• Multiple miRNA-mRNA prediction databases were searched by differentially expressed genes (DEGs) to obtain pairs of a miRNA-DEG regulatory network. (frontiersin.org)
  • An aberrant miRNA expression could contribute to cancer development and progression [ 6 , 7 ] and could affect their target genes that are involved in many biological processes, such as cell differentiation, proliferation, apoptosis, metabolism, and development [ 8 ]. (hindawi.com)
  • miRNAs affect a broad range of biological functions including development, apoptosis, proliferation and differentiation ( 6 - 8 ). (spandidos-publications.com)
  • Small RNAs are important regulators that modulate development, proliferation, differentiation, and apoptosis of organisms [ 15 , 16 ]. (hindawi.com)
  • Ectopic overexpression of miR-31 decreased cell proliferation, viability and invasion capacity, but promoted apoptosis in DDP-resistant cells and in xenograft tumor models. (oncotarget.com)
  • The effect of regulated expression of the miRNA on cell migration, invasion, proliferation and apoptosis was examined by wound healing, transwell assays, CCK-8 assays, colony formation and flow cytometry assays, respectively. (oncotarget.com)
  • TRIM13 inhibited cell proliferation and induced cell apoptosis by regulating NF-κB pathway in non-small-cell lung carcinoma cells. (cancerindex.org)
  • miRNAs are considered to play important roles in cell proliferation, apoptosis, and differentiation during mammalian development. (oncotarget.com)
  • By coordinating the expression of multiple genes, miRNAs are responsible for guiding proper embryonic development, immunity, inflammation, as well as cellular growth and proliferation. (iptoday.com)
  • Krüppel-like factors can bind to specific DNA motifs and regulate various cellular functions, such as metabolism, cell proliferation, and differentiation. (medsci.org)
  • Although KLF6 overexpression in human cancer cells inhibits cell proliferation, induces apoptosis, and attenuates cell migration, the effects of KLF6 on oral cancer remains poorly elucidated. (medsci.org)
  • KLFs regulate a wide range of cellular functions, including cell proliferation, apoptosis, differentiation, and neoplastic transformation, by binding to GC-rich promoter regions [ 1 , 2 ]. (medsci.org)
  • miRNAs regulate target genes through biological processes, such as cell growth, proliferation, differentiation and apoptosis. (biomedcentral.com)
  • There is a growing body of evidence which demonstrates that following ACS, microRNAs might inhibit fibroblast proliferation and scarring, as well as harmful apoptosis of cardiomyocytes, and stimulate fibroblast reprogramming into induced cardiac progenitor cells. (archivesofmedicalscience.com)
  • DEGs Bcl3, ADGRG7, FABP4, IRF4, their regulating miRNAs and TFs have strong impact on proliferation and metastasis of breast cancer in bone tissues. (degruyter.com)
  • Micro-RNAs have been demonstrated to have multiple roles in regulating embryonic development, proliferation, apoptosis, etc. (openaccesspub.org)
  • Experimentally confirmed target genes were identified for the 73 diagnostic miRNAs, from which proliferation genes were selected from CRISPR-Cas9/RNA interference (RNAi) screening assays. (cdc.gov)
  • MicroRNAs (miRNAs) are well-recognized for their abilities to regulate gene expression post-transcriptionally in plants and animals. (frontiersin.org)
  • The miRNA-mRNA interactions were verified by dual-luciferase reporter gene assays and experiments using mimics miRNA or their inhibitors. (frontiersin.org)
  • This class of noncoding RNAs is small, single stranded, and 19-25 nucleotide long that act as negative regulators involved in posttranscriptional silencing of the gene expression [ 5 ]. (hindawi.com)
  • MicroRNA-34a gene (MIR-34A) that is located on chromosome 1p36 belongs to one of evolutionary-conserved miRNA families (MIR-34 family) that consists of three members: MIR-34A, MIR-34B, and MIR-34C [ 10 ]. (hindawi.com)
  • microRNAs (miRNAs) are small non-coding RNAs that post-transcriptionally regulate gene expression, predominantly through imperfect base pairing with the 3′-untranslated region of target mRNAs ( 5 ). (spandidos-publications.com)
  • Also, viral infection has proved to have a great impact on cellular small RNA expression and gene expression [ 9 - 11 ]. (hindawi.com)
  • Small RNAs include microRNA (miRNA), siRNA, tRFs, piRNA, and rasiRNAs, which regulate gene expression in a wide range of processes such as viral replication and host immune response. (hindawi.com)
