MigrationMetabolismAnti-apoptosisGene expressionGenesRegulatesProteinOxidative stressPleiotropic effectsOsteogenic differentiationMesenchymal stemOverexpressionMaturationBiological processesRegulationCellsAbnormalProteinsInhibitsIntegrinsPathwaysInflammationSynthesisAdditionallyInstabilityMechanismsSurvivalInductionExpressionMetabolicDevelopmentAffectsPathwayUpstreamCancerMiceMethods
Migration5
- MAPK pathways refer to various cellular functions, including cell proliferation, differentiation and migration. (springer.com)
- This causes alterations in the expression of a variety of genes, thereby affecting the proliferation, differentiation, migration, and apoptosis of cells. (medscape.com)
- The protein produced from the normal ABL1 gene is involved in many cellular processes, including cell growth and division (proliferation), maturation (differentiation), movement (migration), and self-destruction (apoptosis). (medlineplus.gov)
- Transwell migration, cell cycle analysis, MTT and colony formation assays were performed to determine the effect of DRAM2 overexpression and knockdown on NSCLC-cell migration and proliferation. (cancerindex.org)
- They play an important role in many different vital cell processes including migration, proliferation, differentiation, and apoptosis. (harvard.edu)
Metabolism3
- An aberrant miRNA expression could contribute to cancer development and progression [ 6 , 7 ] and could affect their target genes that are involved in many biological processes, such as cell differentiation, proliferation, apoptosis, metabolism, and development [ 8 ]. (hindawi.com)
- Akt pathways have effects on apoptosis, protein synthesis, metabolism and cell cycle. (springer.com)
- HIFs exert differential effects on tumor growth and affect important cancer hallmarks including cell proliferation, apoptosis, differentiation, vascularization/angiogenesis, genetic instability, tumor metabolism, tumor immune responses, and invasion and metastasis. (lu.se)
Anti-apoptosis1
- STAT5 plays crucial regulatory roles in cell proliferation, anti-apoptosis, early B cell differentiation, and T cell development. (biolegend.com)
Gene expression3
- In this review multiple mechanisms are discussed, such as modulation of gene expression and signal transduction, interference with enzymes of the cellular antioxidant system and generation of reactive oxygen species (ROS), inhibition of DNA repair and DNA methylation, role in apoptosis and disruption of E-cadherin-mediated cell-cell adhesion. (cdc.gov)
- Cadmium interferes with antioxidant defense mechanisms and stimulates the production of reactive oxygen species, which may act as signaling molecules in the induction of gene expression and apoptosis. (cdc.gov)
- An MC3T3-E1-based microarray dataset (accessioned as GSE46400) downloaded from the Gene Expression Omnibus included MC3T3-E1 cells with or without 14-day osteoblast differentiation osteoblast induction. (frontiersin.org)
Genes3
- The Arhgap11a, H2afx, Chek2, Dlgap5, and Chek1 were hub genes downregulated in MC3T3-E1 cells after osteogenic differentiation, verified by RT-qPCR results. (frontiersin.org)
- N. van Belzen, W. N. Dinjens, B. H. Eussen and F. T. Bosman, "Expression of Differentiation-Related Genes in Colorectal Cancer: Possible Implications for Prognosis," Histology and Histopathology, Vol. 13, No. 4, 1998, pp. 1233-1242. (scirp.org)
- Many genes encoding proteins that regulate cell proliferation, differentiation, and apoptosis are modulated in part by Vitamin D [1]. (xps.org)
Regulates1
- It regulates life and death processes that include fertilization, cell proliferation, apoptosis and cell necrosis. (hstalks.com)
Protein5
- and cell differentiation ( SOX2 and TGFB3 ) as well as immunohistochemical assay for VEGFA, TP53, Bcl2, TGFB1, and Ki67 protein expression have been performed in 85 FFPE RCC tumor specimens. (hindawi.com)
- Prior studies of acute phosphate restriction during the endochondral phase of fracture healing showed delayed chondrocyte differentiation was mechanistically linked to decreased bone morphogenetic protein signaling. (researchgate.net)
- 6] Normal APC protein promotes apoptosis in colonic cells. (medscape.com)
