Apoptosis proteins inhibitory inhibitor protein. Medical search. Frequent questions

In the present study, we reported that celastrol potentiated tumor necrosis factor-α (TNF-α)-induced apoptosis, affected activation of caspase-8, caspase-3 and PARP cleavage, and inhibited the expression of anti-apoptotic proteins such as cellular inhibitor of apoptosis protein 1 and 2 (cIAP1 and cIAP2), cellular FLICE-inhibitory protein (FLIP), and B-cell lymphoma 2 (Bcl-2). (spandidos-publications.com)
It has been previously shown that rbf1 pro-apoptotic activity depends on its ability to decrease the level of anti-apoptotic proteins such as the Bcl-2 family protein Buffy. (sdbonline.org)
The expression of pro-apoptotic proteins and anti-apoptotic proteins in MCF-7 and MDA-MB-231 cells was investigated by Western blotting. (researchsquare.com)
Western blot analysis revealed that VALD-3 upregulated pro-apoptotic proteins (Bad and Bax), downregulated anti-apoptotic proteins (Bcl-2, Bcl-xl, survivin and XIAP) and increased the expression of cleaved caspase-3, cleaved caspase-8, Cyto-c and cleaved PARP. (researchsquare.com)
PMID:14996496, table 1 provides links to papers that describe subcellular location of many pro- and anti-apoptotic proteins. (geneontology.org)

Pro‑apoptotic tumor necrosis factor‑related apoptosis‑inducing ligand (TRAIL) is tumor‑specific and has been shown to induce apoptosis and subsequently kill GBM cells. (spandidos-publications.com)
Carbon nanotube s induce apoptosis resistance through FLICE-inhibitory protein. (cdc.gov)
Studies have exhibited that extract has antioxidant properties, and can inhibit tumor cell growth and induce apoptosis (23C26). (insulin-receptor.info)
Isolinderalactone (ILL) is certainly a kind of sesquiterpene substance obtained from the main tuber of (27) confirmed that ILL could induce apoptosis in the individual breast cancers MDA-MB-231 cell series, perhaps via the inhibition of microRNA hsa-miR-30c appearance and raising the appearance of suppressor of cytokine signaling 3 (SOCS3). (insulin-receptor.info)
It offers been reported Cetaben previously that Cetaben or bacterium-derived products induce apoptosis in macrophages, which happens via polyamine-dependent Cetaben mechanisms and signaling via ERK-MAPK and the Src family of tyrosine kinases (Allen et al. (thetechnoant.info)

In accordance with its tumor suppressor role, the Retinoblastoma protein pRb can ensure pro-apoptotic functions. (sdbonline.org)
As compared to passage-matched control cells, SWCNT-transformed BEAS-2B cells exhibited resistance to apoptosis induced by death ligands, e.g., tumor necrosis factor-a and Fas ligand, but not by inducers of mitochondria-mediated apoptosis, e.g., antimycin A and cisplatin, suggesting death receptor pathway as the primary pathway of defective apoptosis in SWCNT-transformed cells. (cdc.gov)
Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) binds to death receptors and induces apoptosis in various cancer cell lines while sparing normal cells. (oncotarget.com)
In an HCT116 xenograft model ADI-TRAIL localized to the tumor and induced dose-dependent tumor regression, the fusion protein was superior to rhTRAIL administered at the same molar amounts. (oncotarget.com)
TRAIL (also known as Apo2 ligand), is a trimeric protein, a TNF superfamily member, expressed as a type-II transmembrane protein and plays a physiological role in anti-tumor immune surveillance [ 1 - 6 ]. (oncotarget.com)
After sensitization with cytotoxic drugs, scFv62-TRAIL induced apoptosis only in K V 10.1-positive cancer cells, but not in non-tumor cells, nor in tumor cells lacking K V 10.1 expression. (biomedcentral.com)
The tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is a promising candidate for the design of bifunctional antibodies. (biomedcentral.com)
Chimeric antigen receptors (CAR) recognize specific proteins on the surface of tumor cells. (msdmanuals.com)
In contrast to TCR T cells, CAR T cells recognize only relatively large proteins on the surface of tumor cells. (msdmanuals.com)

