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  • interferon
  • We investigated genetic polymorphisms in the intrinsic apoptosis pathway to assess their influence on sustained virological response (SVR) to pegylated interferon-α and ribavirin (pegIFN/RBV) treatment of HCV genotypes 1 and 3 infections. (mdpi.com)
  • In this thesis, we identified Fas up-regulation as a mechanism underlying interferon (IFN)-mediated sensitization to Fas-induced apoptosis in the MM cell line U-266-1970. (diva-portal.org)
  • This antiviral state was characterized by (i) a more rapid response to viral infection, which resulted in increased survival, (ii) the involvement of NK-cell- and macrophage-mediated transcript responses rather than B- and/or T-cell dependent cells, and (iii) enhanced apoptosis, described here for the first time, as well as the similar modulation of multigene family/interferon-related genes previously associated to fish that survived lethal viral infections. (frontiersin.org)
  • Functional Implications in Apoptosis by Interferon Inducible Gene Pro" by Insil Joung, Peter C. Angeletti et al. (unl.edu)
  • Overexpression of A20 by means of adenovirus-mediated gene transfer protects islets from IL-1β and interferon γ-induced apoptosis. (rupress.org)
  • ischemia
  • The data support the view that hippocampal neurons might undergo an apoptosis-like death after global ischemia. (nih.gov)
  • In this study, we investigated the potential role of tissue kallikrein in myocardial ischemia/reperfusion injury through adenovirus-mediated human kallikrein gene delivery. (ahajournals.org)
  • These results indicate that kallikrein gene delivery protects against myocardial infarction, ventricular arrhythmias, and apoptosis in ischemia/reperfusion injury via kinin-cGMP signal pathway. (ahajournals.org)
  • 17 18 In this study, we examined the potential roles of the tissue kallikrein-kinin system in ischemia/reperfusion injury through the delivery of the human tissue kallikrein gene and show that adenovirus-mediated kallikrein gene delivery significantly attenuated myocardial infarction and apoptosis after ischemia/reperfusion injury in rats. (ahajournals.org)
  • organism
  • However, the genome of Cricetulus griseus is poorly characterised, and in particular, there is lack of knowledge of genes in that organism which control physiologically important processes. (patentsencyclopedia.com)
  • dependent
  • Rosenblatt J, Raff MC, Cramer LP. An epithelial cell destined for apoptosis signals its neighbors to extrude it by an actin- and myosin-dependent mechanism. (springer.com)
  • The cytoprotective effect of A20 against apoptosis correlates with and is dependent on the abrogation of cytokine-induced NO production. (rupress.org)
  • caspase
  • Its biological function is also associated with cell apoptosis.Se-methylselenocysteine (MSC) at an optimum concentration of 1 μM could reverse the alteration in antioxidative capacity, Bcl2/Bax ratio and caspase-8 activity caused by Clu-knockdown, thus inhibiting apoptosis and maintaining cell viability.The results hereby imply the potentiality of Clu and Se in neuroprotection. (nih.gov)
  • Se-methylselenocysteine (MSC) at an optimum concentration of 1 μM could reverse the alteration in antioxidative capacity, Bcl2/Bax ratio and caspase-8 activity caused by Clu-knockdown, thus inhibiting apoptosis and maintaining cell viability. (nih.gov)
  • cell cycle arrest
  • Furthermore, PPP potently induced cell cycle arrest and apoptosis in all MM cell lines and patient samples tested, also in the presence of survival factors IGF-I and IL-6. (diva-portal.org)
  • TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest. (uniprot.org)
  • liver
  • Unregulated apoptosis (too much or too little apoptosis) at any time from embryogenesis to adulthood, can result in a variety of disease states, such as neurodegenerative disorders, autoimmunity, cardiovascular disease, liver and kidney problems, and cancer. (uwaterloo.ca)
  • The deleted in liver cancer (DLC-1) gene is a recently identified tumor suppressor gene for human non-small cell lung carcinoma (NSCLC). (cdc.gov)
  • mechanisms
  • In this review, we discuss the basic features of apoptosis and have focused on the gene families playing critical roles, activation/inactivation mechanisms, upstream/downstream effectors, and signaling pathways in apoptosis on the basis of cancer studies. (springer.com)
  • To combat this resistance, the mechanisms of apoptosis and survival in MM must be better defined. (diva-portal.org)
  • Toll-like receptor (TLR) signaling triggers cell apoptosis through multiple mechanisms. (biomedcentral.com)
  • However, there is no such p53 consensus sequence in the promoters of a number of p53-responsive genes, suggesting that there might be other mechanisms whereby p53 transactivates the promoters of its target genes. (cdc.gov)
  • homology
  • that shares homology with genes 1-8U and Leu-13/9-27, most of which have little known functions. (unl.edu)
  • Furthermore
  • Furthermore, they inappropriately express somatic genes characteristic of endoderm regulated by maternal VegT, including Xsox17 α, Bix4, Mixer, GATA4 and Edd . (biologists.org)
  • cytotoxic
  • Apoptosis is a genetically regulated form of cell death that occurs when the cell is exposed to physiological, pathogenic, or cytotoxic stimuli. (uwaterloo.ca)
  • RNAs
  • We propose that Nanos1 functions to translationally repress RNAs that normally specify endoderm and promote apoptosis, thus preserving the germline. (biologists.org)
  • lymphoma
  • Four single nucleotide polymorphisms (SNPs) located in the B-cell lymphoma 2-like 1 ( BCL2L1 ) gene were significantly associated with SVR. (mdpi.com)
  • diseases
  • Any abnormality in apoptosis process can cause various types of diseases from cancer to auto-immune diseases. (springer.com)
  • Trade-offs in fitness are expected out of these selective pressures, which could explain the involvement of these genes in various diseases, including cancer. (cshl.edu)
  • actin
  • Mashima T, Naito M, Noguchi K, Miller DK, Nicholson DW, Tsuruo T. Actin cleavage by CPP-32/apopain during the development of apoptosis. (springer.com)
  • The process of morphological change is associated with RhoGAP-domain-related reduction of stress fibers and filopodia early in gene transfection and with collapsing of the actin cytoskeleton at the time of cell apoptosis. (cdc.gov)