• Potential synergistic effects of various combinations including these compounds were tested by measuring cancer cell proliferation and apoptosis. (frontiersin.org)
  • The aim of this study was to characterize the expression of DcR3 in pancreatic carcinoma and to evaluate the role of DcR3 in cell proliferation and apoptosis, which may lead to the development of novel treatments for this disease. (academicjournals.org)
  • 3′-(4, 5 dimethyl-thiazol-2-yl)-2, 5-diphenyl tetrazolium bromide (MTT) assay and flow cytometric analysis were used to measure cell proliferation and apoptosis, respectively in the human pancreatic cancer Capan-1 cells. (academicjournals.org)
  • Gain of function and loss of function experiments showed that PDCD4 induced turnover (proliferation and apoptosis) of HUVECs. (plos.org)
  • PDCD4 induces turnover (proliferation and apoptosis) of HUVECs. (plos.org)
  • New anticancer therapy strategies refer to the inhibition of CDK-cyclin complexes as an important target to prevent uncontrolled proliferation and induce apoptosis in cancer cells ( 2 ). (spandidos-publications.com)
  • Therefore, this study proves that Rh4 inhibits cancer cell proliferation by activating the ROS/p53 signaling pathway and activating autophagy to induce ferroptosis, which provides necessary scientific evidence of the great anticancer potential of Rh4. (hindawi.com)
  • Indeed, distinct from cisplatin, CpR 2TiCl2 failed to perturb cell cycle dynamics, induce γH2AX foci or evoke apoptosis in MDA-MB-468 and HCT-116 cells. (nottingham.ac.uk)
  • All forms of infectious microbes, such as viruses, bacteria and parasites, can induce an inflammatory immune response which, under toxic environmental conditions, can cause cancer cells to grow. (eg.net)
  • CONCLUSIONS: The bioactive compounds of S. miltiorrhiza are shown to inhibit proliferation, metastasis, and angiogenesis, induce apoptosis and autophagy, regulate immunity and tumor microenvironment when combined with chemotherapy drugs. (bvsalud.org)
  • The serine protease Granzyme B (GzB) is primarily expressed by cytotoxic T lymphocytes and natural killer cells, and functions in allowing these cells to induce apoptosis in virally-infected or transformed cells. (biomedcentral.com)
  • The flavonoid kaempferol was reported to induce apoptosis in human HCT116 colon cancer cells. (e-kenkyu.com)
  • In the present study, our aim was to determine the time-dependent, ER-mediated apoptotic and autophagy induction of purvalanol in HCT 116 colon cancer cells. (spandidos-publications.com)
  • however, purvalanol triggered autophagy, which functions as a cell survival mechanism at early time-points. (spandidos-publications.com)
  • Aspirin suppresses proliferation and induces apoptosis and autophagy in colorectal cancer cells, but the precise mechanism is not clear. (oncotarget.com)
  • Collectively, our findings indicate the dual roles of aspirin on autophagy, and demonstrate a new mechanism by which Beclin 1 acetylation impairs the anticancer effect of aspirin in colorectal cancer cells. (oncotarget.com)
  • Substantial evidence indicates aspirin induces apoptosis and autophagy [ 17 - 19 ]. (oncotarget.com)
  • In this study, we investigated the effect of aspirin on Beclin 1 acetylation and autophagy in CRC cells, providing new insight into aspirin for cancer therapy. (oncotarget.com)
  • Taken together, our findings suggest that denbinobin induces apoptosis of human colorectal cancer HCT-116 cells via DNA damage and an AIF-mediated pathway. (tmu.edu.tw)
  • Triple treatment showed synergism in terms of exhibiting anti-tumorigenic effects by activating the Hippo YAP signaling pathway in the HCT116 cell line. (frontiersin.org)
  • IRE1α-XBP1 were essential for expansion of activated mouse and human NK cells and are situated downstream of the mammalian target of rapamycin signaling pathway. (cancerindex.org)
  • VALD-3 also regulated the Wnt/β-catenin signaling pathway in breast cancer cells, inhibiting the activation of downstream molecules. (researchsquare.com)
