition of acyl-CoA(s) binding to hACBP and to the accumulation of lipid droplets inside the IMR-32 cells . (bvsalud.org)
  • Mark L., Lee W. H., Villoutreix B. O., Proctor D., Blackbourn, D., Spiller B. O. and Blom A. M. (2004) KSHV complement control protein mimics human molecular mechanisms for inhibition of the complement system. (lu.se)
  • The work presented here characterizes a novel form of cell death in response to 125 I seeds radiation. (hindawi.com)
  • Up until now, this form of cell death has only been thought to be a possible therapeutic approach to treat tumor cells. (sciencedaily.com)
  • Importantly, this conference aims to become the go-to forum at which the most current and up-to-date therapeutic avenues in the fields of cell death, cell stress and metabolism will be presented and discussed. (celldeath-apoptosis.org)
  • More specifically, the deletion of the ferroptosis-regulating enzyme Gpx4 in a pre-clinical model results in high ferroptosis rates in kidney tubular epithelial cells causing acute renal failure. (sciencedaily.com)
  • In the present study, the team was able to show that Liproxstatin-1 suppresses ferroptosis both in human kidney cells, Gpx4 deletion-induced acute renal failure and in a pre-clinical model of hepatic ischemia reperfusion injury. (sciencedaily.com)
  • Here, we used the σR1-knockout mouse ( Sigmar1 −/− ) to demonstrate unambiguously the role of the σR1 in protecting the retinal ganglion cells against degeneration after acute damage to the optic nerve. (molvis.org)
  • Strikingly, undead cells in the posterior (back) region of the wing imaginal disc-the tissue in the larva that gives rise to the wing in the adult fruit fly-could trigger apoptosis in cells in the anterior (front) half. (elifesciences.org)