Apoptosis murine t cell. Medical search. Frequent questions

Castration of normal male mice induces expansion of the bone marrow B cell population, an effect that can be reversed by androgen replacement. (jci.org)
2012). Group B streptococcus GAPDH is released upon cell lysis, associates with bacterial surface, and induces apoptosis in murine macrophages . (up.pt)
Vascular endothelial growth factor is an important signaling protein involved in both angiogenesis and vasculogenesis.VEGF activity has been mostly studied on cells of the vascular endothelium, although it does have effects on a number of other cell types (e.g. stimulation monocyte/macrophage migration, neurons, cancer cells, kidney epithelial cells ).VEGF mediates increased vascular permeability, induces angiogenesis, vasculogenesis and endothelial cell growth, promotes cell migration, and inhibits apoptosis. (prospecbio.com)
This agent binds CD20 on lymphocytes and induces apoptosis as well as initiating complement-mediated killing of bound cells. (medscape.com)
Interleukin 4 induces apoptosis of acute myeloid leukemia cells in a Stat6-dependent manner. (lu.se)

Apoptosis was detected throughout the cornea as epithelial, keratocyte and endothelial cells were stained. (arvojournals.org)
In addition, a recent report [ 15 ] revealed that SSc autoantibodies bind to CMV late protein UL94 and induce apoptosis in endothelial cells therefore implicating molecular mimicry as a potential mechanism accounting for the link between SSc and CMV. (biomedcentral.com)
The activity was measured in a cell proliferation assay using HUVEC human umbilical vein endothelial cells and was found to be 1-4 ng/ml. (prospecbio.com)

Oleandrin, a cardiac glycoside component of Nerium oleander, has been shown to induce apoptosis in malignant cells. (nih.gov)
It appears to induce apoptosis in malignant lymphocytes upon exposure. (medscape.com)

However, there is no available information to address that TF affects murine leukemia cells in vitro and in vivo. (upm.edu.my)
Here, we investigated in vitro and in vivo effects of TF on murine leukemia WEHI-3 cells. (upm.edu.my)
Apoptosis induced in vitro and in vivo during infection by Ebola and Marburg viruses. (cdc.gov)

Le Tulzo Y , Pangault C , Gacouin A , Guilloux V , Tribut O , Amiot L , Early circulating lymphocyte apoptosis in human septic shock is associated with poor outcome. (cdc.gov)
Phenotypic analysis of lymphocyte subsets and apoptosis were evaluated with flow cytometry. (karger.com)

Here, we describe a novel approach to functionalize human and murine leukocytes with tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) on their surface, along with E-selectin (ES), to capture and induce cancer cell apoptosis both in vitro in human blood and in vivo in mouse circulation. (aiche.org)

Protein kinase C (PKC) d, a member of the novel family of PKC serine-threonine kinases, has been implicated in negative regulation of proliferation and apoptosis in a large number of cell types, including breast cancer cell lines, and postulated as a tumor suppressor gene. (conicet.gov.ar)

A549 xenografts by inducing apoptosis, as confirmed by TUNEL assay. (hindawi.com)
After 7 days cross-sections of the treated eye were done and stained with TUNEL (Terminal deoxynucleotidyl transferase dUTP nick end labelling) technique for apoptosis. (arvojournals.org)
Neointima stained positive for both -smooth muscle actin and PCNA indicating proliferation of smooth muscle cells possibly mediated by growth factors TGF-β 1 , PDGF-A and PDGF-B, while TUNEL indicated apoptosis in the intimal layer in affected arteries. (biomedcentral.com)

Immune cell responses induced by DAMPs may include cytokine and chemokine release to activate inflammatory cells such as neutrophils and macrophages. (nature.com)
Our research team has uncovered several important poxvirus-sensing mechanisms leading to type I interferon (IFN) induction in various cell types including epithelial cells, macrophages and dendritic cell (DC) subtypes. (mskcc.org)
2011). Staphylococcus epidermidis biofilms with higher proportions of dormant bacteria induce a lower activation of murine macrophages . (up.pt)
Our results indicate that several dozens of proteins for each cell type, are PE-lipoxidated in HT-22, MLE, and H9c2 cells and M2 macrophages after they were induced to undergo ferroptosis. (cdc.gov)
To identify cell surface proteins on leukemia cells that inhibit Natural killer cells ( Aim 1a ) or macrophages ( Aim 1b ) using CRISPR screens. (lu.se)

Effect of cadmium on P53 and mitogen-activated protein kinases in a murine macrophage cell line: relation to apoptosis. (cdc.gov)

