Apoptosis cell and tissue based therapy. Medical search. Frequent questions

Necroptosis also acts as an alternative "fail-safe" cell death pathway in cases where cells are unable to undergo apoptosis, such as during viral infection in which apoptosis signaling proteins are blocked by the virus. (wikipedia.org)
Increasing evidence suggests that the inability to undergo apoptosis is an important factor in the development and progression of prostate cancer. (nih.gov)
Human cells can undergo apoptosis in response to coronavirus infection as well, but the study found human cells do so much less frequently than porcine cells. (kashmirtimes.com)
Pig cells are roughly 100 times more likely to undergo apoptosis than human cells, according to the study. (kashmirtimes.com)

C1QBP knockdown and overexpression cells were established via lentiviral infection and subjected to apoptosis and ROS assay in vitro . (medsci.org)
In vitro cell culture and animal studies have demonstrated that mesenchymal stromal cells (MSCs) have the capacity to modify immune responses and to enhance tissue repair. (bmj.com)
In this review, we discuss the rationale for MSC-based cell therapy in COPD, the main findings from in vitro and in vivo preclinical COPD model studies, clinical trials in patients with COPD and directions for further research. (bmj.com)
5 Functional in vitro assays indicate different physiological roles of MSCs related to their heterogeneity and tissue location of origin. (bmj.com)
RD cells transfected with pcWNV-Cp-DJY or pcDNA3.1 sis in vitro through the mitochodrial/caspase-9 pathway. (cdc.gov)
An image depicting head and neck squamous cell carcinoma in vitro can be seen below. (medscape.com)
Head and neck squamous cell carcinoma in vitro (cell culture). (medscape.com)
Relating in vitro to in vivo exposures with physiologically based tissue dosimetry and tissue response models. (cdc.gov)

Necroptosis is a programmed form of necrosis, or inflammatory cell death. (wikipedia.org)
Conventionally, necrosis is associated with unprogrammed cell death resulting from cellular damage or infiltration by pathogens, in contrast to orderly, programmed cell death via apoptosis. (wikipedia.org)
The discovery of necroptosis showed that cells can execute necrosis in a programmed fashion and that apoptosis is not always the preferred form of cell death. (wikipedia.org)
Unlike in apoptosis, necrosis and necroptosis do not involve caspase activation. (wikipedia.org)
Unlike in necrosis, permeabilization of the cell membrane during necroptosis is tightly regulated. (wikipedia.org)
The antitumor effect of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) in gliomas has thus far only been thoroughly established in tumor cell lines. (aacrjournals.org)
The resulting damage cannot be overcome by the antioxidant system to protect the cell from oxidative damage, leading to necrosis, apoptosis, or autophagy of the target cell and tissue ( 10 , 11 ). (spandidos-publications.com)
br/>Human cells are more likely to go through necrosis, another form of cell death that's less controlled than apoptosis. (kashmirtimes.com)
During necrosis, the contents of a cell release into the surrounding space, provoking a strong hyperimmune response that isn't triggered during apoptosis. (kashmirtimes.com)
br/>The researchers surmise that a wide-scale apoptosis response is helpful for avoiding disease because it disposes of infected cells quickly without the immune system overreacting, while wide-scale necrosis and the resulting hyperimmune response is less favorable to host cells. (kashmirtimes.com)
Hypoxic vascular endothelial cells activate white blood cells, which bind to the endothelium and release directly damaging substances (eg, reactive oxygen species, proteolytic enzymes) and inflammatory mediators (eg, cytokines, leukotrienes, tumor necrosis factor). (msdmanuals.com)

Irradiated Ce6 produced singlet oxygen which rapidly induces tumor cell death. (spandidos-publications.com)
Its lead asset, IMX-110, is a negatively-charged TSTx that simultaneously disables resistance pathways with a poly-kinase inhibitor and induces tumor cell death with an apoptosis inducer. (renaissancecapital.com)

However, the role of C1QBP in metabolism, oxidative stress, and apoptosis of renal cell carcinoma (RCC) cells have not yet been explored. (medsci.org)
Renal cell carcinoma is one of the most common cancers in the urinary system, causing over 140,000 deaths worldwide each year[ 1 ]. (medsci.org)
NK cell infiltration into tumor tissue is associated with better disease prognosis in colorectal cancer, clear cell renal cell carcinoma, and lung carcinomas ( 9 - 11 ). (frontiersin.org)
Renal cell carcinoma (RCC) is the most common malignant kidney tumor and has a high incidence rate. (biomedcentral.com)
Renal cell carcinoma (RCC), the most common kidney neoplasm, originates in renal tubular epithelial cells and accounts for 85-90% of adult renal malignancies [ 1 ]. (biomedcentral.com)

Recent studies have shown substantial interplay between the apoptosis and necroptosis pathways. (wikipedia.org)
p62 is a multifunctional protein that mediates cell signaling pathways, autophagy and tumorigenesis, and participates in important regulation processes at the intersection between autophagy and cancer. (spandidos-publications.com)
Ascentage Chairman and CEO Dr. Dajun Yang added, "We are one of the leading biopharmaceutical companies with clinical stage compounds targeting key proteins that control programmed cell death pathways. (fightaging.org)
Curcumin, a natural polyphenolic compound derived from turmeric (Curcuma longa L), has proven to be a modulator of multiple intercellular signalling pathways linked to inflammation, to proliferation, growth, invasion, drug sensitivity, angiogenesis and metastasis of cancer cells. (researchgate.net)
Through cannabinoid receptor and non-receptor signaling pathways, cannabinoids show specific cytotoxicity against tumor cells, while protecting healthy tissue from apoptosis. (weedworldmagazine.org)
The dual antiproliferative and proapoptotic effects of cannabinoids and associated signaling pathways have been investigated on a large panel of cancer cell lines. (weedworldmagazine.org)
The term "oncotarget" encompasses all molecules, pathways, cellular functions, cell types, and even tissues that can be viewed as targets relevant to cancer as well as other diseases. (oncotarget.com)

