Apoptosis ex vivo. Medical search. Frequent questions

Ultraviolet B (UVB) irradiation induces apoptosis of keratinocytes that is known as "sunburn cells. (bioone.org)
Previously we reported that UVB irradiation induces apoptosis accompanied by sequential activation of caspase 8, 3 and 1 in keratinocytes, and that the process is inhibited by various caspase inhibitors. (bioone.org)
Integrin beta 3 (ITGB3) glycoprotein plays multiple roles in platelet physiological processes, and it was reported in other cell types that downregulation of ITGB3 induces apoptosis. (eurekaselect.com)
IL-23 promotes ubiquitin-mediated degradation of your cell survival protein Bcl-2 7KC induces apoptosis in macrophages via activation on the mitochondrial-caspase-9 pathway of apoptosis35. (hivinhibitor.com)
Strongly inhibits chromatin transcription and induces apoptosis. (abcam.com)
Interleukin 4 induces apoptosis of acute myeloid leukemia cells in a Stat6-dependent manner. (lu.se)

This review focuses on the differential responses of cell types to ATZ toxicity, testicular effects of ATZ in both in vitro and in vivo models and chemopreventive strategies, so as to highlight the current state of the art on the toxicological outcomes of ATZ exposure in several experimental model systems. (frontiersin.org)
GLPG1790, a small molecule nanomolar inhibitor of ephrinand a few other tyrosine kinases, shows potent anti-tumor activity in vitro and in vivo in a mouse MDA-MB-231xenograft model.1 Here we report its effects on apoptosis and angiogenesis after 3 days of oral treatment using non-invasive in vivo fluorescence imaging. (bruker-webdev.de)
This notion was further supported by demonstrating that magnolol induced an increase of the caspase activity in U373 in vitro and in vivo, and these effects were abolished by pretransfection of the cell with p27/Kip1 siRNA. (tmu.edu.tw)
Chen, LC & Lee, WS 2013, ' P27/Kip1 is responsible for magnolol-induced U373 apoptosis in vitro and in Vivo ', Journal of Agricultural and Food Chemistry , vol. 61, no. 11, pp. 2811-2819. (tmu.edu.tw)
However, there is no available information to address that TF affects murine leukemia cells in vitro and in vivo. (upm.edu.my)
Here, we investigated in vitro and in vivo effects of TF on murine leukemia WEHI-3 cells. (upm.edu.my)
We aimed to examine the molecular processes underlying the effects of silibinin in oral cancer in vitro and in vivo as well as its potential anticancer effects. (jcancer.org)
Next, we investigated the molecular processes underlying both in vitro and in vivo outcomes of silibinin treatment on oral cancer. (jcancer.org)
In vitro and in vivo (animal and human) studies utilized a variety of LED wavelength, power intensity, and energy density parameters to begin to identify conditions for each biological tissue that are optimal for biostimulation. (researchgate.net)
Multiple preclinical studies in vitro and in vivo have proven curcumin to be effective against various cancers. (wellnessresources.com)
The aim of this study was to examine the effects and mechanisms of tenacigenin B in lymphoma treatment by in vitro and in vivo experiment. (medscimonit.com)
Tenacigenin B had anti-tumor effects on lymphoma via regulation of Aurora-A in vitro and in vivo . (medscimonit.com)
[ 17-20 ] In vitro and in vivo research suggests that NSAIDs and selective cyclooxygenase-2 inhibitors hinder growth and survival of bladder cancer cells and nitrosamine-induced tumors. (medscape.com)
We are continuously evaluating new treatments in our clinically relevant, patient-derived models in vitro and in vivo . (lu.se)

