• In tumor cells, the drug induces 15-fold lower interstrand DNA cross-linking efficiency than cisplatin. (wikipedia.org)
  • We predict that HBx/miR-221-mediated CXCL12/CXCR4 signaling induces NKT cells to promote HBV-related HCC. (techscience.com)
  • This suggests that plumbagin induces apoptosis in both HCT15 cells and HT29 treated. (theinterstellarplan.com)
  • plumbagin induces apoptosis in colonic cancer cells through TNF-α mediated pathway depending on expression of COX-2 expression. (theinterstellarplan.com)
  • We may conclude that CTX induces apoptosis and autophagy in HT-29 KRK cells through raising the expression of p21, p27 , and p57 genes, as well as ATG4A, LC3A , and BECN1 genes. (natprobiotech.com)
  • Therefore, this study proves that Rh4 inhibits cancer cell proliferation by activating the ROS/p53 signaling pathway and activating autophagy to induce ferroptosis, which provides necessary scientific evidence of the great anticancer potential of Rh4. (hindawi.com)
  • Inhibition of cell viability was assessed with focus on apoptosis transcriptionally and translationally. (hindawi.com)
  • It further inhibited cell-cycle progression in the G1 phase by four different mechanisms: rapid downregulation of cyclin D1, induction of Chk2 with simultaneous downregulation of Cdc25A, induction of the Cdk-inhibitor p21 Cip/Waf and inhibition of ribonucleotide reductase activity resulting in reduced dCTP and dTTP levels. (nature.com)
  • Activation of TRPV1 by capsaicin caused significant inhibition of cancer cell growth and induced apoptosis and necrosis. (dovepress.com)
  • Conclusion: Combination of fucoidan with silencing of PrP c has a synergic effect on the inhibition of HT29 colon cancer cell growth. (iiarjournals.org)
  • These include regulation of cell cycle, activation of mitochondrial pathway, induction of mitochondrial outer membrane permeabilization, induction of apoptosis, modulation of oxidative stress, amelioration of inflammation, modulation of insulin signaling and inhibition of angiogenesis. (mdpi.com)
  • consequently, genes encoding some of these proteins are being used to design constructs for the inhibition of multiplying cancer cells. (weeksmd.com)
  • Abaza L, Talorete TP, Yamada P, Kurita Y, Zarrouk M, Isoda H (2007) Induction of growth inhibition and differentiation of human leukemia HL-60 cells by a Tunisian gerboui olive leaf extract. (springer.com)
  • In this next study they investigated the mechanism of human prostate cancer cell growth inhibition by plumbagin, a constituent of the widely used medicinal herb Plumbago zeylanica L. (theinterstellarplan.com)
  • BDNF/TrkB signaling protects HT-29 human colon cancer cells from EGFR inhibition. (natprobiotech.com)
  • In the present study the effect of IP6 on autophagy-mediated death by modulating the mTOR pathway in HT-29 colon cancer cells was studied. (um.edu.my)
  • mTOR pathway regulates autophagy and incubation with IP6 to HT-29 cells showed decreased expression of p-70S6Kinase, 4-EBP-1 in a time-dependent manner. (um.edu.my)
  • Colorectal cancer cells are resistant to anti-EGFR monoclonal antibody through adapted autophagy. (natprobiotech.com)
  • Anti-EGFR antibody sensitizes colorectal cancer stem-like cells to Fluorouracil-induced apoptosis by affecting autophagy. (natprobiotech.com)
  • KP1019 and KP1339 both induce apoptosis in colorectal tumor cell lines SW480 and HT29. (wikipedia.org)
  • In fact, many studies have demonstrated the oleuropein and its derivative have proved pharmacological activity against proliferation of cancer cells and several tumor cell lines by different mechanisms such arrest cell cycle and cause apoptosis in cancerous cells, by modulation of miRNA expression and upregulation and downregulation of several genes. (springer.com)
  • In the present study, we aimed to further examine the potential of formononetin in controlling angiogenesis and tumor cell invasiveness in human colon cancer cells and tumor xenografts. (spandidos-publications.com)