3 4 Since then, it has become evident that MSCs reside in many tissues, including mesenchymal tissues (bone, adipose tissue, connective tissue), umbilical cord and several organs including the liver, spleen and lung. (bmj.com)
However, bone marrow-derived MSCs and adipose tissue-derived MSCs have not yet been directly compared with each other under human platelet lysate conditions. (biomedcentral.com)
The bone marrow- and adipose tissue-derived MSCs were cultured under human platelet lysate conditions and their biological characteristics evaluated for cell therapy (morphology, immunophenotype, colony-forming unit-fibroblast efficiency, proliferation capacity, potential for mesodermal differentiation, secreted proteins, and immunomodulatory effects). (biomedcentral.com)
Under human platelet lysate-supplemented culture conditions, bone marrow- and adipose tissue-derived MSCs exhibited similar fibroblast-like morphology and expression patterns of surface markers. (biomedcentral.com)
Adipose tissue-derived MSCs had greater proliferative potential than bone marrow-derived MSCs, while no significantly difference in colony efficiency were observed between the two types of cells. (biomedcentral.com)
However, bone marrow-derived MSCs possessed higher capacity toward osteogenic and chondrogenic differentiation compared with adipose tissue-derived MSCs, while similar adipogenic differentiation potential wase observed between the two types of cells. (biomedcentral.com)
There were some differences between bone marrow- and adipose tissue-derived MSCs for several secreted proteins, such as cytokine (interferon-γ), growth factors (basic fibroblast growth factor, hepatocyte growth factor, and insulin-like growth factor-1), and chemokine (stem cell-derived factor-1). (biomedcentral.com)
Adipose tissue-derived MSCs had more potent immunomodulatory effects than bone marrow-derived MSCs. (biomedcentral.com)
Over the past decade, MSCs which are isolated from the umbilical cord, umbilical cord blood, bone marrow (BM), adipose tissue (AT) and many other adult tissues have been explored as potential therapeutic strategies for a number of diseases [ 2 ], but AT and BM are the most widely used sources of MSC, especially in autologous cell-based therapies due to ease of harvest and potential autologous application [ 3 ]. (biomedcentral.com)

Necroptosis is well defined as a viral defense mechanism, allowing the cell to undergo "cellular suicide" in a caspase-independent fashion in the presence of viral caspase inhibitors to restrict virus replication. (wikipedia.org)
Necrotic cell death culminates in leakage of cell contents into the extracellular space, in contrast to the organized disposal of cellular contents into apoptotic bodies. (wikipedia.org)
Necrotic cells are cleared from the immune system by a mechanism called pinocytosis, or cellular drinking, which is mediated by macropinosomes, a subcellular component of macrophages. (wikipedia.org)
This process is in contrast to removal of apoptotic cells by the immune system in which cells are removed via phagocytosis, or cellular eating. (wikipedia.org)
However, despite the success of checkpoint inhibitors and the advent of cellular therapies, novel strategies need to be explored to (1) improve treatment in patients where these approaches fail and (2) make such treatments widely and financially accessible. (mdpi.com)
In each category, studies related to growth control genes, cell proliferation, apoptosis, DNA repair genes, antioxidant and drug detoxification genes, genes of drug metabolizing enzymes, tissue remodeling genes and genes of antibody-dependent cellular cytotoxicity were discussed separately. (researchsquare.com)
The defining functional feature of NK cells remains their intrinsic ability to conduct "natural killing" of cellular targets without prior sensitization. (frontiersin.org)
This is the multihit theory of tumorigenesis, in which a series of multiple triggering events in the genetic and cellular makeup of a cell ultimately cause cancer. (medscape.com)
For example cellular focusing on of antibodies or specific ligands is based on the capability of the focusing on providers to selectively bind to the cell surface to result in receptor-mediated endocytosis.3 5 Thus the drug delivery system along with the therapeutic agent would be delivered to the interior of a given cell type. (exposed-skin-care.net)
Cellular function declines, and if shock persists, irreversible cell damage and death occur. (msdmanuals.com)

Accumulating studies have suggested that miRNAs are frequently dysregulated in tumors compared with normal tissues, resulting in aberrant expression of target genes or proteins and cancer progression 13 . (nature.com)
C1QBP significantly increased ROS level, apoptosis, and the expression of apoptotic proteins such as cleaved caspase-3 and bax/bcl2 via regulating XDH. (medsci.org)
In order to explore the underlying mechanisms, we performed tests to assess cell migration and motility, apoptosis, expression of glucose transporter 1 and proapoptotic proteins. (oncotarget.com)
In addition, chronic diagnostic test for follow-up of patients cy and for biochemical determination inflammation associated with the infec- with H. pylori gastritis and were able of tissue COX-2 activity using COX tion leads to damage in proteins, the to predict the risk of development of Activity Assay Kit (Cayman Chemical production of reactive oxygen species stomach cancer. (who.int)

Due to the pleiotropic effect of bortezomibenhanced TRAIL DISC formation upon TRAIL triggering, down-regulation of cFLIP L and activation of the intrinsic apoptosis pathway seem to cooperatively contribute to the antitumor effect of bortezomib/TRAIL cotreatment. (aacrjournals.org)
Apoptosis is induced through the mitochondrial pathway resulting in caspase-9 activation and downstream caspase-3 activation. (cdc.gov)
Among several markers that have been defined for EOC, DNA damage and repair system factors, molecules involved in the G1 cell cycle, PI3K pathway, MAPK pathway, and also growth factors attracted more attention for targeted therapy (3). (iranpath.org)
It is well known that cells can die of apoptosis primarily through the extrinsic death receptor-induced pathway and/or the intrinsic mitochondria-mediated pathway [6]. (cellbasedassayblog.com)
The phosphoinositide 3-kinase (PI3K)/AKT/mammalian target of rapamycin (mTOR) pathway is constitutively activated in RCC and plays a crucial role in regulating cell growth [ 22 ]. (biomedcentral.com)
Taladegib is a small-molecule inhibitor that uses precision therapy approaches to disrupt the Hedgehog signaling pathway, which has been implicated in chronic wound healing that plays a critical role in IPF disease pathology. (endeavorbiomedicines.com)

mesenchymal stem cells are most commonly used because they are easy to obtain and present no ethical problems. (springer.com)
The aims of this article are to review the current knowledge regarding therapeutic mechanisms of mesenchymal stem cells in acute liver failure, to discuss recent advancements in preclinical and clinical studies in the treatment of mesenchymal stem cells, and to summarize the methodological improvement of mesenchymal stem cell transplantation in treating liver failure. (springer.com)
Human orofacial bone-derived mesenchymal stem cells (OMSCs) showed distinct differentiation traits from mesenchymal stem cells (MSCs) derived from long bones, mouse OMSCs have not been isolated due to technical difficulties, which in turn precludes using mouse models to study orofacial diseases. (ca.gov)
In this context, cell therapy using bone marrow mesenchymal stem cells (BMSC) might represent an attractive new therapeutic approach, based partly on their angiogenic ability and their involvement in the natural processes of tissue repair. (univ-lorraine.fr)
Mesenchymal stem cells (MSCs) are promising candidates for cell-based therapies. (biomedcentral.com)