Final validation of the functional role of miR-103b in ITGB3 downregulation and resulting induction of apoptosis was assessed in stored platelets by FACS analysis following ectopic expression of miR-103b. (eurekaselect.com)
Triphala-mediated reduced cell survival correlated with induction of apoptosis, which was associated with reactive oxygen species (ROS) generation. (biomedcentral.com)
This study examined the effect of neutralizing antibody against IL-6 on the induction of pancreatic acinar cell apoptosis and attenuation of the severity of severe acute pancreatitis. (tmu.edu.tw)
Application of IL-6 neutralizing antibody caused the induction of apoptosis in the pancreatic acinar cells of mice with acute pancreatitis. (tmu.edu.tw)
mouse brain resulted in an induction of apoptosis similar to Ultrathin sections were stained with uranyl acetate and lead what is observed in natural infection. (cdc.gov)
Apoptosis induction vested and lysed at 48 h postinjection. (cdc.gov)
Therefore, based on clinical experience as well as cytotoxic activity against multiple human cancer cells, we hypothesized that induction of apoptosis is the underlying mechanism for the treatment of psoriasis. (hindawi.com)
2018. Induction of apoptosis and suppression of tumor growth by Nur77-derived Bcl-2 converting peptide in chemoresistant lung cancer cells. . (oregonstate.edu)
Strong induction of apoptosis in one compartment of the Drosophila wing disc causes apoptosis of cells in the other compartment, indicating that dying cells can release long-range death factors. (elifesciences.org)
Solanum nigrum (SN) is a herb with anticancer effects such as destruction of tumor cell membrane, induction of apoptosis by NF-kappaB, caspase activation, nitric oxide production and inhibition of angiogenesis [ 3 ]. (ijpsonline.com)
Induction of apoptosis leads to characteristic cellular changes leading to death. (ijpsonline.com)

Diminution of p53 by RNA interference induced necrosis instead of apoptosis in A549 cells following terpinen-4-ol treatment, indicating that terpinen-4-ol-elicited apoptosis is p53-dependent. (hindawi.com)
Annexin V-propidium iodide double-staining demonstrated that Sapota fruit extracts potentiate apoptosis rather than necrosis in cancer cells. (nature.com)
We now show that during early apoptosis limited membrane permeabilization occurs in blebs and apoptotic bodies, which allows release of proteins that may affect the proximal microenvironment before the catastrophic loss of membrane integrity during secondary necrosis. (nature.com)
Therefore, the shift from apoptosis to secondary necrosis is more graded than a simple binary switch, with the membrane permeabilization of apoptotic bodies and consequent limited release of DAMPs contributing to the transition between these states. (nature.com)
We identified Eiger, the Drosophila tumor necrosis factor (TNF) homolog, as the signal responsible for apoptosis-induced apoptosis (AiA). (elifesciences.org)
the process of apoptosis and necrosis. (who.int)

On the other hand, Triphala failed to induce apoptosis or activate ERK or p53 in normal human pancreatic ductal epithelial (HPDE-6) cells. (biomedcentral.com)
TP53 protein can induce cell growth arrest, apoptosis, differentiation and DNA repair, and activate or inhibit the expression of downstream genes such as Bax and CDKN1A ( 5 ). (spandidos-publications.com)
This plant had shown to induce antiproliferative effect as well as apoptosis in cancer cells. (upm.edu.my)
These potent effects are driven by curcumin's ability to induce G2/M cell cycle arrest, induce autophagy, activate apoptosis, disrupt molecular signaling, inhibit invasion and metastasis, and increase the efficacy of current chemotherapeutics. (wellnessresources.com)
We identified a novel mode of communication by which apoptotic cells induce additional apoptosis in the same tissue. (elifesciences.org)
At high concentrations, NSAIDs have anticarcinogenic properties operating through cyclooxygenase-2-dependent and -independent pathways to inhibit cellular proliferation, inhibit angiogenesis, and induce apoptosis. (medscape.com)

This study was conducted to evaluate ultrastructure, oxidative stress, and apoptosis in sperm of mice treated with 150 mg/l NaF for 49 days. (fluoridealert.org)
Based on these findings, it was proposed that oxidative stress induced by excessive ROS may trigger sperm apoptosis through mitochondrial impairment, resulting in decreased fertility in mice exposed to fluoride. (fluoridealert.org)
However, oxidative stress could play salient role in the observed cellular and genetic toxicity and apoptosis-like effects which could be abrogated by antioxidant vitamins and flavonoids, including vitamin E, quercetin, kolaviron, myricetin and bioactive extractives with antioxidant effects. (frontiersin.org)
However, the role of C1QBP in metabolism, oxidative stress, and apoptosis of renal cell carcinoma (RCC) cells have not yet been explored. (medsci.org)

