Apoptosis cell wnt signaling pathway. Medical search. Frequent questions

Purified cannabinoids have been reported to prevent proliferation, metastasis, and induce apoptosis in a variety of cancer cell types. (nih.gov)
3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT)-test was used to observe the proliferation of human breast cancer MCF-7 and MDA-MB-231 cells induced on VALD-3. (researchsquare.com)
This suggests the possibility that strictly regulated self-renewal mediated by Wnt signaling in cancer cells may be disturbed by the SUMOylation pathway to allow more malignant proliferation. (frontiersin.org)
The DEmRNAs were mainly enriched in tumorigenesis‑associated GO terms (angiogenesis, positive regulation of cell proliferation, positive regulation of fibroblast apoptotic processes and regulation of neutrophil migration) and pathways (Hippo signaling pathway, cancer pathways, and Wnt signaling pathway). (spandidos-publications.com)
The results demonstrate that DLEU1 and TRAF4 is highly expressed in GBM tissues and promotes proliferation of GBM cells. (spandidos-publications.com)
For example, lncRNA nuclear paraspeckle assembly transcript 1 (NEAT1) is highly expressed in GBM tissues and perturbed expression of NEAT1 suppresses cell proliferation and invasion ( 10 ). (spandidos-publications.com)
Reverse transcription-quantitative polymerase chain reaction (RT-qPCR) and cell proliferation assay were used to explore the functional role of the key lncRNAs in GBM. (spandidos-publications.com)
however, there is no consistent effect on cell viability and proliferation with either of these TiO2 particles. (cdc.gov)
Cell viability, proliferation, toxicity, and apoptosis were determined by cell counting kit-8 (CCK-8), colony formation, lactate dehydrogenase (LDH) activity, TdT-mediated dUTP Nick-End Labeling (TUNEL), and flow cytometry assays. (harvard.edu)
Scutellarin (20 and 80 μmol/L) suppressed proliferation and promoted LDH release and apoptosis. (harvard.edu)
CONCLUSION: Scutellarin suppressed gastric cancer cell proliferation and promoted apoptosis by inhibition of the Wnt/β-catenin pathway. (harvard.edu)
Cancer-preventing strategies of these beneficial bacteria such as binding to carcinogens and degrading them, stimulating anti-cancer enzymes, and preventing the conversion of procarcinogens to carcinogens, production of beneficial compounds that act as signaling molecules affecting the immune system, cell death, and proliferation, and interference with cell signaling pathways are reported [ 16 - 19 ]. (hindawi.com)
Most of these paracrine secretions include soluble factors and exosomes, which regulate the repair and regeneration processes at sites of damage by affecting cell proliferation, migration, and differentiation [ 22 , 23 ]. (hindawi.com)
The Wnt family encodes a large group of signaling molecules that are involved in cell proliferation, differentiation, migration and apoptosis [ 13 , 14 ]. (oncotarget.com)
Emerging evidence has demonstrated that WISP2 is critically involved in cell proliferation, migration, invasion and metastasis in cancers. (biomedcentral.com)
Therefore, we aim to explore the effects and the potential mechanism of WISP2 on proliferation and motility and invasion of ESCC cells. (biomedcentral.com)
Cell proliferation was detected by MTT assay and apoptosis was measured by FACS in ESCC cells after WISP2 downregulation and overexpression. (biomedcentral.com)
One study further identified that WISP2 expression was enhanced by serum and correlated with serum-induced cell proliferation in breast cancer cells, demonstrating that WISP2 could enhance cell proliferation in breast cancer [ 8 ]. (biomedcentral.com)
At the proliferation stage, proliferation related pathways and basic cellular and metabolic processes were inhibited, while regulatory factors that initiate differentiation enter the ready-to-activate state, which provides a precondition for initiating adipose differentiation. (biomedcentral.com)
The Notch signaling pathway, also involved in embryogenesis, plays a key role in regulating cell differentiation, proliferation and programmed cell death (apoptosis), as well as the functioning of normal stem cells. (beforeitsnews.com)
Accumulating evidence supports the view that the role of MSCs in regenerative medicine is mainly achieved by the paracrine pathway rather than direct proliferation and differentiation at the injured site. (biomedcentral.com)
We demonstrated that the bioactivity of PEG-rhGH in promoting Nb2-11 cell proliferation displays a dose-response relationship, which conformed to the four-parameter model. (bvsalud.org)
Aberrant glycolytic reprogramming is involved in lung cancer progression by promoting the proliferation of non-small cell lung cancer cells. (cjphysiology.org)
Paeonol, as a traditional Chinese medicine, plays a critical role in multiple cancer cell proliferation and inflammation. (cjphysiology.org)
Here, we investigated whether paeonol regulates the proliferation and glycolytic reprogramming via ACADM with m6A modification in A549 cells (human non-small cell lung cancer cells). (cjphysiology.org)
Cell counting kit 8, 5-Bromo-2-deoxyuridine, 5-ethynyl-2'-deoxyuridine (EdU) incorporation, flow cytometry analysis, western blotting and seahorse XFe24 extracellular flux analyzer assays showed that paeonol had a significant inhibitory effect against A549 cell proliferation and glycolysis. (cjphysiology.org)
We also showed that the m6A reader YTH domain containing 1 plays an important role in m6A-modified ACADM expression, which is negatively regulated by paeonol, and is involved in A549 cell proliferation and glycolytic reprogramming. (cjphysiology.org)
These results indicated the central function of paeonol in regulating A549 cell glycolytic reprogramming and proliferation via m6A modification of ACADM. (cjphysiology.org)
For example, paeonol inhibits proliferation and induces apoptosis of bladder cancer cells in vitro and in vivo by regulating the phosphorylation expression of phosphatidylinositol 3-kinase and protein kinase B (PKB/AKT). (cjphysiology.org)
[7] Notably, a recent study also illustrated that the proliferation and motility of A549 cells can be suppressed by paeonol by disrupting signal transducer and activator of transcription 3 (STAT3)/nuclear factor kappa B (NF-κB) subunit signaling. (cjphysiology.org)
[8] Nonetheless, whether paeonol participates in the regulation of A549 cell (human non-small cell lung cancer cell) proliferation through other signaling pathways remains to be elucidated. (cjphysiology.org)
Glycolytic reprogramming, known as the "Warburg effect," is the leading factor in the proliferation of cancer cells. (cjphysiology.org)
Results and Conclusions: The adaptation process was characterized by initial cell population growth arrest, and after that extensive cell death, followed by proliferation and long-term survival of clonal cultures. (lu.se)
Proliferation and cell cycle progression of the serum-free cultures closely mimicked that of serum-dependent cells. (lu.se)

