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ApoptosisCell Line, TumorApoptosis Regulatory ProteinsCaspasesTumor Necrosis Factor-alphaCaspase 3Tumor Suppressor Protein p53Proto-Oncogene Proteins c-bcl-2Inhibitor of Apoptosis ProteinsTumor Markers, BiologicalTumor BurdenCell SurvivalSignal TransductionDNA FragmentationIn Situ Nick-End LabelingCell Proliferationbcl-2-Associated X ProteinX-Linked Inhibitor of Apoptosis ProteinGenes, Tumor SuppressorCells, CulturedWilms TumorTumor Suppressor ProteinsCell LineCell DivisionCASP8 and FADD-Like Apoptosis Regulating ProteinApoptosis Inducing FactorBlotting, WesternCaspase 9Neoplasms, ExperimentalCaspase InhibitorsEnzyme ActivationCaspase 8Flow CytometryFas Ligand ProteinMitochondriaCarcinoid TumorRNA, MessengerTransfectionMice, Inbred C57BLProto-Oncogene ProteinsBrain NeoplasmsCell CycleNeoplasm ProteinsXenograft Model Antitumor AssaysAntineoplastic AgentsReverse Transcriptase Polymerase Chain ReactionTime FactorsNeuroendocrine TumorsCytochromes cbcl-X ProteinMice, Inbred BALB CTumor MicroenvironmentNeovascularization, PathologicDose-Response Relationship, DrugMammary Neoplasms, ExperimentalDown-RegulationRNA, Small InterferingAdenocarcinomaTumor Cells, CulturedColonic NeoplasmsTransplantation, HeterologousAnnexin A5ImmunohistochemistryGene Expression Regulation, NeoplasticNeoplasmsEnzyme InhibitorsMice, NudeUp-RegulationNeoplasm MetastasisTNF-Related Apoptosis-Inducing LigandMutationCysteine Proteinase InhibitorsPhosphorylationAmino Acid Chloromethyl KetonesPoly(ADP-ribose) PolymerasesNecrosisCell Transformation, NeoplasticLiver NeoplasmsCell DeathNF-kappa BReactive Oxygen SpeciesMice, SCIDGene ExpressionMice, TransgenicGastrointestinal Stromal TumorsMice, KnockoutJurkat CellsDisease Models, AnimalDNA, NeoplasmMolecular Sequence DataGliomaOvarian NeoplasmsProto-Oncogene Proteins c-aktDrug SynergismAntigens, NeoplasmSkin NeoplasmsDNA DamageDNA-Binding ProteinsReceptors, Tumor Necrosis Factor, Type IGenes, p53
Induces ApoptosisSolid tumorsInductionInduceReactive oxygenLigandPathwayCellsAnti-tumorGenesXenograft tumor modelPathwaysInhibitsSignificantlyMiceActivity and apoptosisGeneMulticellularNeuroendocrine tumorsTerminal deoxynucleotidyl tranFasLCytotoxicityXenograftsColorectal tumorApoptoticCytotoxicCancerReceptorReduction in tumorPrimary tumorsMalignancyProteinsInhibitorsCell cycleMutationsTherapeuticTRAILInhibit tumorMetastasisSuppress tumorSurvivalOrthotopicDisruptionFactorMalignantGrowthTissuesMitosis
Induces Apoptosis3
  • The short-chain fatty acid butyrate induces apoptosis in col. (lww.com)
  • Open up in another window Shape 3 Leucine deprivation induces apoptosis of human being breast tumor BAY 293 cell(A and B) MDA-MB-231 or MCF-7 cells had been incubated in charge (+leu) or leucine-deficient (?leu) moderate for 48h, accompanied by dedication of cleaved caspases inside a and annexin-V assay in B. (C and D) Nude mice. (racetab.org)
  • Furthermore, T44Bf selectively induces apoptosis in leukemia cell lines when compared to normal peripheral blood mononuclear cells. (tmu.edu.tw)
Solid tumors3
  • Single-chain antibodies (scFv) take an important role in the field, because they are less immunogenic than whole antibodies, their smaller size allows faster and deeper penetration into solid tumors, and are by definition recombinant proteins, therefore easier to produce and modify. (biomedcentral.com)
  • Further development of such drugs may be a useful strategy for improved treatment of solid tumors. (hoajonline.com)
  • Disruption of the centrosome is common in many solid tumors including lung cancer. (cdc.gov)
Induction9
  • We isolated primary tumor cells from 13 astrocytoma and oligoastrocytoma patients of all four WHO grades of malignancy and compared the levels of TRAIL-induced apoptosis induction, long-term tumor cell survival, caspase, and caspase target cleavage. (aacrjournals.org)
  • is required for NGF withdrawal-dependent apoptosis, mediated by the induction of XIAP-associated Factor 1 (XAF1). (nus.edu.sg)
  • Present results show that the higher sensitivity to PS-3-PDT in glioma cells arise on account of a higher level of apoptosis and suggest that induction of apoptosis is an important determinant of photodynamic sensitivity in certain cell types. (elsevierpure.com)
  • Decursinol Angelate Arrest Melanoma Cell Proliferation by Initiating Cell Death and Tumor Shrinkage via Induction of Apoptosis. (bvsalud.org)
  • TRAIL-R1 and TRAIL-R2 have distinct crosslinking requirements for apoptosis induction [ 6 ]. (biomedcentral.com)
  • GzB may also contribute to apoptosis induction through the cleavage of other cellular substrates including nuclear lamin B, poly (ADP-ribose) polymerase (PARP), and inhibitor of caspase-activated DNase (ICAD) [ 2 ]. (biomedcentral.com)
  • Mohanty C, Fayad W, Olofsson MH, Larsson R, De Milito A, Fryknäs M and Linder ST. Massive induction of apoptosis of multicellular tumor spheroids by a novel compound with a calmodulin inhibitor-like mechanism . (hoajonline.com)
  • More than 15 years ago, cholesterol decrement was first shown to inhibit tumor cell growth, metastasis of tumor cells, and induction of apoptosis (7). (cdc.gov)
  • TNFRFSF6/Fas-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T cells, or both. (lu.se)