This study is the first to show that VALD-3 induces apoptosis and cell cycle arrest in human breast cancer cells by suppressing Wnt/β-catenin signaling, indicating that it could be a potential drug for the treatment of breast cancer. (researchsquare.com)
Our studies have shown that chronic exposure to single-walled carbon nanotube s (SWCNT) induces apoptosis resistance and malignant transformation of human lung epithelial cells. (cdc.gov)
TRAIL induces apoptosis after binding to death receptor 4 (DR4 or TRAIL-R1) and/or death receptor 5 (DR5 or TRAIL-R2) [ 1 , 2 , 4 - 7 ]. (oncotarget.com)
2002). In addition, a recent study showed that recombinant HP1286 induces apoptosis in gastric epithelial cell collection AGS (Li et al. (thetechnoant.info)

BCL2 proteins are described as 'crucial regulators of apoptosis' (PMID:15868100)and the intrinsic apoptosis pathway is initiated by the release of mitochondrial cytochrome c into the cytoplasm, which results in the activation of caspases (15102863) - help in generating a defintion for intrinsic apoptosis? (geneontology.org)
Mcl-1 and Bcl-xL are crucial regulators of apoptosis, therefore dual inhibitors of both proteins could serve as promising new anticancer drugs. (rcsb.org)

Interestingly, rbf1 -induced apoptosis leads to a debcl - and drp1 -dependent Reactive Oxygen Species production, which in turn activates the Jun Kinase pathway to trigger cell death. (sdbonline.org)
Shouldn't we have an apoptosis signalling pathway terms? (geneontology.org)
The intrinsic apoptotic pathway has been chosen for a Reference Genome project as the curation work will complement and inform a planned apoptosis content meeting scheduled for June the 1st, assisted by domain experts from the Apo-Sys Consortium. (geneontology.org)
Particularly, the stimulation of RTKs may Sofalcone lead to the sustained activation of phosphatidylinositol 3-kinase (PI3K)/Akt/molecular target of rapamycin (mTOR) pathway that in turn may induce the translational machinery and HIF protein synthesis and/or enhanced stabilization of HIF- subunit. (mycareerpeer.com)
Since resistance to apoptosis is a foundation of neoplastic evolution and selection of malignant transformed phenotype, we investigated the apoptosis pathway underlying the resistance its mechanisms to aid the understanding of SWCNT-induced carcinogenesis. (cdc.gov)
The purpose of the research is to investigate the roles of Jak-STAT3 signaling pathway in bufalin-induced apoptosis in colon cancer SW620 cells. (biomedcentral.com)
Western Blot was used to determine the protein expression of the apoptosis inhibitors livin and caspase-3, the apoptosis-related proteins Bax and Bcl-2, as well as the key protein kinases in the Jak-stat3 signaling pathway, stat3 and p-stat3. (biomedcentral.com)
Activation of caspase-3, up-regulation of Bax, down-regulation of livin and Bcl-2, as well as inhibition of Jak-stat3 signaling pathway might be the important mechanisms for the bufalin-induced apoptosis. (biomedcentral.com)
Inactivation of the PI3-kinase pathway, but not of Ras-mitogen-activated protein (MAP) kinase signaling, was essential to elicit cytotoxic responses. (ashpublications.org)
Binding of the trimeric TRAIL to its receptors TRAIL-R1 and TRAIL-R2 induces caspase activation and apoptosis [ 4 ], either through the extrinsic pathway alone or recruiting the intrinsic apoptotic pathway [ 5 ]. (biomedcentral.com)
The autophagic pathway constitutively maintains cellular homeostasis by recycling cytoplasmic organelles and proteins, but it is also stimulated by environmental stress conditions, such as starvation, oxidative stress, and the accumulation of misfolded proteins. (mdpi.com)
Pre-treatment of macrophages with U0126, an inhibitor of the ERK MAPK signaling pathway significantly reduced rHP1286-caused apoptosis. (thetechnoant.info)

This Human Neuronal apoptosis inhibitory protein (NAIP) ELISA Kit employs a two-site sandwich ELISA to quantitate NAIP in samples. (abbkine.com)
Human Neuronal apoptosis inhibitory protein (NAIP) ELISA Kit has high sensitivity and excellent specificity for detection of Human NAIP. (abbkine.com)
Neuronal apoptosis inhibitory protein encoded by NAIP contains regions of homology to two baculovirus inhibitor of apoptosis proteins, and it is able to suppress apoptosis induced by various signals. (abbkine.com)