The expression of pro-apoptotic proteins and anti-apoptotic proteins in MCF-7 and MDA-MB-231 cells was investigated by Western blotting. (researchsquare.com)
SUMOylation is a post-translational modification of proteins that has been found to play a major role in the Wnt/β-catenin signaling pathway. (frontiersin.org)
Proteins associated with the Wnt/β-catenin pathway have been identified as SUMOylated substrates, and evidences suggested that the initiation and progression of cancers depended on the function of the SUMOylation ( 23 ). (frontiersin.org)
Expressions of apoptosis-related and Wnt/β-catenin signaling pathway- related proteins were examined by western blot and quantitative reverse transcription polymerase chain reaction (qRT-PCR). (harvard.edu)
In the presence of Wnt signals, the Wnt proteins bind to (frizzled) frizzled receptors ( FZDs ) and low-density lipoprotein receptor-related protein ( LRP ) receptors, leading to the stabilization of β-catenin , its transfer to the nucleus, and the activation of target genes. (hindawi.com)
By transporting "cargos" such as proteins, RNAs, DNAs, and lipids [ 26 ], exosomes regulate the eventual fate of recipient cells. (hindawi.com)
Histological analysis and western blotting confirmed that CoQ 0 significantly decreased the xenografted tumor progression as demonstrated by induction of apoptosis, suppression of β-catenin, and inhibition of cell cycle-, apoptotic-, and metastatic-regulatory proteins. (oncotarget.com)
CXCR1 and CXCR2 are proteins expressed on cells, including CSCs, which respond to the aforementioned cytokines in a deleterious manner. (beforeitsnews.com)
Several DEATH DOMAIN RECEPTOR SIGNALING ADAPTOR PROTEINS can bind to the death domains of the activated receptors and through a complex series of interactions activate apoptotic mediators such as CASPASES. (bvsalud.org)

The results of these analyses revealed that the differentially expressed exosomal miRNAs participate in multiple biological processes, such as gene expression, synthesis of biomolecules, cell development, differentiation, and signal transduction, among others. (hindawi.com)
Moreover, we found that these differentially expressed exosomal miRNAs connect osteogenic differentiation to processes such as axon guidance, MAPK signaling, and Wnt signaling. (hindawi.com)
However, transcriptional dynamic regulation of adipose differentiation driven by complex signal cascades remains largely unexplored in this model. (biomedcentral.com)
According to weighted gene co-expression network analysis, pathways positively related to adipogenic differentiation are significantly activated at the differentiation stage, while WNT, FOXO and other pathways that inhibit preadipocyte differentiation are negatively regulated. (biomedcentral.com)
Different cancers and immune cells have different dependence on lipid metabolism, playing a pivotal role in differentiation and function of immune cells. (bvsalud.org)
However, when employing MSC transplantation to treat tissue defects, the research found that: less than one percent of MSCs could home and colonize in the tissue defect area, continuously promoting tissue regeneration, and the paracrine mechanism of MSCs plays a more important role than the replacement of damaged cells by differentiation [ 13 ]. (biomedcentral.com)
Dickkopf-3 alters the morphological response to retinoic acid during neuronal differentiation of human embryonal carcinoma cells. (nih.gov)
Additionally, decreased activity and abnormal differentiation of bone marrow mesenchymal stem cells may be an important mechanism in the occurrence and development of SONFH [ 5 ]. (biomedcentral.com)
miR-203 drives breast cancer cell differentiation. (medscape.com)

