• "Sulforaphane and 2-oxohexyl isothiocyanate induce cell growth arrest and apoptosis in L-1210 leukemia and ME-18 melanoma cells" , Oncol Rep. 2003 Nov-Dec;10(6):2045-50. (sproutnet.com)
  • Of note, an increased carbohydrate uptake and/or induction of death receptors of cancer cells was exploited to develop glycoconjugates that potentially induce cellular stress, ROS and apoptosis. (degruyter.com)
  • NF-jB knockdown did not induce death under normal growth conditions, but did reduce TNFa-dependent cell survival. (lsd1receptor.com)
  • The exact mechanism of fen-retinide-induced cell death is not fully understood, although it is reported to induce apoptosis indepen-dently of retinoic acid receptor expression [6-9], lacking the carboxyl group required for binding to these receptors [10]. (lsd1receptor.com)
  • Because of this ability to induce apoptosis, topoisomerase inhibitors have gained interest as therapeutics against infectious and cancerous cells. (wikipedia.org)
  • Differential innate immune cell signatures and effects regulated by toll-like receptor 4 during murine lung tumor promotion. (harvard.edu)
  • Benzoyl peroxide increases UVA-induced plasma membrane damage and lipid oxidation in murine leukemia L1210 cells. (harvard.edu)
  • The in vivo antineoplastic activity of DAC administered as an i.v. infusion was evaluated in mice with murine L1210 leukemia by measurement of survival time, and in mice bearing murine EMT6 mammary tumor by excision of tumor after chemotherapy for an in vitro clonogenic assay. (biomedcentral.com)
  • We have observed that DAC reduced the in vitro clonogenic potential in a dose-dependent manner of both human and murine leukemia and tumor cell lines. (biomedcentral.com)
  • We have examined the effects of a stromal cell-derived cytokine designated interleukin 11 (IL-11) on the proliferation of murine hemopoietic progenitors in methylcellulose culture. (shengsci.com)
  • Most cancer cells undergo metabolic reprogramming that support their survival and proliferation. (degruyter.com)
  • Mitochondria is the central site of cellular energy production and plays an important role in cell survival and death. (bvsalud.org)
  • Autophagy is essential for survival differentiation development and homeostasis in eukaryotic cells. (antiviralbiologic.com)
  • Since autophagy is definitely substantially triggered in malignancy cells it may involve in drug resistance by facilitating malignancy cell survival during metabolic tensions caused by anticancer providers [13]. (antiviralbiologic.com)
  • This indicates the intricate control of metabolism and redox balance for survival of cancer cells that can be targeted by therapeutic agents. (degruyter.com)
  • Furthermore our results highlighted a potential approach to restore the level of sensitivity of cisplatin-resistant nasopharyngeal malignancy cells to nedaplatin in combination with autophagy inhibitors. (antiviralbiologic.com)
  • In cancer cells, however, these checkpoints are typically inactivated, making them selectively sensitive to TopI inhibitors. (wikipedia.org)
  • Numerous vectors have been engineered for the sole purpose of killing cancer cells, and some have successfully suppressed malignant tumours. (weeksmd.com)
  • Consistent with this hypothesis, NF-jB is constitutively acti-vated in a wide variety of tumours permitting cells to evade apoptosis [16-19,21,22]. (lsd1receptor.com)
  • Gene therapy has attracted attention for its potential to specifically and efficiently target cancer cells with minimal toxicity to normal cells. (weeksmd.com)
  • This enhances the direct killing of tumor cells by drug molecules while minimizing the potential toxicity to normal cells. (bvsalud.org)
  • However it has been recorded that nedaplatin was cross-resistant with cisplatin in the L1210/CDDP leukemia mode [9]. (antiviralbiologic.com)
  • For instance upregulation of autophagy resulted in resensitization of H460/cis cells (cisplatin-resistant lung malignancy cells) to cisplatin-induced cell death [14]. (antiviralbiologic.com)
  • However conflicting evidence showed that inhibition of autophagy resensitized SKOV3/DDP cells (cisplatin-resistant ovarian malignancy cells) to cisplatin [15]. (antiviralbiologic.com)
  • Nevertheless it is still unclear whether autophagy is definitely involved in nedaplatin-induced cell death in cisplatin-resistant NPC cells. (antiviralbiologic.com)
  • In addition, hyperpolarized tumor cell membranes and mitochondrial membrane potentially allow selective accumulation of mitochondria-targeted drugs. (bvsalud.org)