  • These findings suggest that formononetin inhibits angiogenesis and tumor cell invasion, and thus support its use in the treatment of advanced and metastatic colon cancers. (spandidos-publications.com)
  • Silencing of the EBF3 locus was observed in brain, colorectal, breast, liver, and bone tumor cell lines and its reactivation was achieved on treatment with 5-aza-2′-deoxycytidine and trichostatin A in a significant portion of these tumor cells. (aacrjournals.org)
  • Results: Fucoidan treatment significantly inhibited growth and reduced cyclin and cyclin-dependent kinase (CDK) expression in HT29 colon cancer cells. (iiarjournals.org)
  • The expression of cyclin-dependent kinase inhibitors was profoundly affected with early activation and then repression of p21 cip1/waf1 and persistent activation of both p27 kip1 and p57 kip2 , whereas genes involved in cell survival and proliferation were suppressed. (aacrjournals.org)
  • Human colonic ADENOCARCINOMA cells that are able to express differentiation features characteristic of mature intestinal cells such as the GOBLET CELLS. (umassmed.edu)
  • In this study we investigated the anti-proliferative and apoptotic activity of plumbagin by using two human colonic cancer cell lines, HT29 and HCT15. (theinterstellarplan.com)
  • It is of interest to explore the inhibitory effect of adenine on the growth of colorectal cancer cells and to determine the underlying mechanism. (hindawi.com)
  • We explored the possible mechanisms underlying the anticancer activity of adenine in colorectal cancer cells. (hindawi.com)
  • Enhancement by Nano-Diamino-Tetrac of Antiproliferative Action of Gefitinib on Colorectal Cancer Cells: Mediation by EGFR Sialylation and PI3K Activation. (umassmed.edu)
  • Adding lunasin to IL-12- or IL-2-stimulated NK cells demonstrated synergistic effects in the induction of IFNG and GZMB involved in cytotoxicity. (weeksmd.com)
  • Apoptosis induction of the essential oil from the leaf of Pycnocycla bashagardiana Mozaff. (icbcongress.com)
  • To decrease side effects from non-specific cytotoxicity, new drugs, such as targeted agents, are being developed to selectively destroy specific cancer cells. (jcpjournal.org)
  • The underlying mechanism responsible for the effects of lunasin on NK cells is likely due to epigenetic modulation on target gene loci. (weeksmd.com)
  • In the present study, we investigated the anticancer effects of adenine and the underlying mechanism in colon cancer cells. (hindawi.com)
  • Anticancer activity of adenine in colon cancer cells is attributable to the activation of apoptotic signaling and in turn the AMPK/mTOR pathway. (hindawi.com)
  • Recently, adenine has been explored for its anticancer property in several types of cancer cell lines. (hindawi.com)
  • Materials and Methods: PrP c expression was suppressed in HT29 human colon cancer cells by utilizing small-interfering RNA (si-PRNP), and cells were subsequently used to study the antiproliferative and anticancer effects of fucoidan treatment of HT29 human colon cancer cells. (iiarjournals.org)
  • The leaf extracts and its derivative compounds have shown potent anticancer effects against different cell lines in different organs. (springer.com)
  • Human colon adenocarcinoma (Caco-2) and human embryonic kidney (HEK-293) cells were maintained and treated with various concentrations (0, 20, 40, 80, 100 and 120 mg/l) of K. africana, M. zehyeri and X. caffra seed oil. (iiarjournals.org)
  • Finally, the oligosaccharides were added at various concentrations to cultured human HT29 colon cancer cells, while a common chemo drug was added to others. (nutritionnews.com)
  • Human non-small cell lung cancer cell lines A549, H292 and H460 were treated with various concentrations of plumbagin. (theinterstellarplan.com)
  • Results: Incubation of cells with IP6 resulted in downregulation of the p-Akt at 3h. (um.edu.my)
