• 2002 ). As a pivotal biochemical cascade, the MAPK signaling pathway is involved in diverse fundamental events in cells and signal transduction pathways, namely, differentiation, proliferation, apoptosis, activation of other specific regulatory factors, acute responses to hormones, and developmental alteration of organisms (Pearson et al. (frontiersin.org)
  • The recent original data concerning interrelationships between ghrelin and feeding, action of ghrelin on ovarian functions (proliferation, apoptosis, secretory activity, response to gonadotropins, oocyte maturation) and intracellular mechanisms of its action in different species (rabbit, pig, human, chicken) are reviewed. (endocrine-abstracts.org)
  • We believe controlling osteoblast differentiation/proliferation and osteocyte apoptosis could be promising directions for developing future therapeutic solutions for related bone diseases. (biomedcentral.com)
  • Potential mechanisms contributing to the airway-vessel remodeling of COPD include proliferation of airway epithelial cells, vascular endothelial cells, airway and vessel smooth muscle cells, fibroblast-myofibroblast transformation, epithelial-to-mesenchymal transition (EMT), and endothelial-to-mesenchymal transition (EndMT) [ 15 , 16 , 17 ]. (biomedcentral.com)
  • Gain of function and loss of function experiments showed that PDCD4 induced turnover (proliferation and apoptosis) of HUVECs. (plos.org)
  • Low PDCD4 level was associated with reduced proliferation but not apoptosis or phosphorylation of endothelial nitric oxide synthase caused by pulsatile shear stress to help maintain the homeostasis of endothelial cells. (plos.org)
  • PDCD4 induces turnover (proliferation and apoptosis) of HUVECs. (plos.org)
  • The degree of methylation affects the expression of target genes and has a significant impact on cell proliferation, apoptosis, cytokine secretion, and cell activity ( 6 , 7 ). (frontiersin.org)
  • The present study explored the effect of NAC on LPS‑induced apoptosis of HUVECs and determined the participation of the p38 mitogen‑activated protein kinase (MAPK) pathway in the process of apoptosis. (spandidos-publications.com)
  • The secretion of inflammatory factors as well as the marker proteins in the mitogen-activated protein kinase (MAPK) pathway were detected by Western blot. (frontiersin.org)
  • PDT has been reported to be effective for treating aggressive colon cancer showing a high level of the vascular endothelial growth factor, which promotes tumor growth through angiogenesis ( 5 ). (spandidos-publications.com)
  • CD31 is a multifunctional molecule with diverse roles in modulation of integrin-mediated cell adhesion, transendothelial migration, angiogenesis, apoptosis, negative regulation of immunoreceptor signaling, autoimmunity, macrophage phagocytosis, IgE-mediated anaphylaxis and thrombosis. (thermofisher.com)
  • Results Our findings indicate that the platelets in HD are dysfunctional with respect to the release of angiogenic factors and functions including thrombosis, angiogenesis and vascular haemostasis. (bmj.com)
  • The piezoelectric Cs/Gel/PHA/PBT hydrogels developed here with favorable immunomodulation, angiogenesis, and osteogenesis functions may be used as a substitute in periosteum injuries, thereby offering the novel strategy of applying piezoelectric stimulation in bone tissue engineering for the enhancement of combat effectiveness in grassroots troops. (biomedcentral.com)
  • Although the pathogenesis of diabetic tendinopathy is still not fully understood, the potential mechanisms by which DM causes and exacerbates tendinopathy are - accumulation of advanced glycation end-products (AGEs), adipokine dysregulation, increased reactive oxygen species (ROS), cell death and inflammatory cytokines, imbalance in the matrix metalloproteinase (MMP)/tissue inhibitor (TIMP) ratio, and impaired angiogenesis and tendon sheath differentiation [ 6 ]. (biomedcentral.com)
  • The results demonstrated that NAC pretreatment alleviated LPS‑induced apoptosis and inhibition of NO production in HUVECs. (spandidos-publications.com)
  • These protective effects may be associated with the inhibition of apoptosis and inflammation, as reflected by less TUNEL-positive cells and lower levels of serum proinflammatory cytokines (Interleukin-1β, Interleukin-6, tumor necrosis factor-α) and cardiac troponin I in the N-CM group compared with the vehicle group. (researchsquare.com)
  • Studies have shown that endothelial cells (ECs) are the direct targets of hypoxia and are involved in the pathogenesis process of HPH leading to cell hyperproliferation, inhibition of apoptosis and plexiform intima injuries (Ranchoux et al. (biomedcentral.com)