  • Conclusions These findings ascertained an conversation between p53, c-myc, p21, p27, Bcl-2, PI3K/Akt pathway, and CF-induced apoptosis in MSTO-211H and HCT-116 cells, suggesting that CF acts as an important regulator of cell growth in human malignancy cell lines. (bioinf.org)
  • This study determines the effects of krill oil extract on the migration of human CRC cells, and its potential role in modulating EGFR signalling pathway and the expression of programmed death ligand 1 (PD-L1). (biomedcentral.com)
  • The authors utilized cultured L. plantarum cells to generate a cell-free supernatant that could be used in experiments on cultured HCT116/5FU cells to determine levels of apoptosis, and cellular activity under a range of different conditions including treatment with butyrate and chemotherapy drugs both alone and in combination. (pall.com)
  • Given the fact that ALK+ ALCL exhibits high levels of apoptosis and is typically responsive to conventional chemotherapy, we examined whether GzB expression might play a role in sensitizing ALK+ ALCL tumour cells to apoptosis. (biomedcentral.com)
  • Taken together LCH inhibits the growth of Ox-sensitive and Ox-resistant CRC cells by targeting EGFR and AKT, and inducing ROS generation and ER stress-mediated apoptosis. (biomolther.org)
  • Purvalanol, a novel cyclin-dependent kinase inhibitor, is referred to as a strong apoptotic inducer which causes cell cycle arrest in various cancer cells such as prostate, breast and colon cancer cell lines. (spandidos-publications.com)
  • Cyclin-dependent kinases (CDKs), are members of the serine-threonine protein kinase family and are responsible for taking control of cell cycle regulation in eukaryotic cells. (spandidos-publications.com)
  • Moreover, SMEAF markedly suppressed phosphorylation of Akt, p38 Mitogen-activated protein kinase (MAPK) and Extracellular signal-regulated kinase 1/2 (ERK1/2) in LPS-induced BV-2 cells. (wikipedia.org)
  • Vascular endothelial growth factor receptor-2 (VEGFR2) is a member of the VEGF family of receptor tyrosine kinase proteins, which are expressed on both endothelial and tumor cells, are one of the key proteins contributing to cancer development, and are involved in drug resistance. (researchgate.net)
  • The protein serine/threonine kinase Akt (also known as protein kinase B or PKB) plays an important role in averting cell death. (bioinf.org)
  • GzB expression is also a hallmark of the non-Hodgkin lymphoma, anaplastic lymphoma kinase-positive, anaplastic large cell lymphoma (ALK+ ALCL). (biomedcentral.com)
  • Although, non-psychoactive cannabidiol (CBD) and cannabigerol (CBG) display antineoplastic effects by repressing tumor growth and angiogenesis both in cell line and animal models, their use as chemotherapeutic agents is awaiting further investigation. (frontiersin.org)
  • Transcriptional coactivator Yes-associated protein (YAP) can promote the proliferation of multiple cancer cells, corneal endothelial cells, and vascular smooth muscle cells, which participate in angiogenesis. (molvis.org)
  • Importantly, MS-444 was well tolerated and inhibited xenograft CRC tumor growth through enhanced apoptosis and decreased angiogenesis upon intraperitoneal administration. (oncotarget.com)
  • These findings indicated that SMEAF possesses anti-inflammatory activities in BV-2 cells by modulating LPS-induced pro-inflammatory mediator production via the inhibition of Akt-dependent NF-κB, p38 MAPK and ERK1/2 activation. (wikipedia.org)
  • The extract also showed a dose dependent growth inhibition of all tested cell lines, IC 50 values against HCT-116, HUVEC, CCD-18CO and HT-29 were 14, 23, 50 and 52 μg mL -1 , respectively. (scialert.net)
  • DcR3 protein in our experimental results showed significant expression among the pancreatic cancer cell lines and their decreased expression by lentivirus-mediated shRNA resulted in the inhibition of cell proliferation and augmentation of apoptosis. (academicjournals.org)