  • Moreover, subsequent co-cultivation of the NK cell product with the patient's serum resulted in a decrease in the proportion of cytotoxic subpopulations of NK cells and a downregulation of the expression of NK-mediated killing molecules. (bvsalud.org)
  • Receptor interacting protein 1 kinase (RIPK1) is a key mediator of not only a process of regulated necrosis, termed necroptosis, but also promotion of caspase-8-dependent apoptosis and pro-inflammatory gene expression 13 . (nature.com)
  • The data showed that adenine activated AMP-activated protein kinase (AMPK) signaling contributing to autophagic cell death through mTOR in both colon cancer cell lines. (hindawi.com)
  • Pelicano H, Zhang W, Liu J, Hammoudi N, Dai J, Xu RH, Pusztai L and Huang P: Mitochondrial dysfunction in some triple-negative breast cancer cell lines: Role of mTOR pathway and therapeutic potential. (spandidos-publications.com)
  • Chemotherapy is known to cause side effects because it damages not only cancerous cells but healthy cells. (jcpjournal.org)
  • A male patient diagnosed with moderately low-differentiated squamous cell carcinoma received diverse treatments, including radiotherapy, chemotherapy, immunotherapy, and targeted therapy to inhibit angiogenesis. (bvsalud.org)
  • Therefore, we tested both IP6 and Ins individually and in combination on human cell lines HT-29, SW-480 and SW-620 derived from colorectal carcinoma in different stages of malignancy. (nih.gov)
  • Paclitaxel enhances the effects of the anti-epidermal growth factor receptor monoclonal antibody ImClone C225 in mice with metastatic human bladder transitional cell carcinoma. (natprobiotech.com)
  • This is induced predominantly by a loss of mitochondrial membrane potential in a high percentage of cells. (wikipedia.org)
  • The present results suggested that 3‑BrPA promoted TXNIP protein expression and reduced HK2 expression in TNBC cells by downregulating c‑Myc expression, inhibiting glycolysis including suppressing lactate generation, intracellular ATP generation and HK activity, inducing mitochondrial‑mediated apoptosis and eventually suppressing TNBC cell proliferation. (spandidos-publications.com)
  • We found that all employed concentrations of IP6 or IP6/Ins decreased proliferation of the cell lines, with the maximum decrease being observed in HT-29 cells. (nih.gov)
  • K. africana oil significantly suppressed Caco-2 cell growth compared to HEK-293 cell growth at all oil concentrations, whereas M. zeyheri and X. caffra seed oils significantly suppressed HEK-293 and Caco-2 cell growth, only at a concentration of 80 mg/l. (iiarjournals.org)
  • In every test using different concentrations, oligosaccharides induced programmed cell death ( apoptosis ) at greater levels than the chemo drug . (nutritionnews.com)
  • The transferrin protein binds to the transferrin receptor and is taken into the cell by endocytosis. (wikipedia.org)
  • This protein and its receptors are overexpressed in cancer cells owing to their increased demand for iron, and it is believed that Tf transport is the reason ruthenium compounds accumulate in tumors. (wikipedia.org)
  • Protein activation and expression were analysed by western blotting, deoxyribonucleoside triphosphate levels by HPLC, ribonucleotide reductase activity by 14 C-cytidine incorporation into nascent DNA and cell-cycle distribution by FACS. (nature.com)
  • The cellular thermal shift assay (CETSA) has recently been reported to monitor the binding of ligand to its target protein in cells and tissue samples. (nature.com)
  • Background: The putative functions of the cellular prion protein (PrP c ) are believed to be associated with cell signaling, differentiation, survival, and cancer progression. (iiarjournals.org)
  • Moreover, a significant increase in the action of a protein associated with programmed cell death (apoptosis). (nutraingredients.com)
  • Thioredoxin‑interacting protein (TXNIP) competes with c‑Myc to reduce glucose consumption in tumor cells to restrain cell proliferation. (spandidos-publications.com)
