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  • mechanisms
  • Because depression of synaptic neurotransmission is the common denominator in the action of AEDs, we investigated whether common AEDs may cause apoptotic neurodegeneration in the developing brain and what the underlying pathogenetic mechanisms are. (pnas.org)
  • receptors
  • In the immature rodent brain, suppression of synaptic neurotransmission via blockade of glutamate N -methyl- d -aspartate receptors or activation of GABA type A receptors may trigger apoptotic neurodegeneration ( 17 , 18 ). (pnas.org)
  • cells
  • We are using Acridine Orange (AO) to stain apoptotic cells. (bio.net)
  • definite apoptotic cells. (bio.net)
  • staining of the cytoplasm with AO in apoptotic and preapoptotic cells. (bio.net)
  • The prompt removal of apoptotic cells by phagocytes is important for maintaining tissue homeostasis. (nih.gov)
  • The detection and disposal of apoptotic cells generally promote an anti-inflammatory response at the tissue level, as well as immunological tolerance. (nih.gov)
  • Conversely, under certain conditions, such as the killing of tumour cells by specific cell-death inducers, the recognition of apoptotic tumour cells can promote an immunogenic response and antitumour immunity. (nih.gov)
  • Prior to or during the onset of apoptotic morphology, apoptotic cells also release 'find-me' signals in the form of soluble factors (for example nucleotides) or microparticle-associated molecules (including CX3C chemokine ligand 1 (CX3CL1) and intercellular adhesion molecule 3 (ICAM3)) to recruit phagocytes for cell clearance. (nih.gov)
  • Nucleotides are released from apoptotic cells via caspase-activated pannexin 1 (PANX1) membrane channels. (nih.gov)
  • 6 Because of its broad effects in the cell, loss of p53 activity confers growth advantage and ensures survival in cancer cells by inhibiting the apoptotic response necessary for tumor suppression. (nature.com)
  • A simple method of selective extraction of fragmented DNA from apoptotic cells without the presence of high molecular weight DNA sections, generating the laddering pattern, utilizes pretreatment of cells in ethanol. (wikipedia.org)
  • Gong JP, Traganos F, Darzynkiewicz Z. (1994) A selective procedure for DNA extraction from apoptotic cells applicable for gel electrophoresis and flow cytometry. (wikipedia.org)
  • process
  • Here, we review the current understanding of the complex process of apoptotic cell clearance in physiology and pathology, and discuss how this knowledge could be harnessed for new therapeutic strategies. (nih.gov)
  • various
  • In addition, novel apoptotic players such as miRNAs and sphingolipid family members in various kind of cancer are discussed. (springer.com)
  • plasma
  • Here we reveal that phenytoin, phenobarbital, diazepam, clonazepam, vigabatrin, and valproate cause apoptotic neurodegeneration in the developing rat brain at plasma concentrations relevant for seizure control in humans. (pnas.org)