Myelomas are antibody-secreting tumor cells derived from terminally differentiated B lymphocytes, and previous work from our laboratory showed that murine SP2/0 myeloma cells and derived B-cell hybridomas were highly sensitive to apoptosis induction by a block of gene expression (cycloheximide). (aacrjournals.org)
While human tumor cells are very sensitive to growth inhibition by oleandrin, murine tumor cells are extremely resistant. (nih.gov)
Cellular uptake of oleandrin and ouabain was 3-4 fold greater in human BRO tumor cells than murine tumor cells. (nih.gov)
For metastasis to occur, cancer cells detach from the primary tumor, invade through the basement membrane, and intravasate into the peripheral circulation as circulating tumor cells (CTCs) (2). (aiche.org)

Short-term treatment with a high dose of ibandronate had no effect on either myeloma cell number or the proportion of myeloma cells undergoing apoptosis. (ox.ac.uk)
These observations suggest that although bisphosphonates induce apoptosis in myeloma cells in vitro, they may not have the same anti-tumour effects in vivo. (ox.ac.uk)

Dying cells have been defined as apoptotic by distinguishing features, including cell contraction, nuclear fragmentation, blebbing, apoptotic body formation and maintenance of intact cellular membranes to prevent massive protein release and consequent inflammation. (nature.com)
One of the research areas at the MDC is immunology and inflammation, which covers tumor immunology, DNA repair in B lymphocytes, the role of tumor stroma-immune cell interaction in cancers, the role of innate immune cells in gliomas and neurodegenerative diseases, and the development of immunotherapy strategies. (mdc-berlin.de)
Compelling evidence has however shown that without the assistance of the helper T lymphocytes, it is indeed difficult for the "helpless" B cells to become functional enough to trigger SLE-related inflammation. (hindawi.com)
Recently, a number of phenotypic and functional alterations which increase the propensity to trigger lupus-related inflammation have been identified in lupus T cells. (hindawi.com)
Breakdown of immune tolerance is believed to be one of the major mechanisms which triggers the production of autoantibodies by B cells and antibody forming cells, leading to inflammation upon binding to autoantigens and consequent tissue damage [ 2 ]. (hindawi.com)
Thus, development of strategies targeting particular subsets of inflammatory cells and providing well-timed resolution of inflammation may be crucial for proper healing and recovery. (springer.com)
In cancer, ROS plays a dual role with anti-tumorigenic and pro-tumorigenic effects in cell signaling pathways that control proliferation, survival, apoptosis, and inflammation. (bvsalud.org)
These pro- has been implicated as contributing apoptosis, inflammation, and several liferating cel s replace dead cel s to the cancer phenotype, through pleiotropic responses. (who.int)

Blebbing, apoptotic body formation and protein release during early apoptosis are dependent on ROCK and myosin ATPase activity to drive actomyosin contraction. (nature.com)
2 , 3 A key feature of apoptosis has been defined as the maintenance of an intact cellular membrane (detectable as exclusion of impermeable dyes such as propidium iodide, PI) throughout the apoptotic program to prevent intracellular protein release and subsequent immunological activation. (nature.com)
The NLRP3 inflammasome consists of the NLRP3 scaffold, the apoptosis-associated speck-like protein containing a caspase recruitment domain (CARD) (ASC) adaptor and caspase-1 ( 5 , 6 ). (spandidos-publications.com)
In vitro impact of a whey protein isolate (WPI) and collagen hydrolysates (CHs) on B16F10 melanoma cells proliferation. (greenmedinfo.com)
OBJECTIVE: Investigation of the inhibitory capacity on melanoma cells (B16F10) proliferation and the influence on % distribution of cell cycle phases, in the presence of various concentrations of whey protein isolate (WPI), bovine collagen hydrolysate (BCH) or its fractions. (greenmedinfo.com)
Background: The phosphorylation of NF-kappaB inhibitor alpha (IκBα) protein is pivotal to the regulation of NF-κB transcription factor activity in the cell. (researchsquare.com)
Most of the important molecular processes in the cell, such as DNA replication, are performed by large molecular network of protein-protein interactions. (researchsquare.com)
We applied a range of molecular and cellular techniques to measure cell survival, cell cycle progression, protein expression and DNA damage combined with a transcriptomic micro-array approach in D283-MED cells, for global gene expression analysis in acute and chronic hypoxic conditions. (biomedcentral.com)
The protein product of the murine double minute gene 2 (mdm-2) plays a central role in the regulation of p53. (lu.se)
DeMarini, and Chapter 20, by Rice and cell death determine the size protein in several signal ing path- and Herceg). (who.int)

