Transcriptional repressorInduces apoptosisProliferationProteinsInhibitorInduction of apoptosisSignaling pathwayInteracts with severalProteinAnti-apoptoticChemotherapeutic agentsMRNARegulatesMitochondrialCytochromeOverexpressionCellsCellularAlterationsGene expressionCell deathComplexActivityActivationTermsContentPresent
Transcriptional repressor3
- This gene encodes a transcriptional repressor that interacts with several members of the BCL-2 family of proteins. (wikipedia.org)
- Phosphorylates SNAI1 at 'Ser-246' promoting its transcriptional repressor activity by increasing its accumulation in the nucleus. (icr.ac.uk)
- Disease relevance of BCLAF 1 Emerin binding to Btf, a death- promoting transcriptional repressor. (wikigenes.org)
Induces apoptosis3
- Overexpression of this protein induces apoptosis, which can be suppressed by co-expression of BCL2 proteins. (wikipedia.org)
- This inhibition of AMPK ultimately leads to inhibition of mTOR and thus induces apoptosis in the HepG2 cells. (biomedcentral.com)
- Recent studies have demonstrated that pharmacological inhibition of the Notch pathway with γ-secretase inhibitor (GSI) induces apoptosis of multiple myeloma (MM) cells via upregulation of the proapoptotic protein Noxa. (aacrjournals.org)
Proliferation10
- Real-time cell analyzer and flow cytometry data reveal that tumor cell proliferation and apoptosis were impacted by FO. (hindawi.com)
- DAVID bioinformatic data showed that most of the biological process GO terms are related to proliferation and apoptosis. (hindawi.com)
- We hypothesized that FO might regulate related genes in apoptosis and PI3K-AKT pathways to mediate the proliferation and apoptosis of liver cancer cells. (hindawi.com)
- Protein kinase involved in intracellular signaling pathways downstream of integrins and receptor-type kinases that plays an important role in cytoskeleton dynamics, in cell adhesion, migration, proliferation, apoptosis, mitosis, and in vesicle-mediated transport processes (PubMed:11896197, PubMed:30290153). (icr.ac.uk)
- MiR-155 also upregulates Mxd1/Mad1, a network of basic helix-loop-helix leucine zipper transcription factors which mediate cellular proliferation, differentiation, and apoptosis, through regulating BCL6. (biomedcentral.com)
- Increasing evidence indicates that EBV miRNAs target the host mRNAs involved in cell proliferation, apoptosis and transformation. (ijbs.com)
- Excessive apoptosis causes atrophy, such as in ischemic damage, whereas an insufficient amount results in uncontrolled cell proliferation, such as cancer. (geneontology.org)
- As a consequence, any modulations of the target transcript expression, miRNAs can affect various signalling pathways and cellular process such as apoptosis, proliferation or differentiation. (ukessays.com)
- Many laboratories have focused on the functions of the clock genes and proteins that are involved in cellular activities, including cell survival, cell cycle regulation, proliferation, apoptosis, DNA damage repair, and tumor promotion or suppression [ 5 , 6 ]. (explorationpub.com)
- These abnormalities result in significant alterations in gene expression related to cell proliferation, apoptosis, migration and immune signaling pathways. (spandidos-publications.com)
Proteins2
- BCL2 proteins are described as 'crucial regulators of apoptosis' (PMID:15868100)and the intrinsic apoptosis pathway is initiated by the release of mitochondrial cytochrome c into the cytoplasm, which results in the activation of caspases (15102863) - help in generating a defintion for intrinsic apoptosis? (geneontology.org)
- does all activation of caspases require other proteins also involved in apoptosis - therefore shouldn't this term be a part of apoptosis? (geneontology.org)
Inhibitor2
- BAG3 protein is an apoptosis inhibitor and is highly expressed in Anaplastic Thyroid Cancer. (oncotarget.com)
- Genetic depletion or inhibition of BCL-2 using venetoclax synergized with the PRMT5 inhibitor by inducing apoptosis of lymphoma cells. (springernature.com)
Induction of apoptosis2
- should the term ['GO:0006919] activation of caspase activity' be a child of positive regulation of apoptosis or induction of apoptosis rather than directly to apoptosis? (geneontology.org)
- Melatonin has oncostatic properties that are mediated by induction of apoptosis, arresting the cell cycle, regulation of metabolic activity, and the inhibition of hypoxia-inducible factor 1α (HIF-1α) activity [ 9 ]. (explorationpub.com)
Signaling pathway1
- Involvement of C/EBPβ-related signaling pathway in methamphetamine-induced neuronal autophagy and apoptosis. (cancerindex.org)
Interacts with several1
- Also, since BCL6 interacts with several co-repressor complexes to inhibit transcription, and its gene is frequently trans-located and hyper-mutated in diffuse large B cell lymphoma (DLBCL), miR-155 acts to enhance transcription and contribute to the pathogenesis of DLBCL. (biomedcentral.com)
Protein7
- The protein localizes to dot-like structures throughout the nucleus and redistributes to a zone near the nuclear envelope in cells undergoing apoptosis. (wikipedia.org)
- Bax Accelerates programmed cell death by binding to, and antagonizing the apoptosis repressor BCL2 or its adenovirus homolog E1B 19k protein. (affbiotech.cn)
- Forms heterodimers with BCL2, E1B 19K protein, BCL2L1 isoform Bcl-X(L), MCL1 and A1. (affbiotech.cn)
- This protein positively regulates cell apoptosis by forming heterodimers with BCL-xL and BCL-2, and reversing their death repressor activity. (affbiotech.com)
- how to decide whether a protein is involved in '+ve reg of apoptosis or induction ([GO:0006917])?emily. (geneontology.org)