Studies have shown that the Wnt/β-catenin signaling pathway controls cell fate and function through the transcriptional and post-translational regulation of omics networks. (frontiersin.org)
Therefore, precise regulation of Wnt/β-catenin signaling as a cancer-targeting strategy may contribute to the treatment of some malignancies. (frontiersin.org)
Here, we review the complex regulation of Wnt/β-catenin signaling by SUMOylation and discuss the potential targets of SUMOylation therapy. (frontiersin.org)
The recently described role of the Wnt/β-catenin pathway in the regulation of immune cell infiltration of microenvironment tumor resumes interest because of its potential impact to rection of immune therapy. (chemdiv.com)
Mechanistically, WISP2 exerts its tumor suppressive functions via regulation of ERK1/2, Slug, and E-cadherin in ESCC cells. (biomedcentral.com)
Notably, non- or sub-cytotoxic concentrations of CoQ 0 markedly inhibited migration and invasion, accompanied by the down-regulation of MMP-2 and -9, and up-regulation of TIMP-1 and -2 expressions in highly metastatic B16F10 cells. (oncotarget.com)
Most importantly, the regulation of lipid metabolism is central to the appropriate immune response of tumour cells, and ultimately to exert the immune efforts to realise the perspective of many anti-tumour effects. (bvsalud.org)
HighlightsThe regulation of lipid metabolism is central to the appropriate immune response of tumour cells, and ultimately to exert the immune efforts to realise the perspective of many anti-tumour effects.Preparations of focusing lipid metabolism have side effects of systemic toxicity and defects of individual drugs. (bvsalud.org)
In contrast, regulation of breast cancer CSCs (BCSCs) occurs by CD44 standard splice isoform (CD44s)-activated platelet-derived growth factor receptor b (PDGFRb)/signal transducer and activator of transcription 3 (STAT3), forkhead box C1 (FOXC1)-activated sonic hedgehog (SHH), and sphingosine-1-phosphate (S1P)/S1PR3-activated NOTCH pathways [ 10 - 13 ] . (oaepublish.com)
Astragalus polysaccharide (APS) is a major active ingredient of Astragalus membranaceus, and possesses various biological functions such as immune regulation, anti-tumor and anti-apoptosis [ 6 ]. (biomedcentral.com)
The effect of WNT signaling on regulation of atrial natriuretic peptide (ANP) secretion is unclear. (kjpp.net)
Most changes were subtle, but frequently the genes with altered expression were involved in basal cellular functions such as cell division, cell cycle regulation, apoptosis and cell signalling. (lu.se)

Abnormally activated Wnt/β-catenin signaling pathway plays a crucial role in promoting malignant tumor occurrence, development, recurrence, and metastasis, particularly in cancer stem cells. (frontiersin.org)
In addition, Wnt/β-catenin has emerged as a critical regulator of cancer stem cells (CSCs), which is considered one of the root causes of cancer recurrence and metastasis because of their heterogeneity and plasticity ( 13 ). (frontiersin.org)
An imbalance in the structural and signaling properties of β-catenin often leads to disease and unregulated growth associated with cancer and metastasis. (chemdiv.com)
Pathway-based biomarkers identification may help elucidate the cellular signature of breast cancer metastasis in bone, further characterizing the etiology and promoting new therapeutic approaches. (degruyter.com)
Samarzija, I. Wnt Signaling Pathway in Liver Metastasis. (encyclopedia.pub)
Wnt Signaling Pathway in Liver Metastasis" Encyclopedia , https://encyclopedia.pub/entry/15642 (accessed November 30, 2023). (encyclopedia.pub)
Herein, the role of the Wnt signaling pathway in liver metastasis is outlined. (encyclopedia.pub)
In vitro and in vivo anti-tumor activity of CoQ 0 against melanoma cells: inhibition of metastasis and induction of cell-cycle arrest and apoptosis. (oncotarget.com)
This study examined the in vitro or in vivo anti-tumor, apoptosis, and anti-metastasis activities of CoQ 0 (0-20 μM) through inhibition of Wnt/β-catenin signaling pathway. (oncotarget.com)
RHAMM regulates MMTV-PyMT-induced lung metastasis by connecting STING-dependent DNA damage sensing to interferon/STAT1 pro-apoptosis signaling. (medscape.com)

RNA profiling identified 2283 differentially expressed genes in F7+F3 treatment, among them genes related to the Wnt signaling pathway and apoptosis-related genes. (nih.gov)
The real-time PCR method was used to analyse the L. rhamnosus supernatant effect on the expression of Wnt signaling pathway genes. (hindawi.com)
The supernatant of this bacterium significantly reduced the expression of Wnt signaling pathway genes. (hindawi.com)
This study is the first report that assessed the potential impact of L. rhamnosus , especially its supernatant on esophageal cancer and Wnt signaling pathway genes. (hindawi.com)
β-catenin forms a complex with T-cell factor ( TCF ) /lymphoid enhancer factor ( LEF ) transcription factors and cofactors such as histone acetyltransferase p300 (p300), CBP, BCL9, and pygopus, to transcribe Wnt signaling target genes such as Cyclin D1 , C-Myc , and survivin [ 9 , 12 - 15 ]. (hindawi.com)
To identify pro-apoptotic genes targeted by the five anti-apoptotic miRNAs, I validated one previously published target and identified nine novel targets by performing photoactivatable ribonucleoside-enhanced crosslinking and immunoprecipitation (PAR-CLIP) in the EBV+ NPC cell line C666. (duke.edu)
Next, I thoroughly demonstrated that the 10 candidate target genes were substantially suppressed by expression of the relevant miR-BARTs, as measured by 3'UTR-containing firefly luciferase (FLuc) expression, mRNA and protein levels, and knockdown of seven of the 10 candidate genes could suppress apoptosis, mimicking the effects of relevant miR-BARTs. (duke.edu)
On the other hand, in order to identify miR-BARTs that can activate the Wnt signaling pathway, I analyzed the PAR-CLIP data set of C666 cells and discovered nine anti-Wnt signaling targets of miR-BARTs, including seven novel genes and two pro-apoptotic genes identified above. (duke.edu)
Using FLuc 3'UTR indicator assays, I proved that the 3'UTRs of all seven newly identified anti-Wnt signaling genes were indeed targeted by the relevant miR-BARTs identified by PAR-CLIP. (duke.edu)
Additional screens for MMTV provirus entry sites in tumors revealed several other upregulated genes that are associated with other gene development pathways such as INT2, INT3, and INT4 [4,5,6]. (chemdiv.com)
Three methods including MetaCore analysis for disease and pathway correlations, concordance analysis between array-CGH database and the expression array database, and literature search for copy number variation genes were performed to select novel lung cancer candidate genes. (biomedcentral.com)
Gene validation for four genes including ARHGAP19 (10q24.1) functioning in Rho activity control, FRAT2 (10q24.1) involved in Wnt signaling, PAFAH1B1 (17p13.3) functioning in motility control, and ZNF322A (6p22.1) involved in MAPK signaling was performed using qPCR and RT-qPCR. (biomedcentral.com)
tumor cells showed a significant deregulation of stemness genes associated with enhanced colony forming properties. (pkc-inhibitor.com)
Lots of the differentially governed genes were involved with inflammation and immune system response, STF-62247 cell adhesion, aswell as apoptosis (Fig. S1A). (pkc-inhibitor.com)
Some alterations were restored when the cells were transferred back to serum-containing medium, indicating that expression of these genes was controlled by components in serum. (lu.se)
Among these were, for example, several genes within the Wnt signalling pathway. (lu.se)