  • miRNAs regulate gene expression in a wide range of physiological and pathological processes such as in immune response and viral replication [ 18 ]. (hindawi.com)
  • MiRNAs are small non-coding RNAs which regulate gene expression by binding to complementary sequences in mRNAs. (duke.edu)
  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. (cancerindex.org)
  • This miRNA functions as a tumor suppressor and dysregulation or loss of the host gene from which this miRNA is processed is associated with cancer progression in numerous cell types. (cancerindex.org)
  • MicroRNAs (miRNAs), single-stranded RNA molecules with 19~25 nucleotides in length, are recognized as key modulators governing multiple gene expression via binding to the 3' untranslated region (3'-UTR) of target mRNA at the posttranscriptional level [ 7 ]. (oncotarget.com)
  • miR-338 is located in an intronic region within the gene for apoptosis-associated tyrosine kinase (AATK). (wikipedia.org)
  • Mature microRNAs (miRNAs) are 21 to 23 nucleotide noncoding RNA molecules that can downregulate multiple gene expression by mRNA degradation or translational repression. (oncotarget.com)
  • miRNAs are approximately 20-25 nucleotides long and affect gene expression by interacting with messenger RNAs. (iptoday.com)
  • Unlike siRNAs, miRNAs are encoded in the human genome and are used as natural regulators of global gene expression. (iptoday.com)
  • Evolutionarily conserved, these 17-22 nucleotide long molecules regulate gene expression at post-transcriptional level generally by repressing translation or increasing degradation of messenger RNAs (mRNAs). (biomedcentral.com)
  • Consequently, the time of day when RNA samples are collected can influence detection of significant changes in gene expression levels. (gene-quantification.de)
  • miRNAs are approximately 22-nucleotide non-coding RNAs that participate in post transcriptional gene expression regulation through mRNA degradation, translational inhibition or chromatin-based silencing mechanisms. (sarcomahelp.org)
  • MicroRNAs (miRNAs) are small endogenous non-coding RNAs with length of about 22 nt and can regulate gene expression mainly through post-transcription [ 1 ]. (biomedcentral.com)
  • MicroRNAs regulate gene expression at the post-transcriptional level by binding to 3′- or less often to 5′-untranslated regions of target messenger RNAs (mRNAs), which in consequence leads to inhibited translation and/or induces degradation of targeted mRNA [ 1 ]. (archivesofmedicalscience.com)
  • MicroRNAs (miRNAs) are an integral part of the post-transcriptional machinery of gene expression and have been implicated in the carcinogenic cascade. (cdc.gov)
  • MicroRNAs (miRNAs) are small, noncoding RNAs that bind to the 3' UTR of target mRNAs, and silence gene expression by inducing degradation of target mRNAs or inhibition of protein translation [ 10 ]. (cdc.gov)
  • Micro-RNAs (miRNAs) are small non-coding RNAs of approximately 21-25 nucleotides that negatively regulate gene expression 1 , 2 , 3 . (openaccesspub.org)
  • It is one of the largest gene families accounting for approximately 1% of the genome and regulate approximately 1/3rd of all human genes 4 , 5 , 6 . (openaccesspub.org)
  • Circular RNAs (circRNAs) are a new member of noncoding RNAs (ncRNAs) that have recently been described as key regulators of gene expression. (biomedcentral.com)
  • We had analyzed circRNA high-throughout sequencing from human tissues and determined bladder cancer related circRNA-3 (BCRC-3, GenBank: KU921434.1) as a new candidate circRNA derived from PSMD1 gene. (biomedcentral.com)
  • Identification and application of a candidate gene AhAftr1 for aflatoxin production resistance in peanut seed (Arachis hypogaea L. (rna-seqblog.com)
  • The expressions of candidate miRNAs and mRNAs were determined by real-time quantitative PCR(RT-qPCR) in MC3T3-E1 cells. (frontiersin.org)
  • The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. (cancerindex.org)
  • Through this mechanism, a single microRNA can alter the function of multiple mRNAs. (archivesofmedicalscience.com)
  • The expression levels of circRNAs, mRNAs and miRNAs in human tissues and cells were detected by quantitative real-time PCR (qRT-PCR). (biomedcentral.com)
  • Some circRNAs contain miRNA response elements (MREs) and function as competing endogenous RNAs (ceRNAs) to interact with miRNAs and regulate the expression of target mRNAs. (biomedcentral.com)