  • Apoptosis refers to the self-regulated and orderly death of cells controlled by genes in order to maintain the stability of internal environment ( 8 ). (spandidos-publications.com)
  • The expressions of retinal GLP-1R, mitochondria-dependent apoptosis-associated genes, reactive gliosis markers, and endoplasmic reticulum stress-related pathway genes were studied by western blotting and immunohistochemistry in vivo and in vitro. (molvis.org)
  • Related proteins or genes were detected with Western blot or real time PCR, respectively, in the cell lysates. (biomedcentral.com)
  • Bone cells can sense physical forces and convert mechanical stimulation conditions into biochemical signals that lead to expression of mechanically sensitive genes and proteins. (biomedcentral.com)
  • However, it is still poorly understood how genes and proteins in bone cells are orchestrated to respond to mechanical stimulations. (biomedcentral.com)
  • By carefully developing protein selection filters and statistical models, we were able to identify 42 proteins representing 21 Rat genes that were significantly associated with bone cells' response to quantitative changes between normal loading and fatigue loading conditions. (biomedcentral.com)
  • We further applied network biology techniques by building a fatigue loading activated protein-protein interaction subnetwork involving 9 of the human-homolog counterpart of the 21 rat genes in a large connected network component. (biomedcentral.com)
  • It still remains unknown what all the mechanically-sensitive genes and proteins in bone cells under mechanical stress are and how their differential expressions are regulated [ 4 ]. (biomedcentral.com)
  • As opposed to other styles of muscles dystrophy, where mutations take place in genes encoding structural protein, calpainopathy was the initial reported kind of dystrophy predetermined by mutations within a gene encoding a proteolytic enzyme. (exposed-skin-care.net)
  • Hsp90 consumer proteins that influence p53 stability include Mdm2, the E3 ligase that right ubiquitylates and promotes the degradation of p53, Chk1, a downstream kinase of Atm that phosphorylates p53 to disrupt its interaction with Mdm2 and Akt that phosphorylates Mdm2 to enhance p53 accumulation. (cd31-signal.com)
  • Receptor-interacting protein kinase 1 (RIPK1), a key molecule mediating necroptosis and regulated by transforming growth factor β-activated kinase 1 (TAK1), was reported to be associated with cognitive impairment in several neurodegenerative diseases. (imperial.ac.uk)
  • The death receptor pathway plays an important role in cell apoptosis ( 12 ). (spandidos-publications.com)
  • The mitochondrial pathway is also referred to as the endogenous apoptosis pathway ( 15 ). (spandidos-publications.com)
  • The impaired homeostasis and platelet dysfunction implicate alterations in the protein C pathway, which might contribute to the loss of endothelial barrier function in fatal infections. (cdc.gov)
  • Repeated LPS injections induced an up-regulation of complement system protein c1q and distinct microglial phenotype with an enrichment of the complement-phagosome pathway. (imperial.ac.uk)
  • Invasion and metastasis of malignant epithelial cells into normal tissues is accompanied by adaptive changes in the mesenchyme-derived supporting stroma of the target organs. (aacrjournals.org)
  • Analysis of chemically distinct conjugates, resistance models, and biomarkers implicates a unique mode of action, with mitotic arrest and apoptosis of malignant epithelial cells coupled to disruption of fibroblastic and vascular structures. (aacrjournals.org)
  • The key mechanisms underlying myocardial I/R injury include increased intracellular calcium concentration, sudden generation of reactive oxygen species (ROS) and inflammatory cytokines, adenosine triphosphate (ATP) depletion, and development of metabolic acidosis. (researchsquare.com)
  • All of these factors are known to result in myocardial apoptosis(5) and the acceleration of allograft rejection or chronic allograft dysfunction. (researchsquare.com)
  • They, are as follows:15 Increased oxygen consumption Ventricular dyssynchrony Tachycardia-induced cardiomyopathy Alterations in intracellular calcium and membrane ionic currents Hemodynamic impairment Alteration in coronary heart price dynamics Myocardial and peripheral vascular autonomic dysregulation. (dnahelix.com)
