• This is the case in strokes and neurodegenerative disorders such as Alzheimer's, Huntington's, and Parkinson's diseases. (rxlist.com)
  • Consequently, several human diseases, including cancer and neurodegenerative disorders, are caused by defects in this highly regulated form of cell death. (nature.com)
  • Free radicals have been associated with pathogenesis of various disorders like cancer, diabetes, cardiovascular diseases, autoimmune diseases, neurodegenerative disorders and are implicated in aging. (nutrimedical.com)
  • Now that we can see how Bax changes its shape to move from the inactive to the active form, it may be possible to block Bax activation, to prevent cell death in conditions such as neurodegenerative disorders, where illness is caused by excessive cell death. (edu.au)
  • The findings within area C can ultimately be translated to neurodegenerative and psychiatric disorders. (uni-regensburg.de)
  • The ultimate aim of his research is to exploit this knowledge to identify novel therapeutic avenues to treat diseases including cancer, neurodegenerative disorders and stroke. (le.ac.uk)
  • Dr. Xue's main research interests lie in studying the mechanisms of programmed cell death (or apoptosis) and various human diseases such as neurodegenerative diseases, cancer, and autoimmune disorders that are caused by abnormal apopotosis. (colorado.edu)
  • Data table showing topics related to specific cancers and associated disorders. (cancerindex.org)
  • Dysregulation of apoptosis can lead to disease states including cancer and neurodegenerative disorders. (studymoose.com)
  • Apoptosis is a morphologically distinct form of programmed cell death that plays a major role during development, homeostasis, and in many diseases including cancer, acquired immunodeficiency syndrome, and neurodegenerative disorders. (scienceopen.com)
  • Todos is also developing blood tests for the early detection of neurodegenerative disorders, such as Alzheimer's disease. (yahoo.com)
  • Several other pro-survival functions of this protein have been described and indicate that it might play a role in other disorders, such as cancer and proliferative diseases. (lih.lu)
  • Irregular apoptosis is a factor in many human conditions, including neurodegenerative diseases, autoimmune disorders and many types of cancer, etc. (cephamls.com)
  • Apples protect brain cells - Apples and some other fruits have been found to play an important role in reducing the risk of neurodegenerative disorders such as Alzheimer's disease by protecting neuron cells against oxidative stress-induced neurotoxicity. (rebootwithjoe.com)
  • Increasing evidences supporting the potential use of SIRT inhibitors (SIRTi) for the treatment of cancer, HIV infection, and muscular diseases and of SIRT activators (SIRTa) for age-related disorders have led to the identification of many SIRT modulators over recent years, mainly through chemical library screening and catalytic mechanism-based design approaches, often combined with structure-activity relationship (SAR) investigations. (biomedcentral.com)
  • Huntington disease (HD) is a genetic, autosomal dominant, neurodegenerative disorder characterized clinically by disorders of movement, progressive dementia, and psychiatric and/or behavioral disturbance. (medscape.com)
  • New anticancer therapy strategies refer to the inhibition of CDK-cyclin complexes as an important target to prevent uncontrolled proliferation and induce apoptosis in cancer cells ( 2 ). (spandidos-publications.com)
  • To induce apoptosis, Bax creates a hole in the membrane of the mitochondria, which represent the power stations of the cells. (rub.de)
  • Emodin has been shown to successfully induce apoptosis, down-regulate cancer inducing genes, proving it to be a therapeutically significant pharmacophore. (longdom.org)
  • Membrane damage: Damage to the cell membrane disturbs the state of cell electrolytes, e.g. calcium, which when constantly increased, induces apoptosis. (wikipedia.org)
  • Hydrogen peroxide treatment induces apoptosis together with a caspase-like enzymatic activity in yeast. (scienceopen.com)