Induce6
  • Exposure of mammalian cells to agents that induce apoptosis results in a rapid and substantial inhibition of protein synthesis. (gla.ac.uk)
  • The serine protease Granzyme B (GzB) is primarily expressed by cytotoxic T lymphocytes and natural killer cells, and functions in allowing these cells to induce apoptosis in virally-infected or transformed cells. (biomedcentral.com)
  • Upon TRAIL binding, DcR1 and DcR2 fail to recruit FADD and, consequently, fail to induce downstream cell signaling events leading to apoptosis (10, 32). (opioid-receptors.com)
  • Cancer cells exhibit an elevated apoptotic threshold and peptides that are able to induce apoptosis in tumor cells are increasingly seen as promising candidates for the development of new effective anticancer therapeutics. (eurogentec.com)
  • tumor suppressor p53 may induce cell cycle arrest or apoptosis in response to a variety of stress signals such as DNA damage oncogenic stimuli or hypoxia (reviewed in reference 49). (bio2009.org)
  • All these ROS induce tumor necrosis factor-alpha (TNF-α). (cdc.gov)
Reactive oxygen5
Ligand14
  • The antitumor effect of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) in gliomas has thus far only been thoroughly established in tumor cell lines. (aacrjournals.org)
  • In MCF-7 breast cancer cells, tumor necrosis factor α (TNFα) and TNF-related apoptosis-inducing ligand inhibit overall translation by a mechanism that requires caspase (but not necessarily caspase-3) activity. (gla.ac.uk)
  • Chicken Tumor necrosis factor related apoptosis inducing ligand ELISA kit is suitable for the detection of samples from chicken species. (elisakit.cc)
  • The tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is a promising candidate for the design of bifunctional antibodies. (biomedcentral.com)
  • Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand Expression Cor" by Rosalia Leonardi, Luis Eduardo Almeida et al. (marquette.edu)
  • This study investigated if tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) immunohistochemical expression in human temporomandibular joint (TMJ)-degenerated disks correlates to the degree of tissue damage to elucidate the possible involvement of this apoptotic pathway in TMJ disk degeneration. (marquette.edu)
  • The extrinsic pathway is mediated by a variety of death receptor ligands, including tumor necrosis factor (TNF) and Fas ligand (FaSL), that trigger apoptosis by binding to cell surface receptors. (cdc.gov)
  • Tumor necrosis element (TNF)-related apoptosis-inducing ligand (TRAIL) is a member of the TNF family that induces cancer cell death by apoptosis with some selectivity. (opioid-receptors.com)
  • member of the tumor necrosis factor superfamily known as TRAIL (tumor necrosis factor-related apoptosis-inducing ligand) (16). (opioid-receptors.com)
  • Death receptor DR5 (DR5/TRAIL-R2) is an apoptosis-inducing membrane receptor for tumor necrosis factor-related apoptosis-inducing ligand (TRAIL). (dsmc.or.kr)
  • Background/Aims Combination therapy utilizing tumor necrosis element (TNF)-related apoptosis-inducing ligand (TRAIL) together with other anticancer real estate agents is a promising technique to overcome TRAIL level of resistance in malignant cells. (researchensemble.com)
  • Fig. 1 The inhibitory aftereffect of mixed parthenolide (PT) and tumor necrosis element (TNF)-related apoptosis-inducing ligand (Path) treatment on cell proliferation. (researchensemble.com)
  • Fig. 2 The apoptotic effect of combined parthenolide (PT) and tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) treatment. (researchensemble.com)
  • It was striking that the expression of tumour-necrosis-factor-alpha -related apoptosis-inducing ligand (TRAIL) among the apoptosis-related genes was elevated approx. (ewha.ac.kr)
Pathway9
  • Loss of mitochondrial membrane potential, upregulation of proapoptotic proteins, activation of MCL-1, PARP-1 and Caspase 9 suggest that MESF treatment leads to activation of mitochondrial pathway of apoptosis. (nature.com)
  • Due to the pleiotropic effect of bortezomibenhanced TRAIL DISC formation upon TRAIL triggering, down-regulation of cFLIP L and activation of the intrinsic apoptosis pathway seem to cooperatively contribute to the antitumor effect of bortezomib/TRAIL cotreatment. (aacrjournals.org)
  • However, BF + GCV only induced apoptosis via Fas/FasL signal pathway accompanied with increased P53 expression. (biomedcentral.com)
  • Overexpression of XAF1 impairs tumor progression whereas knockdown of XAF1 promotes tumor growth, suggesting that XAF1 may be a candidate tumor suppressor in neuroblastoma and its associated pathway may be important for developing future interventions. (nus.edu.sg)
  • Taken together, our findings indicate that SS18-SSX-mediated attenuation of an EGR1-PTEN network regulates synovial sarcoma cell survival, and that HDAC inhibitor-mediated apoptosis operates at least in part through reactivation of this pathway. (nature.com)
  • It is unclear if disruption of the apoptosis pathway plays a role in the signs and symptoms of TRAPS. (medlineplus.gov)