The aim of the present investigation was to elucidate the cellular mechanisms whereby Tanshinone IIA (Tan IIA) leads to cell cycle arrest and apoptosis in vitro in keratinocytes, the target cells in psoriasis. (hindawi.com)

Our results indicated that terpinen-4-ol induced apoptosis through a mitochondria-mediated pathway in NSCLC cells and that the apoptosis elicited by terpinen-4-ol was p53 dependent. (hindawi.com)
Loss of mitochondrial membrane potential, upregulation of proapoptotic proteins, activation of MCL-1, PARP-1 and Caspase 9 suggest that MESF treatment leads to activation of mitochondrial pathway of apoptosis. (nature.com)
In the present study, we analyzed the proliferation and apoptosis of trophoblasts and human decidual cells in patients with recurrent spontaneous abortion and the related cellular pathway mechanism. (spandidos-publications.com)
Eldadah and Faden, 2000 ), we hypothesized that suppression of apoptotic capability during maturation of mammalian brain results from repression of genes involved in the caspase-3 activation pathway, and that injury-induced neuronal apoptosis in the mature brain results from reactivation of these genes. (jneurosci.org)
In the present study, we evaluated the role of the intrinsic pathway in neuronal apoptosis at different stages of rat brain development and during maturation of primary cortical neurons in vivo as well as in response to brain injury. (jneurosci.org)
Apoptosis is induced through the mitochondrial pathway resulting in caspase-9 activation and downstream caspase-3 activation. (cdc.gov)
We consequently investigated whether or not this pathway might also be necessary in IL-23-mediated enhancement of 7KC-induced macrophage apoptosis. (hivinhibitor.com)
Even though the 7KC + IL-23 outcome will not necessarily prove a direct part for caspase-9 in IL-23 enhancement of apoptosis, because this enhancement requires 7KC-induced apoptosis within the initially place, these findings led us to discover further a protein that may be identified to impact the mitochondrial pathway of apoptosis, Bcl-237. (hivinhibitor.com)
Silibinin considerably reduced the development of oral cancer cells by inducing apoptosis, G 0 /G 1 arrest, ROS generation, and activation of the JNK/c-Jun pathway. (jcancer.org)
There was also no translocation of apoptosis-inducing factor (AIF) from mitochondria to the nucleus in apoptotic keratinocytes, indicating Tan IIA-induced apoptosis occurs mainly through the caspase pathway. (hindawi.com)
found that the JNK pathway activated apoptosis in anterior cells. (elifesciences.org)

Bcl-2 is a member of the large Bcl-2 family and protects cells from apoptosis. (bioone.org)
Mutated recombinant human glucagon-like peptide-1 protects SH-SY5Y cells from apoptosis induced by amyloid-beta peptide (1-42). (ncbcs.org)

Ectopic expression of miR-103b decreased the luciferase reporter activity in HeLa cells and decreased ITGB3 mRNA and protein levels in platelets, concomitant with an increase in apoptosis. (eurekaselect.com)
Blebbing, apoptotic body formation and protein release during early apoptosis are dependent on ROCK and myosin ATPase activity to drive actomyosin contraction. (nature.com)
2 , 3 A key feature of apoptosis has been defined as the maintenance of an intact cellular membrane (detectable as exclusion of impermeable dyes such as propidium iodide, PI) throughout the apoptotic program to prevent intracellular protein release and subsequent immunological activation. (nature.com)
In vivo imaging of annexin V (A5) was performed at 12 hr, 24 hr, 48 hr, and 4 days after 90-min transient middle cerebral artery occlusion (tMCAO) in mice with a fluorescent protein Cy5.5. (elsevierpure.com)
Moreover, pretreatment of U373 with a cSrc inhibitor (PP2), a PI3K inhibitor (LY294002), an ERK inhibitor (PD98059), or a p38 MAPK inhibitor (SB203580) but not a JNK inhibitor (SP600125) significantly reduced the magnolol-induced increases of p27/Kip1 protein levels and apoptosis. (tmu.edu.tw)
More were stained with toluidine blue, and photographed with importantly, direct in vivo expression of WNV-Cp protein in Ektachrome 160T film (Eastman Kodak Co., Rochester, NY). (cdc.gov)
Tan IIA inhibited proliferation of mouse keratinocytes in a dose- and time-dependent manner and induced apoptosis, resulting in S phase arrest accompanied by down-regulation of pCdk2 and cyclin A protein expression. (hindawi.com)
[ 8 ] apoptosis may be related to HIV-1 viral protein R. (medscape.com)
This study is to investigate the role of p38 mitogen-activated protein kinase (p38MAPK) in tert -butyl hydroperoxide ( t BHP)-induced apoptosis of human trabecular meshwork (iHTM) cells. (molvis.org)