In the present study, we investigated the therapeutic potential of TRAIL in primary human glioma cells. (aacrjournals.org)
The emerging technology known as targeted therapy facilitates selective delivery of chemotherapeutic agents involving therapeutic genes and drugs to tumor sites, which enhances the therapeutic efficacy and reduces side effects 2 . (nature.com)
Lacking of both prognostic biomarkers and therapeutic targets, triple-negative breast cancer (TNBC) underscores pivotal needs to uncover novel biomarkers and viable therapies. (nature.com)
Unfortunately, due to the devoid of early detection biomarkers and clear therapeutic targets, TNBC patients are often diagnosed late with a high histological grade, and do not benefit from hormonal or targeted therapies 6 . (nature.com)
New therapeutic concepts in anti-tumor therapy aim to modulate the patient's immune system to increase its aggressiveness or targeted effects toward tumor cells. (frontiersin.org)
In a proof of concept in vivo study, we also observed a therapeutic effect of adoptively transferred IL-15 expanded and IL-21 boosted NK cells in combination with image guided high precision radiation therapy using a luciferase-transduced RMS xenograft model. (frontiersin.org)
Therapeutic intervention aims to reverse tumor-induced NK cell suppression and sustain NK cells' tumorlytic capacities. (frontiersin.org)
Here, we review tumor-NK cell interactions, discuss the mechanisms by which NK cells generate an antitumor immune response, and discuss NK cell-based therapeutic strategies targeting activating, inhibitory, and co-stimulatory receptors. (frontiersin.org)
Ibrutinib continues to demonstrate promise for patients living with B-cell malignancies, and we are pleased that the FDA has recognized its potential for people living with CLL and the del17p mutation," said Peter F. Lebowitz, M.D., Ph.D., Global Oncology Therapeutic Area Head, Janssen. (jnj.com)
Agents that induce apoptosis may inhibit tumor growth and provide therapeutic benefit. (nih.gov)
The therapeutic effect of homeopathic treatments observed in the in vivo experiments cannot be explained by mechanisms based on distinct alterations in gene expression related to apoptosis or cytokines. (nih.gov)
Although targeted therapies have significantly improved therapeutic outcomes for advanced RCC patients, their effectiveness is still limited. (biomedcentral.com)
To improve therapeutic efficiency of TPP-IOA we chose to employ branched polyethylene glycol (PEG) functionalized single walled carbon nanotube s (SWCNT) and use it as a carrier to deliver mitochondria-targeted TPP-IOA to tissues. (cdc.gov)
B-cell lymphomas (BCLs) constitute a diverse set of tially identify new functional, diagnostic, and therapeutic tumors, both morphologically and clinically, that are mainly targets. (lu.se)

We isolated a new population of stem cells from human orofacial tissue gingiva, a tissue source easily accessible from the oral cavity, namely GMSC, which exhibited clonogenicity, self-renewal, and multipotent differentiation capacities. (ca.gov)
We developed techniques to isolate mouse OMSCs derived from mandibles and verified their MSC characteristics by single colony formation, multi-lineage differentiation, and in vivo tissue regeneration. (ca.gov)
It possesses a unique forkhead domain combined with a fragment of the target gene to initiate transcription [ 10 ] and regulates various biological processes such as tumor cell differentiation, cell proliferation, and migration [ 11 ]. (hindawi.com)
Cell Death and Differentiation. (elsevierpure.com)
Transcription factors (TFs) are critical for B-cell differentiation, affecting gene expression both by repres- sion and transcriptional activation. (lu.se)
In this study, highly purified, flow-cytometry sorted, classified in relation to normal B-cell differentiation [1]. (lu.se)

Clear cell RCC (ccRCC) is the most common subtype among the malignant RCCs, accounting for 70-80%, followed by papillary (15%), chromophobe (4-5%), and other fewer subtypes[ 2 ]. (medsci.org)
In the last years, adoptive transfer of natural killer (NK) cells came into the focus of translational medicine, because of their high cytotoxic potential against transformed malignant cells. (frontiersin.org)
With their ability to detect and directly destroy virally infected or malignant cells, natural killer (NK) cells form an important part of the first line defense of the immune system. (frontiersin.org)
Through these multiple actions, BTK helps to direct malignant B-cells to lymphoid tissues, thus allowing access to a microenvironment necessary for survival. (jnj.com)
The Z HER2 -affibody conjugate of idarubicin has a more potent cytotoxic effect than idarubicin alone against HER2-overexpressing malignant cells. (iranpath.org)
At the time Grillo wrote his reference textbook, tracheal replacement using the tissue-engineered technique had not yet been applied to malignant tumors, as it required the use of the patient's own cells and because several months were required to construct the graft. (biomedcentral.com)
The clinical manifestations of Waldenström macroglobulinemia result from the presence of the IgM paraprotein and malignant lymphoplasmacytic cell infiltration of the bone marrow and other tissue sites. (medscape.com)
Acute myeloid leukemia (AML), which accounts for 15-20% of all leukemias in childhood, belongs to a heterogeneous group of hematopoietic malignancies of monoclonal origin, which result from the malignant transformation of a stem cell. (bvsalud.org)