  • Binding of the trimeric TRAIL to its receptors TRAIL-R1 and TRAIL-R2 induces caspase activation and apoptosis [ 4 ], either through the extrinsic pathway alone or recruiting the intrinsic apoptotic pathway [ 5 ]. (biomedcentral.com)
  • Silibinin considerably reduced the development of oral cancer cells by inducing apoptosis, G 0 /G 1 arrest, ROS generation, and activation of the JNK/c-Jun pathway. (jcancer.org)
  • Treatment of PTC cell lines with PHA665752, an inhibitor of c-Met tyrosine kinase, inhibited cell proliferation and induced apoptosis via the mitochondrial pathway in PTC cell lines. (aku.edu)
Cells65
  • Annexin V-propidium iodide double-staining demonstrated that Sapota fruit extracts potentiate apoptosis rather than necrosis in cancer cells. (nature.com)
  • Heterozygous mutation of Trp53 decreases p53 and results in attenuated apoptosis and G1-S checkpoint control, allowing Brca1Delta11/Delta11 cells to proliferate. (nih.gov)
  • Renal cell carcinoma primary tumors and lung metastases are infiltrated by activated natural killer (NK) cells. (nih.gov)
  • MbIL-15 on the target did not interfere with resting NK cell activation and target cell cytolysis but rescued NK cells from IL-2 starvation-induced apoptosis through contact-dependent interaction. (nih.gov)
  • These findings suggest that IL-15 produced by renal tumor cells is involved in the maintenance of active NK cells at the tumor site. (nih.gov)
  • The effect of the synthetic pineal peptide Epitalon® (Ala-Glu-Asp-Gly) on proliferative activity in colon tumors, and in mucosal epithelial cells adjacent to and located far from tumors was studied in rats. (spandidos-publications.com)
  • Mitotic activity of tumor cells was significantly inhibited by Epitalon when the treatment was given throughout the experiment (group 2). (spandidos-publications.com)
  • In contrast to cell lines, isolated primary tumor cells from all investigated glioma patients were highly TRAIL resistant. (aacrjournals.org)
  • Cancer gene therapy approaches include the direct killing of tumor cells by injecting a therapeutic gene into the tumor cell or employing vaccine strategies to deliver an immunomodulatory gene that stimulates the immune system to recognize tumor antigens [ 1 ]. (biomedcentral.com)
  • When expressed in tumors, TK converts the non-toxic precursor GCV into GCV- 3-phosphate, a toxic substance that kills tumor cells. (biomedcentral.com)
  • Upon subcutaneous introduction of sNEDD4-overexpressing SK cells into flanks of nude mice, tumors grew faster than those of the control group. (oncotarget.com)
  • Overexpression of sNEDD4 increased the invasive ability of SK cells through upregulation of matrix metalloproteinase 9 and inhibited serum deprivation-induced apoptosis via upregulation of myeloid cell leukemia 1. (oncotarget.com)
  • PS-3-PDT induced a significantly higher level of apoptosis in BMG-1 cells as compared to 4451 cells. (elsevierpure.com)
  • The objective of this study was to optimize conditions for preparing Boswellea sacra essential oil with the highest biological activity in inducing tumor cell-specific cytotoxicity and suppressing aggressive tumor phenotypes in human breast cancer cells. (biomedcentral.com)
  • Boswellia sacra essential oil hydrodistilled at 100 o C was more potent than the essential oil prepared at 78 o C in inducing cancer cell death, preventing the cellular network formation (MDA-MB-231) cells on Matrigel, causing the breakdown of multicellular tumor spheroids (T47D cells), and regulating molecules involved in apoptosis, signal transduction, and cell cycle progression. (biomedcentral.com)
  • However, the idea of genetic mutation leading to increased tumor growth gave way to another possible genetic idea of genes playing a role in decreasing cellular growth and development of cells. (wikipedia.org)
  • Within Harris's experiments, tumor cells were fused with normal somatic cells to make hybrid cells. (wikipedia.org)
  • Each cell had chromosomes from both parents and upon growth, a majority of these hybrid cells did not have the capability of developing tumors within animals. (wikipedia.org)
  • The suppression of tumorigenicity in these hybrid cells prompted researchers to hypothesize that genes within the normal somatic cell had inhibitory actions to stop tumor growth. (wikipedia.org)
  • Steven Bark, Dr. pro-survival features in tumor cells. (demotivate.org)
  • The antitumor activity of polysaccharides is usually mediated by two main pathways: direct killing of tumor cells and activation of the immune system. (yiacupuncture.com)
  • Numerous studies have shown that polysaccharides regulate the production of inflammatory factors by regulating the activation of immune cells, thereby killing tumor cells. (yiacupuncture.com)
  • An arabinogalactan (PTPS-1-2) was isolated and characterized from Pollen Typhae, and its potential antitumor effects on activating macrophages to produce immunomodulatory factors and promoting apoptosis in colorectal cancer cells were investigated. (yiacupuncture.com)
  • An arabinogalactan isolated from Pollen Typhae induces the apoptosis of RKO cells by promoting macrophage polarization.Carbohydr Polym. (yiacupuncture.com)
  • However, the role of C1QBP in metabolism, oxidative stress, and apoptosis of renal cell carcinoma (RCC) cells have not yet been explored. (medsci.org)