  • Recent research has shown that they not only have important effects on the endocrine system, but also promote vascular development and maintain the homeostasis of myocardial cells. (bvsalud.org)
  • LPS (also referred to as endotoxin) is one of the important virulence factors that is known to mediate inflammation and apoptosis ( 2 ). (spandidos-publications.com)
  • Our data show that treatment with FIN improves kidney and vascular damage in a new rat model of DKD with T1D associated with a reduction in inflammation, fibrosis and osteogenic factors independently from changes in glucose homeostasis. (met-vasc.com)
  • The complete blood count, erythrocyte sedimentation rate, and C-reactive protein level may show evidence of acute inflammation in patients with DCM in the presence of active myocarditis. (medscape.com)
  • We review the possible roles for calorie restriction (CR) and very low carbohydrate ketogenic diets (KDs) in modulating the five R's of radiotherapy to improve the therapeutic window between tumor control and normal tissue complication probability. (springer.com)
  • The present study was undertaken to determine the antitumor effects of an antibody-conjugate against fibroblast activation protein-α, a cell surface protease of activated tumor fibroblasts. (aacrjournals.org)
  • We show that loss of the DNA repair protein XPA markedly augments the synthetic lethality between MK2 and p53, enhancing anti-tumor responses alone and in combination with cisplatin chemotherapy. (nature.com)
  • Because most tumors are deficient in one or more aspects of the function of the p53 tumor suppressor, either as a consequence of mutations within p53, or impairment of upstream and downstream modulators of p53 activity 19 , targeting MK2 has the potential to selectively enhance tumor cell killing without increasing the genotoxic effects of chemotherapy on normal p53-wild type tissues. (nature.com)
  • Programmed cell death protein-1 (PD-1) checkpoint immunotherapy efficacy remains unpredictable in glioblastoma (GBM) patients due to the genetic heterogeneity and immunosuppressive tumor microenvironments. (elifesciences.org)
  • Thrombocytopenia is a common feature of hemorrhagic fevers and vascular permeability disorders ( 8 ), but the decrease in platelet counts in acute LF is not low enough to cause spontaneous hemorrhage. (cdc.gov)
  • In this review, we discuss the potential influence of stromal vascular fraction from adipose tissue in the management of alopecia as well as its involvement in preclinical and clinical trials. (jcadonline.com)
  • Adipose tissue is a loose connective tissue composed of cells supported by an intracellular matrix as well as by vascular, lymphatic, and neural networks. (jcadonline.com)
  • 11 However, the greater the abundance of adipose tissue in the human body, the significantly higher the yield of MSCs is compared to other tissues. (jcadonline.com)
  • Blood pressure, pulse wave velocity (PWV) and arterial collagen deposition were lower in D-FIN, associated to an improvement in endothelial function due to a reduction in pro-contractile prostaglandins, as well as reactive oxygen species (ROS) and inflammatory cytokines (IL-1, IL-6, TNFα and TGFβ) in perivascular and perirenal adipose tissue (PVAT and PRAT, respectively). (met-vasc.com)
  • Angiotensin II type 2 receptor as a novel activator of brown adipose tissue in obesity. (met-vasc.com)
  • Electron transport chain (ETC), oxidative phosphorylation, and UCP1 proteins were measured in the interscapular BAT (iBAT) and thoracic perivascular adipose tissue (tPVAT) as well as inflammatory and oxidative parameters. (met-vasc.com)
  • The power of the thiol proteinases to cleave a multitude of substrates in response to calcium mineral activation allows their involvement in a variety of cell processes offering cell motility, sign transduction, apoptosis, cell differentiation and legislation of the cytoskeleton (3). (exposed-skin-care.net)
  • The results of CCK‑8 and flow cytometric analyses showed that pretreatment of HUVECs with NAC or p38MAPK inhibitor (SB203580) attenuated LPS‑induced decrease in cell viability and increase in cell apoptosis. (spandidos-publications.com)
  • A series of caspases proteins have been shown to be activated by the death induced signal complex [a form of death ligand that binds to the corresponding death receptor on the cell surface ( 13 )], which in turn induces apoptosis. (spandidos-publications.com)
  • A TdT-mediated dUTP nick-end labeling (TUNEL) assay was used to identify cell apoptosis. (frontiersin.org)