  • In this setting, we found that staurosporine induces apoptosis but not mitophagy, and we demonstrated that PINK1 protects against staurosporine-induced apoptosis by impairing the proapoptotic cleavage of Beclin1. (lih.lu)
  • In addition to these findings, research continues to indicate that autophagy has the ability to prevent the development of neurodegenerative diseases, like Alzheimer's disease, by clearing away abnormal or harmful protein aggregates such as amyloid beta. (diabetes.co.uk)
  • or vice versa, when they attack healthy cells and cause neurodegenerative diseases such as Parkinson's or Alzheimer's. (ki.se)
  • It is believed that certain diseases, most notably Alzheimer's disease, are the result of compromised cellular machinery that leads to aberrant cell cycle re-entry by neurons, which then leads to apoptosis. (yahoo.com)
  • Interestingly, mitochondrial association of ADF and n-cofilin during apoptosis was preceded by, and dependent on, actin that translocated by a yet unknown mechanism to mitochondria during cell death. (nature.com)
  • 8 Recently, it was shown that n-cofilin translocates to mitochondria during the early phase of apoptosis, but the mechanism for this translocation remained obscure. (nature.com)
  • Although purvalanol-induced cell cycle arrest and apoptotic cell death were demonstrated in prostate ( 5 ), breast ( 6 ) and colon cancer cells ( 7 ), the exact molecular mechanism of purvanol-induced apoptosis has not been elucidated yet. (spandidos-publications.com)
  • Disturbances in this mechanism can be life-threatening, as they may trigger cancer or neurodegenerative diseases. (rub.de)
  • Studies involving mechanism of emodin, an herbal extract, has revealed its potential as anti-inflammatory, antioxidant and anti-cancer agent. (longdom.org)
  • Endoplasmic reticulum stress (ERS) is a self-protective mechanism resulting from an imbalance in quality control of unfolded proteins when cells are stressed, which plays an active role in lung cancer development, but the relationship between ERS and the pathological characteristics and clinical prognosis of LUAD patients remains unclear. (biomedcentral.com)
  • These results suggest that the generation of oxygen radicals is a key event in the ancestral apoptotic pathway and offer an explanation for the mechanism of bax-induced apoptosis in the absence of any established apoptotic gene in yeast. (scienceopen.com)
  • However, orthologs of classical mammalian apoptosis regulators appeared to be missing from the yeast genome, challenging a common mechanism of yeast and mammalian apoptosis. (scienceopen.com)
  • created 'undead' cells in which one of these proteins was turned on, but other downstream proteins (that are responsible for the cellular execution phase of apoptosis) had been turned off: these cells were undergoing apoptosis, but could not complete the process and die. (elifesciences.org)
  • To pursue his research interest in the molecular mechanisms of the fundamental cell death process known as apoptosis, in 2003, he joined the laboratory of Dr Ruth Kluck at the Walter and Eliza Hall Institute of Medical Research (Melbourne, Australia) to investigate how disarming this process is essential for cancers to develop. (le.ac.uk)
  • Every second, around one million cells die in the body as a result of programmed cell death, also known as apoptosis. (rub.de)
  • Thus, we conclude that ADF/cofilin activity is not generally required for induction or progression of apoptosis in mammalian cells. (nature.com)
  • Importantly, the mitochondrial association of n-cofilin and ADF had no impact on apoptosis signaling because ablation of either n-cofilin, ADF, or both proteins together did not change cell death progression. (nature.com)
  • Increased levels of polyamines in cells are considered to be involved in cancer progression. (spandidos-publications.com)
  • Aberrant activation of MAPK3 is associated with cancer development and progression, as it promotes cell proliferation and survival. (creativebiomart.net)
  • MAPK3 also phosphorylates other kinases, such as p90RSK, which further propagate the signal to regulate cellular processes like cell cycle progression, apoptosis, and differentiation. (creativebiomart.net)
