• Recent evidence suggests a role for TNF superfamily member Tumor necrosis factor-like weak inducer of apoptosis (TWEAK, Apo3L, or TNFSF12) in both AKI and CKD, where it has been shown to regulate cell death, inflammation, and fibrosis through activation of the TWEAK receptor Fn14 and a variety of intracellular signaling pathways, including the transcription factor nuclear factor-kappa B (NF-κB) ( 4 , 5 ) (Figure 1 ). (frontiersin.org)
  • Rocco J, Leong C, Kuperwasser N, DeYoung M, Ellisen L. p63 mediates survival in squamous cell carcinoma by suppression of p73-dependent apoptosis. (labome.org)
  • Acting through ataxia telangiectasia mutated (ATM) and its downstream effectors, T-oligos induced apoptosis and senescence of MCF-7 cells but not NME cells, in which these signaling pathways were induced to a far lesser extent. (biomedcentral.com)
  • Interestingly, despite increased levels of p53, p21-null cells were resistant to apoptosis, suggesting a proapoptotic role of p21 and implying that p53 is a necessary but not sufficient condition for noscapine-mediated apoptosis. (aacrjournals.org)
  • In this scenario, the role played by p21 is particularly intriguing because this protein can be activated by both p53-dependent and p53-independent mechanisms and can assume proapoptotic or antiapoptotic functions, depending on the cellular context ( 14 ). (aacrjournals.org)
  • Therefore, persistent expression of c-FLIP(L) is necessary and sufficient to regulate sensitivity to TRAIL-mediated apoptosis in prostate cancer cells. (labome.org)
  • Surprisingly some proteins were differentially affected in the two prostate cancer cell lines: Akt and p27 increasing and HIF-1α decreasing in LNCap cells but not PC-3, while ADAMTS1 was increased in PC-3 cells only. (edu.au)
  • The α gene products ICP0, -4, -22, and -27 have regulatory functions, and they cooperatively act to regulate the expression of all classes of viral genes (reviewed in reference 36 ). (asm.org)
  • In this study, we have used the human BV173 and the mouse BaF3/Bcr-Abl-expressing cell lines as model systems to investigate the molecular mechanisms whereby STI571 and FoxO3a regulate Bim expression and apoptosis. (biomedsearch.com)
  • Thompson R, Vardinogiannis I, Gilmore T. The sensitivity of diffuse large B-cell lymphoma cell lines to histone deacetylase inhibitor-induced apoptosis is modulated by BCL-2 family protein activity. (labome.org)
  • Acts as an inhibitor of TNFRSF6 mediated apoptosis. (genecards.org)
  • Whereas some cells (for example, cardiac and skeletal muscle fibers, CNS neurons) last a lifetime, others (for example, epithelial and glandular cells, erythrocytes) have limited life-spans, at the end of which they are genetically programmed for self-destruction by apoptosis, usually to be replaced by others formed by mitosis from surviving cells. (thefreedictionary.com)
  • This gene encodes a nuclear protein expressed in a variety of tissues. (cancerindex.org)
  • BRCA1 encodes a tumour suppressor protein that plays pivotal roles in homologous recombination (HR) DNA repair, cell-cycle checkpoints, and transcriptional regulation. (biomedsearch.com)
  • We aimed to investigate whether jejunal microbial metabolite butyrate modulates the apoptosis/proliferation balance and immune response in piglets during the post-weaning period of the first 3 weeks of life. (frontiersin.org)
  • The findings suggest that strategies to promote butyrate production can maintain the apoptosis/proliferation balance via minimizing intestinal inflammation, and thereby improving post-weaning jejunal adaptation toward gut health. (frontiersin.org)
  • Expression of this gene has been shown to be repressed by B-cell CLL/lymphoma 6 (BCL6), a transcriptional repressor required for lymph node germinal center development, suggesting that BCL6 regulates apoptosis by its effects on this protein. (cancerindex.org)
  • Accordingly, most current research efforts in this area have focused on limiting the synthesis of viral proteins in an attempt to reduce cell toxicity ( 17 , 18 , 38 , 39 , 46 ). (asm.org)
  • We conclude that cofilin is a major intracellular redox-sensor that, when oxidized at critical cysteine residues, activates mitochondria-dependent apoptosis. (aacrjournals.org)
  • 0.01), leading to the inhibition of cell apoptosis and the stimulation of cell proliferation via decreased pro-inflammatory cytokines and thereby the improvement of intestinal development and function. (frontiersin.org)
  • Two alternatively spliced transcript variants encoding distinct proteins have been described. (wikipedia.org)
  • Activation of this enzyme can occur via the interaction of its N-terminal death effector domain with DEATH DOMAIN RECEPTOR SIGNALING ADAPTOR PROTEINS. (curehunter.com)
  • Bim depletion substantially blocks apoptosis and significantly restores Shp2 null TS cell proliferation, thereby establishing a key mechanism by which FGF4 controls stem cell survival. (labome.org)
  • Lyoniresinol 3α-O-β-D-Glucopyranoside-Mediated Hypoglycaemia and Its Influence on Apoptosis-Regulatory Protein Expression in the Injured Kidneys of Streptozotocin-Induced Mice - Descarga este documento en PDF. (duhnnae.com)
  • FLICE-inhibitory proteins were identified in virus and human and designated v-FLIPs and c-FLIPs, respectively (1,2). (abcam.com)