  • Activation of TRPV1 by capsaicin caused significant inhibition of cancer cell growth and induced apoptosis and necrosis. (dovepress.com)
  • 2] The authors showed that the acquisition of butyrate resistance in a common strain of 5-FU resistant CRC cells (HCT116/5FU) was strongly correlated with the inhibition of the expression and function of the SMCT1 gene, which encodes a major transporter protein used to transfer butyrate across the cell membrane and into colonic epithelial cells. (pall.com)
  • Increased manifestation levels of p53, p21, and p27, downregulation of c-myc and Bcl-2, and inhibition of Akt activation were also found in CF-treated MSTO-211 and HCT-116 cells. (bioinf.org)
  • The dichloromethane extract from the bark of Aglaia lanuginose showed cytotoxicity against HL-60 leukaemia cell line (45% inhibition) at 20 µg/ml and was prioritised for further investigation. (afpm.org.my)
  • Treatment of CRC cells with MS-444 resulted in growth inhibition and increased apoptotic gene expression, while similar treatment doses in non-transformed intestinal cells had no appreciable effects. (oncotarget.com)
  • In contrast, pf3 barely induced apoptosis despite its strong inhibition of cell proliferation. (e-kenkyu.com)
  • Here, we investigated the anti-proliferative activity present in the methanol extract from M. oleifera leaves toward human HCT116 colon cancer cells. (e-kenkyu.com)
  • Fractionation of the methanol extract from M. oleifera leaves by gel filtration chromatography on Sephadex LH-20 enabled us to find anti-proliferative and apoptosis-inducing activities. (e-kenkyu.com)
  • Compared with kaempferol, pf1, pf2, and pf3 were found to exhibit strong anti-proliferative effects on HCT116 cells. (e-kenkyu.com)
  • Taken together, these results suggest that, in addition to kaempferol, M. oleifera leaves may contain new substances having anti-proliferative and apotosis-inducing activities on HCT116 cells. (e-kenkyu.com)
  • The preliminary study is aimed at evaluating the cytotoxic activity of crude extracts from the stem bark of Canarium odontophyllum against colorectal carcinoma cell HCT 116. (scirp.org)
  • Schistosoma hematobium associated with squamous cell carcinoma of the urinary bladder and the liver flukes Opisthorchis and Chlonorchis associated with cholangiocarcinoma of the bile duct. (eg.net)
  • Programmed cell death 4 (PDCD4) is an important tumor suppressor in the development of various human cancers [1] and inhibits translation rather than transcription. (plos.org)
  • The p53 protein is a transcription factor that normally inhibits cell growth and stimulates cell death in response to myriad stressors, including DNA damage (induced by either UV or chemical agents such as hydrogen peroxide), oxidative stress, and deregulated oncogene expression [6-10]. (bioinf.org)
  • Our previous studies have shown that the free fatty acid extract (FFAE) of krill oil inhibits the proliferation of both CRC and osteosarcoma cells, and induces the apoptosis of CRC cells [ 17 , 18 ]. (biomedcentral.com)
  • Finally in colon cancer cell line (HCT-116) we observed an initially weak inhibitory effect and then plateau. (nih.gov)
  • Using short hairpin RNA (shRNA) against XIAP, stably expressed in a parent HCT116 human colon cancer cell line, a series of clones have been developed. (nih.gov)
  • To isolate the anticancer triterpenes with potent cytotoxicity from marine sponge, Siphonochalina siphonella and state the mode of action in cancer cell lines. (phcog.com)
  • In conclusion, the current study revealed the expression profiles of human TRP channels in 60 different breast cancer tissues and cell lines and furthermore validated the antitumor activity of TRPV1 against SUM149PT breast cancer cells, indicating that activation of TRPV1 could be used as a therapeutic target, even in the most aggressive breast cancer types. (dovepress.com)