  • CiRS-7 has more than 70 miR-7 binding sites and thus acts as effective miR-7 suppressor to regulate the expression of miR-7 target mRNAs. (biomedcentral.com)
  • They belong to a class of small (19-24 nt) non coding RNA molecules. (sunway.edu.my)
  • MicroRNAs (miRNAs) are 21-23 nucleotide RNA molecules that modulate the stability or translational efficiency of target messenger RNAs [ 1 , 2 ]. (oncotarget.com)
  • Micro-RNAs (miRNAs) are small RNA molecules that regulate the downstream genes [ 4 ]. (biomedres.info)
  • Growing evidence suggests that transcriptional regulators and secreted RNA molecules encapsulated within membrane vesicles modify the phenotype of target cells. (unicyte.ch)
  • The ~22 nucleotide mature miRNA sequence is excised from the precursor hairpin by the enzyme Dicer. (wikipedia.org)
  • Pre-miRNA is exported to the cytoplasm by exportin-5 and cleaved by Dicer (an RNA degrading enzyme) and produces approximately 22 nucleotide RNA duplexes. (archivesofmedicalscience.com)
  • Single nucleotide polymorphisms (SNPs) in miRNAs and risk of breast cancer have been evaluated in populations of European or Asian ancestry, but not among women of African ancestry. (cdc.gov)
  • Accumulating studies have suggested that miRNAs are frequently dysregulated in tumors compared with normal tissues, resulting in aberrant expression of target genes or proteins and cancer progression 13 . (nature.com)
  • With 100% drug loading ratio, active targeting capability, and enzyme-mediated release of active therapeutics, our drugtamers can strongly induce the apoptosis of cancer cells and inhibit the tumor progression, which enables a new potential for a better targeted cancer therapy. (bvsalud.org)
  • We highlight the role of SE-driven genes, enhancer RNAs (eRNAs), lncRNAs, and miRNAs in the digestive system tumor growth and progression. (ijbs.com)
  • Aberrant changes in epigenetic mechanisms regulating DNA methylation, histone methylation and acetylation, expression of noncoding RNAs, and mRNA methylation are associated with the initiation, growth, and progression of digestive system tumors [ 2 , 4 ]. (ijbs.com)
  • Our findings demonstrate that exosomal circSHKBP1 regulates the miR-582-3p/HUR/VEGF pathway, suppresses HSP90 degradation, and promotes GC progression. (biomedcentral.com)
  • Recently, much attention has focused on the impact of microRNAs (miRNAs) on tumorigenesis and cancer progression. (sarcomahelp.org)
  • miRNA deregulation has been identified in a variety of epithelial origin cancers, where changes in specific miRNAs expression possibly contribute to tumor growth, progression, metastasis, and chemoresistance. (sarcomahelp.org)
  • Atherosclerosis initiation and progression are driven by many pro-inflammatory and pro-thrombotic microRNAs. (archivesofmedicalscience.com)
  • MicroRNAs are powerful modulators of plaque progression and transformation into a vulnerable state, which can eventually lead to plaque rupture. (archivesofmedicalscience.com)
  • The aim of our study was to evaluate if there is differential microRNA (miRNA) expression in various tumor subtypes during this progression. (openaccesspub.org)
  • In general, the circRNA-miRNA-mRNA axis may function as an extensive regulatory network in progression of some diseases. (biomedcentral.com)
  • The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. (cancerindex.org)
  • The biogenesis of miRNAs begins with a primary transcript, termed the pri-miRNA, and the combined action of Drosha and Dicer ribonucleases generates the mature miRNA species [ 3 ]. (oncotarget.com)
  • Recently, miRNA-messenger RNA (mRNA) regulatory relationships have been confirmed during biological processes, including osteogenic differentiation. (frontiersin.org)
  • This study aimed to find out more candidate miRNA-mRNA pairs involved in the osteogenic differentiation of MC3T3-E1 cells. (frontiersin.org)
  • There were 7 overlapped miRNA-mRNA pairs identified during osteogenic differentiation of MC3T3-E1 cells, including mmu-miR-204-5p-Arhgap11a, mmu-miR-211-5p-Arhgap11a, mmu-miR-24-3p-H2afx, mmu-miR-3470b-Chek2, mmu-miR-3470b-Dlgap5, mmu-miR-466b-3p-Chek1, and mmu-miR-466c-3p-Chek1. (frontiersin.org)
  • Next, I thoroughly demonstrated that the 10 candidate target genes were substantially suppressed by expression of the relevant miR-BARTs, as measured by 3'UTR-containing firefly luciferase (FLuc) expression, mRNA and protein levels, and knockdown of seven of the 10 candidate genes could suppress apoptosis, mimicking the effects of relevant miR-BARTs. (duke.edu)