Variations in toxicity and response to therapy are observed among patients despite similar clinicopathologic characteristics which are attributed to single nucleotide polymorphisms (SNPs). (researchsquare.com)
The aim of this review was to evaluate the impact of SNPs on toxicity and response to therapy in HNSCCs. (researchsquare.com)
A web-based search of all original articles about the impact of gene polymorphisms on toxicity and response to therapy in HNSCCs was done until September 2021 using international English language databases including Google Scholar, Scopus, PubMed and Web of science. (researchsquare.com)
Aetna considers continuation of carfilzomib (Kyprolis) therapy medically necessary for members requesting reauthorization for an indication listed in Section I when there is no evidence of unacceptable toxicity or disease progression while on the current regimen. (aetna.com)
Taken together, our study demonstrated that GO-AgNPs potentially induce oxidative damage to DNA, which result in toxicity and cell apoptosis in caprine fetal fibroblast cell due to an increased generation of ROS. (researchsquare.com)
More research is needed to guide the choice, the duration, and the schedule of hormone deprivation therapy and the impact of long-term hormone therapy with regard to toxicity and the patient's quality of life. (medscape.com)
1998. Protection of human upper respiratory tract cell lines against sulphur mustard toxicity by hexamethylenetetramine (HMT). (cdc.gov)

The effectiveness and safety of ibrutinib alone or in combination with other treatments is being studied in several B-cell malignancies, including chronic lymphocytic leukemia/small lymphocytic lymphoma, mantle cell lymphoma, diffuse large B-cell lymphoma, follicular lymphoma, Waldenström's macroglobulinemia and multiple myeloma. (jnj.com)
Clinically, grade 3B follicular lymphoma is treated like diffuse large B-cell lymphoma . (medscape.com)
This enabled identification of TFs that can be uniquely associated to the tumor cells of chronic lymphocytic leukemia (CLL), diffuse large B-cell lymphoma (DLBCL), follicular lymphoma (FL), hairy cell leukemia (HCL), and mantle cell lymphoma (MCL). (lu.se)

Recently, with the advent of immunotherapy and anti-angiogenesis therapy, the survival of RCC patients has been improved[ 4 ]. (medsci.org)
Targets that have been identified as having the potential to improve survival in patients with castration-resistant prostate cancer stem from research in angiogenesis, bone metabolism, immunotherapy, androgen metabolism and receptor regulation, and apoptosis. (cancernetwork.com)

Due to the lack of a testable animal model and limited biological tissue specimens, to date, the patho-physiological mechanisms underlying BRONJ remain largely unknown. (ca.gov)
The aim was to better understand the physiopathological mechanisms of radiation-induced tissue damage and to determine the best treatment strategy. (univ-lorraine.fr)
However, as tumors progress, cancerous cells develop immunosuppressive mechanisms that circumvent NK cell-mediated killing, allowing for tumor escape and proliferation. (frontiersin.org)
BTK is a key mediator of at least three critical B-cell pro-survival mechanisms occurring in parallel - regulating apoptosis, adhesion, and cell migration and homing. (jnj.com)
[ 6 ] These events lead the cancer cell to escape normal cell growth and control mechanisms, to avoid system control mechanisms (ie, immunologic surveillance), and to establish a nutrient supply. (medscape.com)
Apoptosis is an essential part of mechanisms that maintain normal tissue homeostasis [4]. (cellbasedassayblog.com)
Based on newly discovered mechanisms of radiation damage - oxidation of cardiolipin by cytochrome c in mitochondria as a required stage in radiation- induced apoptosis - we designed and synthesized mitochondria-targeted triphenylphosphonium-conjugated imidazole-substituted oleic (TPP-OA) which prevented/mitigated cell death induced by irradiation and protected C57BL6 mice against total body irradiation. (cdc.gov)
In this study, we investigated programmed death-ligand 1 (PDL-1) as a potential biomarker for CAF-induced chemoresistance and evaluated its role and the underlying mechanisms of chemoresistance in non-small cell lung cancer (NSCLC). (cdc.gov)

It inhibits DAXX-mediated apoptosis by inducing its ubiquitination and degradation. (researchandmarkets.com)

Advanced head and neck squamous cell carcinoma (HNSCC) is treated with radiotherapy, chemotherapy, targeted therapy or a combination of these treatments. (researchsquare.com)
Findings were categorized by type of treatment (radiotherapy, chemotherapy, targeted therapy, or combination therapy). (researchsquare.com)
The first part of this work consisted in the development of experimental mouse model of radio-induced tissue degeneration similar to that occurring after radiotherapy. (univ-lorraine.fr)
Besides surgery, radiotherapy and chemotherapy, immune activation by direct application of cytokines, antibodies or adoptive cell therapy are promising approaches. (frontiersin.org)
Twenty pairs of gastric cancer and adjacent nontumor tissues, which were not subjected to radiotherapy or chemotherapy, were obtained from the First Affiliated Hospital of Xi'an Jiaotong University. (hindawi.com)
One reason for the poor survival of pancreatic cancer is the insensitivity to most conventional therapies including chemotherapy and radiotherapy [3]. (cellbasedassayblog.com)

The microenvironment surrounding tumor tissues provides a favorable niche for bacteria to inhabit. (nature.com)
In addition, the presence of available nutrients in necrotic tumor tissues attracts facultative anaerobes like Salmonella and Escherichia to the cancerous site via chemotaxis. (nature.com)

A recent study showed that the hypoxic environment produced by PDT can induce autophagy in tumor cells ( 17 ). (spandidos-publications.com)
Hence, we established a two-phase expansion protocol with IL-15 to induce an early NK cell expansion, followed by short exposure to IL-21 that boosted the cytotoxic activity of NK cells against RMS cells. (frontiersin.org)

Importantly, the regulatory functions of 4 DEmiRNAs and 3 verified target genes on cell proliferation and migration were explored in TNBC cell lines. (nature.com)
The authors investigated the effect of a homeopathic treatment regimen containing Conium maculatum, Sabal serrulata, Thuja occidentalis, and a MAT-LyLu Carcinosin nosode on the expression of cytokines and genes that regulate apoptosis. (nih.gov)
GO-AgNPs induced significant cytotoxicity by the loss of cell viability, production of reactive oxygen species (ROS), cell cycle arrest, increasing leakage of lactate dehydrogenase (LDH) and level of Malondialdehyde (MDA), increasing expression of pro-apoptotic genes and decreasing expression of anti-apoptotic genes. (researchsquare.com)