  • C1QBP knockdown and overexpression cells were established via lentiviral infection and subjected to apoptosis and ROS assay in vitro . (medsci.org)
  • C1QBP promotes the catabolism of hypoxanthine and elevates the apoptosis of RCC cells by modulating XDH-mediated ROS generation. (medsci.org)
  • The real-time analysis in GBM-on-a-Chip showed that mesenchymal GBM niche attracted low number of allogeneic CD154+CD8+ T-cells but abundant CD163+ tumor-associated macrophages (TAMs), and expressed elevated PD-1/PD-L1 immune checkpoints and TGF-β1, IL-10, and CSF-1 cytokines compared to proneural GBM. (elifesciences.org)
  • After sensitization with cytotoxic drugs, scFv62-TRAIL induced apoptosis only in K V 10.1-positive cancer cells, but not in non-tumor cells, nor in tumor cells lacking K V 10.1 expression. (biomedcentral.com)
  • In co-cultures with K V 10.1-positive cancer cells the fusion protein also induced apoptosis in bystander K V 10.1-negative cancer cells, while normal prostate epithelial cells were not affected when present as bystander. (biomedcentral.com)
  • We could design a strategy that selectively kills tumor cells based on a K V 10.1-specific antibody. (biomedcentral.com)
  • However, the smaller the residual mass, the lower the chance that it harbors viable tumor cells. (medscape.com)
  • The classic theory suggests that germ cell tumors (GCTs) in these areas are derived from local transformation of primordial germ cells misplaced during embryogenesis. (medscape.com)
  • Normally, these cells are eliminated by apoptosis. (medscape.com)
  • Cancers of both lymphoid and non-lymphoid origin also express GzB, and in some cases this expression has been linked to pathogenesis or sensitizing tumour cells to cell death. (biomedcentral.com)
  • Given the fact that ALK+ ALCL exhibits high levels of apoptosis and is typically responsive to conventional chemotherapy, we examined whether GzB expression might play a role in sensitizing ALK+ ALCL tumour cells to apoptosis. (biomedcentral.com)
  • While spontaneous apoptosis was similar in ALK+ ALCL cell lines expressing either GzB or control shRNA, GzB shRNA-expressing cells were less sensitive to staurosporine or doxorubicin-induced apoptosis as evidenced by reduced PARP cleavage and decreased DNA fragmentation. (biomedcentral.com)
  • Redirecting endogenous antibodies in the bloodstream to tumor cells utilizing artificial molecules is a promising strategy to set off anti-tumor immune responses. (kashbiotech.com)
  • TRAIL has gained considerable interest in oncology since it displays specific antitumoral activity against a wide range of tumor cells (14, 41, 47) without significant side effects, at least in mice and monkeys (3, 21, 22). (opioid-receptors.com)
  • Transient overexpression of DcR1 or DcR2 in TRAIL-sensitive Sav1 tumor cells prevents cell death triggering by TRAIL (10, 11), and recent evidence indicates that tumor and normal cells can acquire resistance to TRAIL-induced killing by up-regulating TRAIL antagonistic receptors (6, 8, 9, 34). (opioid-receptors.com)
  • Tumor derived, tumor associated antigens (TAA) or homing peptides are used as targets for the development of cancer vaccines (such as NY-ESO-1 peptide vaccine) as they illicit an immune response against cells containing the cancer antigen. (eurogentec.com)
  • Cell permeable peptides (CPP) such as TAT, or antennapedia, conjugated to anti-cancer drugs are under evaluation for their ability to penetrate and deliver anti-tumor molecules into cancer cells. (eurogentec.com)
  • Finally, we show that siRNA- or inhibitor-mediated blockade of integrin α6β4-Src-AKT signaling switches the post-irradiation fate from senescence to apoptosis, under p53 activated condition, in both cancer cells and tumor tissues of xenograft mice. (korea.ac.kr)
  • Moreover, it induced cell cycle arrest in the G0/G1 phase, apoptosis, and ROS generation in these cells. (jcancer.org)
  • In further examination, we found that the ATRA-induced apoptosis in GIST-T1 cells was accompanied by the down-regulated expression of survivin and up-regulated expression of Bax protein. (biomedcentral.com)
  • Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal neoplasms occurring throughout the entire region of the gastrointestinal tract and are considered to originate from intestitial cells of Cajal, the pacemaker cells of the gut [ 1 ]. (biomedcentral.com)
  • However there is no reported study on anti-tumor effects of sunitinib in xenografts of basal-like TNBC (MDA-MB-468) cells. (biomedcentral.com)
  • MDA-MB-468 cells were exposed to sunitinib for 18 hours for measuring proliferation (3H-thymidine incorporation), migration (BD Invasion Chamber), and apoptosis (ApopTag and ApoScreen Anuexin V Kit). (biomedcentral.com)
  • Breast cancer stem cells (CSCs) isolated from the tumors were determined by flow cytometry analysis using CD44 + /CD24 - or low. (biomedcentral.com)
  • Sunitinib significantly inhibited the proliferation, invasion, and apoptosis resistance in cultured basal like breast cancer cells. (biomedcentral.com)
  • These findings support the hypothesis that the possibility should be considered of sunitinib increasing breast CSCs though it inhibits TNBC tumor angiogenesis and growth/progression, and that effects of sunitinib on Notch expression and hypoxia may increase breast cancer stem cells. (biomedcentral.com)