  • The mature miR-338 miRNA sequence is complementary to a short section of the 3' untranslated region of COX4 mRNA. (wikipedia.org)
  • This mRNA sequence is presented atop a stem-loop structure, indicating it is accessible to miRNA processing. (wikipedia.org)
  • miRNAs binding to 3′-untranslated region (UTR) of the targeted mRNA leads to its degradation or translational repression [ 4 ]. (oncotarget.com)
  • MiRNAs post-transcriptionally silence target genes by binding to the 3′ untranslated region (3'UTR) of messenger RNA (mRNA) [ 10 ]. (biomedcentral.com)
  • A microRNA strand is transferred to the Argonaute complex (AGO), forming an RNA-induced silencing complex (RISC), and guides it to pair with the target mRNA through binding of the microRNA seed sequence with the microRNA recognition site on the mRNA. (archivesofmedicalscience.com)
  • In-depth analysis revealed that lncRNAs is an extensive and very heterogenic group from mRNA-like transcripts to circular RNAs. (biomedcentral.com)
  • In this study, by data mining of the Cancer Genome Atlas database, we screened out 4 differentially-expressed microRNAs (DEmiRNAs) between TNBC and normal samples: miR-135b-5p, miR-9-3p, miR-135b-3p and miR-455-5p. (nature.com)
  • Bioinformatic analysis was performed in order to identify putative targets of the differentially expressed microRNAs and to explore potential associations with specific biological processes. (biomedcentral.com)
  • The core transcription regulatory loop of the digestive system tumors is complex and a high density of transcription regulatory complexes in the SEs and the crosstalk between SEs and the noncoding RNAs. (ijbs.com)
  • miR-494 and miR-125a-5p were found to be differentially regulated in tumors with an anaplastic component and even the well-differentiated component (FTC) of these tumors were found to be aligned with the anaplastic profile. (openaccesspub.org)
  • Recently, Nikiforva et al showed that miR-187 was the most up-regulated miRNA in tumors harboring RET/PTC rearrangements and RAS mutations, however it's expression is much lower in tumors with BRAF mutation 10 . (openaccesspub.org)
  • Simple Summary: This study identified a set of 73 microRNAs (miRNAs) that can accurately detect lung cancer tumors from normal lung tissues. (cdc.gov)
  • Based on the consistent expression patterns associated with patient survival outcomes and in tumors vs. normal lung tissues, 10 miRNAs were considered to be putatively tumor suppressive and 4 miRNAs were deemed as oncogenic in lung cancer. (cdc.gov)
  • This study identified a set of 73 microRNAs (miRNAs) that classified lung cancer tumors from normal lung tissues with an overall accuracy of 96.3% in the training patient cohort (n = 109) and 91.7% in unsupervised classification and 92.3% in supervised classification in the validation set (n = 375). (cdc.gov)
  • MicroRNAs (miRNAs) are a group of endogenous non-coding RNAs, which are single-stranded and ~21 nucleotides (~21 nt) in length. (nature.com)
  • Potential host target genes were predicated and validated by qRT-PCR to study the impact of microRNAs on the host genes. (hindawi.com)
  • Here, I present two studies utilizing the phenotypic and the target approaches, respectively, to demonstrate that miR-BARTs can inhibit apoptosis and activate the Wnt signaling pathway. (duke.edu)
  • To discover miR-BARTs that can inhibit apoptosis, I individually expressed miR-BARTs in the EBV- GaCa cell line AGS, and identified five miR-BARTs that conferred this phenotype. (duke.edu)
  • Using transgenic and xenograft models of cancer, scientists at Mirna, as well as leading cancer researchers at academic institutions, have demonstrated that therapeutic candidates featuring the miR-34a sequence significantly inhibit tumor development, tumor growth, and metastasis. (iptoday.com)
  • These highly upregulated microRNAs may have crucial roles in Adv pathogenesis and are potential biomarkers for adenovirus-infected pneumonia. (hindawi.com)
  • Synovial fluid represents a potential source of disease-specific small non-coding RNAs (sncRNAs) that could aid in the understanding of the pathogenesis of osteoarthritis. (biomedcentral.com)
  • The biological processes they regulate may play an important role in understanding early osteoarthritis pathogenesis. (biomedcentral.com)
  • It has been reported that the dysregulations of miRNAs could contribute the pathogenesis of multiple human diseases [ 5 ]. (biomedres.info)
  • Therefore, identification of disease-related miRNAs would benefit research on pathogenesis and diagnosis. (biomedcentral.com)