Furthermore, the cell death mechanism in the spleen tissue of treated mice was found via apoptosis. (upm.edu.my)
Furthermore, knockdown of PVT1 reversed Ang II-induced AAA-associated alterations in mice, as evidenced by attenuation of aortic diameter dilation, marked adventitial thickening, loss of elastin in the aorta, enhanced aortic cell apoptosis, elevated MMP-2 and MMP-9, reduced TIMP-1, and increased pro-inflammatory cytokines. (molcells.org)
Injecting the mice with a common inflammatory agent that increases the production of TNF-α, called complete Freund's adjuvant (CFA), and a preparation of spleen cells reversed type 1 diabetes in mice with end-stage disease and allowed the beta islet cells to regenerate. (wikipedia.org)
We applied our workflow to quantify cell-cycle effects of three antimitotic cancer drugs over 8 d in HT-1080 fibrosarcoma xenografts in living mice using a data set of 38,000 cells and compared the induced phenotypes. (nature.com)
Apoptosis in lymphoid and parenchymal cells during sepsis: findings in normal and T- and B-cell-deficient mice. (cdc.gov)
Androgens only affected B cell development in chimeric mice with androgen-sensitive stromal cells. (jci.org)
To examine cancer cell capture and killing in vivo , mice were injected with ES/TRAIL retro-orbitally, followed by injection of FL-labeled COLO 205 cells via tail vein injection. (aiche.org)
Mice underwent intrarenal implantation using luciferase-expressing Renca, a murine renal adenocarcinoma cell line. (biologists.com)

This plant had shown to induce antiproliferative effect as well as apoptosis in cancer cells. (upm.edu.my)

Pentostatin inhibits adenosine deaminase, resulting in deoxyadenosine and deoxyadenosine 5+-triphosphate accumulation that may inhibit DNA or RNA synthesis, causing cell death. (medscape.com)
A nucleotide analogue of vidarabine, fludarabine is converted to 2-fluoro-ara-A, which enters the cell and is phosphorylated to form active metabolite 2-fluoro-ara-ATP, which inhibits DNA synthesis. (medscape.com)
Ofatumumab is an anti-CD20 human monoclonal antibody that inhibits B-cell activation in early stages. (medscape.com)

Exposure to low level GSM 935 MHZ radiofrequency fields does not induce apoptosis in proliferating or differentiated murine neuroblastoma cells med. (emf-portal.org)
This study was performed to examine whether radiofrequency fields characteristic of mobile phones at non-thermal levels can induce apoptosis in murine neuroblastoma cells in both proliferating and differentiated states. (emf-portal.org)
No statistically significant differences in apoptosis levels were found between the exposed and sham-exposed murine neuroblastoma cells neither in proliferating nor in differentiated state using the three assays at any time point post- radiofrequency irradiation . (emf-portal.org)
Does MW Radiation Affect Gene Expression, Apoptotic Level, and Cell Cycle Progression of Human SH-SY5Y Neuroblastoma Cells? (emf-portal.org)
Thus, the recombinant form of EPO (rEPO) might be a potential tool for neuroprotectionand neurogenesis of brain-damaged areas.Experimental approach: The in vitro neuroprotective activity of rEPO was determined by measuring the capacity of the cytokineto reverse the staurosporine (STP)-induced apoptosis using a murine neuroblastoma cell line (N2a) and primary cultures fromhippocampal neurons (HNPC). (conicet.gov.ar)

Medulloblastoma (MB) is a malignant embryonal brain tumour originating from neural stem cells or granule-cell progenitors of the cerebellum, due to a deregulation of signalling pathways involved in neuronal development such as Wnt or Sonic Hedgehog (SHH) [ 1 ]. (biomedcentral.com)
Breast metastatic tumors in lung can be substituted by lung-derived malignant cells transformed by alternative splicing H19 lncRNA. (medscape.com)

HRas and Myc synergistically induce cell cycle progression and apoptosis of murine cardiomyocytes. (cam.ac.uk)
HRas G 12 V and constitutive Myc expression together co-operate to drive cell-cycle progression of adult mammalian cardiomyocytes. (cam.ac.uk)
Visualizing spatiotemporal dynamics of multicellular cell-cycle progression. (nature.com)

Increased sub-G1 population and annexin-V binding, activation of caspases 9 and 3, cleavage of poly(ADPribose) polymerase (PARP), and a decrease of mitochondrial membrane potential (MMP) indicated involvement of the mitochondrial apoptotic pathway in terpinen-4-ol-treated A549 and CL1-0 cells. (hindawi.com)
Our results indicated that terpinen-4-ol induced apoptosis through a mitochondria-mediated pathway in NSCLC cells and that the apoptosis elicited by terpinen-4-ol was p53 dependent. (hindawi.com)
Conclusions: Therefore, we identified novel phosphorylation site of IκBα by AURK, and its site was related to apoptosis and necroptosis pathway in breast cancer cells. (researchsquare.com)
These findings demonstrate that in addition to their functions at mitochondria, Bax and Bak also localize to the ER and function to initiate a parallel pathway of caspase activation and apoptosis. (rupress.org)
Whilst U87MG shared the same dampened p53 activity, upon chemotherapeutic drug treatment in chronic hypoxic conditions, these cells used a different mechanism, independent of the DNA damage pathway. (biomedcentral.com)

