Cell AgingApoptosisApoptosis Regulatory ProteinsCaspasesCaspase 3Tumor Suppressor Protein p53Proto-Oncogene Proteins c-bcl-2Inhibitor of Apoptosis ProteinsCell Line, TumorDNA FragmentationSignal TransductionCells, CulturedIn Situ Nick-End Labelingbcl-2-Associated X ProteinCell SurvivalCell ProliferationX-Linked Inhibitor of Apoptosis ProteinCyclin-Dependent Kinase Inhibitor p16FibroblastsApoptosis Inducing FactorMitochondriaCASP8 and FADD-Like Apoptosis Regulating ProteinCell CycleCyclin-Dependent Kinase Inhibitor p21Caspase 9DNA DamageCaspase InhibitorsCell LineEnzyme ActivationCaspase 8Tumor Cells, CulturedAgingReactive Oxygen SpeciesBlotting, WesternTelomereFas Ligand ProteinCell DivisionCytochromes cbcl-X ProteinRNA, Small InterferingDown-RegulationFlow CytometryTelomeraseAnnexin A5Plant LeavesOxidative StressProto-Oncogene ProteinsAntineoplastic AgentsCysteine Proteinase Inhibitorsbeta-GalactosidaseUp-RegulationTransfectionAmino Acid Chloromethyl KetonesAging, PrematurePoly(ADP-ribose) PolymerasesEnzyme InhibitorsCell DeathTime FactorsRNA, MessengerPhosphorylationGene Expression RegulationReverse Transcriptase Polymerase Chain ReactionRNA InterferenceTumor Suppressor ProteinsCell Cycle CheckpointsGene Expression Regulation, NeoplasticProtein-Serine-Threonine KinasesMice, Inbred C57BLDose-Response Relationship, DrugTNF-Related Apoptosis-Inducing LigandDNA-Binding ProteinsMice, KnockoutJurkat CellsMembrane Potential, MitochondrialModels, BiologicalRetinoblastoma ProteinProto-Oncogene Proteins c-aktMutationHydrogen PeroxideCaspase 7HL-60 CellsTumor Necrosis Factor-alphaGenes, bcl-2Nuclear ProteinsCell Transformation, NeoplasticNF-kappa BGene ExpressionNecrosisImmunohistochemistryTranscription FactorsEpithelial CellsCell Cycle ProteinsCarrier ProteinsPhenotypeCell Line, Transformedbcl-2 Homologous Antagonist-Killer ProteinHeLa CellsNeoplasm ProteinsMembrane GlycoproteinsNeoplasms