  • P-selectin, soluble endothelial protein C receptor, soluble thrombomodulin, plasminogen activator inhibitor 1, ADAMTS-13, von Willebrand factor, tissue factor, soluble intercellular adhesion molecule 1, and vascular cell adhesion molecule 1 were more elevated in LF patients than in controls. (cdc.gov)
  • Pathologic changes seen on autopsy lack major cell and tissue injury but include signs of pleural effusion, pulmonary edema, ascites, and gastrointestinal mucosa bleeding ( 5 , 6 ), all indications of systemic vascular leakage. (cdc.gov)
  • p62 is a multifunctional protein that mediates cell signaling pathways, autophagy and tumorigenesis, and participates in important regulation processes at the intersection between autophagy and cancer. (spandidos-publications.com)
  • Cells overexpressing p62 showed a higher cell death rate than cells not expressing this protein. (spandidos-publications.com)
  • The resulting damage cannot be overcome by the antioxidant system to protect the cell from oxidative damage, leading to necrosis, apoptosis, or autophagy of the target cell and tissue ( 10 , 11 ). (spandidos-publications.com)
  • E4 may protect retinal cells from diabetic attacks by activating GLP-1R, decreasing retinal cell apoptosis, and reducing retinal reactive gliosis. (molvis.org)
  • CD31 (platelet endothelial cell adhesion molecule-1, PECAM-1) is an inhibitory coreceptor involved in regulation of T cell and B cell signaling by a dual immunoreceptor tyrosine-based inhibitory motif (ITIM) that upon associated kinases-mediated phosphorylation provide docking sites for protein-tyrosine phosphatases. (thermofisher.com)
  • however, a variety of other cell types are found as well, collectively labeled as stromal vascular fraction (SVF). (jcadonline.com)
  • It has been found that some of the SVF cell types possess regenerative and anti-inflammatory potentials in damaged tissues due to their ability to secrete growth factors and anti-inflammatory molecules. (jcadonline.com)
  • 43 Therefore, cell sheets with enhanced thickness and mechanical properties obtained through appropriate cyclic mechanical stimulation possess great potential for bone tissue engineering applications. (researchgate.net)
  • Cell sheet-based scaffold-free technology holds promise for tissue engineering applications and has been extensively explored during the past decades. (researchgate.net)
  • Findings from this study reveal that thermo-responsive elastomer, together with mechanical conditioning, can potentially be applied to prepare high-quality cell sheets for bone tissue engineering. (researchgate.net)
  • This protein is ubiquitously expressed and known to confer toxicity to multiple cell types. (bmj.com)
  • The use of fetal bovine serum (FBS) as a cell culture supplement is discouraged by regulatory authorities to limit the risk of zoonoses and xenogeneic immune reactions in the transplanted host. (biomedcentral.com)
  • Levels of cleaved-caspase3, 8-OHdG, and S100A4 were measured in airways and associated vessels to evaluate cell apoptosis, oxidant stress, epithelial-to-mesenchymal transition (EMT), and endothelial-to-mesenchymal transition (EndMT)-associated factors. (biomedcentral.com)
  • UA decreased oxidant stress and cell apoptosis in airway and accompanying vascular walls of cigarette smoke-induced emphysema model rats. (biomedcentral.com)
  • To enhance PD-1 inhibitor nivolumab efficacy, we co-administered a CSF-1R inhibitor BLZ945 to ablate CD163+ M2-TAMs and strengthened CD154+CD8+ T-cell functionality and GBM apoptosis on-chip. (elifesciences.org)
  • 5. Moritz DR, Rodewald H, Gheyselinck J, Klemenz R. The IL-1 receptor-related T1 antigen is expressed on immature and mature mast cells and on fetal blood mast cell progenitors. (southernbiotech.com)
  • To study the potential role in this metabolic shift of von Hippel-Lindau (VHL), a protein component of a ubiquitin ligase complex, the authors generated nephron progenitor cell-specific VHL knockout mice. (lww.com)
  • Oxidative stress has been shown to correlate with increasing protein toxicity, linking loss of protein, accumulation of ROS, and protein aggregate formation. (spandidos-publications.com)
  • Additionally, immunohistochemistry (IHC) was performed in multiple ovarian cancers, benign tumours and normal tissues to evaluate Gli2 and MMP-7 protein expression. (jcancer.org)
  • Meanwhile, patients with moderate or severe COPD often show pronounced pulmonary vascular remodeling, leading to pulmonary hypertension and pulmonary heart disease, which are directly related to patient prognosis. (biomedcentral.com)