  • Our study aimed to determine the inhibitory and also proliferative effects of a methanol plant extract of Siberan ginseng (E. senticosus) on various cancer and normal cell lines including: A-549 (small cell lung cancer), XWLC-05 (Yunnan lung cancer cell line), CNE (human nasopharyngeal carcinoma cell line), HCT-116 (human colon cancer) and Beas-2b (human lung epithelial). (nih.gov)
  • Next, in CNE (human nasopharyngeal carcinoma cell line) there was a dose dependent proliferative response, whereas in Beas-2 (human lung epithelial cell line), an inhibitory effect. (nih.gov)
  • For example, GzB expression in urothelial carcinoma was implicated in promoting tumour cell invasion, whereas its expression in nasal-type NK/T lymphomas was found to correlate with increased apoptosis. (biomedcentral.com)
  • CF treatment on leukemia cell lines induces cell death due to apoptotic mechanisms and altering 123653-11-2 manufacture cell metabolism through HIF-1 and GLUT-1 regulation [3]. (bioinf.org)
  • On top of this, 5-FU resistant CRC cells have been shown to exhibit an aggressive phenotype with increased cell invasion and metastasis. (pall.com)
  • Kakar, S. S. et al: Withaferin a alone and in combination with cisplatin suppresses growth and metastasis of ovarian cancer by targeting putative cancer stem cells. (natur-wiki.de)
  • The addition of a pan-caspase inhibitor (zVAD-fmk) did not suppress the denbinobin-induced apoptotic effect, and denbinobin-induced apoptosis was not accompanied by processing of procaspase-3, -6, -7, -9, and -8. (tmu.edu.tw)
  • X-linked inhibitor of apoptosis (XIAP) is the most potent endogenous caspase inhibitor preventing cell death via caspase-9, -7 and -3 (initiator and executioner caspase pathways). (nih.gov)
  • The inability to utilize butyrate leads to a buildup inside the CRC cells, particularly within the nucleus where it acts as a histone deacetylase inhibitor and works to suppress CRC cell proliferation while promoting apoptosis. (pall.com)
  • GzB may also contribute to apoptosis induction through the cleavage of other cellular substrates including nuclear lamin B, poly (ADP-ribose) polymerase (PARP), and inhibitor of caspase-activated DNase (ICAD) [ 2 ]. (biomedcentral.com)
  • Furthermore, butyrate is detrimental to cancerous cells due to the Warburg effect, a well-documented phenomenon common to most cancers wherein the cancerous cells can only derive energy from simple sugars via aerobic glycolysis, or fermentation. (pall.com)
  • demonstrated the role and mode of action of the beneficial gut bacteria L.plantarum in increasing the sensitivity of 5-FU resistant CRC cells to chemotherapy, as well as reducing proliferation, and inducing apoptosis in the cancerous cells. (pall.com)
  • A failure in regulating proliferation together with suppression of apoptosis are the 123653-11-2 manufacture minimal requirements for a cell to become cancerous [4]. (bioinf.org)
  • These bioactive compounds are capable of killing cancerous cells without damaging normal cells. (ijpbp.com)
  • In this study, we performed deep RNA-Seq analysis of rRNA-depleted total RNA libraries to characterize circRNA expression in three isogenically-matched human colon cancer cell lines Haloperidol Decanoate that differ only in the mutation status of the oncogene. (diferencias-entre.org)
  • This gene product is a bZIP protein, which was also identified as a cellular transcription factor that binds to an enhancer in the promoter of the T cell leukemia virus type 1 promoter. (cancerindex.org)
  • Immunofluorescent double staining was used to detect YAP cellular localization with CD31 (an endothelial cell marker) antibody. (molvis.org)
  • HSPs are involved in a variety of cellular processes and essential to cell survival. (eg.net)
  • The term "oncotarget" encompasses all molecules, pathways, cellular functions, cell types, and even tissues that can be viewed as targets relevant to cancer as well as other diseases. (oncotarget.com)
  • Using the pipeline, we analyzed both cellular and exosomal circRNAs in the three cell lines, with confirmation of altered circRNAs in a second set of isogenically matched cell lines. (diferencias-entre.org)
