X-Linked Inhibitor of Apoptosis ProteinInhibitor of Apoptosis ProteinsApoptosisCaspasesCaspase 3Caspase InhibitorsApoptosis Regulatory ProteinsCaspase 9Proto-Oncogene Proteins c-bcl-2Cell Line, TumorMicrotubule-Associated ProteinsCaspase 7Neoplasm Proteinsbcl-2-Associated X ProteinCell SurvivalMitochondrial ProteinsDNA FragmentationProteinsIn Situ Nick-End LabelingSignal TransductionApoptotic Protease-Activating Factor 1Neuronal Apoptosis-Inhibitory ProteinCytochromes cEnzyme ActivationCaspase 8TNF-Related Apoptosis-Inducing LigandMitochondriaCASP8 and FADD-Like Apoptosis Regulating Proteinbcl-X ProteinIntracellular Signaling Peptides and ProteinsDown-RegulationAntineoplastic AgentsTumor Cells, CulturedCell ProliferationCells, CulturedFas Ligand ProteinBlotting, WesternCell LineNF-kappa BCysteine Proteinase InhibitorsTumor Suppressor Protein p53RNA, Small InterferingApoptosis Inducing FactorCarrier ProteinsTransfectionTumor Necrosis Factor-alphaFlow CytometryCell CycleGene Expression Regulation, NeoplasticDrug Resistance, NeoplasmReverse Transcriptase Polymerase Chain ReactionPoly(ADP-ribose) PolymerasesApoptosomesHeLa CellsUp-RegulationProto-Oncogene Proteins c-aktEnzyme InhibitorsCell DeathRNA InterferencePhysical PhenomenaJurkat CellsRNA, MessengerProto-Oncogene ProteinsBH3 Interacting Domain Death Agonist ProteinCell DivisionMembrane Potential, MitochondrialDose-Response Relationship, DrugImmunohistochemistryBiomimetic MaterialsAnnexin A5PhosphorylationMembrane GlycoproteinsCytochrome c Groupbcl-Associated Death ProteinAzocinesUbiquitinAdaptor Proteins, Signal TransducingMolecular Sequence DataModels, BiologicalDrug SynergismImmunoblottingAmino Acid Chloromethyl KetonesAntineoplastic Agents, PhytogenicTime FactorsAmino Acid SequenceOligopeptidesMitochondrial MembranesProteasome Endopeptidase ComplexTNF Receptor-Associated Factor 1Protein BindingCaspase 6UbiquitinationReceptors, TNF-Related Apoptosis-Inducing LigandMice, Inbred C57BLHCT116 CellsXenograft Model Antitumor AssaysGene Expression RegulationReceptors, Tumor Necrosis FactorDrug Screening Assays, AntitumorMice, Knockout