  • A number of anticancer drug candidates have been identified by cell-based screens utilizing tumor cells grown in monolayer culture. (hoajonline.com)
  • A chemical library was used to screen for compounds capable of reducing viability and inducing apoptosis of colon carcinoma cells grown as multicellular spheroids. (hoajonline.com)
  • Interestingly, quiescent cells in spheroid cores were resistant to NSC647889-induced apoptosis and appeared to die by other mechanisms. (hoajonline.com)
  • Mixture PT and Path treatment inhibited cell development and induced apoptosis of HT-29 cells significantly. (researchensemble.com)
  • Co-treatment with TRAIL and 3-Butylidenephthalide PT caused a 3-fold increase in the proportion of annexin V-positive cells (41.86%) indicating that PT promotes TRAIL-induced apoptosis in TRAIL-resistant cells. (researchensemble.com)
  • In combined treatment a much greater sub-G1 population (27.77%) was observed indicating that the combination of two agents dramatically promoted apoptosis in TRAIL-resistant cells (Fig. 2B). (researchensemble.com)
  • The purpose of BAY 293 our current research would be to investigate the result of leucine deprivation on breast tumor cells and also to elucidate the root mechanisms. (racetab.org)
  • Outcomes Leucine deprivation decreases viability of tumor cells We 1st determined the result of leucine deprivation on viability of tumor cells. (racetab.org)
  • Four varieties of tumor cells were examined: malignant melanoma A375, lung caner A549, ovarian carcinoma breast and A2780 cancer MCF-7 and MDA-MB-231 cells. (racetab.org)
  • Open up in another window Shape 2 Leucine deprivation inhibits breasts tumor cell proliferation(A) MDA-MB-231 or CORIN MCF-7 cells had been seeded in 12-well plates and incubated in charge (+leu) or leucine-deficient (?leu) moderate. (racetab.org)
  • These phenomena might partly contribute to apoptosis in the mammary epithelial cells for entering involution. (ewha.ac.kr)
  • The transcriptional activation from CACNA1F the p21 gene by these inhibitors is normally marketed by chromatin redecorating pursuing acetylation of histones H3 and H4 in the p21 promoter area (32 54 This activation of p21 takes place within a p53-unbiased fashion and for that reason HDAC inhibitors are appealing realtors for cancers therapy being that they are operative in cells with mutated p53 genes a hallmark of several tumors. (bio2009.org)
  • GEP analyses were performed on highly purified, flow-cytometry sorted tumor-cells from eight subgroups of BCLs. (lu.se)
  • This enabled identification of TFs that can be uniquely associated to the tumor cells of chronic lymphocytic leukemia (CLL), diffuse large B-cell lymphoma (DLBCL), follicular lymphoma (FL), hairy cell leukemia (HCL), and mantle cell lymphoma (MCL). (lu.se)
Anti-tumor1
  • A mouse xenograft model of MCL demonstrated that MLN8237 (10 or 30 mg/kg) or docetaxel (10 mg/kg) alone had modest anti-tumor activity. (elsevierpure.com)
Genes10
  • Eight genes related to apoptosis and ten genes regulating key points of cell cycle were investigated. (oncotarget.com)
  • Meanwhile, gatekeeper genes directly regulate cell growth by either inhibiting cell cycle progression or inducing apoptosis. (wikipedia.org)
  • The discovery of oncogenes and their ability to deregulate cellular processes related to cell proliferation and development appeared first in the literature as opposed to the idea of tumor suppressor genes. (wikipedia.org)
  • In order to verify that the loss of function of tumor suppressor genes causes increased tumorigenicity, interstitial deletion experiments on chromosome 13q14 were conducted to observe the effect of deleting the loci for the Rb gene. (wikipedia.org)
  • Unlike oncogenes, tumor suppressor genes generally follow the two-hit hypothesis, which states both alleles that code for a particular protein must be affected before an effect is manifested. (wikipedia.org)
  • A) Heatmap of the topological overlap between genes indicated in tumors. (informationalwebs.com)
  • B) Heatmap of the topological overlap between genes indicated in SR. The story follows S4A Fig.(TIF) pcbi.1005680.s009.tif (265K) GUID:?0869C3B0-ACDA-441A-A033-B0A67D656ABB S5 Fig: Manifestation patterns of the green tumor module. (informationalwebs.com)
  • To reveal the effects of IL-10 on involution, expression profiles of apoptosis-related genes were examined in mice transgenic for IL-10 as well as in IL-10(-/-) mice. (ewha.ac.kr)
  • The aim of this work was to examine the regulation of apoptosis-related genes in GOT1 tumors short-time after i.v. administration of 177 Lu-octreotate with and without A1M or A1M alone. (lu.se)
  • Gene expression analysis of apoptosis-related genes in GOT1 tissue was performed with RT-PCR. (lu.se)
Xenograft tumor model2
  • Bifidobacterium (BF) or BF-rTK was injected intratumorally with or without ganciclovir in a human colo320 intestinal xenograft tumor model. (biomedcentral.com)
  • Finally, NSC647889 induced tumor apoptosis in a xenograft tumor model. (hoajonline.com)
Pathways3