- This study is to investigate the role of p38 mitogen-activated protein kinase (p38MAPK) in tert -butyl hydroperoxide ( t BHP)-induced apoptosis of human trabecular meshwork (iHTM) cells. (molvis.org)
- Like the ABL1 protein, the abnormal protein produced from the fusion gene, called BCR-ABL1, can promote cell proliferation and block apoptosis. (medlineplus.gov)
Oxidative stress1
Pleiotropic effects1
- CD30 ligation by CD30L mediates pleiotropic effects including cell proliferation, activation, differentiation and cell death by apoptosis. (rndsystems.com)
Osteogenic differentiation7
- Recently, miRNA-messenger RNA (mRNA) regulatory relationships have been confirmed during biological processes, including osteogenic differentiation. (frontiersin.org)
- This study aimed to find out more candidate miRNA-mRNA pairs involved in the osteogenic differentiation of MC3T3-E1 cells. (frontiersin.org)
- The MC3T3-E1 cells were cultured and incubated in the osteogenic differentiation medium for 14 days. (frontiersin.org)
- There were 7 overlapped miRNA-mRNA pairs identified during osteogenic differentiation of MC3T3-E1 cells, including mmu-miR-204-5p-Arhgap11a, mmu-miR-211-5p-Arhgap11a, mmu-miR-24-3p-H2afx, mmu-miR-3470b-Chek2, mmu-miR-3470b-Dlgap5, mmu-miR-466b-3p-Chek1, and mmu-miR-466c-3p-Chek1. (frontiersin.org)
- Our study characterizes miR-211-5p targeting Arhgap11a promotes the osteogenic differentiation of MC3T3-E1 cells, which provides novel targets to promote the osteogenesis process during bone repair. (frontiersin.org)
- Transfection of MDS-MSCs with the miR-103-3p mimic improved osteogenic differentiation and decreased adipogenic differentiation in vitro, while inhibition of miR-103-3p showed the opposite results in NOR-MSCs. (techscience.com)
- The miR-103-3p mimics may boost MDS-MSCs osteogenic differentiation while weakening lipid differentiation, thereby providing possible target for the treatment of MDS pathogenesis. (techscience.com)
Mesenchymal stem2
- We found that myocilin is expressed in bone marrow-derived mesenchymal stem cells (MSCs) and affects their differentiation into osteoblasts. (nih.gov)
- The pathogenesis of myelodysplastic syndrome (MDS) may be related to the abnormal expression of microRNAs (miRNAs), which could influence the differentiation capacity of mesenchymal stem cells (MSCs) towards adipogenic and osteogenic lineages. (techscience.com)
Overexpression3
- Overexpression of TRIM13 in NCI-H1975 and SPC-A-1 cells hampered cell proliferation. (cancerindex.org)
- Overexpression of this gene is associated with tumor cell proliferation and metastasis. (cancerindex.org)
- Additionally, DRAM2 overexpression promoted cell metastasis and proliferation in vitro, while knockdown of DRAM2 expression yielded opposite result. (cancerindex.org)
Maturation1
- Alkaline phosphatase (ALP), osteocalcin (OCN), osteopontin (OPN), and runt-related transcription factor 2 (Runx2) are commonly used to evaluate differentiation and maturation of osteoblasts. (frontiersin.org)
Biological processes1
- miRNAs are involved in several biological processes, like cell proliferation, differentiation, apoptosis and metastatization. (degruyter.com)
Regulation4
- Our findings identify a novel role for VHL in mediating nephron progenitor differentiation through metabolic regulation, and suggest that VHL is required for normal kidney development. (lww.com)
- Even though its sequence along with its expressional pattern in cancer cell lines are evident, the functional aspects concerning cell proliferation, viability, differentiation and cell cycle regulation of NDRG1 remains vague. (scirp.org)
- NFkB is involved in regulation of various cellular events including cell growth, differentiation, proliferation, apoptosis and inflammation. (thermofisher.com)
- A member of zinc finger-containing transcription factors that belongs to the KRUPPEL-LIKE FACTOR family, involved in the regulation of diverse cellular processes such as cell growth, proliferation, differentiation, and APOPTOSIS. (bvsalud.org)
Cells17
- Tight control of the cell cycle in eukaryotic cells exists to control proliferation, differentiation or apoptosis. (benthamscience.com)