Wnt/β-catenin signaling is a delicate and complex signal transduction pathway mediated by multiple signaling molecules, which plays a significant role in regulating human physiology and pathology. (frontiersin.org)
This has led to an improved understanding of the multilayered mechanisms of this pathway transduction proceeds as well as the molecular mechanism regulating this pathway ( 28 ). (frontiersin.org)
Generally speaking, signal transduction pathways in the initiation and progression of cancer are essential. (hindawi.com)
The Wnt pathway mediates the biological processes of the canonical or non-canonical pathway, depending on the involvement of β-catenin in signal transduction. (chemdiv.com)
WNT signal transduction is an elaborate and complex aggregation of signaling pathways that regulate a wide range of cellular functions during development and in adult organisms. (kjpp.net)

This study is the first to show that VALD-3 induces apoptosis and cell cycle arrest in human breast cancer cells by suppressing Wnt/β-catenin signaling, indicating that it could be a potential drug for the treatment of breast cancer. (researchsquare.com)

APC, WNT signaling pathway regulator is a protein that in humans is encoded by the APC gene. (wikipedia.org)
This gene encodes a tumor suppressor protein that acts as an antagonist of the Wnt signaling pathway. (wikipedia.org)
Signaling is initiated when the Wnt ligand binds to the Frizzled receptor on the cell membrane and the LDL receptor-associated protein 5/6 (LRP5/6) co-receptor. (frontiersin.org)
In the absence of Wnt signals, the cytoplasmic catenin beta-1 ( β-catenin ) is associated with a complex including auxin, glycogen synthase kinase 3 ( GSK-3 ), and adenomatous polyposis coli ( APC ) (the APC protein acts as the primary regulator of β-catenin function). (hindawi.com)
What pathways are this gene/protein implicaed in? (cancerindex.org)
In EBV latently infected epithelial cells, such as nasopharyngeal carcinoma (NPC) and gastric carcinoma (GaCa) cells, viral protein expression is low. (duke.edu)
Given that protein aggregates in liver cells are closely linked to alcoholic liver disease, these findings suggest that quercetin could be a useful treatment for patients with this condition. (qualitycounts.com)
Molecular 'switch' reverses chronic inflammation and aging - Science Daily, 2/6/20 - 'By studying mice and immune cells called macrophages, the team found that a protein called SIRT2 is responsible for deacetylating the NLRP3 inflammasome. (qualitycounts.com)
The roles of b-catenin are 'classically' defined: as an adhesion protein and as a signaling protein, transducing extracellular signals to the nucleus to modify gene expression. (chemdiv.com)
β -catenin has many binding partners that mediate a diverse set of cellular functions, and the protein probably acts as a 'hub' on which many cellular signaling networks impinge. (chemdiv.com)
It is a catalytic subunit of the protein kinase complex that is important for cell cycle G1 phase progression. (thermofisher.com)
1 Prostate-specific antigen is a protein produced by the cells of the prostate gland, including both cancerous cells as well as cells that are benign. (lifeextension.com)
For instance, CSC maintenance in glioblastoma, colon cancer, gastric cancer, and prostate cancer is regulated by CD133-mediated AKT, leucine-rich G-protein-coupled receptor 5 (LGR5)-mediated Wnt/β-catenin and speckle-type POZ protein (SPOP)-mediated Nanog pathways [ 4 - 8 ] . (oaepublish.com)
The dickkopf protein family interacts with the Wnt signaling pathway and its members are characterized by two conserved cysteine-rich domains. (nih.gov)
In the canonical WNT pathway, activated WNT phosphorylates the dishevelled (DVL) protein leading to dissociation of β-catenin from its destruction complex. (kjpp.net)

This cancer is divided into two types: (1) squamous cell carcinoma, which appears in the middle or top of the esophagus and (2) adenocarcinoma, seen in the glandular cells of the esophagus [ 1 ]. (hindawi.com)
However, the function of WISP2 in esophageal squamous cell carcinoma (ESCC) is largely unclear. (biomedcentral.com)
In a whole-genome sequencing in 17 Esophageal Squamous Cell Carcinoma cases and whole-exome sequencing in 71 cases, Song (2014), reported ASH1L alterations. (cancerindex.org)
The Clinical Significance of Dickkopf Wnt Signaling Pathway Inhibitor Gene Family in Head and Neck Squamous Cell Carcinoma. (nih.gov)
risk of esophageal squamous cell carcinoma. (who.int)
PMID:18786442 mutations and the risk of esophageal squamous cell carcinoma. (who.int)
Arbyn M, Bergeron C, Klinkhamer P, Martin-Hirsch squamous cell carcinoma in a high-risk region in Iran. (who.int)