Suliman A, Lam A, Datta R and Srivastava RK: Intracellular mechanisms of TRAIL: apoptosis through mitochondrial-dependent and -independent pathways. (spandidos-publications.com)
However, the mechanisms of bufalin-induced apoptosis remain elusive. (biomedcentral.com)
The bacterial immunity proteins Im7 and Im9 fold with mechanisms of different kinetic complexity. (shengsci.com)
Understanding the regulation of apoptosis during hypoxia and the mechanisms of resistance to apoptosis might lead to more specific treatments for solid tumours. (bmj.com)
Here, we have determined the growth-inhibitory and proapototic mechanisms of 2 small molecule inhibitors of FLT3, AG1295 or PKC412, in hematopoietic progenitor cells, human leukemic cell lines, and primary AML cells expressing FLT3-ITD. (ashpublications.org)
This seminal observation instigated the ensuing decades of research that characterized the complex mechanisms of intrinsic cell death and lay the foundations for the development of therapeutics capable of restoring apoptosis in malignant cells. (biomedcentral.com)
Several mechanisms participate in the drug and apoptosis resistance phenotype in CSCs in various cancers. (oaepublish.com)
This article will review the CSCs drug and apoptosis resistance mechanisms and how to target CSCs. (oaepublish.com)
study is, to the best of our knowledge, the first to confirm that ILL can inhibit the invasion and migration of A549 cancer cells, with the possible mechanisms potentially involving the inhibition of MMP-2 and -catenin protein expression resulting from the up regulation of NM23-H1 expression. (insulin-receptor.info)
However, it GSK2126458 small molecule kinase inhibitor remains unclear whether ILL can inhibit lung malignancy cell metastasis and the associated mechanisms require further investigation. (insulin-receptor.info)
Mark L., Lee W. H., Villoutreix B. O., Proctor D., Blackbourn, D., Spiller B. O. and Blom A. M. (2004) KSHV complement control protein mimics human molecular mechanisms for inhibition of the complement system. (lu.se)

BH3-mimetics are a novel drug class of small molecule inhibitors of BCL2 family proteins which restore apoptosis in malignant cells. (biomedcentral.com)
In contrast with oblimersen, BH3-mimetics are specific, potent and selective small molecule inhibitors of BCL2 family proteins, which disable their capacity to sequester "pro-death" BH3-only molecules. (biomedcentral.com)

Overexpression of FLIP increased apoptosis resistance of the cells, whereas RNAi knockdown of FLIP reversed the apoptosis resistance of cells in response to death ligands. (cdc.gov)
Together, our study demonstrated a novel mechanism of apoptosis resistance induced by chronic exposure to SWCNT in human lung epithelial cells and identified FLIP as a key regulator of apoptosis avoidance that contributes to the development of malignant transformed phenotype. (cdc.gov)
However, clinical success has been limited due to poor PK and development of resistance to death receptor-induced apoptosis. (oncotarget.com)
Cells adapt to this environmental stress, so that after repeated periods of hypoxia, selection for resistance to hypoxia induced apoptosis occurs. (bmj.com)
Initially identified as the fusion partner of the immunoglobulin heavy chain gene locus in the classic t(14;18) translocation of follicular lymphoma (FL), BCL2 overexpression was recognized to confer resistance to apoptosis [ 2 ]. (biomedcentral.com)
Resistance to anticancer agents and apoptosis results in cancer relapse and is associated with cancer mortality. (oaepublish.com)

Mitochondrial porin , also known as the voltage-dependent anion channel (VDAC), is a multi-functional channel protein that shuttles metabolites between the mitochondria and the cytosol and implicated in cellular life and death decisions. (sdbonline.org)
Apoptosis is a programmed form of cell death involving the degradation of cellular constituents by a group of cysteine proteases called caspases. (geneontology.org)
β-Catenin is a fascinating protein with many important cellular and developmental functions. (chemdiv.com)
β -catenin has many binding partners that mediate a diverse set of cellular functions, and the protein probably acts as a 'hub' on which many cellular signaling networks impinge. (chemdiv.com)
Dying cells have been defined as apoptotic by distinguishing features, including cell contraction, nuclear fragmentation, blebbing, apoptotic body formation and maintenance of intact cellular membranes to prevent massive protein release and consequent inflammation. (nature.com)
2 , 3 A key feature of apoptosis has been defined as the maintenance of an intact cellular membrane (detectable as exclusion of impermeable dyes such as propidium iodide, PI) throughout the apoptotic program to prevent intracellular protein release and subsequent immunological activation. (nature.com)
p53 affects the transcription of many target genes and interacts with key cellular proteins. (molvis.org)
Kask L., Hillarp A., Ramesh B., Dahlbäck B., and Blom A. M. (2002) Structural requirements for the intra-cellular subunit polymerization of the complement inhibitor C4b-binding protein. (lu.se)