On infusion, culture-expanded MSCs regulate inflammatory and immune responses and tissue repair. (bmj.com)
This gene provides instructions for producing a protein called wolframin that is thought to regulate the amount of calcium in cells. (medlineplus.gov)
Jalali et al reported that levels of soluble programmed cell death protein 1 (PD-1) ligands are elevated in patients with Waldenström macroglobulinemia and, in addition to surface-bound ligands in bone marrow, could regulate T-cell function. (medscape.com)

In apoptosis, extrinsic signaling via cell surface receptors or intrinsic signaling by release of cytochrome c from mitochondria leads to caspase activation. (wikipedia.org)

We isolated primary tumor cells from 13 astrocytoma and oligoastrocytoma patients of all four WHO grades of malignancy and compared the levels of TRAIL-induced apoptosis induction, long-term tumor cell survival, caspase, and caspase target cleavage. (aacrjournals.org)
However, direct injection of IL-2 has been shown to be accompanied by severe side effects, such as vascular leak syndrome, activation-induced cell death, and strong induction of regulatory CD4 pos T cells, which did not occur after IL-15 administration ( 15 , 16 ). (frontiersin.org)
mouse brain resulted in an induction of apoptosis similar to Ultrathin sections were stained with uranyl acetate and lead what is observed in natural infection. (cdc.gov)
Apoptosis induction vested and lysed at 48 h postinjection. (cdc.gov)
Most chemotherapies act by the induction of apoptosis. (cellbasedassayblog.com)

In apoptotic responses to infection, the contents of an infected cell (including the pathogen) are contained and engulfed by phagocytosis. (wikipedia.org)
Therefore, a clearer understanding capsid expression was analyzed by immunofluorescent assay of WNV is necessary in order to identify new strategies to treat in HeLa, 293-T, RD, or SH-SY5Y cells by using anti-His tag or prevent this viral infection (3). (cdc.gov)
NK cells are now accepted to play an important role in both the adaptive and innate immune responses that govern infection, autoimmunity, and tumor immunosurveillance ( 2 , 3 ). (frontiersin.org)
Triggering apoptosis early in the infection essentially causes minimal tissue damage and confines viral replication, thus limiting severe illness. (kashmirtimes.com)
Attempts to do this with the use of foreign materials led to chronic infection, airway obstruction, migration of the prosthesis, erosion into major blood vessels and proliferation of granulation tissue. (biomedcentral.com)
The etiopathogenetic cascade currently available treatments, surgery to multiple endoscopic gastric mucosal of the infection leads to various errors in and radio-chemotherapy, is less than tissue biopsies. (who.int)

risk of esophageal squamous cell carcinoma. (who.int)
PMID:18786442 mutations and the risk of esophageal squamous cell carcinoma. (who.int)
Arbyn M, Bergeron C, Klinkhamer P, Martin-Hirsch squamous cell carcinoma in a high-risk region in Iran. (who.int)

Immunoreceptor signaling during development, homeostasis, and effector function of T cells and NK cells. (upstate.edu)
2 MSCs were first described in the bone marrow where they constitute a small fraction of cells (0.001%-0.01%) that closely interact with haematopoietic cells to support haematopoiesis and skeletal homeostasis. (bmj.com)
11 12 MSCs furthermore contribute to tissue homeostasis through anti-apoptotic and regenerative properties. (bmj.com)

MSC mediated bone formation involves in both donor and recipient cells, but only recipient cells contribute to marrow element formation. (ca.gov)
Our study suggests that both OMSCs and host cells contribute to bone formation in vivo. (ca.gov)
The second part of this work investigated the feasibility of autologous BMSC therapy on the murine model of radiation previously established with emphasis on two pre-requisites : the retention of the injected cells within the target tissue and the evaluation of the graft on bone metabolism. (univ-lorraine.fr)
The predominance of patients with metastatic disease in bone has made it difficult to acquire sufficient tissue to perform correlative studies. (cancernetwork.com)
A study by Pasricha et al found that bone marrow features, particularly the degree of plasma cell infiltration, correlates with IgM paraprotein concentration at diagnosis. (medscape.com)
Thus, evaluation of the plasma cell compartment in the bone marrow at baseline and after therapy may be helpful. (medscape.com)
Among the leukemias, the most prevalent type is acute lymphoblastic leukemia (ALL), which is characterized by accumulation of immature lymphoid cells in the bone marrow 2,3 and accounts for roughly 80% of all cases of leukemia in childhood. (bvsalud.org)

In this paper, we focus on the role of gut hormones and their related neuronal networks (the gut-brain axis) in appetite control, and their potentials as novel therapies for obesity. (hindawi.com)
The rationale for the implementation of novel therapies should be based on hallmarks of cancer. (oncotarget.com)

Rhabdomyosarcoma (RMS) is the most common soft tissue malignancy in children. (frontiersin.org)
Surgery and chemotherapy based on platinum-based agents are the most commonly available protocols for the treatment of ovarian malignancies but the occurrence of drug-resistance and relapse of the malignancy in many cases could result in short-term survival of affected patients (2). (iranpath.org)
In addition, immunosuppressive therapy should not be prescribed for the treatment of a malignancy. (biomedcentral.com)

Overexpression of p62 may contribute to colorectal cancer cell death. (spandidos-publications.com)
Overexpression of p62 is likely related to tumorigenesis and has been observed in many types of tumors ( 13 , 21 - 23 ), such as chemotherapy-resistant epithelial cell carcinoma ( 24 ). (spandidos-publications.com)
Human gastric cancer cell lines AGS and MKN28 were cultured and transfected with miR-149 overexpression plasmid and its control or FOXC1 siRNA and its control. (hindawi.com)
miRNA-149 was underexpressed in gastric cancer tissues and cells, while overexpression of miRNA-149 promoted cell apoptosis, retarded cell cycle, and inhibited proliferation and migration in AGS and MKN28 cells. (hindawi.com)
Overexpression of human epidermal growth factor receptor 2 (HER2) causes cell transformation and development of various types of malignancies. (iranpath.org)