The Wnt pathway is one of the most critical signaling pathways activated by mutation in many cancers [ 7 - 9 ]. (hindawi.com)
Following NK1R blockage by aprepitant, a significant growth inhibition of hepatoblastoma cells and colon cancer cells as well as induction of apoptosis was detected, which was associated with the downregulation of two critical signaling pathways, namely Wnt and PI3K/AKT/mTOR. (uni-muenchen.de)

Gliotoxin, a Wnt signaling pathway inhibitor, induces growth inhibition and apoptosis in multiple colorectal cancer cell lines with mutations of the Wnt signalin. (targetmol.com)

Here, I present two studies utilizing the phenotypic and the target approaches, respectively, to demonstrate that miR-BARTs can inhibit apoptosis and activate the Wnt signaling pathway. (duke.edu)
To discover miR-BARTs that can inhibit apoptosis, I individually expressed miR-BARTs in the EBV- GaCa cell line AGS, and identified five miR-BARTs that conferred this phenotype. (duke.edu)
Curcumin has been found to inhibit the Hedgehog pathway through a number of different mechanisms. (beforeitsnews.com)
Mechanistically, SP1 targeted miR-200b-3p to inhibit Wnt/β-catenin pathway. (biomedcentral.com)

Furthermore, the Wnt/β-catenin can crosstalk with other signaling pathways including Notch, FGF, Hedgehog, and TGF-β/BMP signaling cascades to form a signaling network to regulate the survival and progression of cancer cells ( 14 - 16 ). (frontiersin.org)
Many of the biological effects of flavonoids appear to be related to their ability to modulate a number of cell-signaling cascades. (oregonstate.edu)

Thus, we aimed at investigating the impact of NK1R inhibition with aprepitant on cell growth, apoptosis, downstream mechanims and cancer stem cells in three human hepatoblastoma cell lines HepT1, HepG2 and HuH6 and the human colon cancer cell lines LiM6 and DLD1. (uni-muenchen.de)
Publisher Correction: RAGE inhibition blunts insulin-induced oncogenic signals in breast cancer. (medscape.com)

The Wnt cascade consists of canonical and non-canonical pathways, of which the former is believed to be involved in self-regeneration. (hindawi.com)
Speaking more specifically, β-catenin is an integral structural component of cadherin-based adhesive junctions as well as it a key nuclear effector of canonical in nucleus Wnt signaling. (chemdiv.com)

VALD-3 also regulated the Wnt/β-catenin signaling pathway in breast cancer cells, inhibiting the activation of downstream molecules. (researchsquare.com)
Conceptually, it is an efficient way to treat cancer involved the hijacking of PTMs of the key molecules in Wnt/β-catenin. (frontiersin.org)
Thus, targeting signal molecules can be helpful for cancer therapy [ 6 ]. (hindawi.com)
The term "oncotarget" encompasses all molecules, pathways, cellular functions, cell types, and even tissues that can be viewed as targets relevant to cancer as well as other diseases. (oncotarget.com)
These cells, surrounding the hair follicles, secrete signaling molecules that control the progression of the hair cycle. (jcadonline.com)
It has been found that some of the SVF cell types possess regenerative and anti-inflammatory potentials in damaged tissues due to their ability to secrete growth factors and anti-inflammatory molecules. (jcadonline.com)
The surface molecules of EVs enable them to target recipient cells. (biomedcentral.com)

Adipose cells organized in small clusters under the reticular dermis closely interact with hair follicular cells and regulate the hair cycle. (jcadonline.com)
Mitochondria, a powerhouse of the cell, are rich in a large number of enzymes, which not only participate in cellular oxidative phosphorylation and ATP synthesis, but also regulate intracellular calcium ions and reactive oxygen species to maintain cellular homeostasis. (biomedcentral.com)

Abnormal activation of this pathway plays an essential role in chemoradiotherapy resistance ( 12 ). (frontiersin.org)
Abnormal activation of the Wnt cascade leads to carcinogenesis [ 10 , 11 ]. (hindawi.com)
Abnormal functioning of this pathway is implicated in a wide range of cancers and in the stimulation of CSCs and associated increases in tumor recurrence after conventional treatment. (beforeitsnews.com)
WNT signaling plays an important role in cardiac development, but abnormal activity is often associated with cardiac hypertrophy, myocardial infarction, remodeling, and heart failure. (kjpp.net)

It is also involved in other processes including cell migration and adhesion, transcriptional activation, and apoptosis. (wikipedia.org)
The suppression of β-catenin was seen with CoQ 0 administration accompanied by a decrease in the expression of Wnt/β-catenin transcriptional target c-myc, cyclin D1, and survivin through GSK3β-independent pathway. (oncotarget.com)

Utilizing a Wnt signaling FLuc reporter TOPflash which measures the Wnt signaling activation, I confirmed that expression of many miR-BARTs that target Wnt signaling inhibitors can indeed upregulate the Wnt signaling pathway. (duke.edu)
ChemDiv's Inhibitors of beta-Catenin Signaling Library contains 8,000 compounds. (chemdiv.com)