Excessive apoptosis causes atrophy, such as in ischemic damage, whereas an insufficient amount results in uncontrolled cell proliferation, such as cancer. (geneontology.org)
The inhibitory effects of bufalin on cell proliferation were determined by MTT (Methyl thiazolyltetrazolium) assay. (biomedcentral.com)
During hypoxia, an intricate balance exists between factors that induce or counteract apoptosis, or even stimulate proliferation. (bmj.com)
A prior research uncovered that sesquiterpene lactone substances also, including ILL, linderane and linderalactone, could actually inhibit the proliferation of the A549 malignancy cells, with ILL exhibiting the best inhibitory properties (28). (insulin-receptor.info)
Specify the components and their interactions and set up cluding proliferation, differentiation, apoptosis, embryonic the system of equations. (lu.se)

In co-cultures with K V 10.1-positive cancer cells the fusion protein also induced apoptosis in bystander K V 10.1-negative cancer cells, while normal prostate epithelial cells were not affected when present as bystander. (biomedcentral.com)
Substantial data have provided convincing evidence establishing that human cancers emerge from cancer stem cells (CSCs), which display self-renewal and are resistant to anticancer drugs, radiation, and apoptosis, and express enhanced epithelial to mesenchymal progression. (oaepublish.com)
By induction of apoptosis in gastric epithelial cells, HP1286 along with additional known apoptosis-inducing factors of (Kuck et al. (thetechnoant.info)
Past initiatives to pharmacologically disrupt the advancement and growth of renal cystic lesions focused primarily in normalizing the experience of a particular signaling molecule however the effects of rousing apoptosis in the proliferating epithelial cells never have been very well studied. (healthdisparitiesks.org)
TNF-α mRNA was further XL184 free base (Cabozantinib) elevated in response to exterior TNF-α arousal in null MEK cells and PN24 cells (Amount 1 A and B). This response is normally mediated through canonical NF-κB signaling because adding an NF-κB inhibitor SN50 avoided the upsurge in TNF-α mRNA in mutant renal epithelial cells treated with TNF-α (Amount 1A). (healthdisparitiesks.org)

The Drosophila retinoblastoma protein, Rbf1, induces a debcl and drp1 -dependent mitochondrial apoptosis. (sdbonline.org)

The apoptosis rate was 34.63 ± 2.57% (vs 19.69 ± 1.63%, P = 0.002) in JAK kinase inhibitor AG490 plus bufalin treatment group. (biomedcentral.com)
extract could inhibit the development of Lewis GSK2126458 small molecule kinase inhibitor lung, A549 and SBC-3 cancers cells, and induce cancers cell apoptosis (23). (insulin-receptor.info)
Acanthamoeba -mediated brain endothelial cell death was abolished using LY294002, a phosphatidylinositol 3-kinase inhibitor. (asm.org)

The human gene API5 encodes the protein Apoptosis inhibitor 5. (wikipedia.org)
This gene encodes an apoptosis inhibitory protein whose expression prevents apoptosis after growth factor deprivation. (wikipedia.org)
Western blot analysis and real-time PCR showed that celastrol dose-dependently suppressed TNF-α-induced MMP-9 gene expression at both the mRNA and protein levels in MDA-MB-231 cells. (spandidos-publications.com)
This study demonstrates that debcl and the pro-fission gene drp1 are necessary downstream of buffy to trigger a mitochondrial fragmentation during rbf1 -induced apoptosis. (sdbonline.org)
An apoptosis-inhibiting gene from a nuclear polyhedrosis virus encoding a polypeptide with Cys/His sequence motifs. (embl.de)
Using a genetic complementation assay to identify additional genes which inhibit apoptosis during infection with a p35 mutant, we have isolated a gene from Orgyia pseudotsugata NPV (OpMNPV) that was able to functionally substitute for AcMNPV p35. (embl.de)
The roles of b-catenin are 'classically' defined: as an adhesion protein and as a signaling protein, transducing extracellular signals to the nucleus to modify gene expression. (chemdiv.com)
Similar findings were made in bone marrow cells from gene-targeted mice lacking Bim and/or Puma infected with FLT3-ITD and treated with inhibitor, where loss of Puma only provided transient protection from apoptosis, but loss of Bim preserved clonal survival upon FLT3-ITD inhibition. (ashpublications.org)
We identified a novel SNP variant, Chr12:g.53494591T>C. c.T430C (p.S144P) in the insulin-like growth factor binding protein-6 (IGFBP6) gene. (cusabio.com)
The protein encoded by this gene is prenylated at its C-terminus, and localizes to the cytoplasm and plasma membrane. (cancerindex.org)
What does this gene/protein do? (cancerindex.org)