  • This review is focused on hereditary diseases in the pathogenesis of which long non-coding RNAs play an important role. (biomedcentral.com)
  • In this study, we investigated the role of miRNAs targeting RUNX3 in early tumorigenesis. (oncotarget.com)
  • Several studies have reported that miRNA dysfunction could cause tumorigenesis [7]. (scirp.org)
  • Moreover, let-7 is a potential therapeutic miRNA for prevention of tumorigenesis. (biomedcentral.com)
  • Together, my results identified and validated a substantial number of novel targets of miR-BARTs involved in apoptosis and the Wnt signaling pathway, indicating that EBV may employ miR-BARTs to heavily target these two pathways to facilitate chronic infection. (duke.edu)
  • miRNAs are the most well-studied small RNAs during the latest decades. (hindawi.com)
  • Recent studies reported microRNAs as promising biomarkers for early cancer detection, accurate prognosis, and molecular targets for future treatment. (hindawi.com)
  • To identify pro-apoptotic genes targeted by the five anti-apoptotic miRNAs, I validated one previously published target and identified nine novel targets by performing photoactivatable ribonucleoside-enhanced crosslinking and immunoprecipitation (PAR-CLIP) in the EBV+ NPC cell line C666. (duke.edu)
  • In contrast, miR-30a that targets calcium channels for membrane transportation was down-regulated. (sunway.edu.my)
  • Deregulated miRNAs may function as tumor suppressors such as miR-205 and let-7 [ 6 , 7 ], or oncogenes such as miR-17-92 cluster and miR-214 [ 8 , 9 ], depending on the regulated targets. (oncotarget.com)
  • 8 The results demonstrated that miRNA expression signatures were clearly distinct among the tumor types studied, suggesting their possible role in sarcomagenesis, and their potential as diagnostic markers or even therapeutic targets. (sarcomahelp.org)
  • In this regard, computational methods are used to predict miRNAs that are most likely associated with a disease and provide experimental targets for biological experiments to save cost and time. (biomedcentral.com)
  • Identified genes, miRNAs, and TFs can be possible drug targets that may be used for the therapeutics. (degruyter.com)
  • There is evidence that clearly demonstrates that, apart from genetic and epigenetic abnormalities, the dysregulation of miRNAs may also contribute to the aberrant activation of oncogenes and the inactivation of tumor suppressor genes in human carcinogenesis ( 9 , 10 ). (spandidos-publications.com)
  • Aberrant expression of miRNAs has been widely reported in human cancers with both up- and downregulation detected in HCC tumor tissue relative to the corresponding normal tissue ( 11 - 13 ). (spandidos-publications.com)
  • Previous studies demonstrated that aberrant miRNAs levels may be introduced as new biomarkers for early diagnosis and prognosis in bladder cancer [ 8 ]. (biomedres.info)
  • In the global globe of RNA, round RNAs (circRNAs) display a subclass of non-coding RNAs caused by back-splicing of exons. (phytid.org)
  • Circular RNAs (circRNAs) play important regulatory roles in the development of various cancers. (biomedcentral.com)
  • Differentially expressed circRNAs were identified by RNA sequencing. (biomedcentral.com)
  • Circular RNAs (circRNAs), a new member of noncoding RNAs (ncRNAs), have attracted great attentions for their closed continuous loop structure and potential value in clinical work [ 9 , 10 ]. (biomedcentral.com)
  • Non-coding RNAs represent a potential course of disease-associated biomarkers looking into little non-coding RNAs such as for example microRNAs (miRNAs) and lengthy non-coding RNAs (lncRNAs), respectively5. (phytid.org)
  • Before, we among others supplied proof that miRNAs aswell as lncRNAs are connected with HCM in bloodstream and heart tissues6C9. (phytid.org)
  • The second group includes rRNAs and long non-coding RNAs (lncRNAs), which to date are very poorly functionally annotated. (biomedcentral.com)
  • This study aimed to investigate cisplatin (DDP)-susceptibility regulated by expression of the miRNAs and underlying pathways in GBC. (oncotarget.com)
  • Moreover, M1 has enormous effects on genomic DNA ascribed to FUDR's primary function of impeding DNA/RNA synthesis combined with diminishing PP2A-activated DNA repair pathways. (bvsalud.org)
  • Scientists at Mirna have shown that miR34a functions as a key tumor suppressor and affects multiple cancer-related genes and pathways, such as those involved in cell viability, cell senescence and apoptosis. (iptoday.com)