Taken together, these findings give important insight into the molecular mechanisms of the NK1R as a critical component in tumorigenesis and can help in the development of future anticancer therapies for Wnt-activated cancers such as hepatoblastoma and colon cancer. (uni-muenchen.de)
Deregulation of components involved in Wnt/β-catenin signaling has been implicated in a wide spectrum of diseases including a number of cancers and degenerative diseases. (chemdiv.com)
Aberrant Notch signaling has been implicated in a wide range of cancers. (beforeitsnews.com)
Substantial data have provided convincing evidence establishing that human cancers emerge from cancer stem cells (CSCs), which display self-renewal and are resistant to anticancer drugs, radiation, and apoptosis, and express enhanced epithelial to mesenchymal progression. (oaepublish.com)
Several mechanisms participate in the drug and apoptosis resistance phenotype in CSCs in various cancers. (oaepublish.com)

These receptors, which include Toll-like receptors, are portion of an internal sponsor defense Paroxetine HCl realizing nucleic acids aberrantly present in the cytoplasm from illness or cell stress. (columbiagypsy.net)
A family of cell surface receptors that signal via a conserved domain that extends into the cell CYTOPLASM. (bvsalud.org)

Furthermore, Wnta1 upregulated the expression of T cell factor (TCF) 3, TCF4, and lymphoid enhancer factor 1 (LEF1), and these effects were blocked by U73122 and Go 6983. (kjpp.net)
Subsequently, β-catenin translocates to the nucleus and interacts with transcription factors including T cell factor (TCF)/lymphoid enhancer-binding factor (LEF). (kjpp.net)

In this study, we investigated the cytotoxic and apoptotic effects of VALD-3, a Schiff base ligand synthesized from o-vanillin derivatives, on human breast cancer cells and the possible underlying mechanisms. (researchsquare.com)
In this study, we explore different signaling pathways and associated molecular mechanisms of underlying primary breast cancer development, along with the formation of metastases in the bone. (degruyter.com)
Studying such mechanisms not only provides mechanistic insights into these cells that are unresponsive to drugs, but may lead to the development of targeted and effective therapeutics to eradicate CSCs. (oaepublish.com)
This article will review the CSCs drug and apoptosis resistance mechanisms and how to target CSCs. (oaepublish.com)

The Wnt signaling pathway regulates a wide range of processes during embryonic development, but are also dsyregulated in cancer. (beforeitsnews.com)
Another pathway involved in embryogenesis, the Hedgehog pathway also regulates normal stem cell activity. (beforeitsnews.com)

Furthermore, TiO2-treated cells showed minimal effects on VEGF upregulation and Wnt signaling pathway thereby showing no potential effect on angiogenesis and malignant transformation. (cdc.gov)

An in vivo investigation in nude mice was done to assess the anti-tumor activity of L. rhamnosus supernatant and whole-cell culture. (hindawi.com)

Wnt/β-catenin signaling is a branch of a functional network that is involved in a broad range of biological systems including stem cells, embryonic development and adult organs. (chemdiv.com)

IL-8, another cytokine, is released after tumor cell death, subsequently stimulating CSCs to regrow the tumor and resist chemotherapy. (beforeitsnews.com)
IL-1, a family of cytokines, are involved in response to injury and infection, with IL-1 β playing a key role in cancer cell growth and the stimulation of CSCs. (beforeitsnews.com)
This pathway plays a key role in regulating normal stem cells, with aberrant signaling stimulating CSCs, resulting once again in tumor recurrence and resistance to chemotherapy. (beforeitsnews.com)
Curcumin has been found in multiple studies to destroy CSCs through inhibiting this pathway. (beforeitsnews.com)
CSCs represent a heterogeneous tumor cell population and lack specific cellular targets, which makes it a great challenge to target and eradicate them. (oaepublish.com)
The biological importance of activation targets of Nanog, Oct4, SOX-2, and c-Myc in CSCs, which are more frequently overexpressed in poorly differentiated tumors than in well-differentiated tumors, has been shown by correlating signature characteristics of these cells and poor survival [ 3 ] . (oaepublish.com)
Interestingly, specific dysregulated signaling pathways maintain CSCs renewal capacity with unique patterns among various tumor types. (oaepublish.com)

95% of the global population, and can give rise to a number of malignancies in B cells and epithelial cells. (duke.edu)
It is likely that miR-BARTs play a crucial role in EBV-infected epithelial cells, however a comprehensive understanding of miR-BARTs is currently lacking. (duke.edu)
Bile acid treatment also increased the expression of KLF5, CDX2, MUC2 and villin in esophageal epithelial cells in a time-dependent manner. (jcancer.org)

This review will first focus on emerging research progress of lipid metabolic reprogramming mechanism, and then explore the complex role of lipid metabolism in the tumour cells including the effect on immune cells and their nano-preparations of monotherapy and multiple therapies used in combination, in a shift away from conventional cancer research. (bvsalud.org)
In periodontitis, EVs play a pivotal role in regulating the biological functions of both periodontal tissue cells and immune cells, as well as the local microenvironment, thereby promoting periodontal injury repair and tissue regeneration. (biomedcentral.com)
and the properties of immune cells regulating autoimmunity. (columbiagypsy.net)
this activation occurs following a uptake of ICs into innate immune cells and the interaction of the cargo DNA or RNA with internal nucleic acid detectors. (columbiagypsy.net)

Salinomycin sodium salt, an antibiotic potassium ionophore, is an effective inhibitor of Wnt/β-catenin signaling. (targetmol.com)