  • SPIN1 ablation activates p53, suppresses cell growth, reduces clonogenic ability, and induces apoptosis of human cancer cells. (elifesciences.org)
  • under CF reduces the clonogenic survival of MSTO-211 and HCT-116 cell lines of Results section should be updated to 'Colony formation was reduced in HCT-116 and MSTO-211, while yields of HFF and Met-5A colonies were not affected. (biomedcentral.com)
  • HCT 116 colon cancer cells were exposed to purvalanol, which activated ER stress via upregulation of PERK, IRE1α gene expression, eIF-2α phosphorylation and ATF-6 cleavage at early time-points in the HCT 116 colon cancer cells. (spandidos-publications.com)
  • However, how DcR3 expression is modulated in pancreatic cancer cells is enigmatic. (academicjournals.org)
  • In the present study, we examined five cell lines including three cell lines from pancreatic cancer (SW1990, Capcan-1 and PANC-1) and two cell lines from colon cancer (HCT116 and RKO) for DcR3 expression by reverse transcriptase-polymerase chain reaction (RT-PCR) and quantitative real time PCR. (academicjournals.org)
  • Expression is particularly high in the pancreas where it is thought to play a role in the differentiation of pancreatic beta cells. (embl.de)
  • It is this gene that becomes silenced in butyrate insensitive CRC cells, a conclusion that is further supported by previously published studies showing a positive correlation between SMCT1 expression levels in CRC cells with remission and patient survival. (pall.com)
  • We investigated whether atheroprotective unidirectional pulsatile shear stress affects the expression of PDCD4 in endothelial cells. (plos.org)
  • The expression of pro-apoptotic proteins and anti-apoptotic proteins in MCF-7 and MDA-MB-231 cells was investigated by Western blotting. (researchsquare.com)
  • Proliferating cell nuclear antigen (PCNA) expression in CNV mice without or with YAP siRNA intravitreal injection and the colocalization of PCNA and CD31 were measured with western blotting and immunofluorescent double staining, respectively. (molvis.org)
  • Additionally, after laser exposure, YAP siRNA inhibited the increased expression of PCNA, which was colocalized with endothelial cells. (molvis.org)
  • Cancers of both lymphoid and non-lymphoid origin also express GzB, and in some cases this expression has been linked to pathogenesis or sensitizing tumour cells to cell death. (biomedcentral.com)
  • Expression of several GzB shRNAs in multiple ALK+ ALCL cell lines resulted in a significant decrease in GzB levels and activity. (biomedcentral.com)
  • Our findings are the first to demonstrate that GzB expression sensitizes ALK+ ALCL cell lines to drug-induced apoptosis. (biomedcentral.com)
  • It is now obvious that circRNAs are evolutionarily conserved, exhibit cell-specific expression patterns, and are regulated impartial of their linear transcripts10,14,15. (diferencias-entre.org)
  • Obtaining quantitative gene-expression of cells in their native context has significantly advanced through single-cell RNA sequencing technologies along with mechanical and enzymatic tissue manipulation. (molcells.org)
  • Natural polyamines, putrescine, spermidine and spermine, play essential roles in the regulation of cell growth and proliferation. (spandidos-publications.com)
  • Next, we established cell lines with VEGFR2 OE to evaluate the effects of MSI2 on AKT signaling via VEGFR2 regulation. (researchgate.net)
  • Transcriptome and chromatin immunoprecipitation analysis revealed c-Myc as a new and direct downstream target of XBP1 for regulation of NK cell proliferation. (cancerindex.org)
  • LCH significantly inhibited cell viability and colony growth in both Ox-sensitive and Ox-resistant CRC cells. (biomolther.org)
  • This review discusses the current technologies for spatial transcriptomics ranging from the methods combining mechanical dissociation and single-cell RNA sequencing to computational spatial re-mapping. (molcells.org)
