Cell CycleCell AgingCell Cycle ProteinsApoptosisTumor Suppressor Protein p53Cell Cycle CheckpointsCyclin-Dependent Kinase Inhibitor p21Cell Line, TumorCell ProliferationCyclin-Dependent Kinase Inhibitor p16Cell DivisionFibroblastsCells, CulturedSignal TransductionCaspasesApoptosis Regulatory ProteinsDNA DamageG1 PhaseCaspase 3Proto-Oncogene Proteins c-bcl-2Cell LineRetinoblastoma ProteinTelomereCell SurvivalCyclinsAgingMitosisInhibitor of Apoptosis ProteinsTelomeraseS PhasePlant LeavesFlow CytometryTumor Cells, CulturedBlotting, WesternDNA FragmentationTumor Suppressor ProteinsProtein-Serine-Threonine KinasesPhosphorylationDown-RegulationDNA-Binding ProteinsIn Situ Nick-End LabelingG2 PhaseRNA, Small Interferingbcl-2-Associated X Proteinbeta-GalactosidaseGene Expression RegulationTime FactorsNuclear ProteinsCyclin-Dependent Kinase Inhibitor p27MutationEnzyme ActivationG2 Phase Cell Cycle CheckpointsRNA, MessengerModels, BiologicalReactive Oxygen SpeciesAging, PrematureMitochondriaTranscription FactorsMolecular Sequence DataRNA InterferenceProto-Oncogene ProteinsTransfectionAntineoplastic AgentsUp-RegulationOxidative StressCell NucleusX-Linked Inhibitor of Apoptosis ProteinReverse Transcriptase Polymerase Chain ReactionGene Expression Regulation, NeoplasticHeLa CellsCell Transformation, NeoplasticMenstrual CycleEnzyme InhibitorsPhenotypeCell DifferentiationG0 PhaseApoptosis Inducing FactorCaspase 9Caspase InhibitorsCell DeathCyclin-Dependent Kinase 2G1 Phase Cell Cycle CheckpointsCyclin D1CASP8 and FADD-Like Apoptosis Regulating ProteinCyclin-Dependent Kinase 4Gene ExpressionBase SequenceTranscription, GeneticGene Expression ProfilingCDC2 Protein KinaseNeoplasmsDose-Response Relationship, DrugMice, KnockoutDNA ReplicationCyclin ECaspase 8Telomere ShorteningMice, Inbred C57BLbcl-X ProteinCell Line, Transformed