Cell migration and invasion were analyzed by wound healing assay and transwell migration assay, respectively. (biomedcentral.com)
WISP2 overexpression inhibited cell growth and induced cell apoptosis, suppressed cell migration and invasion in ESCC cells. (biomedcentral.com)

Curcumin has been found to suppress tumor cells along the Notch pathway. (beforeitsnews.com)

Molecular subtypes of small cell lung cancer: a synthesis of human and mouse model data. (cancerindex.org)

MATERIALS AND METHODS: Gastric cancer cells were treated with scutellarin and transfected with the Wnt1 overexpression plasmid. (harvard.edu)
Consistent with the key role of Dkk2 for Wnt/-Catenin signaling an enrichment of several signatures such as MORF_WNT1 (= 0.00) for primary and recurrent liver cancer (Fig. (pkc-inhibitor.com)

Various cells release lipid-enclosed particles known as extracellular vesicles (EVs), which are rich in bioactive substances. (biomedcentral.com)

Over the last decades, mesenchymal stem cells (MSCs) have attracted extensive attention in the field of bone regeneration [ 4 - 7 ]. (hindawi.com)
6,7 Mesenchymal stem cells (MSCs) have also been isolated from other sources, such as bone marrow, 8 the placenta, 9 muscle, 10 or blood. (jcadonline.com)
thus, due to the unique characteristics of mesenchymal stem cells (MSCs), they have become the focus of attention and may be the most promising new therapy for periodontitis. (biomedcentral.com)

Indeed, as many as 20% of the normally healthy individuals can communicate an ANA as recognized by the usual serological assays.3 Among these assays is the immunofluorescence assay (IFA) using HEp-2 cells, long considered the criterion standard for ANA detection. (columbiagypsy.net)
Colony forming assay Colony forming assays of cells isolated from Dkk2? (pkc-inhibitor.com)

Gene Ontology (GO) and Kyoto Encyclopedia of Gene and Genomes pathway analysis of DEmRNAs in the DElncRNA‑miRNA‑DEmRNA network was performed. (spandidos-publications.com)
Based on the ceRNA hypothesis ( 15 ), the lncRNA-miRNA-mRNA network was constructed and Gene Ontology (GO) and Kyoto Encyclopedia of Gene and Genomes (KEGG) pathway analysis of mRNAs in the network were performed. (spandidos-publications.com)

MSCs are a population of nonhematopoietic adult stem cells that have the property of self-renewal and can differentiate into multiple lineages [ 8 - 10 ]. (hindawi.com)
Among these, adipose-derived stem cells (ADSCs) are a type of mesenchymal stem cell isolated from adipose tissue, which has the advantages of abundant storage in vivo , easy acquisition, and expansion [ 13 - 15 ]. (hindawi.com)
Recently, a number of studies have confirmed that ADSCs possess the ability to differentiate into adipocytes, osteoblasts, and chondrocytes [ 16 - 18 ], suggesting that a broader source of stem cells is available for application in tissue engineering. (hindawi.com)
A new study finds turmeric extract selectively and safely killing cancer stem cells in a way that chemo and radiation can not. (beforeitsnews.com)
MSCs are multipotent stem cells with the ability to self-renew and differentiate in multiple directions [ 3 ]. (biomedcentral.com)
By performing local transplants, other non-periodontal-derived MSCs such as dental pulp stem cells (DPSCs), bone marrow stem cells (BMSCs), and adipose tissue-derived stem cells (ADSCs) also aid in the regeneration of periodontal tissue [ 12 ]. (biomedcentral.com)
The cell(s) of origin are believed to be the hepatic stem cells, although this remains the subject of investigation. (medscape.com)

AAV-NRP-1 and LV-NRP-1 treatments increased the wingless integration (Wnt)-associated signals and β-catenin nuclear localization. (biomedcentral.com)