Moreover, the expression of C1QBP and XDH was lower in RCC tumors compared with the tumor-associated normal tissues, and their down-regulation was associated with higher Fuhrman grade. (medsci.org)

A few gene therapy trials now target head and neck cancer, which makes up only 4% of all cancers but has a dismal prognosis in advanced stages. (medscape.com)
Cancer tumor may be developed with a multistep carcinogenesis procedure entailing numerous mobile physiological systems such as for example cell signaling and apoptosis.3 Cancers includes a physiological hurdle like vascular endothelial skin pores heterogeneous blood circulation heterogeneous structures etc. (exposed-skin-care.net)
High-risk types (e.g., types 16 and 18) can cause low-grade cervical cell abnormalities, high-grade cervical cell abnormalities that are precursors to cancer, and cancers ( 5 - 7 ). (cdc.gov)

In this study, we addressed feeder cell-free expansion methods using common γ-chain cytokines, especially IL-15 and IL-21. (frontiersin.org)
In vivo development and survival of NK cells require cytokines ( 6 - 8 ). (frontiersin.org)
In this context, cytokines have been shown to activate NK cells potently during ex vivo expansion ( 9 - 12 ). (frontiersin.org)
Cytokines, cancer vaccines, adoptive cell transfers, and especially checkpoint inhibitors constitute valuable elements in the immunotherapeutic armamentarium. (frontiersin.org)
However, CD56 dim NK cells can produce cytokines, specifically IFN-γ, after cell triggering via NKp46 of NKp30 activating receptors or after stimulation with combinations of IL-2, IL-12, and IL-15 ( 7 ). (frontiersin.org)
Some of these mediators bind to cell surface receptors and activate nuclear factor kappa B (NF κ B), which leads to production of additional cytokines and nitric oxide (NO), a potent vasodilator. (msdmanuals.com)
MATERIALS AND METHODS: A systemic search of gene expression profiles of multiple tissues in NSCLC was carried out to determine the expression intensities of traditional fibroblast biomarkers and CAF-secreted protumorigenic cytokines. (cdc.gov)

Cell-based therapy using systemic infusion of GMSC in experimental colitis significantly ameliorated both clinical and histopathological severity of the colonic inflammation, restored the injured gastrointestinal mucosal tissues, reversed diarrhea and weight loss, and suppressed the overall disease activity in mice. (ca.gov)
COPD is characterised by tissue destruction and inflammation. (bmj.com)
Capsid gene delivery into the striatum of mouse brain or interskeletal muscle resulted in cell death and inflammation, likely through capsid-induced apoptosis in vivo. (cdc.gov)
Semithin (1.0-µm) sections resulted in apoptosis and inflammation of muscle cells. (cdc.gov)
Immix is developing a novel class of Tissue-Specific Therapeutics ("TSTx") in oncology and inflammation. (renaissancecapital.com)
Histopathological examination of the cyst revealed thick fibrous connective tissue interspersed with areas of chronic inflammation. (bvsalud.org)

In recent years, a growing number of studies have shown that stem cells can effectively treat acute liver failure. (springer.com)
The long-term goal of this proposal is to develop stem cell-based treatment for major defects in the orofacial regions. (ca.gov)
1 Unique MSC-specific markers have not yet been identified, and MSCs constitute a heterogeneous cell population, including both multipotent (stem) cells and progenitor cells and might even contain pluripotent cell fractions. (bmj.com)
More recently, few clinical attempts have offered encouraging results with ex vivo or stem cell-based engineered airways and tracheal allografts implanted after heterotopic revascularization. (biomedcentral.com)
Autologous stem cell transplantation is a consideration in select cases. (medscape.com)
RESULTS: We demonstrated that chemotherapy-stimulated CAFs promoted tumorigenic and stem cell-like properties of NSCLC cells, which contribute to their chemoresistance. (cdc.gov)
Silencing PDL-1 expression suppressed CAFs' ability to promote stem cell-like properties and invasiveness of lung cancer cells, favoring chemoresistance. (cdc.gov)
CONCLUSION: Our results show that PDL-1-positive CAFs modulate stem cell-like properties of NSCLC cells by secreting elevated HGF, thereby promoting chemoresistance. (cdc.gov)

Some pathogens, such as human cytomegalovirus, express caspase inhibitors that arrest the apoptotic machinery of the host cell. (wikipedia.org)

In general, lesions are characterized by ischemia, cell apoptosis and fibrosis. (univ-lorraine.fr)

T lymphocytes for adoptive cell therapy against hematological cancer. (upstate.edu)

In vivo experiments were conducted using a co-implantation xenograft mouse model with live cell imaging and immunohistochemistry. (cdc.gov)

In the current study, we assessed the cytotoxic effects of idarubicin-Z HER2 affibody conjugate on the positive-HER2 cancer cell lines. (iranpath.org)
The cytotoxic effects of constructed idarubicin-Z HER2 affibody conjugate on the SK-BR-3, SK-OV-3, and MCF-7 cells with various levels of HER2 expression were evaluated by MTT assay after 48 hours of incubation time. (iranpath.org)
Idarubicin showed a potent and dose-dependent cytotoxic effect against all treated cell lines while the SK-OV-3 cells were significantly more sensitive. (iranpath.org)
The Z HER2 -affibody conjugate of idarubicin has a more specific cytotoxic effect compared with idarubicin alone against HER2-overexpressing ovarian cancerous cells. (iranpath.org)
Idarubicin has a potent and dose-dependent cytotoxic effect against breast and ovarian cancerous cells. (iranpath.org)
We assessed their cytotoxic effect after sensitizing cancer cells with insulin. (oncotarget.com)