Ramanian et al.PageTo test the part of IL-23 in lesional macrophage apoptosis in vivo, we administered recombinant mouse IL-23 (rIL-23) to Ldlr-/- or Csf2-/-Ldlr-/- mice as per the scheme illustrated in Figure 5A. (hivinhibitor.com)
Clinical scores, histopathologic severity, macrophage apoptosis and depletion, and T cell subset development were evaluated. (nih.gov)

A549 xenografts by inducing apoptosis, as confirmed by TUNEL assay. (hindawi.com)

Resveratrol, a natural polyterpenoid, can scavenge reactive oxygen species in vivo to carry out the functions of antioxidation and antiaging. (mdpi.com)
Flow cytometry was used to examine apoptosis, cell cycle distribution, and accumulation of reactive oxygen species (ROS). (jcancer.org)

Fluoride-induced apoptosis and gene expression profiling in mice sperm in vivo. (fluoridealert.org)
An increased ROS and a decreased TAC accompanied with distinct morphological changes and significant apoptosis were observed in mice sperm from the fluoride group. (fluoridealert.org)
AID-Cre(+) GNA13-deficient mice demonstrate disordered GC architecture and dark zone/light zone distribution in vivo, and demonstrate altered migration behavior, decreased levels of filamentous actin, and attenuated RhoA activity in vitro. (duke.edu)
Reduced tumor-growth in Triphala fed mice was due to increased apoptosis in the tumors cells, which was associated with increased activation of p53 and ERK. (biomedcentral.com)
The primary aim was to restore lesional IL-23 levels in the GMCSF-deficient mice and to evaluate the impact of this restoration on lesional cell apoptosis. (hivinhibitor.com)
In addition, consistent with all the lack of an effect of IL-17 on apoptosis susceptibility in cultured macrophages (above), neutralization of IL-17 activity by administration of anti-IL-17 antibody34 did not affect lesional cell apoptosis within the IL-23-restored mice or any from the other groups of mice (Figure 5E). (hivinhibitor.com)
These data, combined with our information with cultured macrophages (above), support the hypothesis that the lower in lesional IL-23 in Csf2-/-Ldlr-/- mice plays a vital role inside the decrease of lesional cell apoptosis in these mice. (hivinhibitor.com)
Furthermore, the cell death mechanism in the spleen tissue of treated mice was found via apoptosis. (upm.edu.my)
The HA+DOX delivery system was also tested in-vivo on osteosarcoma bearing mice. (lu.se)
For instance, mice are able to reconstitute most lymphomas in monkeys and humans woodchuck hepatitis virus induces major components of the human provides strong support for a direct hepatocellular carcinoma (HCC) haematolymphoid system including oncogenic role of EBV in vivo. (who.int)

Neuronal apoptosis plays an essential role in early brain development and contributes to secondary neuronal loss after acute brain injury. (jneurosci.org)
Recent studies have provided evidence that neuronal susceptibility to apoptosis induced by traumatic or ischemic injury decreases during brain development. (jneurosci.org)
Apoptosis is one of the mechanisms contributing to neuronal degeneration in ischemic stroke. (elsevierpure.com)
Accumulation and deposition of amyloid beta peptide (Abeta) within the mind causes neuronal apoptosis and finally results in Alzheimer's illness (AD). (ncbcs.org)

The mechanism of recurrent abortion is considered to be related to the proliferation and apoptosis of human decidual cells and cytotrophoblasts ( 4 ). (spandidos-publications.com)
or = 0.02 ng/ml of mGLP-1 facilitated cell proliferation and 0.1 ng/ml and 0.5 ng/ml of mGLP-1 rescued SH-SY5Y cells from Abeta(1-42)-induced apoptosis. (ncbcs.org)
Locally delivered DOX via the HA particles had a stronger tumor eradication effect compared to the controls as seen by PET-CT and immunohistochemical staining of proliferation and apoptosis markers. (lu.se)