Domain found in inhibitor of apoptosis proteins (IAPs) and other proteins. (embl.de)
Baculoviruses apoptosis inhibitors (IAPs). (embl.de)

In higher eukaryotes, BIR domains inhibit apoptosis by acting as direct inhibitors of the caspase family of protease enzymes. (embl.de)
Curcumin (CUM) and protease inhibitor cocktail (kitty. (insulin-receptor.info)

This protein suppresses the transcription factor E2F1-induced apoptosis and also interacts with, and negatively regulates acinus, a nuclear factor involved in apoptotic DNA fragmentation. (wikipedia.org)
Receptor targeted toxins upregulated TRAIL death receptors (DR4 and DR5) and suppressed the expression of anti‑apoptotic FLICE‑inhibitory protein (FLIP) and X‑linked inhibitor of apoptosis protein (XIAP). (spandidos-publications.com)
The critical motifs required for anti-apoptotic activity of IAP proteins are the BIRs. (embl.de)
BCL2 family proteins (BCL2, BCL-X L , MCL1, etc.) sequester BH3-only proteins and prevent apoptosis, and these anti-apoptotic properties are frequently upregulated in malignancy, making them an attractive therapeutic target [ 3 ]. (biomedcentral.com)
Released from the inhibitory action of BCL2 and related proteins, these pro-apoptotic BH3-only proteins are then able to activate BAX and BAK and initiate apoptosis (Fig. 1 ). (biomedcentral.com)
We now show that during early apoptosis limited membrane permeabilization occurs in blebs and apoptotic bodies, which allows release of proteins that may affect the proximal microenvironment before the catastrophic loss of membrane integrity during secondary necrosis. (nature.com)
Blebbing, apoptotic body formation and protein release during early apoptosis are dependent on ROCK and myosin ATPase activity to drive actomyosin contraction. (nature.com)
We identified 231 proteins released from actomyosin contraction-dependent blebs and apoptotic bodies by adapted SILAC (stable isotope labeling with amino acids in cell culture) combined with mass spectrometry analysis. (nature.com)
These results indicate that limited membrane permeabilization occurs in blebs and apoptotic bodies before secondary necrosis, leading to acute and localized release of immunomodulatory proteins during the early phase of active apoptotic membrane blebbing. (nature.com)
Therefore, the shift from apoptosis to secondary necrosis is more graded than a simple binary switch, with the membrane permeabilization of apoptotic bodies and consequent limited release of DAMPs contributing to the transition between these states. (nature.com)

The key structure for Bcl-xL inhibition was further confirmed through the substructural analysis of ABT-263, a representative Bcl-xL/Bcl-2/Bcl-w inhibitor developed by Abbott Laboratories. (rcsb.org)

The only currently approved BH3-mimetic, the selective BCL2 inhibitor venetoclax, is highly efficacious in chronic lymphocytic leukemia and has rapidly advanced to an approved standard of care in frontline and relapsed disease in combination with anti-CD20 monoclonal antibodies. (biomedcentral.com)
Single-chain antibodies (scFv) take an important role in the field, because they are less immunogenic than whole antibodies, their smaller size allows faster and deeper penetration into solid tumors, and are by definition recombinant proteins, therefore easier to produce and modify. (biomedcentral.com)

IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. (cusabio.com)
For instance, Li (23) identified that extract could Rabbit Polyclonal to ZADH1 inhibit the development of lung cancers A549 and SBC-3 cell lines, and induce cell apoptosis. (insulin-receptor.info)
These potent effects are driven by curcumin's ability to induce G2/M cell cycle arrest, induce autophagy, activate apoptosis, disrupt molecular signaling, inhibit invasion and metastasis, and increase the efficacy of current chemotherapeutics. (hindawi.com)

DRAM2 overexpression also increased proteins CDK4, CyclinD3, and decreased p27 expression, all of which are cell cycle-related factors. (cancerindex.org)

The enhanced mobile build up and activation of HIF- proteins subunit which may be induced through the stimulation of different receptor tyrosine kinases (RTKs) in cancer cells under normoxic and hypoxic conditions are also illustrated. (mycareerpeer.com)
Protein kinases represent promising anticancer drug targets. (rcsb.org)
We describe here the meriolins, a new family of inhibitors of cyclin-dependent kinases (CDK). (rcsb.org)

Meriolins thus constitute a new CDK inhibitory scaffold, with promising antitumor activity, derived from molecules initially isolated from marine organisms. (rcsb.org)

Results DIM, but not I3C, increased adipocyte differentiation through upregulation of peroxisome proliferator‐activated receptor γ and CCAAT/enhancer‐binding protein α. (researchgate.net)
ADI downregulates survivin, upregulates DR5 receptor and sensitizes cancer cells to TRAIL induced apoptosis. (oncotarget.com)
Receptor tyrosine kinase inhibitors targeting FLT3 have developed as attractive treatment options. (ashpublications.org)
For instance, CSC maintenance in glioblastoma, colon cancer, gastric cancer, and prostate cancer is regulated by CD133-mediated AKT, leucine-rich G-protein-coupled receptor 5 (LGR5)-mediated Wnt/β-catenin and speckle-type POZ protein (SPOP)-mediated Nanog pathways [ 4 - 8 ] . (oaepublish.com)
More specifically, substrates with certain FYVE domains (named after the first four proteins in this motif, Fab1, YotB, Vac1p, and EEA1) bind PIP, and these pathways have been implicated in vesicular trafficking or receptor-mediated endocytosis ( 5 ). (asm.org)
The TNF-α/TNFR1 complicated also contains the TNF-α receptor-associated protein with loss of life domains (TRADD) TNF-α receptor-associated protein 2 receptor-associated protein kinase 1 (RIPK1) and mobile inhibitor of apoptosis protein 1 (cIAP1) and cIAP2. (healthdisparitiesks.org)

This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag. (cusabio.com)

Macrophages constitute a powerful collection of defense against secreted protein HP1286 is a book regulator of macrophage reactions. (thetechnoant.info)
These observations show that rHP1286 caused a caspase-dependent and TNF-independent macrophage apoptosis. (thetechnoant.info)
Considering the ability of HP1286 to induce macrophage apoptosis, the protein could probably help in the bacterial escape from the triggered macrophages and perseverance in the belly. (thetechnoant.info)

The transcription of COX-1 yields a 2.7-kilobase (kb) messenger ribonucleic acid (mRNA) that encodes a 576-residue, 65-kd protein. (medscape.com)
Conversely, the transcription of COX-2 yields a 4.5-kb mRNA that encodes a 70-kd protein with roughly 70-75% homology to the COX-1 protein. (medscape.com)

The K V 10.1-specific scFv62 antibody -TRAIL fusion protein was expressed in CHO-K1 cells, purified by chromatography and tested for biological activity. (biomedcentral.com)

The 'baculovirus inhibitior of apoptosis protein repeat' (BIR) [ ( PUBMED:8139034 ) ( PUBMED:8552191 ) ] is a domain of about 70 residues arranged in tandem repeats separated by a variable length linker, that seems to confer cell death-preventing activity. (embl.de)

DNA microarray and Western blot analyses of key apoptosis-regulatory proteins in the transformed cells revealed FLICE-inhibitory protein (FLIP) as an important target of regulation by SWCNT. (cdc.gov)

The key regulator of this process, hypoxia inducible factor 1 (HIF-1), can initiate apoptosis by inducing high concentrations of proapoptotic proteins, such as BNIP3, and can cause stabilisation of p53. (bmj.com)
The most enriched proteins released were the nucleosomal histones, which have previously been identified as damage-associated molecular pattern proteins (DAMPs) that can initiate sterile inflammatory responses. (nature.com)