  • Clonogenic assays were performed on leukemic and tumor cell lines to evaluate the in vitro antineoplastic activity of DAC. (biomedcentral.com)
  • Increasing the DAC concentration and duration of exposure produced a greater loss of clonogenicity for both human leukemic and tumor cell lines. (biomedcentral.com)
  • Topoisomerase plays important roles in cellular reproduction and DNA organization, as they mediate the cleavage of single and double stranded DNA to relax supercoils, untangle catenanes, and condense chromosomes in eukaryotic cells. (wikipedia.org)
  • In mice with L1210 leukemia and in mice bearing EMT6 tumors, the antineoplastic action of DAC also increased with the dose. (biomedcentral.com)
  • We also observed a correlation between in vitro and in vivo concentrations needed to produce optimal responses in mice with L1210 leukemia or with EMT6 tumor. (biomedcentral.com)
  • Germ-cell deficient (gcd), an insertional mutation manifested as infertility in transgenic mice. (shengsci.com)
  • This is associated with increased tumourigenicity of ES cells in nude mice [25]. (lsd1receptor.com)
  • Drugs targeting diseased tissues or cells can significantly improve the efficacy of drugs. (bvsalud.org)
  • Our results thus identify an unexpected noncell autonomous role for mitochondria in the regulation of cellular lifespan and provide a basis for the coordinated development of gametic and nongametic cells. (shengsci.com)
  • The NF-jB family of transcription factors are involved in the regulation of several physiological processes such as inflammation, cell cycle regulation and apoptosis. (lsd1receptor.com)
  • consequently, genes encoding some of these proteins are being used to design constructs for the inhibition of multiplying cancer cells. (weeksmd.com)
  • While inhibition of ERK1/2 by MEK1/2 inhibitor U0126 could reduce the manifestation of LC3-II in nedaplatin-resistant NPC cells. (antiviralbiologic.com)
  • The reactivation of the TSGs ( p57KIP2 in HL-60 leukemic cells and p16CDKN2A in Calu-6 lung carcinoma cells) and the inhibition of global DNA methylation in HL-60 leukemic cells increased with DAC concentration. (biomedcentral.com)
  • The in vitro antineoplastic action of DAC correlated well with its inhibition of DNA methylation and reactivation of TSG in human neoplastic cells. (biomedcentral.com)
  • Interestingly, the half maximal inhibitory concentration (IC50) of BLMs in different cancer cell lines varies from nM to μM ranges. (lookformedical.com)
  • In recent studies, this linker modified analog of goniothalamin was shown to be cytotoxic against PC-3 (prostate cancer) and MCF-7 (human breast cancer) cell lines with half maximal inhibitory concentration values of 0.13 μM and 2.6 μM, respectively. (lookformedical.com)
  • This mini review highlights the development of compounds that target cancer cells by taking advantage of redox or metabolic alteration in cancer cells. (degruyter.com)
  • Treatment of drug-resistant Caco-2 cells with the most active C. jambhiri and C. pyriformis compounds increased their sensitivity to doxorubicin and completely reversed doxorubicin resistance, which agrees with a decreased P- gp activity. (gotomydoctor.com)
  • Cancer cells also enhance glucose-uptake to fuel these enhanced metabolic activities [ 2 ]. (degruyter.com)
  • High abundance of glucose in the cytoplasm of a cancer cell also increases flux into other metabolic pathways such as hexosamine biosynthetic pathway (HBP) [ 7 ]. (degruyter.com)
  • "Molecular Targets and Anticancer Potential of Indole-3-Carbinol and Its Derivatives" Cell Cycle. (sproutnet.com)
  • Consequently, ROS-modulation has emerged as an anticancer strategy with synthesis of various ROS-inducing or responsive agents that target cancer cells. (degruyter.com)
  • Once inside, the anticancer activities rely on their abilities to produce DNA breaks, thus leading to cell death. (lookformedical.com)
  • SYCO localizes to the mitochondria, and ultrastructural analysis of mutant central cells revealed that the protein is necessary for mitochondrial cristae integrity. (shengsci.com)
  • Both BLM and A5 are hydrophilic molecules that depend on transporters or endocytosis receptors to get inside of cells. (lookformedical.com)
  • Adding lunasin to IL-12- or IL-2-stimulated NK cells demonstrated synergistic effects in the induction of IFNG and GZMB involved in cytotoxicity. (weeksmd.com)
  • Redirection of glutamine to cellular energetics destabilizes glutathione homeostasis in glioblastoma cells and other cancer cells [ 9 ]. (degruyter.com)