  • Since each miRNA appears to regulate the expression of tens to hundreds of different genes, miRNAs can function as "master-switches," efficiently regulating and coordinating multiple cellular pathways and processes. (iptoday.com)
  • In addition, Ingenuity Pathway Analysis (IPA) integrated with PCR array data showed that the JAK1/STAT3 pathway was significantly altered in cells overexpressing DEFB1, suggesting this to be one of the pathways by which defensin regulates IAV replication in HBEpCs. (cdc.gov)
  • Differential expression of miRNAs between normal and tumor tissues has been observed in various cancer types, suggesting a possible link between miRNA expression and the development of cancer [ 5 ]. (oncotarget.com)
  • MicroRNAs have broad biological functions in cancers and may serve as ideal biomarkers. (nature.com)
  • Exosomes are nanosized extracellular vesicles secreted by most cells, harboring abundant RNAs and proteins that can modulate the biological processes of cells and act as circulating biomarkers for various diseases. (biomedcentral.com)
  • Biological experiments have confirmed the association between miRNAs and various diseases. (biomedcentral.com)
  • Computational methods help select potential disease-related miRNAs to improve the efficiency of biological experiments. (biomedcentral.com)
  • Many disease-related miRNAs have been identified through biological experiments. (biomedcentral.com)
  • In the central dogma RNA acts as a simple intermediary between the DNA that carries the genetic information and the proteins that define the whole variety of biological processes in the cell. (biomedcentral.com)
  • It is estimated that microRNAs regulate production of approximately 60% of all human proteins and enzymes that are responsible for major physiological processes. (archivesofmedicalscience.com)
  • Because miRNAs may regulate approximately 60% of human genes [ 11 ], the relationship between miRNAs and human diseases has been extensively explored in the last decade. (cdc.gov)
  • They are capable of secreting a broad range of biomolecules such as proteins, nucleic acids, exosomes, microRNAs, and membrane vesicles, collectively known as secretomes. (techscience.com)
  • Role of extracellular RNA-carrying vesicles in cell differentiation and reprogramming. (unicyte.ch)
  • Dysregulation of miRNAs is also implicated in various diseases, including cancer. (spandidos-publications.com)
  • Dysregulation of miRNA could possibly be an important contributing factor to LPS sarcomagenesis, especially to the process of dedifferentiation. (sarcomahelp.org)
  • It regulates Sp7 protein expression and induces expression of major bone matrix protein genes, such as Col1a1, Spp1, Ibsp, Bglap2, and Fn1 ( 7 , 8 ). (frontiersin.org)
  • miRNAs are notably stable in blood, and their expression patterns appear to be tissue-specific. (spandidos-publications.com)
  • Knowing the miRNA expression profile will help understand the role of miRNAs in modulating the host response to adenovirus infection and possibly improve the diagnosis of adenovirus-infected pneumonia. (hindawi.com)
  • Expression profiles of whole blood microRNAs were altered and distinctly different in adenovirus-infected children. (hindawi.com)
  • Cell apoptosis and DDP-chemosensitivity was remarkably increased by knockdown of Src proto-oncogene (Src) expression, which was subsequently reversed by rescue of Src expression in miR-31-expressing cells. (oncotarget.com)
  • miR-338 is a brain-specific miRNA which regulates the expression of cytochrome c oxidase IV (COX4). (wikipedia.org)
  • Furthermore, miR-338 is one of seven microRNAs whose expression profiles can be combined to give a prediction of the probability of survival of a patient with gastric cancer. (wikipedia.org)
  • Combination of miR-130a and miR-495 significantly decreased apoptosis determined by Annexin V-FITC/propidium iodide staining and flow cytometric analysis, and the expression of Bim in SNU484 gastric cancer cells. (oncotarget.com)
  • The expression of circSHKBP1 was evaluated using quantitative real-time PCR and RNA in situ hybridization, and the molecular mechanism of circSHKBP1 was demonstrated by western blot, RNA pulldown, RNA immunoprecipitation, luciferase assays and rescue experiments. (biomedcentral.com)
  • however, forced KLF6 expression in lung cancer cell lines can trigger cells to undergo apoptosis and reduce colony formation ability [ 6 ]. (medsci.org)