Trouw L., Nilsson S., Goncalvez I., Landberg G. and Blom A. M. (2005) C4b-binding protein binds to necrotic cells and DNA, which limits DNA release and inhibits complement activation. (lu.se)

Jin ML, Park SY, Kim YH, Park G and Lee SJ: Halofuginone induces the apoptosis of breast cancer cells and inhibits migration via downregulation of matrix metalloproteinase-9. (spandidos-publications.com)
Hoechst 33258 staining was performed to determine if VALD-3 induced apoptosis of MCF-7 and MDA-MB-231 cells and Annexin V/PI staining was performed to quantify the percentages of apoptosis. (researchsquare.com)
Flow cytometry analysis showed that VALD-3 triggered cell cycle arrest and induced apoptosis of breast cancer cells. (researchsquare.com)
when looking at experimental data - often counting number of cells they've died and committed to apoptosis so how can we work out induction or positive regulation? (geneontology.org)
Phosphorylation at CDK1, CDK4, and CDK9 sites on, respectively, protein phosphatase 1alpha, retinoblastoma protein, and RNA polymerase II is inhibited in neuroblastoma SH-SY5Y cells exposed to meriolins. (rcsb.org)
Bufalin not only inhibited the growth of colon cancer SW620 cells, but also induced apoptosis of SW620 cells. (biomedcentral.com)
Many cancer cells are intrinsically resistant to TRAIL-induced apoptosis. (oncotarget.com)
A hypoxic environment devoid of nutrients prevents the cell undergoing energy dependent apoptosis and cells become necrotic. (bmj.com)
7 Severe hypoxia in the presence of energy stimulates cells to undergo apoptosis, whereas oxygen levels above 0.5% prevent cell death. (bmj.com)
Several inhibitors have been described, such as AG1295, CEP701, PKC412, and SU-11 248, with cytotoxic effects to cell lines and primary AML cells in vitro expressing mutant FLT3. (ashpublications.org)
TRAIL is normally present as a membrane protein (memTRAIL) on immune effector cells, like natural killer cells. (biomedcentral.com)
Apoptosis allows for efficient and immunologically silent removal of damaged or superfluous cells in multicellular organisms. (nature.com)
Using an apoptosis-specific enzyme-linked immunosorbent assay, we showed that Acanthamoeba induces programmed cell death in brain microvascular endothelial cells. (asm.org)
Acanthamoeba binding to HBMEC is mediated by a mannose-binding protein expressed on the surface of Acanthamoeba cells ( 2 ). (asm.org)
In this study, we have analyzed the apoptosis-inducing ability of HP1286 on additional possible target cells such as macrophages, monocytes, neutrophils, and Capital t cells. (thetechnoant.info)
We provide evidence indicating that although rHP1286 interacts with many resistant cells, it is certainly able of causing apoptosis in just macrophages. (thetechnoant.info)
Pertoft H. and Fries E. (1995) Inter-a-inhibitor is required for the formation of the hyaluronan-containing coat on fibroblasts and mesothelial cells. (lu.se)

These results provide a mechanism by which Drosophila Bcl-2 family proteins can control apoptosis and shed light on a link between Rbf1 and mitochondrial dynamics, in vivo. (sdbonline.org)

The molecular weight of proteins were 102, 88 and 80 kDa, so they were named α, β and γ-catenin. (chemdiv.com)

should the term ['GO:0006919] activation of caspase activity' be a child of positive regulation of apoptosis or induction of apoptosis rather than directly to apoptosis? (geneontology.org)
Although the presence of active caspases and DNA fragmentation is helpful in identifying possible apoptosis, they should not be employed as an exclusive means to demonstrate this process as apototic cell death can occur without DNA fragmentation or caspase activity. (geneontology.org)
The results were confirmed using caspase specific inhibitors and caspase activity assays. (cdc.gov)

A cocrystal structure of a pyrazolo[1,5-a]pyridine derivative with Mcl-1 protein was successfully determined and revealed the protein-ligand binding mode. (rcsb.org)
Such a peculiar arrangement of phenylalanyl residues at the distal ligand binding site has not been observed before in the globin family, and is unique to HbI, a protein functionally devoted to sulfide transport. (shengsci.com)

Apoptosis is a fundamental homeostatic mechanism essential for the normal growth, development and maintenance of every tissue and organ. (nature.com)

