• activation
  • hccs downregulation induces apoptosome-independent caspase-9 activation in mitochondriaA-C. TUNEL assays on st30 embryos co-injected with hccs-MO and Apaf1-MO (A), wt embryos exposed to staurosporine (B) and embryos injected with Apaf1-MO exposed to staurosporine (C) (n = 100/each treatment). (nih.gov)
  • These data clearly involve non-canonical, apoptosome-independent caspase-9 activation in the pathogenesis of microphthalmia. (nih.gov)
  • cell death
  • The apoptosome drives autocatalytic processing of caspase-9, triggering a proteolytic caspase cascade that results in the biochemical and morphological changes characteristic of cell death. (sciencemag.org)
  • Our results indicate that IAP-dependent suppression of apoptosome predominantly occurs in IAP-overexpressing tumor, and the IAP-targeting Smac peptide is an effective molecule to increase tumor cell death induced by chemotherapy in vitro and in vivo . (aacrjournals.org)
  • Chinnaiyan AM. The apoptosome: heart and soul of the cell death machine. (springer.com)