  • The apoptosis was transduced by multiple signaling pathways mediated by FasL and TNFR2 and mainly activated the mitochondrial control of apoptosis via Bid and Bim, which was rescued by silencing Bid or/and Bim . (biomedcentral.com)
  • Cell cycle and apoptosis are key pathways of multicellular homeostasis and deregulation of these pathways is associated with cancerogenesis. (oncotarget.com)
  • Western blot analysis was performed to study Boswellia sacra essential oil-regulated proteins involved in apoptosis, signaling pathways, and cell cycle regulation. (biomedcentral.com)
Inhibits1
  • mdm2 sequesters p53 and inhibits its function as G1-S checkpoint controller and apoptosis inducer. (medscape.com)
Significantly7
  • The analysis of inflammatory markers (TNF-α) in tumor indicated that BF-rTK + GCV significantly inhibited TNF-α expression. (biomedcentral.com)
  • We previously found that bladder tumor growth was significantly reduced in rats treated with BI-TK + GCV after 15 days of treatment [ 10 ]. (biomedcentral.com)
  • In clinical specimens, sNEDD4 was significantly overexpressed in tumors and serves as a poor prognostic factor for male patients with HCC ( P = 0.035). (oncotarget.com)
  • C1QBP significantly increased ROS level, apoptosis, and the expression of apoptotic proteins such as cleaved caspase-3 and bax/bcl2 via regulating XDH. (medsci.org)
  • Silibinin significantly inhibited xenograft tumor growth in nude mice, with no obvious toxicity. (jcancer.org)
  • The xenograft models showed that oral sunitinib significantly reduced the tumor volume of TNBCs in association with the inhibition of tumor angiogeneisis, but increased breast CSCs. (biomedcentral.com)
  • leucine deprivation alone didn't influence tumor size [14] significantly. (racetab.org)
Mice7
  • More importantly, we show that MESF treatment leads to significant inhibition of tumor growth and a 3-fold increase in the life span of tumor bearing animals compared to untreated tumor mice. (nature.com)
  • However, most female Brca1Delta11/Delta11 Trp53+/- mice develop mammary tumors with loss of the remaining Trp53 allele within 6-12 months. (nih.gov)
  • Importantly, silibinin effectively suppressed xenograft tumor growth in nude mice. (jcancer.org)
  • Finally, cotreatment with PHA665752 and TRAIL caused more pronounced effects on PTC xenograft tumor growth in nude mice. (aku.edu)
  • Therefore, to search for indole compounds with more efficacy and less side effect for cancer therapy, we developed a novel indole compound SK228 and examined its effects and mechanisms on antitumor growth and invasion inhibition in cell and tumor xenografts in nude mice models. (ntnu.edu.tw)
  • SK228-induced apoptosis was confirmed by terminal deoxynucleotidyl transferase dUTP nick end labeling assay and immunohistochemistry of cleaved caspase-3 in tumors from treated mice. (ntnu.edu.tw)
  • Human GOT1 tumor-bearing mice received 30 MBq 177 Lu-octreotate or 5 mg/kg A1M or co-treatment with both. (lu.se)
Activity and apoptosis2
  • Kossoy G, Zandbank J, Tendler E, Anisimov V, Khavinson V, Popovich I, Zabezhinski M, Zusman I and Ben-Hur H: Epitalon and colon carcinogenesis in rats: Proliferative activity and apoptosis in colon tumors and mucosa. (spandidos-publications.com)
  • The Ki-67 immunohistochemistry and Tunel methods were used to detect mitotic activity and apoptosis, respectively. (omu.edu.tr)
Gene14
  • About 8% of cases are hereditary, and approximately half of these are associated with germline mutations of the breast tumor suppressor gene BRCA1 (refs. (nih.gov)
  • Directly targeting therapeutic suicide gene to a solid tumor is a hopeful approach for cancer gene therapy. (biomedcentral.com)
  • Treatment of a solid tumor by an effective vector for a suicide gene remains a challenge. (biomedcentral.com)
  • Meanwhile, three human digestive system xenograft tumor models (colorectal cancer colo320, gastric cancer MKN-45 and liver cancer SSMC-7721) and a breast cancer (MDA-MB-231) model were employed to validate the universality of BF-rTK + GCV in solid tumor gene therapy. (biomedcentral.com)
  • Survival analysis results of multiple cancer models confirmed that BF-rTK + GCV system has a wide field of application in solid tumor gene therapy. (biomedcentral.com)
  • The Herpes Simplex Virus thymidine kinase/ganciclovir (HSV-TK + GCV) system is currently one of the best-studied tumor suicide gene therapy systems [ 9 - 11 ]. (biomedcentral.com)
  • In conclusion, sNEDD4 is a novel metastasis-associated gene, which prevents apoptosis under nutrient restriction conditions. (oncotarget.com)
  • Since, apoptosis induced by PDT treatment plays an important role in determining the photodynamic efficacy, in the present work we have investigated the role of apoptotic cell death in relation to the observed differences in sensitivity to HpD-PDT between a human glioma cell line (BMG-1) carrying wild-type tumour suppressor gene p53 and a human squamous carcinoma cell line (4451) with mutated p53. (elsevierpure.com)
  • A tumor suppressor gene (TSG), or anti-oncogene, is a gene that regulates a cell during cell division and replication. (wikipedia.org)
  • When a tumor suppressor gene is mutated, it results in a loss or reduction in its function. (wikipedia.org)