  • However, denbinobin triggered the translocation of the apoptosis-inducing factor (AIF) from the mitochondria into the nucleus. (tmu.edu.tw)
  • Distinct pathways of cell migration and antiapoptotic response to epithelial injury: structure-function analysis of human intestinal trefoil factor. (embl.de)
  • ALK+ ALCL cell lines stably expressing GzB or non-targeting (control) shRNA were generated and apoptosis was examined by anti-PARP western blotting and terminal deoxynucleotidyl transferase dUTP nick end labelling. (biomedcentral.com)
  • Various purified compounds derived from Swietenia macrophylla were further examined and was revealed to possesses potent PPARγ binding activity which might capable of stimulating glucose uptake in muscle cells. (wikipedia.org)
  • BTC is proteolytically processed from a larger membrane-anchored precursor and is a potent mitogen for a wide variety of cell types. (embl.de)
  • Treatment of HCT116 cells with each pooled fraction (pf1, pf2, or pf3) inhibited the cell proliferation in a dose-dependent manner, and the inhibitory activities contained in pf2 and pf3 were more potent than that in pf1. (e-kenkyu.com)
  • Although PDCD4 in general suppresses the development and progression of tumors, its specific biological functions differ by cell type [8] . (plos.org)
  • Sulforaphane suppresses the growth of triple-negative breast cancer stem-like cells in vitro and in vivo. (ijpbp.com)
  • In the older cells of aging animals, to take one example, researchers have found that one out of every three proteins is rendered dysfunctional by unchecked free radical damage. (lifeextension.com)
  • Two proteins involved intimately in regulating cell proliferation are Akt and the tumor suppressor p53 (p53). (bioinf.org)
  • In conclusion, acetone and methanol extracts from C. odontophyllum stem bark exhibited promising cytotoxic activity against human colorectal cancer cell line HCT 116 and paves way for further investigation in view of its mode of cancer cell death. (scirp.org)
  • Butyrate is efficiently absorbed by colonic epithelial cells and provides the primary energy source for the cells of the colon. (pall.com)
  • Butyrate is a short-chain fatty acid (SCFA) derived from dietary fiber by bacterial fermentation in the colon and is an important mediator of colonic cell homeostasis. (pall.com)
  • Many physiological processes, including proper tissue development and homeostasis, require a balance between apoptosis and cell 123653-11-2 manufacture proliferation. (bioinf.org)
  • Complex cell-to-cell communication underlies the basic processes essential for homeostasis in the given tissue architecture. (molcells.org)
  • have reported anti-carcinogenic activity of both koetjapic acid and 3-oxo-olean-12-en-29-oic acid. (scialert.net)
  • XIAP knockdown induced a 2-fold increase in the basal level of apoptosis without modification of caspase 3/7 activity. (nih.gov)
  • In vitro antitumour activity and mode of cell death incurred by enantiopure TiCl2{n-C5H4CHEt(2 MeOPh)}2 (abbreviated CpR 2TiCl2) has been investigated. (nottingham.ac.uk)
  • Moreover, induced Akt activity (p-AKT) (due to overexpression) is sufficient to block apoptosis triggered by many death stimuli [5]. (bioinf.org)
  • We investigated the antiproliferative activity of licochalcone H (LCH), a regioisomer of licochalcone C derived from the root of Glycyrrhiza inflata, in oxaliplatin (Ox)-sensitive and -resistant CRC cells. (biomolther.org)
  • The apoptosis-inducing activity found in each pooled fraction was higher than that of kaempferol. (e-kenkyu.com)
  • This study showed that YAP upregulation promoted CNV formation by upregulating the proliferation of endothelial cells, providing evidence for the molecular mechanisms of CNV and suggesting a novel molecular target for nAMD treatment. (molvis.org)
