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  • spindles
  • In the first place, cells must coordinate centrosome duplication with DNA replication, and a failure in this coordination will generate monopolar or multipolar mitotic spindles, which generally will produce abnormal chromosome segregation, because in this case, chromosome distribution will not take place in a balanced way. (wikipedia.org)
  • It can also be triggered by agents influencing the stability of microtubule spindles, various anticancer drugs and mitotic failure caused by defective cell cycle checkpoints. (wikipedia.org)
  • mechanisms
  • BIRC5 and BIRC6 inhibit apoptosis through two different mechanisms: direct interaction with caspase-3 and -7, and regulation of cytokine levels [ 16 , 17 ]. (jcancer.org)
  • These non-mitotic mechanisms include vascular remodeling that leads to increased tumor perfusion and mitigation of tumor hypoxia, phenotypic changes consistent with reversal of epithelial-mesenchymal transition (EMT), and decreased capacity for migration and invasion leading to reduced metastatic capacity as measured in a preclinical experimental metastasis model. (wikipedia.org)
  • tumor
  • TRAIL (TNF related apoptosis-inducing ligand) is a member of the TNF family of apoptosis-inducing ligands TP53 is another anti-cancer/anti-tumor gene (elephants have twenty copies of the TP53 gene). (wikipedia.org)
  • autophagy
  • Apoptosis or Type I cell-death, and autophagy or Type II cell-death are both forms of programmed cell death, while necrosis is a non-physiological process that occurs as a result of infection or injury. (wikipedia.org)
  • centrosomes
  • The structure formed by the centrosomes and the microtubules is named mitotic spindle, due to its characteristic shape, holding the chromosomes between the two centrosomes. (wikipedia.org)
  • genetic
  • There is some evidence that certain symptoms of "apoptosis" such as endonuclease activation can be spuriously induced without engaging a genetic cascade, however, presumably true apoptosis and programmed cell death must be genetically mediated. (wikipedia.org)
  • prevents
  • PARTICIPANT/MATERIALS, SETTING, METHODS: We cultured human preimplantation embryos overnight in a time-lapse imaging system, in control or in a nocodazole-containing medium that prevents the formation of a proper mitotic spindle. (vub.be)
  • failure
  • Apoptosis resistance is the major cause of chemotherapy failure in most kinds of cancers, including Burkitt lymphomas (BL). (hu-berlin.de)