ATZ also induces morphological changes similar to apoptosis and initiates mitochondria-dependent cell death in several experimental models. (frontiersin.org)

TUNEL method was used to detect the apoptosis rate. (spandidos-publications.com)
Both in vivo near-infrared imaging of caspase activity and TUNEL staining demonstrated that TRA-8 rapidly induced apoptosis of macrophages in inflamed synovium. (nih.gov)

Inhibits histone acetylation in vivo . (abcam.com)

Furthermore, Tan IIA-induced apoptosis and mitochondrial membrane potential changes were also further demonstrated by DNA fragmentation, single-cell gel electrophoresis assay (SCGE), and flow cytometry methods. (hindawi.com)

In this investigation, the role of autophagy and apoptosis in Solanum nigrum fruit extract-induced cytotoxicity in MDA-MB-468, a triple negative breast cancer cell line was studied. (ijpsonline.com)
These findings indicated that Solanum nigrum extract induced cell death in MDA-MB-468 cells by two distinct mechanisms, apoptosis and autophagy, and these findings further suggest a possibility that this extract could be used to treat triple negative breast cancer. (ijpsonline.com)
A previous study reported that the extract of the whole plant of SN activated cell death in hepatoma cells through autophagy and apoptosis [ 7 ]. (ijpsonline.com)
Autophagy and apoptosis are two forms of programmed cell death, which are essential for cellular homeostasis. (ijpsonline.com)

Cellular miR-103 downregulates certain genes in other cell types and promotes apoptosis. (eurekaselect.com)
This study elucidates the molecular mechanism of Triphala against human pancreatic cancer in the cellular and in vivo model. (biomedcentral.com)
Our preclinical studies demonstrate that Triphala is effective in inhibiting the growth of human pancreatic cancer cells in both cellular and in vivo model. (biomedcentral.com)
created 'undead' cells in which one of these proteins was turned on, but other downstream proteins (that are responsible for the cellular execution phase of apoptosis) had been turned off: these cells were undergoing apoptosis, but could not complete the process and die. (elifesciences.org)

In addition, cell apoptosis was measured by double staining, DNA fragmentation and annexin V-fluorescein isothiocyanate binding assays. (ijpsonline.com)

C5a blockade dramatically reduced thymocyte apoptosis as measured by thymic weight, binding of annexin V to thymocytes, and laddering of thymocyte DNA. (jci.org)
Cell apoptosis was investigated using 4',6-diamidino-2-phenylindole (DAPI), annexin V, and propidium iodide (PI) fluorescence flow cytometry, which was also used to investigate the cell cycle. (medscimonit.com)
Cell apoptosis was analyzed by Hoechst 33258 staining and annexin V-PI labeling. (molvis.org)

In vivo , orthotopic tumor xenografts assay was performed to investigate the role of C1QBP in RCC progression. (medsci.org)
This study aimed to investigate the effects of xanthoxyletin, a plant-derived coumarin, on human oral squamous cancer cells in vitro and in mouse xenografts in vivo . (medscimonit.com)
Mouse xenografts were used for the in vivo evaluation of the effects of xanthoxyletin. (medscimonit.com)

The expression levels of apoptosis-related genes Bcl2 and Bax were determined by real-time PCR. (ijpsonline.com)

The Critical Role of X Chromosome-Linked Inhibitor of Apoptosis (XIAP) in Differential Synergism Induced by Pentachlorophenol and Copper-1,10-Phenanthroline Complex in Normal and Cancer Liver Cells. (oregonstate.edu)
Another procent of cases is due to defects in in the gene that encodes the X-linked inhibitor-of-apoptosis XIAP (BIRC4) required for the survival and/or differentiation of NKT cells and also a potent regulator of lymphocyte homeostasis in vivo. (lu.se)