Cell surface sensors on immune cells that ordinarily recognize pathogen-associated molecular patterns produced by infectious agents may also interact with DAMPs, leading to the activation of signaling pathways resulting in a nonpathogen-induced 'sterile' inflammatory response. (nature.com)
The DKFZ is a multidisciplinary center covering cancer biology from basic molecular and cell biology to clinical research and care. (mdc-berlin.de)
Finally, unanswered questions relating to vitamin D mechanisms in CD4 + T cells are highlighted to promote further research that may lead to a deeper understanding of autoimmune disease molecular etiology. (frontiersin.org)
In this study, the antitumor effects of terpinen-4-ol and the cellular and molecular mechanisms responsible for it were evaluated and studied, respectively on human nonsmall cell lung cancer (NSCLC) cells. (hindawi.com)
Collectively, these data provide insight into the molecular mechanisms underlying terpinen-4-ol-induced apoptosis in NSCLC cells, rendering this compound a potential anticancer drug for NSCLC. (hindawi.com)
Arrayed molecular barcoding identifies TNFSF13 as a positive regulator of acute myeloid leukemia-initiating cells. (lu.se)

Expression of the bcl-2 proto-oncogene has been shown to inhibit the apoptotic cell death of many types of cells. (aacrjournals.org)
Recent work also has revealed the existence of several bcl-2-related genes that also can inhibit ( e.g., bcl-X L and Mcl-1 ) or activate ( e.g., bax, bcl-X S , bag , and bad ) apoptosis in several systems. (aacrjournals.org)
Partially purified Na+, K(+)-ATPase from human BRO cells was inhibited at a concentration that was 1000-fold less than that was required to inhibit mouse B16 enzyme to the same extent. (nih.gov)
Whey and collagen hydrolysates inhibit melanoma cell proliferation. (greenmedinfo.com)

Here, potential mechanisms involving alterations in T-cell receptor expressions, postreceptor downstream signalling, epigenetics, and oxidative stress which favour activation of lupus T cells will be discussed. (hindawi.com)
Phenotypic and functional alterations in lupus T cells including expansion of the Th17 population, perturbations of the physiology of T-cell receptors (TCRs) and postreceptor downstream signalling, oxidative stress, and epigenetic changes result in exaggeration of TCR response to stimuli and the propensity of lupus T cells to get activated [ 6 ]. (hindawi.com)

In this study we show that in murine NMuMG mammary cells PKCd promotes a mitogenic response. (conicet.gov.ar)
Our results provide evidence for a role of PKCd as a positive modulator of proliferative and survival signals in immortalized mammary cells. (conicet.gov.ar)

Our scientists pursue every aspect of cancer research-from exploring the biology of genes and cells, to developing immune-based treatments, uncovering the causes of metastasis, and more. (mskcc.org)
To elucidate the biological mechanisms underlying pulmonary metastasis and identify superior therapeutic strategies, we developed a novel and clinically relevant murine RCC model exhibiting enhanced pulmonary metastasis. (biologists.com)
RHAMM regulates MMTV-PyMT-induced lung metastasis by connecting STING-dependent DNA damage sensing to interferon/STAT1 pro-apoptosis signaling. (medscape.com)

Hotchkiss RS , Tinsley KW , Swanson PE , Schmieg RE Jr , Hui JJ , Chang KC , Sepsis-induced apoptosis causes progressive profound depletion of B and CD4+ T lymphocytes in humans. (cdc.gov)
Depletion of peripheral blood T lymphocytes and NK cells during the course of Ebola hemorrhagic fever in cynomolgus macaques. (cdc.gov)
Evidence for CD4 + T-cell involvement in autoimmune disease pathogenesis and for paracrine calcitriol signaling to CD4 + T lymphocytes is summarized to support the thesis that calcitriol is sunlight's main protective signal transducer in autoimmune disease risk. (frontiersin.org)
Gene-environment interactions, sunlight and vitamin D, and T lymphocytes as autoimmune disease initiators and vitamin D targets are discussed to explain the rationale for reviewing vitamin D mechanisms in T cells. (frontiersin.org)
The CD20 antigen is expressed on the surface of pre-B cells and mature B lymphocytes. (medscape.com)