  • The effect of tested chemicals on the cells was measured using metabolic activity assay (WST-1), DNA synthesis assay (BrdU), protein synthesis assay (Brilliant Blue) and apoptosis (caspase-3 activity). (nih.gov)
  • KP1019 does not appear to be susceptible to the same cancer cell mechanism of acquiring drug resistance as other metal-based drugs, and remains potent in cell-lines known for their drug resistance. (wikipedia.org)
  • Our established semi-automated system allows evaluation of the structure-activity relationship using native RIPK1 in culture cell lines, and also enables estimation of drug occupancy ratio in mouse peripheral blood mononuclear cells. (nature.com)
  • These effects of honey have been thoroughly investigated in certain cancers such as breast, liver and colorectal cancer cell lines. (mdpi.com)
  • Dr Scharlau and his co-workers used two sets of human colon cell lines, one as a model early stage colon cancer and the other as a model of late stage colon cancer. (nutraingredients.com)
  • One such peptide, Lunasin , has been shown to selectively act on newly transformed cells while having no cytotoxic effect on non-tumorigenic or established cancer cell lines. (weeksmd.com)
  • Subsequent study using multiple human cancer cell lines, including those of the colon, stomach and liver, further indicated the universal growth-inhibitory and pro-apoptotic effects of AST. (spandidos-publications.com)
  • A comparative analysis was performed in the present study in TNBC (HCC1143) and non‑TNBC (MCF‑7) cell lines to explore the effect of 3‑BrPA on energy metabolism in TNBC cells and to investigate the possible mechanism of action. (spandidos-publications.com)
  • In addition, we found maximum increase in caspase-3 activity at concentration 5 mM IP6 or IP6/Ins in HT-29 cells and with IP6 at concentration of 0.2 mM or IP6/Ins in SW-480 cells with clear indication of Ins enhancing the proapoptotic effect of IP6 in all the cell lines studied. (nih.gov)
  • The suppression of Caco-2 and HEK-293 cell proliferation by K. africana, M. zeyheri and X. caffra seed oils suggest a potential antiproliferative effect of these tree seed oils on the two cell lines. (iiarjournals.org)
  • Apoptosis - In this case study they tested the effects of plumbagin on proliferation and apoptosis in non-small cell lung cancer cell lines, and investigate the underlying mechanisms. (theinterstellarplan.com)
  • Colorectal cancer cell lines were treated with different doses of cetuximab to create ten test groups, which were then incubated for 24 and 48 hours. (natprobiotech.com)
  • Expression is particularly high in the pancreas where it is thought to play a role in the differentiation of pancreatic beta cells. (embl.de)
  • Animal-derived oils and purified fatty acids, but not indigenous fruit-tree-derived seed oils, have been used to study cell growth and differentiation. (iiarjournals.org)
  • Role of p27(Kip1) in human intestinal cell differentiation. (natprobiotech.com)
  • Docosahexaenoic acid is a potent inducer of apoptosis in HT-29 colon cancer cells. (harvard.edu)
  • BTC is proteolytically processed from a larger membrane-anchored precursor and is a potent mitogen for a wide variety of cell types. (embl.de)
  • We therefore undertook a preliminary screening study of the three IFBTS seed oils in vitro using human colon adenocarcinoma cells (Caco-2), a commonly used gastrointestinal cell line, and human embryonic kidney (HEK-293), an epithelial immortalised cell line. (iiarjournals.org)
  • Apoptosis was measured by Hoechst 33258/propidium iodide double staining of nuclear chromatin and the formation of gaps into the lymphendothelial barrier in a three-dimensional co-culture model consisting of MCF-7 tumour cell spheroids and human lymphendothelial monolayers. (nature.com)
  • Apoptosis was detected by annexin V/propidium iodide double-labeled flow cytometry and TUNEL assay. (theinterstellarplan.com)