Both proteins can localize at the mitochondrion , but the way they control apoptosis still remains unclear. (sdbonline.org)

Therefore inhibits the phosphorylation of indication transducer and activator of transcription 3 (STAT3) and regulates the downstream digesting of STAT3 pathways, raising B-cell lymphoma-2 (Bcl-2) and Bcl-extra huge proteins appearance, and inhibiting X-linked inhibitor of apoptosis appearance. (insulin-receptor.info)

TRAIL-R1 and TRAIL-R2 have distinct crosslinking requirements for apoptosis induction [ 6 ]. (biomedcentral.com)

Both compounds induced up-regulation of proapoptotic BH3-only proteins Bim and Puma, and subsequent cell death. (ashpublications.org)

This also led to the induction of the cleavage of caspase‑8 and caspase‑9 and resulted in the sensitization of highly resistant established GBM and patient‑derived GBM stem cell (GSC) lines to TRAIL‑mediated apoptosis. (spandidos-publications.com)

In addition, the web host provides been identified by us cell signaling pathways that regulate rHP1286-induced apoptosis in macrophages. (thetechnoant.info)

To design Mcl-1/Bcl-xL dual inhibitors, we performed structure-guided analyses of the corresponding selective Mcl-1 and Bcl-xL inhibitors. (rcsb.org)
Development of RTK inhibitors selective for FLT3 has emerged as attractive drugs for treatment of AML patients. (ashpublications.org)

apoptosis has a signalling and also the actual dying of the cell - DNA fragmentation, blebbing etc. (geneontology.org)
Cell death is frequently considered to be 'caspase-dependent' when it is suppressed by broad-spectrum caspase inhibitors such as N-benzyloxycarbonyl-Val-Ala-Asp-fluoromethylketone (Z-VAD-fmk). (geneontology.org)
The cell cycle arrest and apoptosis were tested by flow cytometry analysis. (biomedcentral.com)
ADI-TRAIL fusion protein was efficacious in a number of cell lines and synergized with some standard of care drugs. (oncotarget.com)
In brief, apoptosis is triggered when "pro-death/damage sensing" BH3-only proteins activate the downstream effector molecules BAX and BAK, which dimerize on the mitochondrial outer membrane surface and permeabilize it, triggering the release of cytochrome C, caspase activation and committing the cell to programmed death. (biomedcentral.com)
Rho proteins promote reorganization of the actin cytoskeleton and regulate cell shape, attachment, and motility. (cancerindex.org)
p53 participates in relevant aspects of cell biology, including apoptosis and cell cycle control and must be strictly regulated to maintain normal tissue homeostasis. (molvis.org)
Induction of programmed cell death or apoptosis in macrophages is definitely a well-known bacterial strategy that helps in the colonization and perseverance of the bacterium. (thetechnoant.info)

We tested a range of concentrations of the Rho inhibitor C3 transferase (C3) and ROCK Nocodazole purchase inhibitor Y27632 that have been shown to promote SCI repair in vivo. (anti-cancers.com)

how to decide whether a protein is involved in '+ve reg of apoptosis or induction ([GO:0006917])?emily. (geneontology.org)

Anatomy19

Organisms10

Diseases11

Chemicals and Drugs137

Analytical, Diagnostic and Therapeutic Techniques and Equipment22

Phenomena and Processes53

Disciplines and Occupations1

Technology, Industry, Agriculture1

Information Science3

Health Care1

Anti-apoptotic proteins5

Induce apoptosis5

Tumor9

Induces apoptosis4

Crucial regulators of apoptosis2

Pathway12

Neuronal3

Mechanisms11

Small molecule inhibitors2

Resistance6

Cellular8

Proliferation5

Epithelial5

Mitochondrial apoptosis1

Kinase inhibitor3

Gene11

IAPs2

Protease2

Apoptotic10

Inhibition1

Antibodies2

Inhibit3

Overexpression1

Kinases3

Antitumor activity1

Receptor6

Recombinant1

Macrophage3

Encodes2

Antibody1

Baculovirus1

FLICE1

Initiate2

Binds1

Cells17

Family proteins1

Molecular1

Caspase activity3

Ligand2

Mechanism1

Remains unclear1

Inhibits1

TRAIL-R11

Proapoptotic1

Resistant1

Pathways1

Selective2

Cell8

Concentrations1

Induction1