Efron PA , Tinsley K , Minnich DJ , Monterroso V , Wagner J , Lainee P , Increased lymphoid tissue apoptosis in baboons with bacteremic shock. (cdc.gov)
The stromal cell requirement for androgen-mediated effects was confirmed in vivo by experiments using chimeric animals created by bone marrow transplantation in which androgen receptor expression was restricted to either the stromal or lymphoid cells of the bone marrow. (jci.org)

Additional work revealed that a related murine myeloma cell line, P3X63Ag8.653, was resistant to apoptosis induction in similar conditions. (aacrjournals.org)

Proto-oncogene activation and genomic instability of cadmium -induced cell transformation in BALB/c-3T3 cells. (cdc.gov)

It combines image analysis and machine learning methods for automated 3D segmentation and cell-cycle state identification of individual cell-nuclei with widely varying morphologies embedded in complex tumor environments. (nature.com)
Methods: Previously we observed that aurora kinase (AURK) binds IκBα in the cell. (researchsquare.com)
Described here are some of the general requirements of in vitro test methods for skin sensitization, and progress that has been made in developing suitable approaches with particular emphasis on the utility of dendritic cell culture systems. (cdc.gov)

Foam-cell infiltration and visceromegaly are common features in all forms, but neurologic involvement occurs only in types A and C and not in type B. (medscape.com)

CONCLUSION: Co-expression of Cyclin T1 and Myc may be a therapeutically tractable approach for cardiomyocyte neo-genesis post injury, while cell death induced by HRas G 12 V and Myc expression likely limits this option as a regenerative therapeutic target. (cam.ac.uk)
The development of an increasing number of tumors has been shown to involve the deregulation of not only cell proliferation but also normal cell death by apoptosis. (aacrjournals.org)
Amyotrophic lateral sclerosis (ALS) is a progressive disease associated with neuronal cell death that is thought to involve aberrant immune responses. (nih.gov)
Under some conditions, TNF-α causes T cells to undergo apoptosis, or programmed cell death. (wikipedia.org)
Recently, two independent models, one from rodents and the other from insects, have demonstrated that nuclei are not lost from skeletal muscle fibers when they undergo either atrophy or programmed cell death. (frontiersin.org)
Changes in dietary fatty acids, specifically the polyunsaturated fatty acids of the ω-3 and ω-6 families and some derived eicosanoids from lipoxygenases, cyclooxygenases, and cytochrome P-450, seem to control the activity of transcription factor families involved in cancer cell proliferation or cell death. (springer.com)
Animal modeling and human mechanistic data are summarized to support the view that vitamin D probably influences thymic negative selection, effector Th1 and Th17 pathogenesis and responsiveness to extrinsic cell death signals, FoxP3 + CD4 + T-regulatory cell and CD4 + T-regulatory cell type 1 (Tr1) cell functions, and a Th1-Tr1 switch. (frontiersin.org)
Research on vitamin D regulation of thymocyte selection, Th1 and Th17 cells, T-cell programed cell death, and T-regulatory (Treg) cells is summarized and integrated into model mechanisms. (frontiersin.org)
Oleandrin and ouabain induced apoptosis was detected in BRO cells while no evidence of cell death was observed in B16 cells even at concentrations 1000-fold higher than that used for BRO cells. (nih.gov)
Recent reports have indicated that terpinen-4-ol exerts its antitumor effects by triggering caspase-dependent apoptosis in human melanoma cells or by inducing necrotic cell death and cell-cycle arrest in mouse mesothelioma and melanoma cell lines without affecting normal cells [ 14 , 15 ]. (hindawi.com)
BACKGROUND: Porcine skin gelatine presented anti-tumoral effect on murine hepatoma cells (MH134), inducing programmed cell death (apoptosis). (greenmedinfo.com)
Mediation may be (1) through engagement of immune effector cells, (2) by directly activating intracellular death-signaling pathways, and/or (3) by activation of the complement cascade. (medscape.com)
Infants suffering of cell death occurring as a series of changes from chronic illnesses, chromosomal abnor- in dying cells under several physiological malities and those on medication prior to conditions [ 6,7 ] and has been implicated enrolment were excluded from the study. (who.int)
Ferroptosis is an iron dependent form of cell death, that is triggered by the discoordination of iron, lipids, and thiols. (cdc.gov)
Its unique signature that distinguishes it from other forms of cell death is the formation and accumulation of lipid hydroperoxides, particularly oxidized forms of polyunsaturated phosphatidylethanolamines (PEs), which drives cell death. (cdc.gov)
Pretreatment of cells with the strong nucleophile, 2-mercaptoethanol, prevented the formation of PE-lipoxidated proteins and blocked ferroptotic death. (cdc.gov)