  • 10 TRPV1 agonist, capsaicin, is capable of inducing apoptosis 11 , 12 and inhibiting cancer cell growth by cell cycle arrest in many different types of cancer, for example, osteosarcoma, colon, and pancreatic cancer cells, while normal cells remained unharmed. (dovepress.com)
  • Purvalanol is a purine-derived CDKI that binds with a high selectivity and competitively to the ATP binding side of CDK1/2 and leads to G2/M cell cycle arrest ( 4 ). (spandidos-publications.com)
  • Flow cytometry analysis showed that VALD-3 triggered cell cycle arrest and induced apoptosis of breast cancer cells. (researchsquare.com)
  • This study is the first to show that VALD-3 induces apoptosis and cell cycle arrest in human breast cancer cells by suppressing Wnt/β-catenin signaling, indicating that it could be a potential drug for the treatment of breast cancer. (researchsquare.com)
  • The antiproliferative of 3 was attributed to significant S-phase cell cycle arrest. (phcog.com)
  • 2002). G(1) and G(2) cell-cycle arrest following microtubule depolymerization in human breast cancer cells. (sciendo.com)
  • A new study shows how gut microbiota increases the sensitivity of colorectal cancer cells to chemotherapy. (pall.com)
  • There is clearly a need for therapeutic strategies in addressing CRC that increase the sensitivity of the tumor cells to chemotherapy compounds, allowing reduced dosing, minimizing side effects, and enabling effective therapy to continue. (pall.com)
  • Background: This study aimed to investigate the efficacy and safety of chemotherapy combined with programmed cell death protein 1 (PD-1) inhibitors in the treatment of advanced cervical cancer and the effect of optimal combination timing on prognosis. (bvsalud.org)
  • These cell lines were treated with an extract from E. senticosus that was evaporated and re- constituted in DMSO. (nih.gov)
  • Treatment of A-549 (small cell lung cancer) cells with E. senticosus methanolic extract showed a concentration-dependent inhibitory trend from 12.5 - 50μg/mL, and then a plateau, whereas at 12.5 and 25 μg/mL, there is a slight growth suppression in QBC-939 cells, but then a steady suppression from 50, 100 and 200μg/mL. (nih.gov)
  • Further, in XWLC-05 (Yunnan lung cancer cell line), E. senticosus methanolic extract displayed an inhibitory effect which plateaued with increasing dosage. (nih.gov)
  • These results showed that n-hexane extract of S. koetjape possess both anti-angiogenic and apoptotic properties on colon cancer cell lines making it a good candidate for further studies. (scialert.net)
  • Compounds isolated in freeze-dried açaí extract have been shown to enter human cells and neutralize free radicals at very low doses. (lifeextension.com)
  • In this study, we investigated a plausible therapeutic synergism of a triple combination of CBD/CBG, curcumin, and piperine in the colon adenocarcinoma using HCT116 and HT29 cell lines. (frontiersin.org)
  • Our findings revealed that different genetic backgrounds of HCT116 and HT29 cell lines resulted in divergent responses to the combination treatments. (frontiersin.org)
  • XIAP mRNA levels were established by RT-PCR, the four X (XIAP knockdown) clonal cell lines show 82-93% reduction in XIAP mRNA when compared to the four L (luciferase control) cell lines. (nih.gov)
  • Immunoblot analysis showed a 67-89% reduction in XIAP protein in X cell lines compared to L. RNA was analysed by microarray and XIAP knockdown was confirmed in 7 probe sets, there was no significant compensation of other IAP family members. (nih.gov)
  • Human HCT116 colon cancer cell lines were transfected with either XIAP (X) or luciferase (L) shRNA. (nih.gov)
  • confirmed an apoptotic death for both cell lines. (bioinf.org)
  • KMD 901 isolated from marine sediment on HCT116 colon cancer cell lines. (ijpbp.com)
  • In order to assess whether additional granzymes might be important in promoting cell death in ALK+ ALCL, we examined whether other human granzymes were expressed in ALK+ ALCL cell lines using reverse-transcriptase PCR and western blotting. (biomedcentral.com)