  • Pharmacologic manipulation of microRNA expression has been undertaken in the form of in vivo miRNA delivery of downregulated miRNAs and "antagomirs" targeting upregulated miRNAs. (sarcomahelp.org)
  • Not much is known about the expression and deregulation of miRNA in STS generally and in LPS specifically. (sarcomahelp.org)
  • In a recent study using a microarray approach, 27 STS of seven different histological subtypes were profiled for miRNA expression. (sarcomahelp.org)
  • consequently, no major conclusions regarding the expression and regulation of miRNA in LPS could be made. (sarcomahelp.org)
  • Our studies, supported by the Liddy Shriver Sarcoma Initiative, aimed to identify unique miRNA expression profiles of WDLPS and DDLPS with the hope that such signatures could provide insights into our understanding of the molecular determinants driving these two entities. (sarcomahelp.org)
  • As in other cancer entities, altered microRNA expression is also being recognized as an important player in neuroblastoma. (biomedcentral.com)
  • DEFB1 expression after transfection with two micro RNAs (miRNAs), hsa-miR-186-5p and hsa-miR-340-5p, provided evidence that DEFB1 expression could be modulated by these miRNAs and hsa-miR-186-5p had a higher binding efficiency with DEFB1. (cdc.gov)
  • These are one stranded RNAs using a covalently shut round structure and will be discovered nuclease-resistant in tissue as well such as fluids. (phytid.org)
  • However, most researchers detected the miRNAs level in tissue and blood samples [ 9 ]. (biomedres.info)
  • This may include oncomir (oncogenic miRNA) inhibition, or tumor suppressor-miRNA replacement therapies [ 6 , 9 ]. (hindawi.com)
  • Based on the role of miRNA in tumor development, it can be classified as tumor-suppressive miRNA (TS-miRNA) or oncogenic miRNA [6]. (scirp.org)
  • To our knowledge, there have been no studies on miR-637 as an oncogenic miRNA or TS-miRNA. (scirp.org)
  • miR-637 is among the primate-specific miRNAs first reported by Cummins et al. (scirp.org)
  • After transcription, Pri-miRNA is cleaved by the enzymatic complex DROSHA into a micro-RNA precursor (pre-miRNA). (archivesofmedicalscience.com)
  • More than 900 miRNAs are encoded in the human genome and comprise approximately 2% of all mammalian genes. (iptoday.com)
  • A total of 61 DEGs, included 27 down-regulated and 34 up-regulated, were found to be significant in breast cancer bone metastasis. (degruyter.com)
  • circSHKBP1 is a promising circulating biomarker for GC diagnosis and prognosis and an exceptional candidate for further therapeutic exploration. (biomedcentral.com)
  • 6 Furthermore, several recent studies have highlighted the potential of miRNA profiles for diagnosis and prognosis. (sarcomahelp.org)
  • Circulating miRNAs have been suggested as diagnostic markers for various types of cancer ( 14 - 19 ). (spandidos-publications.com)
  • In our study, we sought to present the different miRNA profiles between Adv-infected pneumonia children and healthy controls, identify candidate diagnostic biomarkers for pneumonia with Adv infection in children, and examine the role of miRNAs in host defense response in Adv-infected children. (hindawi.com)
  • Considering that bladder cancer as a genitourinary tumor and the convenience of urine collections,we further examined whether urinary miRNAs detection can serve as a diagnostic markers for bladder cancer, especially in patients with hematuria. (biomedres.info)
  • These studies have also addressed the various diagnostic and prognostic implications of micro-RNAs in thyroid carcinomas. (openaccesspub.org)
  • From the list of genes that were targeted by the 73 diagnostic miRNAs, DGKE and WDR47 had significant associations with responses to both systemic therapies and radiotherapy in lung cancer. (cdc.gov)
  • Hu-antigen R (HUR), a member of the ELAV family, is one of the best known RNA binding proteins (RBPs) that selectively recognizes and binds to adenylate/uridylate-rich elements (AREs) [ 16 ]. (biomedcentral.com)
  • Krüppel-like factors (KLFs) are highly conserved zinc-finger proteins that regulate cellular transcription machinery [ 1 , 2 ]. (medsci.org)
  • there is increasing data to suggest that miRNAs may act as either tumor suppressors or oncogenes. (sarcomahelp.org)
  • 300 miRNAs with applications in oncology and other diseases. (iptoday.com)
  • This method not only depends on known miRNA-diseases associations but also accurately measures miRNA and disease similarity and resolves the problem of overestimation. (biomedcentral.com)