- Identification of early growth response protein 1 (EGR-1) as a novel target for JUN-induced apoptosis in multiple myeloma. (uams.edu)
- Homo sapiens BCL2 related protein A1 (BCL2A1), transcript variant 2, mRNA. (genscript.com)
Anti-apoptotic1
- Amy and Sor cotreatment resulted in the highest glutathione levels and induction of pro-autophagic genes AMPK, HGMB1, ATG5, Beclin 1, and LC3, suppressed the mTOR and BCL2 anti-apoptotic gene. (biomedcentral.com)
Chemotherapeutic agents1
- Signaling through the receptor/transcriptional regulator Notch plays an important role in the survival of tumor cells and their protection from apoptosis induced by chemotherapeutic agents. (aacrjournals.org)
MRNA4
- Conversely, early developmental stage ZF1 did not affect cell viability or apoptosis, albeit increasing Bax/Bcl-2 mRNA ratio. (livingroom.health)
- Homo sapiens BCL2 apoptosis regulator (BCL2), transcript variant alpha, mRNA. (genscript.com)
- Homo sapiens BCL2 apoptosis regulator (BCL2), transcript variant beta, mRNA. (genscript.com)
- Homo sapiens BCL2-like 1 (BCL2L1), transcript variant X4, mRNA. (genscript.com)
Regulates2
- KEGG enrichment analysis showed that FO mainly regulates PI3K-AKT- and apoptosis-related signals, in which BBC3, DDIT3, NOXA, and CDKN1A on the surface serve as the novel targets of FO inducing HCC cell apoptosis. (hindawi.com)
- This indolamine advances apoptosis, which arrests the cell cycle and regulates metabolic activity. (explorationpub.com)
Mitochondrial1
- Wild-type herpes simplex virus 1 blocks programmed cell death and release of cytochrome c but not the translocation of mitochondrial apoptosis-inducing factor to the nuclei of human embryonic lung fibroblasts. (uchicago.edu)
Cytochrome1
- Induces the release of cytochrome c, activation of CASP3, and thereby apoptosis. (affbiotech.cn)
Overexpression1
- information on BCLAF 1 Indeed, the sustained overexpression of Btf in HeLa cells induced apoptosis, which. (wikigenes.org)
Cells7
- Therefore, the current study used integrated in vitro and in silico approaches to figure out Amy and Sor's possible synergistic activity in targeting AMPK/mTOR and BCL-2 for anti-angiogenesis and apoptosis cell death in HepG2 cells. (biomedcentral.com)
- Can directly phosphorylate BAD and protects cells against apoptosis. (icr.ac.uk)
- Activity is inhibited in cells undergoing apoptosis, potentially due to binding of CDC2L1 and CDC2L2. (icr.ac.uk)
- Apoptosis is the mechanism responsible for the physiological deletion of cells and appears to be intrinsically programmed. (lookformedical.com)
- when looking at experimental data - often counting number of cells they've died and committed to apoptosis so how can we work out induction or positive regulation? (geneontology.org)
- Bcl-2 blocks a caspase-dependent pathway of apoptosis activated by herpes simplex virus 1 infection in HEp-2 cells. (uchicago.edu)
- The RUNX2/BMI-1/SMAD2/3 complex is associated predominantly with genes not expressed in undifferentiated BG01V cells, consistent with the reported role of those TFs as transcriptional repressors. (biomedcentral.com)
Cellular1
- Apoptosis is a programmed form of cell death involving the degradation of cellular constituents by a group of cysteine proteases called caspases. (geneontology.org)
Alterations1
- This is particularly true for galectin family members because changes in their expression levels correlate with alterations in cancer cell growth, apoptosis, and cell-cell and cell-matrix interactions. (fdocuments.net)
Gene expression1
- ZF1 also induced the transcription of TERT , encoding the catalytic subunit of telomerase, as well as the gene expression of Bmi-1 , a chromatin remodeler acting as a major telomerase-independent repressor of senescence. (livingroom.health)
Cell death1
- Although the presence of active caspases and DNA fragmentation is helpful in identifying possible apoptosis, they should not be employed as an exclusive means to demonstrate this process as apototic cell death can occur without DNA fragmentation or caspase activity. (geneontology.org)
Complex2
- These data suggest a working mechanism for the release of CED-4 from the CED-4/CED-9 complex upon EGL-1 binding and provide a mechanistic framework for understanding apoptosis activation in C. elegans. (nih.gov)
- Biochemical studies expose a basal recruitment of \catenin to the messenger ribonucleoprotein and translational pre\initiation complex, fulfilling a translational repressor function. (informationalwebs.com)
Activity2
- N- trans -Feruloyloctopamine (FO) is the extract of garlic skin, which possesses high antioxidant activity and selectively induces cell apoptosis in leukemia tumors [ 6 ]. (hindawi.com)
- Can reverse the death repressor activity of Bcl-X(L), but not that of Bcl-2 (By similarity). (affbiotech.com)
Activation1
- Phosphorylates RAF1 at 'Ser-338' and 'Ser-339' resulting in: activation of RAF1, stimulation of RAF1 translocation to mitochondria, phosphorylation of BAD by RAF1, and RAF1 binding to BCL2. (icr.ac.uk)
Terms1
- Shouldn't we have an apoptosis signalling pathway terms? (geneontology.org)
Content1
- The intrinsic apoptotic pathway has been chosen for a Reference Genome project as the curation work will complement and inform a planned apoptosis content meeting scheduled for June the 1st, assisted by domain experts from the Apo-Sys Consortium. (geneontology.org)
Present1
- The domains of glycoprotein D required to block apoptosis depend on whether glycoprotein D is present in the virions carrying herpes simplex virus 1 genome lacking the gene encoding the glycoprotein. (uchicago.edu)