  • 2007 ). Therefore, dysfunctional ECs are important players in the imbalance of pulmonary vascular homeostasis and the pathogenesis of HPH. (biomedcentral.com)
  • LF could be characterized as a disease of enhanced vascular permeability but the underlying pathophysiology remains ambiguous. (cdc.gov)
  • vasculogenesis and vascular permeability and has been implicated in the pathogenesis of pre-eclampsia. (who.int)
  • it is also affected by venous return, peripheral vascular tone, and neurohumoral factors. (msdmanuals.com)
  • A novel antibody-maytansinoid conjugate, monoclonal antibody (mAb) FAP5-DM1, was developed to target a shared epitope of human, mouse, and cynomolgus monkey fibroblast activation protein-α, enabling preclinical efficacy and tolerability assessments. (aacrjournals.org)
  • 3. Vaine M, Wang S, Hackett A, Arthos J, Lu S. Antibody responses elicited through homologous or heterologous prime-boost DNA and protein vaccinations differ in functional activity and avidity. (southernbiotech.com)
  • The periodontium of periodontitis patients contains citrullinated proteins which may play a role in ACPA (anti-citrullinated protein antibody) formation. (southernbiotech.com)
  • population: The state of phosphorus using a pack of illustration, metabolic or metastatic, been by a randomized condition for Protein and reduced antibody to have to diseases. (siriuspixels.com)
  • In heart to the verbalization in modifying constitution leads, the tissue of d natriuretic represents its intracellular muscle. (worldclassbows.com)
  • This 130-140 kDa surface protein is expressed by endothelial cells and at low levels on leukocytes and platelets. (thermofisher.com)
  • Objectives Seeking to elucidate the origin of these vascular and BBB abnormalities, we studied platelets that are known to play a role in maintaining the integrity of the vasculature and thrombotic pathways linked to this, given they surprisingly contain the highest concentration of mHtt of all blood cells. (bmj.com)
  • Platelet activation allows binding of these proteins, which bridges adjacent platelets. (medscape.com)
  • Vascular reactivity and western-blot assays were performed in the thoracic aorta. (met-vasc.com)
  • Losmapimod effectively improved memory, reduced the frequency of seizures, protected the neuron from damage, and limited the apoptosis of neurons in epilepsy rats. (frontiersin.org)
  • We harvested ulna midshafts and isolated proteins from the control, loaded, and fatigue loaded Rats. (biomedcentral.com)
  • It is one of key regulatory molecules in vascular system. (thermofisher.com)
  • Moreover, the early stage of atherosclerosis is associated with increased levels of ox-LDL, oxidative stress, adhesion molecules and inflammatory cytokines in the vascular endothelium [ 6 - 8 ]. (biomedcentral.com)
  • The measurement of serum testosterone in women is difficult with most automated immunoassays because of poor sensitivity, accuracy and precision at low concentrations. (endocrine-abstracts.org)
  • The use of fetal bovine serum (FBS) and other animal derivatives for the ex-vivo expansion of MSCs has been discouraged by regulatory authorities [ 12 - 14 ] to reduce the risk of transmitting prions and other zoonoses and to avoid xenogeneic immune reactions in the host. (biomedcentral.com)
  • ABSTRACT We evaluated the prognostic value of serum endostatin and vascular endothelial growth factor (VEGF) for diagnosis of pre-eclampsia. (who.int)
  • Novel vascular lesions in mice given a non-peptide vitronectin receptor antagonist. (southernbiotech.com)
  • 4673 The protein C zymogen is activated when it binds to thrombin, another protein heavily involved in coagulation, and protein C's activation is greatly promoted by the presence of thrombomodulin and endothelial protein C receptors (EPCRs). (wikipedia.org)
  • Endothelial protein C receptor, thrombomodulin, intercellular adhesion molecule 1, plasminogen activator inhibitor 1, D-dimer, and hepatocyte growth factor were higher in fatal than nonfatal LF cases. (cdc.gov)
  • Klotho, an anti-aging protein, has been reported to protect against atherosclerosis and ameliorate endothelial dysfunction in vivo. (biomedcentral.com)
  • in 1960, who gave protein C its original name, autoprothrombin II-a.: 6822 Protein C was first isolated by Johan Stenflo from bovine plasma in 1976, and Stenflo determined it to be a vitamin K-dependent protein. (wikipedia.org)
  • The mRNA levels of Gli2 and MMP-7 in normal ovarian tissues and cancerous tissues in various stages together with the corresponding clinical information were acquired from the indicated GEO datasets to elucidate associations between MMP-7 expression and cancer progression and prognosis. (jcancer.org)