  • This editorial highlights the relevance of interfering in cancer cell progression through the pharmacological manipulation on the cell metabolism of cyclic nucleotides such as cAMP, and on the intracellular Ca2+ signaling, which may avail the reduction of toxic effects promoted by chemotherapy, radiotherapy and immunotherapy, thus decreasing the incidence of interruption in antitumoral treatment. (researchgate.net)
  • It was suggested that the ERS signaling pathway also plays an active part in cancer progression [ 12 ]. (biomedcentral.com)
  • METHODS: Xenograft mouse models were used to assess the effect of ACSL1 on the regulation of endometrial cancer progression. (bvsalud.org)
  • Changes in lipids in serum samples from mice with endometrial cancer xenotransplants were examined in an untargeted lipidomic study that combined multivariate statistical methods with liquid chromatographyâ mass spectrometry (LC/MS). RESULTS: Patient sample and tissue microarray data suggested that higher ACSL1 expression is strongly associated with the malignant progression of EC. (bvsalud.org)
  • Monitoring the cell's progression to apoptosis, detecting the apoptotic cells, and developing drugs that regulate the apoptotic pathways are the essential parts of the apoptosis research. (cephamls.com)
  • They filled test tubes with fluid from the eggs and triggered apoptosis, which they watched unfold by tagging involved proteins with fluorescent light. (livescience.com)
  • In fruit flies, apoptosis is activated by proteins known as Grim, Hid and Reaper. (elifesciences.org)
  • Applying a small library of cysteine-reactive fragments to the proteins found in two types of human cancer cells, the scientists found that the fragments successfully "liganded" more than 750 different cysteines found on more than 600 distinct proteins-which equated to more than 20 percent of all the proteins assayed in the samples. (innovationtoronto.com)
  • A group of proteins, the Bcl-2 proteins, including Bax, play a crucial role in apoptosis. (rub.de)
  • Huntington disease can be a neurodegenerative disorder due to the polyglutamine do it again in AZD5438 the N terminus from the huntingtin proteins (37). (cancer-ecosystem.com)
  • For apoptotic inducing activity, human osteogenic sarcoma (HOS) cell proliferation, chromosomal DNA degradation and changes in apoptosis-related protein levels were measured. (nutrimedical.com)
  • Ellagic acid significantly reduced HOS cell proliferation, and induced apoptosis evidenced by chromosomal DNA degradation and apoptotic body appearance. (nutrimedical.com)
  • However, any dysregulation in apoptosis can lead to various neoplastic processes (NEOPLASIA is the abnormal growth and proliferation of abnormal cells or abnormal amount of cells due to a benign or malignant process). (studymoose.com)
  • Sirtuins are NAD + -dependent histone deacetylases regulating important metabolic pathways in prokaryotes and eukaryotes and are involved in many biological processes such as cell survival, senescence, proliferation, apoptosis, DNA repair, cell metabolism, and caloric restriction. (biomedcentral.com)
  • Signals that trigger apoptosis - the natural process of programmed cell death - cascade through cells in waves at 30 micrometers per minute. (samurai-mag.com)
  • Apoptosis is a process of programmed cell death that occurs in multicellular organisms. (studymoose.com)
  • Apoptosis is a process of programmed cell death, which takes place in multicellular organisms and generally characterized by the distinct morphological characteristics and biochemical processes. (cephamls.com)
  • 4 Although the mechanisms of caspase activation in the cytosol are well characterized, the steps that control cytochrome c release from mitochondria and thereby activate the apoptosis program have remained largely elusive. (nature.com)
  • We found that, upon induction of apoptosis in control MEFs, n-cofilin, and its homolog ADF translocated to mitochondria together with actin. (nature.com)
  • In 2011, he was appointed laboratory head in the Cell Signalling and Cell Death Division where his lab aims to clarify the molecular mechanisms regulating apoptosis and also mitophagy (mitochondria quality control), and how these processes go awry to promote cancer and other diseases. (le.ac.uk)