However, whether miR-103b can target and downregulate ITGB3 in stored platelets and such miRNA regulation promotes apoptosis is not known. (eurekaselect.com)
Our data show that knock-down of p27/Kip1 expression significantly suppressed the magnolol-induced apoptosis, suggesting that p27/Kip1 might play an important role in the regulation of magnolol-induced apoptosis. (tmu.edu.tw)
Mitochondrial regulation of apoptosis further downstream was investigated, showing changes in the mitochondrial membrane potential, cytochrome c release into the cytoplasm, and enhanced activation of cleaved caspase-3 and Poly ADP-ribose polymerase (PARP). (hindawi.com)
This process plays a major role in development and tissue homeostasis, and abnormal regulation of apoptosis is associated with a variety of human diseases ( Fuchs and Steller, 2011 ). (elifesciences.org)

Collectively, these data provide insight into the molecular mechanisms underlying terpinen-4-ol-induced apoptosis in NSCLC cells, rendering this compound a potential anticancer drug for NSCLC. (hindawi.com)
However, underlying mechanisms of apoptosis are not well understood in stored platelets. (eurekaselect.com)
Further study on the mechanisms of p38MAPK in human TM cell apoptosis may help to illuminate the pathogenesis of POAG. (molvis.org)

In the present study, we comparatively analyzed the cell apoptosis and cell signaling pathways of healthy patients and those with recurrent spontaneous abortion, providing a theoretical basis for clinical treatment. (spandidos-publications.com)
To delineate the possible signaling pathways involved in the magnolol-induced increases of p27/Kip1 expression and apoptosis, we found that magnolol (100 μM) increased the levels of phosphorylated cSrc (p-cSrc), p-ERK, p-p38 MAP kinase (p-p38 MAPK), and p-AKT but not p-JNK in U373. (tmu.edu.tw)
In this review, we focused our attentions on carcinogenic metal-induced signal transduction pathways leading to the activation of NF-kappaB, cell apoptosis and cell cycle progression, three crucial steps or events involved in the transformation and carcinogenesis. (cdc.gov)

Capsid gene delivery into the striatum of mouse brain or interskeletal muscle resulted in cell death and inflammation, likely through capsid-induced apoptosis in vivo. (cdc.gov)
Semithin (1.0-µm) sections resulted in apoptosis and inflammation of muscle cells. (cdc.gov)

[ 10 , 12 ] G-CSF suppresses apoptosis and prolongs the survival of neutrophils in vivo in a CD34 + cell population. (medscape.com)

Apoptosis was partially blocked by the caspase-3 inhibitor Ac-DEVD-CHO. (hindawi.com)

C1QBP significantly increased ROS level, apoptosis, and the expression of apoptotic proteins such as cleaved caspase-3 and bax/bcl2 via regulating XDH. (medsci.org)
When C5a was generated in vivo by infusion of purified cobra venom factor (CVF), thymocyte apoptosis was significantly increased. (jci.org)

Objective: Our objective of this study is to validate the abundance of miR-103b in stored platelets and identify whether ITGB3 is a target of miR-103b for the downregulation and this interaction promotes apoptosis. (eurekaselect.com)
Scholars@Duke publication: GNA13 loss in germinal center B cells leads to impaired apoptosis and promotes lymphoma in vivo. (duke.edu)
C1QBP promotes the catabolism of hypoxanthine and elevates the apoptosis of RCC cells by modulating XDH-mediated ROS generation. (medsci.org)
2017. Identification of a Raloxifene Analog That Promotes AhR-Mediated Apoptosis in Cancer Cells. . (oregonstate.edu)

Zonal ex vivo fluorescent signals were surrounding the ischemic core, and double-positive cells with Cy5.5/exogenous A5 antibody were found in this area. (elsevierpure.com)

Caspase-3-generated cytokeratin-18 fragments were measured in situ via immunohistochemistry and in vivo using a novel enzyme-linked immunosorbent assay. (nih.gov)
Apoptosis was determined by cell death assay and western blotting. (biomedcentral.com)
C1QBP knockdown and overexpression cells were established via lentiviral infection and subjected to apoptosis and ROS assay in vitro . (medsci.org)

Recent reports have indicated that terpinen-4-ol exerts its antitumor effects by triggering caspase-dependent apoptosis in human melanoma cells or by inducing necrotic cell death and cell-cycle arrest in mouse mesothelioma and melanoma cell lines without affecting normal cells [ 14 , 15 ]. (hindawi.com)
The in vivo effects of silibinin were evaluated using a Ca9-22 xenograft mouse model. (jcancer.org)
Antibodies Targeting IL1RAP Show Strong In Vivo Therapeutic Effects and Exhibit a Dual Mode of Action in Acute Myeloid Leukemia. (lu.se)