  • Ferroptosis, characterized by glutamate overload, glutathione depletion, and cysteine/cystine deprivation during iron- and oxidative-damage-dependent cell death, is a particular mode of regulated cell death. (bvsalud.org)
  • of nedaplatin in HNE1/DDP and CNE2/DDP cells suggesting that the resistance to TCS 5861528 nedaplatin-induced cell death was caused by enhanced autophagy in TCS 5861528 nedaplatin-resistant NPC cells. (antiviralbiologic.com)
  • BAY 11-7082-induced cell death through an NF-jB-independent mechanism and enhanced cell death when combined with fenretinide. (lsd1receptor.com)
  • of cell death [7]. (lsd1receptor.com)
  • In this study we have investigated the role of NF-jB in fenretinide-induced cell death and the importance of NF-jB in ESFT. (lsd1receptor.com)
  • These topoisomerase-DNA-inhibitor complexes are cytotoxic agents, as the un-repaired single- and double stranded DNA breaks they cause can lead to apoptosis and cell death. (wikipedia.org)
  • Normal cells have multiple DNA checkpoints that can initiate the removal of these stabilized complexes, preventing cell death. (wikipedia.org)
  • In most cell types, NF-jB is sequestered in the cytoplasm by association with IjBa [20]. (lsd1receptor.com)
  • In addition, NK cells stimulated with lunasin plus cytokines displayed higher tumoricidal activity than those stimulated with cytokines alone using in vitro and in vivo tumor models. (weeksmd.com)
  • an ATP-binding ), coumarins () and terpenoids cassette (ABC) transporter (150-170 kDa), which pumps out lipo- have been reported as philic agents from cells that have entered them by free diffusion agents for overcoming multidrug resistance, and could be used aloneat very low concentrations or in combination to reverse multidrugresistance in vitro. (gotomydoctor.com)
  • One such peptide, Lunasin , has been shown to selectively act on newly transformed cells while having no cytotoxic effect on non-tumorigenic or established cancer cell lines. (weeksmd.com)
  • Eukaryotic expression vectors containing genes encoding plant proteins for killing of cancer cells. (weeksmd.com)
  • Also, using 311H as a reagent to trace the kinetic expression of EBV DNase proteins in EBV-infected Akata cells, the Western blotting results indicated that DNase antigen could be detected at 12 h postactivation. (karger.com)
  • This study aimed to explore the role and mechanism of action of sulforaphane (SFN) in protecting mouse Leydigs (TM3) cells from cadmium (Cd)-induced damage. (lookformedical.com)
  • Additionally Baf A1 enhanced reactive oxygen varieties (ROS) generation and apoptosis induced by nedaplatin in HNE1/DDP cells. (antiviralbiologic.com)
  • BAY 11-7082 decreased cell viability, which was accompanied by caspase-3 cleavage. (lsd1receptor.com)
  • Plant germ cells develop in specialized haploid structures, termed gametophytes. (shengsci.com)
  • The underlying mechanism responsible for the effects of lunasin on NK cells is likely due to epigenetic modulation on target gene loci. (weeksmd.com)
  • They frequently play an anti-apopto-tic role [14-16], but may also be pro-apoptotic in some cell types and conditions [16-19]. (lsd1receptor.com)
  • Toward this end, an insertional transgenic mouse mutant has been isolated that results in abnormal germ-cell development. (shengsci.com)
  • With the goal of further improving cytokine-based immunotherapy, we examined the effects of a soybean peptide called lunasin that synergistically works with cytokines on natural killer (NK) cells. (weeksmd.com)
  • Cancer cells often maintain high basal level of ROS and are vulnerable to any further increase in ROS levels beyond a certain protective threshold. (degruyter.com)
  • Basal levels of phosphorylated NF-jB were low in all ESFT cells. (lsd1receptor.com)
  • Peripheral blood mononuclear cells of healthy donors and post-transplant lymphoma patients were stimulated with or without lunasin in the presence of IL-12 or IL-2. (weeksmd.com)
  • The combination of lunasin and cytokines (IL-12 plus IL-2) was capable of restoring IFNγ production by NK cells from post-transplant lymphoma patients. (weeksmd.com)
  • This protocol is used to treat low risk leukemia patients (Mykayla is technically intermediate risk). (whydontyoutrythis.com)
  • Using mAb 4F10 as a probe, the Zta protein could be detected as a 36-kD molecule in L5 cells and as a 38-kD molecule in B95-8 cells, reflecting the fact reported by other laboratories, using rabbit polyclonal antisera, that the Zta protein was variously modified in different host cells. (karger.com)
  • Intro Nasopharyngeal carcinoma (NPC) is definitely a type of cancer arising from the epithelial cells that collection the nasopharynx. (antiviralbiologic.com)