ApoptosisCaspasesEnzyme ActivationCaspase 3Cell SurvivalProto-Oncogene Proteins c-aktSignal TransductionPhosphatidylinositol 3-KinasesCell Line, TumorCell LineProtein-Serine-Threonine KinasesTransfectionApoptosis Regulatory ProteinsProto-Oncogene Proteins c-bcl-2Inhibitor of Apoptosis ProteinsDNA Fragmentationbcl-2-Associated X ProteinIn Situ Nick-End LabelingCells, CulturedX-Linked Inhibitor of Apoptosis ProteinCaspase 9CASP8 and FADD-Like Apoptosis Regulating ProteinCaspase InhibitorsApoptosis Inducing FactorCaspase 8MitochondriaTumor Cells, CulturedTumor Suppressor Protein p53Blotting, WesternCell ProliferationEnzyme InhibitorsFas Ligand ProteinCytochromes cPhosphorylationbcl-X ProteinProto-Oncogene ProteinsRNA, Small InterferingAnnexin A5Dose-Response Relationship, DrugNF-kappa BFlow CytometryCell CycleCysteine Proteinase InhibitorsAntineoplastic AgentsUp-RegulationReactive Oxygen SpeciesAmino Acid Chloromethyl KetonesPoly(ADP-ribose) PolymerasesDown-RegulationRNA, MessengerMice, Inbred C57BLCell DivisionTumor Necrosis Factor-alphaJurkat CellsMitogen-Activated Protein KinasesCell DeathGene Expression RegulationReverse Transcriptase Polymerase Chain ReactionTNF-Related Apoptosis-Inducing LigandMice, KnockoutTime Factorsp38 Mitogen-Activated Protein KinasesHL-60 CellsCaspase 7Membrane Potential, MitochondrialRats, Sprague-DawleyMembrane GlycoproteinsMAP Kinase Signaling SystemGene Expression Regulation, NeoplasticRNA InterferenceCarrier ProteinsEpithelial CellsNecrosisDNA DamageMyeloid Cell Leukemia Sequence 1 ProteinImmunohistochemistryCytochrome c GroupOxidative StressStaurosporineModels, BiologicalGenes, bcl-2Intracellular Signaling Peptides and Proteinsbcl-Associated Death ProteinDNA-Binding ProteinsGene ExpressionHeLa CellsCeramidesCell NucleusMembrane Proteinsbcl-2 Homologous Antagonist-Killer ProteinDrug SynergismTranscription FactorsExtracellular Signal-Regulated MAP KinasesReceptors, TNF-Related Apoptosis-Inducing LigandBH3 Interacting Domain Death Agonist ProteinNeoplasm ProteinsAntineoplastic Agents, PhytogenicCell DifferentiationMutationProtein Binding