This study demonstrated clinical and experimental evidences supporting a potential efficacy and safety of utilizing autologous PDL cells in the treatment of human periodontitis. (ca.gov)
Many culturing strategies are based on the addition of feeder or accessory cells, which need to be removed prior to the clinical application of the final NK cell product. (frontiersin.org)
There is compelling clinical and experimental evidence to suggest that natural killer (NK) cells play a critical role in the recognition and eradication of tumors. (frontiersin.org)
Enacted as part of the 2012 FDA Safety and Innovation Act (FDASIA), Breakthrough Therapy Designation is intended to expedite the development and review time for a potential new medicine "to treat a serious or life-threatening disease or condition and preliminary clinical evidence indicates that the drug may demonstrate substantial improvement over existing therapies on one or more clinically significant endpoints, such as substantial treatment effects observed early in clinical development. (jnj.com)
Although curcumin has shown significant efficacy in cell culture studies, it has shown limited efficacy in clinical studies when administered in conventional oral formulations. (researchgate.net)
However, while our knowledge of biology has enabled us to design more specific treatments, patients are still entered in phase III trials based on clinical rather than molecular parameters. (cancernetwork.com)
However, neoadjuvant therapy may provide an important paradigm for the discovery of active agents for the treatment of prostate carcinoma, in addition to improving clinical outcomes for men with early, high-risk disease. (medscape.com)
1987. Mustard gas clinical toxicological and mutagenic aspects based on modern experience. (cdc.gov)
Diagnosis is clinical, including blood pressure measurement and sometimes measurement of markers of tissue hypoperfusion (eg, blood lactate, base deficit). (msdmanuals.com)

The malformations have a normal endothelial cell growth cycle that affects the veins, the capillaries, or the lymphatics, and they do not involute. (medscape.com)

Viral culture is also related, with cells as hosts for the viruses. (cellbasedassayblog.com)

This was assessed in prostate cancer tissues, extracted from animals responsive to these drugs, using ribonuclease protection assay or reverse transcription polymerase chain reaction. (nih.gov)
Since the current gold standard for approval of drugs in castration-resistant prostate cancer is based on overall survival, prospective evaluation of these types of markers as a surrogate for survival is clearly needed, particularly with the plethora of new agents. (cancernetwork.com)
Current concerns regarding prostate cancer progression have led to a renewed interest in the use of neoadjuvant androgen deprivation (NAD) therapy prior to radical prostatectomy ( RP ). (medscape.com)
As with any therapy, the ultimate benefit of neoadjuvant NAD in prostate cancer will be determined only through properly designed trials with long-term follow-up. (medscape.com)

Ibrutinib has been granted Breakthrough Therapy Designation as a monotherapy in the treatment of patients with chronic lymphocytic leukemia or small lymphocytic lymphoma with deletion of the short arm of chromosome 17 (del17p). (jnj.com)
In February 2013 , FDA granted Breakthrough Therapy Designations for ibrutinib as a monotherapy for two B-cell malignancies: in patients with relapsed or refractory Mantle cell lymphoma (MCL) who have received prior therapy, and in patients with Waldenström's macroglobulinemia (WM). (jnj.com)
5] Small Lymphocytic Lymphoma (SLL) is a slow-growing lymphoma in which too many immature white blood cells cause lymph nodes to become larger than normal. (jnj.com)

The inflammatory rupturing of the cell releases Damage Associated Molecular Patterns (DAMPs) into the extracellular space. (wikipedia.org)
GMSC can function as an immunomodulatory and anti-inflammatory component of the immune system in vivo and is a promising cell source for cell-based treatment in experimental inflammatory diseases. (ca.gov)
Neutrophil apoptosis may be inhibited, enhancing the release of inflammatory mediators. (msdmanuals.com)

There are currently no approved therapies that stop the progression of fibrosis or treat the underlying causes of the disease," said John Hood, Ph.D., Co-Founder, CEO and Chairman of Endeavor BioMedicines. (endeavorbiomedicines.com)

As in all forms of necrotic cell death, cells undergoing necroptosis rupture and leak their contents into the intercellular space. (wikipedia.org)

In addition to basic science investigations in such areas as tumor cell invasion, oncogenes, immunotherapy and genetic inheritance, our scientists and physicians participate in national cancer trials. (upstate.edu)
instead of targeting tumor cells, the goal of immunotherapy is to augment and expand the immune system's intrinsic antitumor response. (frontiersin.org)

To treat patients with colorectal cancer, an approach that selectively targets cancer cells without damaging normal cells and which minimizes the risk of perforating the intestinal barrier is needed ( 2 ). (spandidos-publications.com)
PDT uses a modality-based photosensitizer, which selectively affects cancer cells, using excitation and light-absorption in the presence of oxygen to produce a high concentration of reactive oxygen species (ROS), such as singlet oxygen and other free radicals ( 7 - 9 ). (spandidos-publications.com)
In the past couple of years research groups have produced classes of drug - now called senolytic compounds - that can selectively drive senescent cells to self-destruct via the process of apoptosis . (fightaging.org)
Conjugation of glucose with metabolic agents to selectively target cancer cells was inspired by the widespread use of radiolabeled glucose analog to visualize tumors and their metastases. (oncotarget.com)

However, whether the efficacy of PDT depends on the expression level of p62 in colorectal cancer cell lines is not known. (spandidos-publications.com)
The present study aimed to examine the role of p62 expression levels in chlorin e6‑based PDT in colorectal cancer cells. (spandidos-publications.com)
These results provide preliminary evidence for use of p62 as a therapy target to treat colorectal cancer. (spandidos-publications.com)
Photodynamic therapy (PDT) can be used to treat colorectal cancer. (spandidos-publications.com)
PDT is considered as a complementary therapy aimed at preventing tumor recurrence after surgical resection of colorectal cancer ( 3 ), making it a suitable approach for continuous removal of small fractions of tumors ( 4 ). (spandidos-publications.com)
Bacterial cancer therapy was developed using probiotic Escherichia coli Nissle 1917 (EcN) for medical intervention of colorectal cancer. (nature.com)
1. Equipped with HlyE, EcNe significantly caused tumor regression in mice xenografted with human colorectal cancer cells. (nature.com)

Virtual screening approaches can roughly be divided into target structure-based screening (often referred to as docking) and screening using active compounds as templates (ligand-based virtual screening). (benthamscience.com)
In this review, we first provide an overview of widely used ligand-based virtual screening approaches including various database filters and then discuss recent trends in this field and new methodological developments. (benthamscience.com)

the tumor microenvironment enhancing drug bioavailability and effectiveness due to the practical differences between normal and tumor cells. (exposed-skin-care.net)