  • IHC analysis demonstrated abnormally increased Gli2 and MMP-7 expression levels in benign tumours and ovarian cancer tissues. (jcancer.org)
  • 34 : 3162 Because of the crucial role that protein C plays as an anticoagulant, those with deficiencies in protein C, or some kind of resistance to APC, suffer from a significantly increased risk of forming dangerous blood clots (thrombosis). (wikipedia.org)
  • Objective: Androsterone glucuronide (ADTG) concentrations have been suggested as a more reliable marker of the effects of androgen at the target tissue level and is significantly elevated in hirsute compared to non-hirsute women with PCOS. (endocrine-abstracts.org)
  • The protein levels of AMPKα, p-CREB and antioxidant systems (heme oxygenase-1 (HO-1) and catalase) were significantly reduced in HF but normalized in HF-Chow mice. (met-vasc.com)
  • In the diabetic rat Achilles tendon, NOX1 protein expression and mRNA expression of NOX1, IL-6, MMP-2, TIMP-2, and type III collagen were significantly lower while type I collagen expression was significantly higher in the DHEA group than in the control group. (biomedcentral.com)
  • In co-cultivated supernatants, the concentration of inflammatory factors in the experimental group was significantly lower than that in the control group, while that of immunosuppressive factors was significantly higher. (frontiersin.org)
  • Resistin significantly promoted the expression of inflammatory proteins in AML cells. (frontiersin.org)
  • first associated protein C deficiency with symptoms of venous thrombosis. (wikipedia.org)
  • It relates targeted that the venous information of L-arginine can Determine living in controls discharged by exercise-related improvement, that was blood of Larginine as a Source for advances can form in EC tissue somatic to environment of albumin failure( SOA) and anti-fibrotic 31-AUG-2006 organ interventions and that obesity with sensory L-arginine can be EC reticulum. (siriuspixels.com)
  • Protein C, also known as autoprothrombin IIA and blood coagulation factor XIX,: 6822 is a zymogen, that is, an inactive enzyme. (wikipedia.org)
  • In Sierra Leone during 2015-2018, we assessed LF patients' day-of-admission plasma samples for levels of proteins necessary for coagulation, fibrinolysis, and platelet function. (cdc.gov)
  • The power from apical to required compound is introduced by diastolic specific Canadian metalloproteinases, clicking a calcium in the unit ventricular end fetal diet from currently this834 weak Body( FAO) to the more vascular muscle, a heart of congestive state. (worldclassbows.com)
  • The congestive venules of entire proteins will select such contraction, whether or then their process directs. (siriuspixels.com)
  • PDT uses a modality-based photosensitizer, which selectively affects cancer cells, using excitation and light-absorption in the presence of oxygen to produce a high concentration of reactive oxygen species (ROS), such as singlet oxygen and other free radicals ( 7 - 9 ). (spandidos-publications.com)
  • Reactive oxygen species (ROS) production, apoptosis, and messenger RNA (mRNA) expression of NADPH oxidase (NOX) 1 and 4, and interleukin-6 (IL-6) were determined. (biomedcentral.com)
  • 50 Moreover, the mechanical properties of engineered tissues can also be improved by culturing under mechanical stimulation. (researchgate.net)
  • We have recently reported that HD brains are also characterised by vascular abnormalities, which include changes in blood vessel density/diameter as well as increased blood-brain barrier (BBB) leakage. (bmj.com)
  • The alpha granules contain hemostatic proteins such as fibrinogen, vWf, and growth factors (eg, platelet-derived growth factor and transforming growth factors). (medscape.com)
  • The accumulation of plaque then narrows the artery and impedes blood delivery to the body, which directly causes shortages in oxygen and nutrientsin various tissues. (biomedcentral.com)
  • This treatment is used to hasten tissue recovery and improve its physiological aspects, by providing an increased supply of oxygen to the damaged tissue. (mdpi.com)
  • The use of bone tissue engineering scaffold material, which can provide a microenvironment for bone regeneration, is an effective alternative strategy to support bone regeneration [ 6 ]. (biomedcentral.com)
  • Binding of CAPN3 to titin, a huge myofibrillar proteins that acts as a scaffold for sarcomeric. (exposed-skin-care.net)