  • This initial hypothesis eventually lead to the discovery of the first classic tumor suppressor gene by Alfred Knudson, known as the Rb gene, which codes for the retinoblastoma tumor suppressor protein. (wikipedia.org)
  • This deletion caused increased tumor growth in retinoblastoma, suggesting that loss or inactivation of a tumor suppressor gene can increase tumorigenicity. (wikipedia.org)
  • This gene provides instructions for making a protein called tumor necrosis factor receptor 1 (TNFR1). (medlineplus.gov)
  • TIF) pcbi.1005680.s007.tif (686K) GUID:?6956405C-98F9-4994-9C6E-788FDD2743CF S3 Fig: Gene expression heatmap from the 70 bloodstream markers of lumC tumors. (informationalwebs.com)
Multicellular3
  • Anti-invasive and anti-multicellular tumor properties were evaluated by cellular network and spheroid formation models, respectively. (biomedcentral.com)
  • Since such cultures are poor models of 3-D tumor micro-environments, we here aimed to identify novel compounds showing anti-proliferative activity on multicellular spheroids. (hoajonline.com)
  • NSC647889 induced dramatic increases in tumor cell apoptosis in multicellular spheroids compared to standard antineoplastic agents. (hoajonline.com)
Neuroendocrine tumors3
Terminal deoxynucleotidyl tran2
  • Cell apoptosis was detected by terminal deoxynucleotidyl transferase dUTP nick end labeling and Hoechst 33342 staining, and quantified by flow cytometry. (wjgnet.com)
  • ALK+ ALCL cell lines stably expressing GzB or non-targeting (control) shRNA were generated and apoptosis was examined by anti-PARP western blotting and terminal deoxynucleotidyl transferase dUTP nick end labelling. (biomedcentral.com)
FasL1
  • BF-rTK + GCV induced tumor apoptosis mediated by FasL and TNFR2 through the mitochondrial control of apoptosis via Bid and Bim without inducing necroptosis and autophagy. (biomedcentral.com)
Cytotoxicity1
  • Our study provides the first evidence that SK228 exhibits cancer cell-specific cytotoxicity by inducing mitochondria-mediated apoptosis. (ntnu.edu.tw)
Xenografts2
  • In vivo , orthotopic tumor xenografts assay was performed to investigate the role of C1QBP in RCC progression. (medsci.org)
  • Therapy of xenografts with NOTCH3-ADCs results in sustained tumor regressions, outperforms standard-of-care chemotherapy , and permits concentrating on of tumors that overexpress NOTCH3 impartial of signaling inhibition. (kashbiotech.com)
Colorectal tumor1
  • At least 50% of the Western population will develop a colorectal tumor by age 70 years. (medscape.com)
Apoptotic2
  • Essential oil prepared by distillation of the gum resin traditionally used for aromatic therapy has also been shown to have tumor cell-specific anti-proliferative and pro-apoptotic activities. (biomedcentral.com)
  • Co-administration of A1M did not negatively affect the transcriptional apoptotic response of 177 Lu-octreotate in GOT1 tumors. (lu.se)
Cytotoxic1
  • May be involved in cytotoxic T cell mediated apoptosis and in T cell development. (lu.se)
Cancer7
  • To investigate the effect of gambogic acid (GA) on apoptosis in the HT-29 human colon cancer cell line. (wjgnet.com)
  • A colorectal cancer model was used to decipher the molecular mechanism of BF-rTK + GCV (bifidobacterial recombination thymidine kinase/ganciclovir) using a human apoptosis antibody array kit in a murine cancer model in vivo . (biomedcentral.com)
  • Some retroperitoneal extragonadal germ cell tumors may represent metastases from a testicular cancer , with subsequent spontaneous necrosis of the primary tumor. (medscape.com)
  • More recently, tumor specific antigens or tumor specific neoantigens (TSNA) that arise from tumor cell mutations are being identified in a large number of cancer patients. (eurogentec.com)
  • Oral cancer is one of the most prevalent malignant tumors worldwide. (jcancer.org)
  • Sunitinib has been used as anticancer treatments in several tumor types including breast cancer [ 19 ], however clinical observations indicate this therapy may have limited efficacy. (biomedcentral.com)
  • The resulting aneuploidy is a key event in the progression of cancer and is correlated with tumor stage. (cdc.gov)
Receptor2
  • Tumor necrosis factor receptor-associated periodic syndrome (commonly known as TRAPS) is a condition characterized by recurrent episodes of fever. (medlineplus.gov)
  • TRAIL triggers apoptosis upon engagement of one of its two agonistic receptors, named DR4 (death receptor 4) (33) and DR5 (death receptor 5) (7, 46). (opioid-receptors.com)
Reduction in tumor1
  • Besides, administration of concentrated extracts of Morinda citrifolia in tumor containing animals increased the immune response of the animals with a concomitant reduction in tumor burden 7 . (nature.com)
Primary tumors1
  • MES GBM accounts for 30-50% of primary tumors and is associated with particularly poor response to therapy, while PN GBM is associated with a somewhat better prognosis. (elifesciences.org)
Malignancy3
  • BCL2 expression increased over BAX expression with increasing malignancy of the tumor from TC to SCLC. (oncotarget.com)
  • [ 1 , 2 ] In extragonadal germ cell tumors, no evidence of a primary malignancy is present in either the testes or ovaries by radiologic imaging or physical examination. (medscape.com)