- This cytokine induces cell division/proliferation in its target cells. (wikipedia.org)
- A role for IL-21 in modulating the differentiation programming of human T cells was first reported by Li et al. (wikipedia.org)
- We found that the expanded cells possessed significantly improved immune effector functions, including proliferation, differentiation, and cancer cell killing, both in vitro and in the humanized mouse model. (nature.com)
- The upregulation of miR‑145 and miR‑221 was associated with the enhanced proliferation of periosteal cells and chondrogenic potential, respectively. (spandidos-publications.com)
- A switch from glycolysis to mitochondrial respiration drives these cells toward differentiation, but the mechanisms that control this switch are poorly defined. (lww.com)
- TRIM13 inhibited cell proliferation and induced cell apoptosis by regulating NF-κB pathway in non-small-cell lung carcinoma cells. (cancerindex.org)
- Activation of p38MAPK plays an important role in t BHP-induced apoptosis of iHTM cells. (molvis.org)
- These results revealed that NDRG1 is functional in prostate cancer cells and able to induce expression of differentiation factors through p53 independent pathway. (scirp.org)
- T. Napso, N. Azzam, A. Lerner and F. Fares, " N-myc Downstream Regulated Gene 1 Increases Differentiation Factors Level in Human Prostate Cancer Cells without Affecting Cell Proliferation and Cell Cycle Profiles," Journal of Cancer Therapy , Vol. 4 No. 2, 2013, pp. 568-574. (scirp.org)
- It maintains normal hematopoietic function by interacting with hematopoietic stem cells (HSCs) to control their proliferation and differentiation ( Morrison and Scadden, 2014 ). (techscience.com)
- PKC isozymes are LR-dependent molecules that link psychosine-induced LR disruption to reduced PKC function and altered cell signaling activity, possibly driving demyelination and apoptosis in oligodendrocytes and Schwann cells. (medscape.com)
- Low-level laser therapy has been investigated as a possible stimulus for enhancement of proliferation and differentiation of various cell types, but few reports relate undifferentiated mouse pulp cells (OD-21) response to irradiation in in vitro models. (bvsalud.org)
- Irradiation time of group I influenced positively the proliferation and viability of OD-21 cells in late cell culture period. (bvsalud.org)
- ABSTRACT This study examined haematopoietic stem cells of 19 high-risk cases of myelodysplastic syndrome (MDS) for apoptotic and anti-apoptotic signals and cellular proliferation and correlated these with clinical and cytogenetic subtypes, particularly trisomy 8. (who.int)
- A potential mechanism for the role of calcium in prostate cancer development and progression is that intracellular calcium controls the growth of prostate cancer cells and the process of apoptosis (9). (cdc.gov)
- 1,25-dihydroxyvitamin D (1,25[OH]2D) (10), which promotes the differentiation and inhibits the proliferation of prostate cells (11). (cdc.gov)
Abnormal2
- Homozygous null mice display abnormal T cell numbers, increased T cell proliferation, abnormal cytokine physiology, and decreased susceptibility to experimental autoimmune encephalomyelitis. (jax.org)
- This condition is thought to be secondary to dysfunctional genetics, abnormal differentiation of the metanephros or in utero ureteral obstruction. (medscape.com)
Proteins1
- We are interested in understanding how proteins called BMP can control sensory neuron development and regulate important cellular processes such as proliferation, differentiation, and apoptosis. (stjohns.edu)
Inhibits1
- The low pH of the skin-referred to as the acid mantle-inhibits the proliferation of bacteria. (ernolaszlo.com)
Integrins1
- Thus any modification of ECM components can be transmitted via integrins and impact on cell movement during development and proliferation, differentiation, apoptosis. (springer.com)
Pathways2
- It is involved in p53 pathways and is implicated in cell death/survival signaling, the cell cycle, and differentiation, thereby playing a regulatory role in carcinogenesis [ 12 ]. (hindawi.com)