  • In this research, we applied integrated proteomics, statistical, and network biology techniques to study proteome-level changes to bone tissue cells in response to two different conditions, normal loading and fatigue loading . (biomedcentral.com)
  • 3161, 6 Near the end of that year, Drotrecogin alfa (activated), a recombinant human activated protein C, became the first drug approved by the U.S. FDA for treating severe sepsis. (wikipedia.org)
  • These microorganisms are long patients( severe concentrations) which may characterize specific displacement of print the impact of electronic presence. (worldclassbows.com)
  • It is thought that vascular insuf- pre-eclampsia, and 24 patients with severe ficiencies during placentation contribute pre-eclampsia). (who.int)
  • RESULTS: Our results confirmed that maternal apelin concentration was increased in women with preeclampsia, but APJ expression was reduced in the preeclamptic placentas. (bvsalud.org)
  • Increased low density lipoprotein (LDL) and its oxidative form, oxidized low density lipoprotein (ox-LDL), inthe vascular sub-endothelium is characteristic of atherogenesis. (biomedcentral.com)
  • Demographic and that this particular family of angiogenic clinical data were collected during routine proteins plays an important role in placental obstetric visits. (who.int)
  • 17-DMAG induced an accumulation of p53 protein but not RNA, implicating regulation of p53 turnover. (cd31-signal.com)
  • Because of EPCR's role, activated protein C is found primarily near endothelial cells (i.e., those that make up the walls of blood vessels), and it is these cells and leukocytes (white blood cells) that APC affects. (wikipedia.org)
  • However, few studies have investigated LPS-induced apoptosis of vascular endothelial cells. (spandidos-publications.com)
  • The apoptosis of endothelial cells is a key event that may impair the integrity of the vessel wall and lead to the formation of atherosclerotic plaques ( 9 ). (spandidos-publications.com)
  • CD31 is expressed ubiquitously within the vascular compartment and is located mainly at junctions between adjacent cells. (thermofisher.com)
  • If this had been the situation, the broken Atm_/_ cells would fail to engage G1 arrest and progress by means of S-phase, major alternatively to Atr-dependent stalled replication forks and an increase in p53-dependent apoptosis in lieu of DNA repair. (cd31-signal.com)
  • En face co-immunostaining of the mouse aortic arch revealed a low level of PDCD4 in endothelial cells undergoing pulsatile shear stress. (plos.org)
  • Vascular endothelial cells, as a monolayer in direct contact with the flowing blood, bear the most of the wall shear stresses and have important homeostatic functions in response to stress [16] . (plos.org)
  • Quantitative reverse transcription polymerase chain reaction (qRT-PCR) was used to evaluate mRNA expression, and immunoblotting (IB) was conducted to evaluate protein expression. (jcancer.org)
  • NOX1 and NOX4 protein expression and mRNA expression of NOX1, NOX4, IL-6, matrix metalloproteinase (MMP)-2, tissue inhibitors of matrix metalloproteinase (TIMP)-2, and type I and III collagens in the Achilles tendon were determined. (biomedcentral.com)
  • Lipopolysaccharide (LPS) can regulate the expression of apoptotic factors, including caspase‑3, Bcl‑2 and Bcl‑2‑associated X protein (Bax). (spandidos-publications.com)
  • The expression of caspase‑3, Bax, Bcl‑2, phosphorylated (p)‑p38MAPK/total (t‑)p38MAPK and p‑endothelial e nitric oxide synthase (eNOS)/t‑eNOS proteins were determined by western blotting. (spandidos-publications.com)
  • It also downregulated the expression of glial fibrillary acidic protein and reduced retinal reactive gliosis. (molvis.org)
  • In addition, apelin-13 suppressed CoCl2-induced apoptosis by increasing the expression of bcl-2/bax ratio and by decreasing the expression of active caspase-3 in placental trophoblasts. (bvsalud.org)
  • Tissue expression and subcellular localization of the pro-survival molecule Bcl-w. (southernbiotech.com)
  • 11. de Haas AH, Boddeke HW, Biber K. Region-specific expression of immunoregulatory proteins on microglia in the healthy CNS. (southernbiotech.com)
  • In 2002, Science published an article that first showed protein C activates protease-activated receptor-1 (PAR-1) and this process accounts for the protein's modulation of the immune system. (wikipedia.org)
  • Vascular growth during implantation normal non-pregnant controls, 20 normal and placentation is critical for successful pregnant controls, 20 patients with mild gestation. (who.int)