  • In 10% of these individuals, the tumor progresses to malignancy. (medscape.com)
Proteins1
Inhibitors1
  • Inhibitors of apoptosis (IAPs) can prevent caspase activation under certain conditions. (cdc.gov)
Cell cycle2
Mutations1
  • The more sporadic occurrence of unilateral development of retinoblastoma was hypothesized to develop much later in life due to two de novo mutations that were needed to fully lose tumor suppressor properties. (wikipedia.org)
Therapeutic3
  • PTPS-1-2 might be a therapeutic option for the prevention and treatment of tumors. (yiacupuncture.com)
  • To ensure a maintained therapeutic effect, we previously demonstrated that A1M does not affect the 177 Lu-octreotate induced decrease in GOT1 tumor volume. (lu.se)
  • B-cell lymphomas (BCLs) constitute a diverse set of tially identify new functional, diagnostic, and therapeutic tumors, both morphologically and clinically, that are mainly targets. (lu.se)
TRAIL7
  • Regardless of the tumor heterogeneity, cotreatment with the proteasome inhibitor bortezomib efficiently sensitized all primary glioma samples for TRAIL-induced apoptosis and tremendously reduced their clonogenic survival. (aacrjournals.org)
  • TNF superfamily member (TRAIL) is a type II transmembrane protein and is responsible for initiating apoptosis. (ekb.eg)
  • To date, the molecular mechanisms by which DcR1 and DcR2 confer resistance to TRAIL-induced apoptosis remain unclear (1, 6, 9, 13). (opioid-receptors.com)
  • In the current study, we demonstrate that DcR1 and DcR2 inhibit TRAIL-induced apoptosis by distinct mechanisms. (opioid-receptors.com)
  • In this study, we showed that curcumin, a plant product containing the phenolic phytochemical, is a potent enhancer of TRAIL-induced apoptosis through upregulation of DR5 expression. (dsmc.or.kr)
  • Both treatment with DR5/Fc chimeric protein and silencing of DR5 expression using small interfering RNA (siRNA) attenuated curcumin plus TRAIL-induced apoptosis, showing that the critical role of DR5 in this cell death. (dsmc.or.kr)
  • Taken together, the present study demonstrates that curcumin enhances TRAIL-induced apoptosis by CHOP-independent upregulation of DR5. (dsmc.or.kr)
Inhibit tumor1
  • Studies have suggested that statins may inhibit tumor cell growth and possibly prevent carcinogenesis. (cdc.gov)
Metastasis1
  • Furthermore, sNEDD4-mediated promotion of tumor metastasis was demonstrated in the orthotopic mouse model. (oncotarget.com)
Suppress tumor1
  • Moreover, Fc-ARMs recruited antibodies to suppress tumor progress in a mouse mannequin. (kashbiotech.com)
Survival1
  • However, MLN8237 plus docetaxel demonstrated a statistically significant tumor growth inhibition and enhanced survival compared to single agent therapy. (elsevierpure.com)
Orthotopic1
  • Using 3D tumor organoids and orthotopic PDX models we showed that KSP-inhibition is a powerful treatment strategy against neuroblastoma. (lu.se)
Disruption1
  • GzB primarily initiates apoptosis either through direct proteolytic processing and activation of initiator (caspase 8) or executioner (caspases 3 and 7) caspases, or through disruption of mitochondrial outer membrane potential via cleavage of the Bid protein [ 2 ]. (biomedcentral.com)
Factor3
  • Jeffrey, I. W. , Bushell, M. , Tilleray, V. J. , Morley, S. and Clemens, M. J. (2002) Inhibition of protein synthesis in apoptosis: differential requirements by the tumor necrosis factor alpha family and a DNA-damaging agent for caspases and the double-stranded RNA-dependent protein kinase. (gla.ac.uk)
  • The only known risk factor for extragonadal germ cell tumors is Klinefelter syndrome (47XXY), which is associated with mediastinal nonseminomatous germ cell tumors, which are characterized by their location on the midline from the pineal gland to the coccyx. (medscape.com)
  • Literature suggests that the only known risk factor for extragonadal germ cell tumors (EGCTs) is Klinefelter syndrome (47XXY), which is associated with mediastinal nonseminomatous germ cell tumors. (medscape.com)
Malignant1
  • Malignant gliomas are the most aggressive human brain tumors without any curative treatment. (aacrjournals.org)
Growth3
  • Growth of an A549 tumor cell xenograft was markedly inhibited without significant side effects. (ntnu.edu.tw)
  • In this work, for the first time we have demonstrated that ATRA affected on cell proliferation of GIST-T1 and GIST-882 cell line through inhibition of cell growth in a dose dependent manner and induced apoptosis. (biomedcentral.com)
  • The Keratocystic Odontogenic Tumor (KOT) is a pathology classified as an odontogenic cyst and began to be considered an odontogenic tumor in 2005, because of the presence of intrinsic characteristics compatible with neoplasm, such as its high rate of recurrence and differentiated mechanism of growth. (bvsalud.org)
Tissues2
  • The tumor tissues were analyzed using apoptosis antibody arrays, real time PCR and western blot. (biomedcentral.com)
  • Moreover, the expression of C1QBP and XDH was lower in RCC tumors compared with the tumor-associated normal tissues, and their down-regulation was associated with higher Fuhrman grade. (medsci.org)
Mitosis2