  • Distinct pathways of cell migration and antiapoptotic response to epithelial injury: structure-function analysis of human intestinal trefoil factor. (embl.de)
  • In addition, 3‑BrPA combines with photodynamic therapy to inhibit TNBC cell migration. (spandidos-publications.com)
  • Feng X, Wang P, Liu Q, Zhang T, Mai B and Wang X: Glycolytic inhibitors 2-deoxyglucose and 3-bromopyruvate synergize with photodynamic therapy respectively to inhibit cell migration. (spandidos-publications.com)
  • However, the mechanism by which adenine inhibits the proliferation of cancer cells is sketchy. (hindawi.com)
  • Thus, the secretion of gall wasps stimulates plant cell growth and overrules homeostasis of the affected leaf area - this is similar to tumour outgrowth. (nature.com)
  • Adenine significantly inhibited the viability of colon cancer cells, HT29 and Caco-2 cells, in a dose-dependent manner. (hindawi.com)
  • All three tree seed oils suppressed both Caco-2 and HEK-293 cell growth in a dose-dependent manner. (iiarjournals.org)
  • The yeast strain Saccharomyces cerevisiae serves as a cellular model for KP1019 and manifests induced DNA damage, cell cycle delay, and cell death. (wikipedia.org)
  • In turn, the plant produces GA, which seems to combat the improper growth signals and re-establishes cell-cycle control. (nature.com)
  • Mutation of cell-cycle regulators biological and clinical implications for human neoplasia. (natprobiotech.com)
  • The hypoxic environment of cancer cell tissue facilitates this reduction and the specific action on cancer cells over healthy cells. (wikipedia.org)
  • Transient receptor potential (TRP) channels, which are membranous ion channels that conduct calcium and sodium ions, have been shown to influence cancer cell growth. (dovepress.com)
  • To our knowledge, this is the first report, showing mechanistic and cancer cell specific apoptosis‐inducing effects of plumbagin in breast cancer cells, suggesting the potential role of plumbagin in the prevention and/or treatment of breast cancer. (theinterstellarplan.com)
  • Gene therapy has attracted attention for its potential to specifically and efficiently target cancer cells with minimal toxicity to normal cells. (weeksmd.com)
  • In this study, we investigated the effects of adenine against the proliferation of colon cancer cells. (hindawi.com)
  • Differential innate immune cell signatures and effects regulated by toll-like receptor 4 during murine lung tumor promotion. (harvard.edu)
  • "The present results indicate growth-inhibiting and apoptosis-inducing effects of fermentation supernatant fractions of inulin," ​ concluded the researchers. (nutraingredients.com)
  • With the goal of further improving cytokine-based immunotherapy, we examined the effects of a soybean peptide called lunasin that synergistically works with cytokines on natural killer (NK) cells. (weeksmd.com)
  • In this study, we determined the effects of the Kigelia africana, the Mimusops zeyheri and the Ximenia caffra seed-oil on cell proliferation in culture. (iiarjournals.org)
  • Seventy to eighty percent of cancer patients in chemotherapy experienced side effects such as anemia, the decreased number of white blood cells and/or platelets, oral mucositis, vomiting, diarrhea, hair loss, and disabled generative functions as chemotherapy also affects the rapidly proliferating normal cells. (jcpjournal.org)
  • In this study, stimulation by the TRPV1 agonist, capsaicin, of SUM149PT cells, a model system for the most aggressive breast cancer subtype, triple-negative breast cancer, led to intracellular calcium signals that were diminished by the specific TRPV1 antagonist, capsazepin. (dovepress.com)
  • Another important mechanism for the progression of colorectal cancer is the ability of the transformed cells to invade and traverse the basement membrane, which in turn facilitates the conversion of adenomas into carcinomas and then metastases ( 1 ). (spandidos-publications.com)