  • FCMDAP also exhibits satisfactory performance in predicting diseases without any related miRNAs and miRNAs without any related diseases. (biomedcentral.com)
  • Austin, TX -- Mirna Therapeutics, Inc. ("Mirna") announced today that the United States Patent and Trademark Office has allowed patent claims related to the therapeutic application of the potent tumor suppressor microRNA, mir34a. (iptoday.com)
  • For some of the genomic regions that are deleted in some neuroblastomas, on 1p, 3p and 11q, candidate tumor suppressor genes have been identified. (biomedcentral.com)
  • This allowance from the USPTO provides further evidence of the critical position that the Company holds in the burgeoning field of miRNA-based therapies. (iptoday.com)
  • Based on our prior observations that miRNA‑101 (miR‑101) is downregulated by HBV and induces epigenetic modification, we sought to test whether circulating miR‑101 may serve as a potential biomarker for HCC. (spandidos-publications.com)
  • MicroRNAs (miRNAs) are associated with viral replication and host immune response. (hindawi.com)
  • In contrast, a cluster of viral microRNAs (miRNAs) called miR-BARTs is highly expressed. (duke.edu)
  • The impact of host miRNAs on immune activation, shutdown of host protein synthesis, apoptosis, signal transduction and viral replication are discussed. (sunway.edu.my)
  • Previously, we reported that miRNA-101 (miR-101) is downregulated by the HBV X protein ( 20 ). (spandidos-publications.com)
  • The latest version of miRBase consists of 1881 human miRNAs, and most of them regulate more than 60% of human protein-coding genes. (biomedcentral.com)
  • Based on our identified miRNA-regulated molecular machinery, an inhibitor of PDK1/Akt BX-912, an anthracycline antibiotic daunorubicin, and a multi-targeted protein kinase inhibitor midostaurin were discovered as potential repositioning drugs for treating lung cancer. (cdc.gov)
  • The microarray was used to select the candidate miRNA in two DDP-resistant GBC cell lines. (oncotarget.com)
  • TRIM13-induced NSCLC cell apoptosis was attenuated by a caspase-3 inhibitor Ac-DEVD-CHO, suggesting that TRIM13 induced cell apoptosis partially through a caspase-3-dependent pathway. (cancerindex.org)
  • Although the conventional activities of p53 such as cell cycle arrest, senescence, and apoptosis are well accepted as the major checkpoints in stress responses, accumulating evidence implicates the importance of other tumor suppression mechanisms. (nature.com)
  • Is p53-dependent ferroptosis sufficient for tumor suppression in the absence of cell cycle arrest, senescence, and apoptosis? (nature.com)
  • To date, various mechanisms have been suggested to explain the powerful tumor-suppressive effect of p53, including the induction of cell cycle arrest, senescence, and apoptosis. (nature.com)
  • moreover, normal cell regulation can be disrupted by tumor-suppressive or oncogenic miRNAs. (scirp.org)
  • There is a constant crosstalk between microRNAs derived from various cell sources. (archivesofmedicalscience.com)
  • MicroRNAs are small non-coding post-translational biomolecules which, when expressed, modify their target genes. (archivesofmedicalscience.com)
  • As miRNAs play a major role in the host regulatory system, there is a huge opportunity for interplay between host miRNAs and EV-A71 expressions. (sunway.edu.my)
  • p53 has a crucial but complex role in regulating ferroptosis. (nature.com)
  • Misregulation of miRNAs appears to play a fundamental role in many cancers and replacement of down regulated miRNAs in tumor cells results in a positive therapeutic response. (iptoday.com)
  • However, the specific role of some miRNAs in cancer remains unclear. (scirp.org)
  • Stemming from these initial reports, ongoing investigations are evaluating the potential usefulness of miRNA-based therapy in cancer, and point to a potential role of sensitize cancer cells following chemo- and radiotherapy. (sarcomahelp.org)
  • In this review, we focus on the role of cardiomyocyte-derived and cardiac fibroblast-derived microRNAs that are involved in the regulation of genes associated with cardiomyocyte and fibroblast function and in atherosclerosis-related cardiac ischemia. (archivesofmedicalscience.com)
  • In conclusion, the reduction in IAV copy number in DEFB1 overexpressing cells suggests that beta-defensin-1 plays a key role in regulating IAV survival through STAT3 and is a potential target for antiviral drug development. (cdc.gov)