  • While spontaneous apoptosis was similar in ALK+ ALCL cell lines expressing either GzB or control shRNA, GzB shRNA-expressing cells were less sensitive to staurosporine or doxorubicin-induced apoptosis as evidenced by reduced PARP cleavage and decreased DNA fragmentation. (biomedcentral.com)
  • Furthermore, we found that GzB is the only granzyme that is expressed at significant levels in ALK+ ALCL cell lines. (biomedcentral.com)
  • confirmed in two impartial colon cancer cell lines HCT116 (mutant) and HKe3 (WT). (diferencias-entre.org)
  • In all three cell lines, circRNAs were also found in secreted extracellular-vesicles, and circRNAs were more abundant in exosomes than cells. (diferencias-entre.org)
  • The parental DLD-1 cells contain both wild-type and G13D mutant alleles, whereas the isogenically-matched derivative cell lines DKO-1 and DKs-8 contain only a mutant and a wild-type allele, respectively. (diferencias-entre.org)
  • Panobinostat therapy significantly repressed mRNA for DNMT1 and DNMT3a in the two cell lines while no modifications had been observed in DNMT3b levels. (thrombininhibitors.com)
  • Increased levels of polyamines in cells are considered to be involved in cancer progression. (spandidos-publications.com)
  • Decoy receptor 3 (DcR3) is highly expressed in various cancer cells and plays a significant role in immune suppression and tumor progression. (academicjournals.org)
  • Ample evidence shows that pro-atherosclerotic disturbed flow induces sustained activation of atherogenic genes in endothelial cells to promote their oxidation, inflammation, cell cycle progression and proliferation, whereas pulsatile shear stress tends to maintain endothelial cells in a quiescent and less proliferative state with a low level of oxidation and inflammation [16] , [17] . (plos.org)
  • All somatic cells proliferate via a mitotic process determined by progression through the cell cycle. (bioinf.org)
  • The gut microbiota provides a beneficial therapeutic effect by targeting cancer cells through several anti-cancer pathways. (pall.com)
  • Olomoucine, roscovitine and purvalanol are examples of CDK inhibitors (CDKIs) designed and investigated for their apoptotic potential on cancer cells ( 3 ). (spandidos-publications.com)
  • We showed that denbinobin induces apoptosis in human colorectal cancer cells (HCT-116) in a concentration-dependent manner. (tmu.edu.tw)
  • ERK levels are generally higher in cancer cells adjacent to stromal cells at the invasive front and lower in more central areas of cancer specimens. (researchgate.net)
  • The critical challenge in cancer treatment is how to effectively kill cancer cells without affecting healthy cells. (hindawi.com)
  • In this study, we investigated the cytotoxic and apoptotic effects of VALD-3, a Schiff base ligand synthesized from o-vanillin derivatives, on human breast cancer cells and the possible underlying mechanisms. (researchsquare.com)
  • By xenografting human breast cancer cells into nude mice, we found that VALD-3 significantly suppressed tumor cell growth while showing low toxicity against major organs. (researchsquare.com)
  • In this study, we demonstrated that aspirin induced autophagosome formation in colorectal cancer cells, but autophagic degradation was blocked through aspirin-mediated Beclin 1 acetylation. (oncotarget.com)
  • Pharmacologic ascorbic acid concentrations selectively kill cancer cells: action as a pro-drug to deliver hydrogen peroxide to tissues. (ijpbp.com)
  • GzB primarily initiates apoptosis either through direct proteolytic processing and activation of initiator (caspase 8) or executioner (caspases 3 and 7) caspases, or through disruption of mitochondrial outer membrane potential via cleavage of the Bid protein [ 2 ]. (biomedcentral.com)
  • Cells treated with pf2 displayed the typical characteristics of apoptosis, such as membrane blebbing, nuclear condensation and apoptotic bodies, whereas cells treated with pf1 showed early apoptotic morphologies. (e-kenkyu.com)