Following cecal ligation and puncture (CLP) in rats, thymocytes underwent apoptosis in a time-dependent manner. (jci.org)

The aim of this study was to quantify hepatocyte apoptosis in plasma from patients with NAFLD and correlate it with histological severity. (nih.gov)
Conclusion: Blocking IL-6 suppresses STAT-3 activation in the pancreas and consequently attenuates the severity of severe acute pancreatitis by promotion of pancreatic acinar cell apoptosis. (tmu.edu.tw)

In vivo fluorescence was strongly observed at 48 hr over the head, especially with removal of both head skin and skull bone. (elsevierpure.com)
The in vivo Cy5.5 fluorescence representing A5 signal spatially surrounding the ischemic core temporally detects an early-stage apoptosis after cerebral ischemia. (elsevierpure.com)

Thus, GNA13 loss is associated with GC B-cell persistence, in which impaired apoptosis and ongoing somatic hypermutation may lead to an increased risk of lymphoma development. (duke.edu)

In vivo and in organized cells, and proper symmetry are healthy individuals, macrophages can characteristics of higher-quality embryos, which phagocytize DNA that has been passively point to healthy development and higher rates of released into the blood from apoptotic or necrotic implantation. (who.int)

In vivo CRISPR screening identifies an essential role for CXCR4 in MLL-AF9 driven acute myeloid leukemia independently of CXCL12. (lu.se)

Multiorgan apoptosis occurs during sepsis. (jci.org)

Similarly, Triphala induced apoptosis in another pancreatic cancer cell line BxPC-3 by activating ERK. (biomedcentral.com)
Apoptosis in pancreatic sections was determined by the terminal deoxynucleotidyltransferase-mediated dUTP-biotin nick-end labelling method. (tmu.edu.tw)

While substance P has been extensively studies in human hair follicles in vitro, in vivo studies have not been performed. (medscape.com)
To investigate the effect of gambogic acid (GA) on apoptosis in the HT-29 human colon cancer cell line. (wjgnet.com)
Moreover, The use of animals as surrogate rine host, can provide a platform for animal models for tumour viruses in hosts for the study of human tu- in vivo infection. (who.int)

Cell apoptosis was detected by terminal deoxynucleotidyl transferase dUTP nick end labeling and Hoechst 33342 staining, and quantified by flow cytometry. (wjgnet.com)

Apoptosis has been thought to resemble a form of silent suicide by cells, but more recent work suggests that apoptotic cells can also transmit signals. (elifesciences.org)

Apoptosis is a distinct form of programmed cell death in which cells activate an intrinsic suicide program to self-destruct. (elifesciences.org)

Cell cycle analysis suggested activation of apoptosis, without arresting cell cycle progression. (nature.com)
Moreover, it induced cell cycle arrest in the G0/G1 phase, apoptosis, and ROS generation in these cells. (jcancer.org)

Anatomy31

Organisms9

Diseases11

Chemicals and Drugs131

Analytical, Diagnostic and Therapeutic Techniques and Equipment20

Phenomena and Processes54

Disciplines and Occupations1

Information Science3

Induces Apoptosis6

Vitro and In Vivo14

Induction11

Necrosis6

Induce6

Oxidative stress4

Arrest and apoptosis1

Pathway11

Cells from apoptosis2

Protein9

Macrophage apoptosis2

Confirmed by TUNEL assay1

Reactive oxygen2

Mice10

Neuronal4

Proliferation3

Morphological changes1

TUNEL2

Inhibits1

Methods1

Autophagy4

Cellular4

Assays1

Annexin3

Xenografts3

Genes1

XIAP2

Regulation4

Mechanisms3

Pathways3

Inflammation2

Survival1

Inhibitor1

Significantly increased2

Promotes4

Fluorescent1

Assay3

Effects3

Time-dependent manner1

Severity2

Fluorescence2

Lymphoma1

Macrophages1

Acute1

Occurs1

Pancreatic2

Human3

DUTP nick1

Apoptotic cells1

Distinct1

Cell cycle2