Faustman hypothesized that this regeneration may be attributed in part to the re-differentiation of the spleen cells - that although the splenic stem cells were not obligatory for regeneration to occur, these cells could hasten regeneration. (wikipedia.org)
VSV infection triggered rapid differentiation of blood monocytes into immature dendritic cells as well as their apoptosis, which depended on caspase 3/7 activation. (karger.com)
Monocyte differentiation required infectious VSV, but loss of CD14+ cells was also associated with the presence of a cytokine/chemokine milieu produced in response to VSV infection. (karger.com)
FGF-10 immunostaining could be related to cell proliferation in epithelium and cell differentiation in epithelium and ectomesenchyme. (bvsalud.org)
miR-203 drives breast cancer cell differentiation. (medscape.com)

Here, we present an integrated workflow for quantitative in vivo cell-cycle profiling. (nature.com)
Analysis of mitosis and antimitotic drug responses in tumors by in vivo microscopy and single-cell pharmacodynamics. (nature.com)
Single-cell and subcellular pharmacokinetic imaging allows insight into drug action in vivo . (nature.com)
We have shown that leukocytes functionalized with ES/TRAIL can capture and induce cancer cell apoptosis in vitro in human blood and in vivo in mouse experiments. (aiche.org)
I will also provide in vivo proof of concept for a therapeutic effect by inhibiting the identified cell surface proteins in mouse models of leukemia. (lu.se)

IL4 promotes phagocytosis of murine leukemia cells counteracted by CD47 upregulation. (lu.se)

Cancer cells and mononuclear cells were isolated, cultured overnight, and analyzed for viability using flow cytometry (FC). (aiche.org)

CONCLUSION: It is suggested that a mechanism for tumorigenesis inhibition may involve the caspases cascade and apoptosis. (greenmedinfo.com)
Alanine transition of S63 and S262 (S63A and S262A) of IκBα induced inhibition of cell proliferation and suppression of p65 transcription activity. (researchsquare.com)

Baize S , Leroy EM , Georges-Courbot MC , Capron M , Lansoud-Soukate J , Debre P , Defective humoral responses and extensive intravascular apoptosis are associated with fatal outcome in Ebola virus-infected patients. (cdc.gov)
Enhanced apoptosis in the leukocytes of peripheral blood of PEM patients may be a marker of increased infection and immune disturbances. (who.int)
In comparison with healthy subjects, a number of studies have demonstrated that T cells isolated from patients with SLE are abnormal, with regard to their phenotypes and functions [ 4 , 5 ]. (hindawi.com)
To characterize the function and expression patterns of the identified cell surface proteins in acute myeloid leukemia cells from patients. (lu.se)

Additionally, Ang II treatment significantly increased PVT1 expression, both in cultured mouse VSMCs and in AAA murine abdominal aortic tissues. (molcells.org)
Faustman's current research is based on the observation that autoreactive T cells (T cells that mistakenly attack the body's own cells and tissues) are more sensitive than normal T cells to the effects of TNF-alpha (TNF-α), a cytokine that influences the immune system. (wikipedia.org)
10 9 apoptotic events occurring per day in human adult tissues, it is surprisingly difficult to histologically detect apoptotic cells due to the rapid recognition and clearance of apoptotic cells. (nature.com)
Researchers are uncovering ever more details about the complex system of organs, tissues, and different cell types that make up the human immune system. (mdc-berlin.de)

In cells stimulated to undergo ferroptosis we identified PE-truncated species with sn-2 truncations ranging from 5 to 9 carbons. (cdc.gov)

These infiltrating cells secrete various inflammatory cytokines, such as tumour necrosis factor (TNF)-α, interleukin (IL)-1β, and IL-6. (molcells.org)

We now show that during early apoptosis limited membrane permeabilization occurs in blebs and apoptotic bodies, which allows release of proteins that may affect the proximal microenvironment before the catastrophic loss of membrane integrity during secondary necrosis. (nature.com)
Therefore, the shift from apoptosis to secondary necrosis is more graded than a simple binary switch, with the membrane permeabilization of apoptotic bodies and consequent limited release of DAMPs contributing to the transition between these states. (nature.com)
Diminution of p53 by RNA interference induced necrosis instead of apoptosis in A549 cells following terpinen-4-ol treatment, indicating that terpinen-4-ol-elicited apoptosis is p53-dependent. (hindawi.com)

T cells recognize antigens presented to them by the major histocompatibility complex of antigen-presenting cells via the TCRs expressed on their surface. (hindawi.com)

The incidence of renal cell carcinoma (RCC) is high, and its outcomes remain poor. (biologists.com)

Virus release was evaluated in a murine cell line (L929). (karger.com)
We used two MB cell line (D283-MED and MEB-Med8A) and a widely used glioblastoma cell line (U87MG) for comparison. (biomedcentral.com)