Following early observations that MSCs inhibit T-cell proliferation, 9 MSCs were found to interact with the majority of innate and adaptive immune cells. (bmj.com)

MSCs have the capacity of multiple differentiations and self-renewal and have been proven to be able to differentiate into a series of cell lineages, such as adipocytes, osteoblasts, chondroblasts, and hepatocyte-like cells (HLCs). (springer.com)
Mesenchymal stromal cells (MSCs) are cells of non-haematopoietic origin, with the capacity to differentiate into multiple lineages of the mesenchyme, that is, chondrocytes, osteoblasts and adipocytes. (bmj.com)

Radiation therapy induced acute and late sequelae within healthy tissue included in the irradiated area. (univ-lorraine.fr)

Dr Tamara Jamaspishvili is a research pathologist, translational research scientist focusing on developing, evaluating, validating, and applying tissue-based prognostic and predictive biomarkers and models for improved disease prognostication and management of cancer patients. (upstate.edu)

After surgery, my PSA was at 0.1, and with eight(8) lymph nodes dissected during surgery all were negative for microscopic cancer cells. (cancer.org)
Photodynamic therapy (PDT) is a treatment that involves photosensitizing agents and light to kill cancer cells. (spandidos-publications.com)
To study the effect of p62 on cancer cell death, we used PDT to treat a stable cell line overexpressing p62. (spandidos-publications.com)
China-based Ascentage - which is currently working on apoptosis-targeted cancer treatments - will work with UNITY Biotechnology to develop senolytic treatments for age-related diseases in an attempt to roll the back years for seniors. (fightaging.org)
It has been suggested that radiation sensitivity and chemosensitivity of cancer cells may play an important role in the local control of the tumor following these therapies. (researchsquare.com)
In the early phases of cancer immune surveillance, NK cells directly identify and lyse cancer cells. (frontiersin.org)
The recent FDA approvals of the programmed cell death protein 1 (PD-1)-targeted checkpoint inhibitors pembrolizumab and nivolumab mark the latest successes in the rapidly expanding field of cancer immunotherapies. (frontiersin.org)
Additionally, a 11-year prospective cohort study of Japanese inhabitants linked low peripheral-blood NK cell cytotoxicity with increased cancer risk ( 12 ). (frontiersin.org)
Chronic Lymphocytic Leukemia (CLL) is a slow-growing cancer of the white blood cells (lymphocytes), most commonly B-cells. (jnj.com)
qRT-PCR was used to detect the expression of miRNA-149 and FOXC1 in gastric cancer tissues and cells. (hindawi.com)
In this study, we investigated the inhibitory effects of miR-149 on the biological functions of gastric cancer cells by targeting FOXC1. (hindawi.com)
The human gastric epithelial permanent cell line (GES-1), human gastric cancer cell lines (AGS, BGC-823, MKN45, and SGC-7901), and HEK293 cells were provided by the Biomedical Experiment Center of Xi'an Jiaotong University. (hindawi.com)
In turn, as a result of research into the abnormal cancer cell, the basic understanding of the cell has greatly improved. (medscape.com)
Cancer is characterized by uncontrolled growth and division of a cell, with extension beyond the normally limiting basement membrane and through the boundaries of normal cells. (medscape.com)
A reasonable model is based on colon cancer development. (medscape.com)
Furthermore, evaluation of the effect of various kinds of targeted therapy for the cure of epithelial ovarian cancer (EOC) is under active investigation (3). (iranpath.org)
Deregulation of the apoptosis machinery and evasion of apoptosis is a general mechanism in cancer. (cellbasedassayblog.com)
Two novel compounds labelled as thioglycoside A and B were designed and evaluated on breast and colon cancer cell lines. (oncotarget.com)
This phenomenon, recognized as one of the hallmarks of cancer, has attracted a great deal of interest in anticancer therapies. (oncotarget.com)
Endeavor's forward-thinking approach to precision therapies used to treat pulmonary disease and cancer has already exhibited immense potential since the company launched," said Srikanth Pendyala, M.D., Chief Medical Officer, Endeavor BioMedicines. (endeavorbiomedicines.com)
Childhood cancer corresponds to a group of diseases characterized by the uncontrolled proliferation of atypical cells, which may occur anywhere in the body 1 . (bvsalud.org)
Transcriptomic profiling of T-cell populations in non-muscle invasive and muscle invasive bladder cancer. (lu.se)
Mechanistically, an upregulation of PDL-1 in chemotherapy-treated CAFs led to an increase in hepatocyte growth factor (HGF) secretion, which stimulates cancer progression, cell invasion, and stemness of lung cancer cells, while inhibiting apoptosis. (cdc.gov)

Anatomy15

Organisms6

Diseases3

Chemicals and Drugs74

Analytical, Diagnostic and Therapeutic Techniques and Equipment13

Phenomena and Processes32

Disciplines and Occupations1

Information Science1

Undergo apoptosis4

Vitro8

Necrosis11

Induces tumor cell death2

Renal cell carc5

Pathways7

Adipose tissue9

Cellular10

Proteins4

Pathway6

Mesenchymal stem5

Therapeutic14

Differentiation6

Malignant8

Toxicity7

Diffuse large B-3

Angiogenesis2

Mechanisms8

Inhibits1

Radiotherapy6

Tumor tissues2

Induce2

Genes3

Regulate3

Extrinsic1

Induction5

Infection6

Squamous cell carc3

Homeostasis3

Bone7

Novel therapies2

Malignancy3

Overexpression5

Normal tissues1

Cancers3

Cytokines7

Inflammation6

Stem8

Apoptotic1

Ischemia1

Adoptive cell therapy1

Vivo experiments1

Cytotoxic6

Clinical9

Endothelial1

Viral1

Prostate cancer4

Lymphoma3

Inflammatory3

Fibrosis1

Necrotic1

Immunotherapy2

Selectively4

Colorectal cancer7

Approaches2

Microenvironment1

Inhibit1

MSCs2

Healthy tissue1

Biomarkers1

Cancer23