- PKC is an important signaling molecule in numerous cell pathways, including cell differentiation, proliferation and apoptosis. (medscape.com)
Inflammation1
Synthesis2
- Unpredictably, cell cycle progression, cell proliferation and DNA synthesis were unaffected fol lowing NDRG1 expression. (scirp.org)
- The steady deterioration of the dermal and epidermal layers of the skin with age is caused by a combination of factors including reduced cellular proliferation and collagen synthesis, extracellular matrix remodeling, and changes in epidermal morphology (Crane 2015). (ernolaszlo.com)
Additionally1
- JAM3 knockdown additionally inhibited trophoblast proliferation and increased the number of trophoblasts in the sub-G1 and G2/M phases, indicating cell-cycle disturbance and apoptosis. (bioone.org)
Instability1
- However, the underlying mechanisms involved in the induction of genomic instability, genotoxicity, mutations and consequent increased cell proliferation are still a matter of intense research. (benthamscience.com)
Mechanisms1
- Further study on the mechanisms of p38MAPK in human TM cell apoptosis may help to illuminate the pathogenesis of POAG. (molvis.org)
Survival1
- We discovered that myocilin increased cell proliferation and survival. (nih.gov)
Induction1
- Further, inflammatory cytokines can impair erythroid proliferation and differentiation via radical formation and/or induction of apoptosis. (msdmanuals.com)
Expression4
- Keratin 12 expression was not altered in Tgfb2(-/-) mice, implicating normal corneal type epithelial differentiation. (nih.gov)
- Osterix (OSX) is a transcription factor in the SP family, which is essential for osteoblast differentiation, and its expression is closely related to Runx2 ( 9 ). (frontiersin.org)
- This resulted in over-expression of NDRG1, which in turn markedly up regulated two differentiation markers of the prostate tissue, p21 and cytokeratin 8/18. (scirp.org)
- Thus, the expression of miR-103-3p decreases in MDS BM plasma and MDS-MSCs, significantly impacting MDS-MSCs differentiation. (techscience.com)
Metabolic1
- In addition to identifying VHL as a critical regulator of nephron progenitors' metabolic switching, the authors' findings demonstrate that this switch also plays a large role in the differentiation process, and suggest that VHL is required for normal kidney development. (lww.com)
Development4
- Cyst development is generally attributed to increased proliferation of tubular epithelium, abnormalities in tubular cilia, and excessive fluid secretion. (medscape.com)
- Small RNAs are important regulators that modulate development, proliferation, differentiation, and apoptosis of organisms [ 15 , 16 ]. (hindawi.com)
- As development progresses, nephron progenitors switch from glycolysis to mitochondrial respiration for energy-mediated by an unknown mechanism-and undergo differentiation. (lww.com)
- The resultant loss of APC function prevents apoptosis and allows b-catenin to accumulate intracellularly and to stimulate cell growth with the consequent development of adenomas. (medscape.com)
Affects1
- Cadmium affects cell proliferation, differentiation, apoptosis and other cellular activities. (cdc.gov)
Pathway1
- TRIM13-induced NSCLC cell apoptosis was attenuated by a caspase-3 inhibitor Ac-DEVD-CHO, suggesting that TRIM13 induced cell apoptosis partially through a caspase-3-dependent pathway. (cancerindex.org)
Upstream1
- Runx2 belongs to the Run family and is an essential upstream transcription factor during osteoblast differentiation. (frontiersin.org)
Cancer1
- Differentiation and apoptosis have cell cycle withdraw in common, while cancer and degenerative processes both show altered control of the cell cycle. (benthamscience.com)
Mice1
- To explore VHL as a regulator defining nephron progenitor self-renewal versus differentiation, we bred Six2-TGC tg mice with VHL lox/lox mice to generate mice with a conditional deletion of VHL from Six2 + nephron progenitors. (lww.com)
Methods1
- A Novel Gene Which Is Up-Regulated during Colon Epithelial Cell Differentiation and Down-Regulated in Colorectal Neoplasms," Laboratory Investigation: A Journal of Technical Methods and Pathology, Vol. 77, No. 1, 1997, pp. 85-92. (scirp.org)