This study was designed to determine the effects of the long non-coding RNA (lncRNA) plasmacytoma variant translocation 1 ( PVT1 ) on vascular smooth muscle cell (VSMC) apoptosis and extracellular matrix (ECM) disruption in a murine abdominal aortic aneurysm (AAA) model. (molcells.org)
In conclusion, our findings demonstrate that knockdown of lncRNA PVT1 suppresses VSMC apoptosis, ECM disruption, and serum pro-inflammatory cytokines in a murine Ang II-induced AAA model. (molcells.org)

Our results suggest that recruitment of inflammatory monocytes plays an important role in disease progression and that modulation of these cells is a potential therapeutic approach. (nih.gov)
Together our results demonstrate a new mechanism explaining hypoxia-induced resistance involving the alteration of the response to DSB in D283-MED cells, but also highlight the cell type to cell type diversity and the necessity to take into account the differing tumour genetic make-up when considering re-sensitisation therapeutic protocols. (biomedcentral.com)
Lastly, while currently available outcomes of clinical trials evaluating therapeutic agents which manipulate the T cells such as calcineurin inhibitors indicate that they are at least as efficacious and safe as conventional immunosuppressants in treating lupus glomerulonephritis, larger clinical trials are undoubtedly required to validate these as-yet favourable findings. (hindawi.com)
Therefore, SLE is currently believed to be a T cell-driven condition and, indeed, targeting molecules expressed on T cells and their signalling pathways can be one of the potential therapeutic strategies in SLE. (hindawi.com)
The current state of clinical trials evaluating therapeutic agents which target molecules expressing on and inside T cells for the treatment of SLE will be updated. (hindawi.com)
Successful completion of these projects will identify new therapeutic targets in acute myleoid leukemia (AML) and expand our knowledge regarding how cancer cells evade the immune system, findings that may translate into new therapeutic opportunities. (lu.se)
To demonstrate proof of concept for a therapeutic effect by inhibiting the identified cell surface proteins in patient-derived xenograft models of leukemia. (lu.se)

We identified 231 proteins released from actomyosin contraction-dependent blebs and apoptotic bodies by adapted SILAC (stable isotope labeling with amino acids in cell culture) combined with mass spectrometry analysis. (nature.com)
In addition to maintenance of membrane integrity, apoptotic cells can be discriminated from viable counterparts based on several morphological hallmarks, including cell contraction, nuclear condensation and fragmentation, and actomyosin contraction-dependent membrane blebbing and apoptotic body formation. (nature.com)
Besides, S63A and/or S262A of IκBα regulated apoptotic and necroptic effects in breast cancer cells. (researchsquare.com)
Mouse blood was removed via cardiac puncture, and viable and apoptotic cancer cells were analyzed using FC. (aiche.org)
Viable and apoptotic cancer cells lodged within the mouse lung, liver, and lymph nodes were quantified using multiphoton microscopy. (aiche.org)
Cancer cells lodged within the mouse lung were apoptotic after treatment with ES/TRAIL leukocytes, as determined by multiphoton microscopy. (aiche.org)

It was found that the growth of leukemia cells in vitro was inhibited by the various extracts of TF. (upm.edu.my)
With a basis in stem cell biology, genetics, immunology and cancer, the major goal of our research is to develop new immunotherapies that target leukemia and other malignancies. (lu.se)
Core Circadian Clock Genes Regulate Leukemia Stem Cells in AML. (lu.se)
The major goals of my research are to identify how acute myeloid leukemia (AML) cells suppress the innate immune system and use this knowledge to develop new immunotherapies. (lu.se)
I will accomplish this by identifying and mechanistically characterize cell surface proteins that protect leukemia cells against the innate immune system. (lu.se)

Curcumin suppresses PPARδ expression and related genes in HT-29 cells. (wjgnet.com)

In short, the silver stopped the inflammatory response that characterizes dermatitis, and even caused inflammatory cells to die so healing could take place. (thesilveredge.com)

In this brief review, a detailed account of the putative mechanisms by which the normal physiology of T cells are disturbed and why regulatory T cells fail to alleviate proinflammatory response in SLE will be discussed. (hindawi.com)
The immune effector cell mechanisms include antibody-dependent cellular cytotoxicity and antibody-dependent cellular phagocytosis. (medscape.com)

Faustman hypothesizes that BCG could induce a permanent gene expression that restores regulatory T cells (Tregs), helping to prevent the immune system attack which characterizes type 1 diabetes. (wikipedia.org)

Bax and Bak play a redundant but essential role in apoptosis initiated by the mitochondrial release of apoptogenic factors. (rupress.org)