  • Asgharzade S, Sheikhshabani SH, Ghasempour E, Heidari R, Rahmati S, Mohammadi M, Jazaeri A, Amini-Farsani Z (2020) The effect of oleuropein on apoptotic pathway regulators in breast cancer cells. (springer.com)
  • Aerobic glycolysis is commonly observed in tumor cells, including triple‑negative breast cancer (TNBC) cells, and the rate of aerobic glycolysis is higher in TNBC cells than in non‑TNBC cells. (spandidos-publications.com)
  • We tested our hypothesis using ER‐positive MCF‐7 and ER‐negative MDA‐MB‐231 (triple negative) breast cancer cells, and we found that plumbagin significantly inhibits the growth of breast cancer cells with no effect on normal breast epithelial cells. (theinterstellarplan.com)
  • Peripheral blood mononuclear cells of healthy donors and post-transplant lymphoma patients were stimulated with or without lunasin in the presence of IL-12 or IL-2. (weeksmd.com)
  • H-29 cells were used for in vitro experiments in this study. (wjgnet.com)
  • In addition, NK cells stimulated with lunasin plus cytokines displayed higher tumoricidal activity than those stimulated with cytokines alone using in vitro and in vivo tumor models. (weeksmd.com)
  • As an inhibitor of HK2, 3‑bromopyruvic acid (3‑BrPA) exhibits good therapeutic efficacy in intrahepatic and extrahepatic tumors and inhibits the proliferation of human tumor cells with high expression levels of c‑Myc in vivo and in vitro . (spandidos-publications.com)
  • METHODS: We used mouse C2C12 cell line and 2-month-old male mice as in vitro and in vivo models, respectively. (bvsalud.org)
  • In vitro investigations demonstrated that the allogeneic NK cell product reduced interleukin-6 levels in the patient's serum. (bvsalud.org)
  • Benzoyl peroxide increases UVA-induced plasma membrane damage and lipid oxidation in murine leukemia L1210 cells. (harvard.edu)
  • Among its different constituents, Astragalus polysaccharides have been most widely studied particularly for their immunopotentiating properties, such as stimulation of murine B cell proliferation and cytokine production ( 6 ). (spandidos-publications.com)
  • Ferroptosis is a novel type of regulated cell death caused by iron-dependent lipid peroxidation [ 26 ]. (hindawi.com)
  • The products of prebiotic fermentation in the gut may prevent the growth, and promote the death of cancer cells in the colon, says a new study from Germany. (nutraingredients.com)
  • Cell Death Dis. (umassmed.edu)
  • Differential roles of RIPK1 and RIPK3 in TNF-induced necroptosis and chemotherapeutic agent-induced cell death. (umassmed.edu)
  • Importantly, the tree seed oils did not cause increased cell death as the number of dead cells remained unchanged under control and oil-treated conditions. (iiarjournals.org)
  • Our findings suggest that adenine inhibits the growth of colon cancer cells. (hindawi.com)
  • "In comparison with HT29 cells, LT97 cells responded more sensitively to the growth-inhibitory activities," ​ wrote the researchers. (nutraingredients.com)
  • Our previous findings demonstrated that formononetin initiates growth-inhibitory and pro-apoptotic activities in human colon cancer cells. (spandidos-publications.com)
  • The trypan blue dye exclusion method was used to determine cell growth 48-hours after oil treatment. (iiarjournals.org)
  • Anti-Cancer - We present here first time that Plumbagin (PL), a medicinal plant‐derived 1,4‐naphthoquinone, inhibits the growth and metastasis of human prostate cancer (PCa) cells in an orthotopic xenograft mouse model. (theinterstellarplan.com)
  • These results suggest that PL inhibits tumor growth and metastasis of human PCa PC3‐M‐luciferase cells, which could be used as a therapeutic agent for the prevention and treatment of human PCa. (theinterstellarplan.com)
  • Epidermal growth factor receptor blockade with C225 modulates proliferation, apoptosis, and radiosensitivity in squamous cell carcinomas of the head and neck. (natprobiotech.com)