This study was aimed to specify the cytotoxic effect of C. sativa -derived extracts on colon cancer cells and adenomatous polyps by identification of active compound(s) and characterization of their interaction. (nih.gov)
Ethanol extracts of C. sativa were analyzed by high-performance liquid chromatography and gas chromatograph/mass spectrometry and their cytotoxic activity was determined using alamarBlue-based assay (Resazurin) and tetrazolium dye-based assay (XTT) on cancer and normal colon cell lines and on dysplastic adenomatous polyp cells. (nih.gov)
The unheated cannabis extracts (C2F), fraction 7 (F7), and fraction 3 (F3) had cytotoxic activity on colon cancer cells, but reduced activity on normal colon cell lines. (nih.gov)
C. sativa compounds interact synergistically for cytotoxic activity against colon cancer cells and induce cell cycle arrest, apoptotic cell death, and distinct gene expression. (nih.gov)
Flow cytometry analysis showed that VALD-3 triggered cell cycle arrest and induced apoptosis of breast cancer cells. (researchsquare.com)
By xenografting human breast cancer cells into nude mice, we found that VALD-3 significantly suppressed tumor cell growth while showing low toxicity against major organs. (researchsquare.com)
Hence, some studies have indicated that targeting the SUMOylation modification in Wnt/β-catenin might be a strategy for the treatment cancer ( 24 ). (frontiersin.org)
In this study, the cytotoxicity effects of L. rhamnosus supernatant and whole-cell culture on a cancer cell line (Kyse30) compared to 5fu were evaluated by the MTT assay. (hindawi.com)
However, little is known about the NK1R complex as a potential target in hepatoblastoma and colon cancer cells. (uni-muenchen.de)
Further, treatment of colon cancer or hepatoblastoma cells grown under cancer stem cell conditions reduced sphere formation in number and size as well as expression of the stemness markers SOX2, NANOG, and OCT4. (uni-muenchen.de)
Promoter hypermethylation is an alternative pathway for gene silencing in neoplastic cells and a promising cancer detection marker. (nih.gov)
This article presents the roles of the Wnt/β-catenin pathway in cancer and current therapeutic strategies involving this pathway. (chemdiv.com)
An elaborate network of signaling pathways orchestrates the communication between cancer cells and the surrounding stroma. (degruyter.com)
We investigated the expression of receptor tyrosine kinase-like orphan receptor (ROR) 2 and Wnt5a and their prognostic significance in non-small cell lung cancer (NSCLC). (oncotarget.com)
80% of lung cancer patients have non-small cell lung cancer (NSCLC) [ 1 - 3 ]. (oncotarget.com)
Small cell lung cancer (SCLC) is an exceptionally lethal malignancy for which more effective therapies are urgently needed. (cancerindex.org)
2 If PSA readings begin to elevate, there are interventions that can reduce or stabilize the production of PSA, shutting down a mechanism used by cancer cells to escape their confinement within the prostate gland. (lifeextension.com)
Due to its heterogeneities, 90% of ovarian carcinoma are epithelial ovarian cancer (EOC), while the rest could be classified as non-EOC, including asexual cell tumor, ovarian yolk cystic tumor, granulosa cell tumor, metastatic OC, etc. (amegroups.org)
Resistance to anticancer agents and apoptosis results in cancer relapse and is associated with cancer mortality. (oaepublish.com)
The cancer stem cell (CSC) paradigm emerged from investigating a subpopulation of less-differentiated CD34+/CD38- cells possessing stem cell-like renewal ability and robust malignant-initiating capacity in acute myeloid leukemia (AML) [ 1 ] . (oaepublish.com)
[6] Paeonol may activate CXCL4/CXCR3-B-mediated growth inhibitory signals to increase BTB and CNC homology 1 and decrease nuclear factor E2-related factor 2 expressions and exert anticancer and apoptotic effects in breast cancer. (cjphysiology.org)
[9] , [10] The main metabolic process of cancer cells is the transformation of glucose into lactic acid in the presence of oxygen. (cjphysiology.org)

Proviral infection at the "site of the highest degree" was thought to be the mechanism of carcinogenesis, giving the first name to the gene found along this pathway as INT1. (chemdiv.com)
The data suggest that CoQ 0 unveils a novel mechanism by down-regulating Wnt/β-catenin pathways and could be used as a potential lead compound for melanoma chemotherapy. (oncotarget.com)

The F7 and F7+F3 cytotoxic activity involved cell apoptosis and cell cycle arrest in S or G0/G1 phases, respectively. (nih.gov)
We found that CoQ 0 treatment caused G 1 cell-cycle arrest by reducing the levels of cyclin E and CDK4. (oncotarget.com)

It is believed that mutations in the deoxyribonucleic acid (DNA) signal the cells related to the esophagus to multiply abnormally [ 4 , 5 ]. (hindawi.com)

Flow cytometry assessed cell apoptosis. (biomedcentral.com)

APS induced autophagy and suppressed apoptosis in SONFH cell model. (biomedcentral.com)
APS regulated osteocyte autophagy and apoptosis via SP1/miR-200b-3p axis and activated Wnt/β-catenin signaling, thereby alleviating SONFH, shedding new insights for therapy of SONFH. (biomedcentral.com)
Recently, APS was reported to improve SONFH via regulating cell autophagy and apoptosis [ 9 ]. (biomedcentral.com)

The expression of lncRNAs is closely related to the above processes of OC cells, and participates in the occurrence, development, prognosis and targeted therapy of the disease. (amegroups.org)

The microenvironment is fundamental in attracting tumor cells to the bone as well as promoting tumor progression. (degruyter.com)

It is localized to many small speckles in the nucleus, and also to cell-cell tight junctions. (cancerindex.org)

CoQ 0 exhibits a significant cytotoxic effect on melanoma cell lines (B16F10, B16F1, and A2058), while causing little toxicity toward normal (HaCaT) cells. (oncotarget.com)

Anatomy20

Organisms7

Diseases5

Chemicals and Drugs100

Analytical, Diagnostic and Therapeutic Techniques and Equipment17

Phenomena and Processes43

Disciplines and Occupations1

Information Science3

Proliferation34

Proteins9

Differentiation9

Regulation12

Metastasis10

Genes16

Transduction5

Induces apoptosis1

Protein15

Squamous cell carc7

Critical signalin2

Colorectal Cancer Cell Lines1

Inhibit4

Cascades2

Inhibition2

Canonical2

Molecules7

Regulate2

Abnormal4

Transcriptional2

Inhibitors2

Cancers5

Cytoplasm2

Lymphoid enhancer2

Mechanisms4

Regulates2

Upregulation1

Anti-tumor1

Embryonic development1

CSCs7

Epithelial cells3

Immune4

Inhibitor1

Migration and invasion2

Notch1

Molecular1

Wnt12

Extracellular1

Mesenchymal stem3

Assays2

Gene Ontology2

Stem cells7

Wingless1

Cancer22

Mechanism2

Cycle arrest2

Abnormally1

Flow cytometry1

Autophagy3

Processes1

Tumor cells1

Nucleus1

Melanoma1