Using human BRO and mouse B16 melanoma cell lines, we explored several possible determinants of cell sensitivity to oleandrin and compared with ouabain. (nih.gov)

How is the tissue specificity of immune cells generated and how is it affected by environmental influences, plasticity and the tissue microenvironment? (mdc-berlin.de)
Neutrophils are the first immune cells that infiltrate the damaged tissue as early as 24 h after injury. (springer.com)

Faustman's hypothesis is that certain autoimmune diseases can be treated by stimulating TNF-α to trigger apoptosis in autoimmune T cells. (wikipedia.org)

To understand the genetic basis of this differential susceptibility, we examined the expression of apoptosis-related genes in these cell lines. (aacrjournals.org)
Northern blot experiments showed no significant difference in the expression of myc and bax apoptosis-promoting genes in susceptible (SP2/0 and D5) and resistant (P3X63) cell lines. (aacrjournals.org)
Using transcriptomic analysis in D283-MED cells, we found a large transcriptional remodelling upon long term hypoxia, in particular the expression of a number of genes involved in detection and repair of double strand breaks (DSB) was altered. (biomedcentral.com)

Of note, the effects of Ang II in facilitating cell apoptosis, increasing matrix metalloproteinase (MMP)-2 and MMP-9, reducing tissue inhibitor of MMP (TIMP)-1, and promoting switching from the contractile to synthetic phenotype in cultured VSMCs were enhanced by overexpression of PVT1 but attenuated by knockdown of PVT1 . (molcells.org)

Quantification of cell-cycle state at a single-cell level is essential to understand fundamental three-dimensional (3D) biological processes such as tissue development and cancer. (nature.com)
Among lung cancers, nonsmall cell lung carcinomas (NSCLC) account for approximately 80% of lung cancer cases [ 1 ]. (hindawi.com)
In addition, there is no report on the antitumor effects of terpinen-4-ol against human nonsmall cell lung cancer cells. (hindawi.com)
We investigated the new phosphorylation site for IκBα and identified its biological function in breast cancer cells. (researchsquare.com)
205 or PC-3 cancer cells suspended in buffer or spiked in peripheral human blood were subjected to shear flow in a cone-and-plate viscometer. (aiche.org)
Exposure of functionalized ES/TRAIL leukocytes into cancer cell-spiked blood successfully targeted and killed cancer cells under shear flow, compared to controls (Fig. 1B). (aiche.org)
The fact that PKCd exerts differential responses depending on the cell context not only highlights the necessity to carefully understand the signaling events controlled by this PKC in each cell type but also suggests that we should be cautious in considering this kinase a target for cancer therapy. (conicet.gov.ar)

In vitro, VEGF has been shown to stimulate endothelial cell mitogenesis and cell migration. (prospecbio.com)

Obinutuzumab is a CD20-directed cytolytic antibody, which, upon binding to CD20, mediates B-cell lysis. (medscape.com)

Our results suggest that the NLRP3/ASC/caspase-1 axis participates in the regulation of pro-imflammatory cytokine secretion in RAW264.7 cells, particularly the generation of IL-1β and IL-18. (spandidos-publications.com)
The disease is characterized by up-regulation of growth factors (TGF-β 1 , PDGF-A and B). Apoptosis was detected in the intimal layer of affected aortas. (biomedcentral.com)

Anatomy34

Organisms17

Diseases9

Chemicals and Drugs121

Analytical, Diagnostic and Therapeutic Techniques and Equipment21

Phenomena and Processes53

Disciplines and Occupations1

Information Science3

Health Care1

Induces5

Endothelial cells3

Induce apoptosis in malignant2

Vitro and in vivo3

Lymphocyte2

Human and murine1

Proliferation and apoptosis1

TUNEL3

Macrophages5

Macrophage1

Tumor cells4

Myeloma cells2

Inflammation8

Protein10

Mice8

Shown to induce1

Inhibits3

Neuroblastoma5

Malignant2

Cycle progression3

Pathway5

Molecular6

Inhibit4

Oxidative stress2

Mammary2

Metastasis3

Lymphocytes5

Lymphoid2

Induction1

BALB1

Methods3

Infiltration1

Death16

Differentiation5

Vivo5

Promotes1

Flow cytometry1

Inhibition2

Patients4

Tissues4

Undergo1

Interleukin1

Necrosis3

Antigens1

Renal1

Line2

LncRNA2

Therapeutic7

Apoptotic6

Leukemia5

Suppresses1

Inflammatory cells1

Mechanisms2

Gene expression1

Mitochondrial1

Melanoma cell lines1

Immune2

Autoimmune1

Genes3

Inhibitor1

Cancer7

VEGF1

Lysis1

Regulation2