  • Apoptosis is also sometimes called "cellular suicide," because it is a process of self-destruction. (livescience.com)
  • Bertrand Joseph, Professor of Molecular Cancer Biology specialising in Cell Death at the Institute of Environmental Medicine, researches signals at cellular level that determine if cells are to die or not. (ki.se)
  • Yeast can undergo cell death accompanied by cellular markers of apoptosis. (scienceopen.com)
  • Inappropriate kinase activity triggers a variety of biological cellular responses relating to cell growth, cell differentiation, cell function, survival, apoptosis, and cell mobility implicated in the aforementioned and related diseases. (justia.com)
  • There are six types of necrosis: Coagulative necrosis Liquefactive necrosis Caseous necrosis Fat necrosis Fibroid necrosis Gangrenous necrosis Apoptosis is the programmed cell death of superfluous or potentially harmful cells in the body. (wikipedia.org)
  • Unlike necrotic cell death, Neighbouring cells are not damaged by apoptosis as cytosolic products are safely isolated by membranes prior to undergoing phagocytosis. (wikipedia.org)
  • Apoptosis plays a crucial role in developing and maintaining the health of the body by eliminating old cells, unnecessary cells, and unhealthy cells. (rxlist.com)
  • When apoptosis does not work correctly, cells that should be eliminated may persist and become immortal, for example, in cancer and leukemia . (rxlist.com)
  • When apoptosis works overly well, it kills too many cells and inflicts grave tissue damage. (rxlist.com)
  • These proteases are responsible for the dismantling of cells during apoptosis. (nature.com)
  • To test the relevance of ADF/cofilin activity for apoptotic processes, we here employed a genetically well-defined system of mouse embryonic fibroblasts (MEFs) devoid of any ADF/cofilin activity and challenged these cells with well-characterized apoptosis inducers. (nature.com)
  • In summary, our work demonstrates that in mammalian cells ADF/cofilin activity is not generally required for efficient induction of apoptosis. (nature.com)
  • Further evaluation revealed that ellagic acid was a potent antiestrogen in MCF-7 breast cancer-derived cells, increasing, like the pure estrogen antagonist ICI182780, IGFBP-3 levels. (nutrimedical.com)
  • CONCLUSION: Ellagic acid exhibited both antioxidant activity in V79-4 cells and apoptosis-inducing activity in HOS cells through the up-regulation of Bax and activation of caspase-3. (nutrimedical.com)
  • Cell death, called apoptosis, is important for controlling the number of cells in the body. (edu.au)
  • Insufficient cell death can cause cancer by allowing cells to become immortal while excessive cell death of neurons may be a cause of neurodegenerative conditions. (edu.au)
  • Similarly, agents that drive Bax into its active form could force immortal cells such as cancer cells to die, providing the basis for a potential new class of anti-cancer agents. (edu.au)
  • Apoptosis - or programmed cell death - is necessary for clearing our bodies of unnecessary or harmful cells, such as those that are infected by viruses. (livescience.com)
  • Sometimes our cells die when we really don't want them to - say, in neurodegenerative diseases. (livescience.com)
  • And sometimes our cells don't die when we really do want them to - say, in cancer," senior author Dr. James Ferrell, a professor of chemical and systems biology and biochemistry at Stanford University, said in a statement . (livescience.com)
  • Purvalanol, a novel cyclin-dependent kinase inhibitor, is referred to as a strong apoptotic inducer which causes cell cycle arrest in various cancer cells such as prostate, breast and colon cancer cell lines. (spandidos-publications.com)
  • In the present study, our aim was to determine the time-dependent, ER-mediated apoptotic and autophagy induction of purvalanol in HCT 116 colon cancer cells. (spandidos-publications.com)
  • HCT 116 colon cancer cells were exposed to purvalanol, which activated ER stress via upregulation of PERK, IRE1α gene expression, eIF-2α phosphorylation and ATF-6 cleavage at early time-points in the HCT 116 colon cancer cells. (spandidos-publications.com)
  • Olomoucine, roscovitine and purvalanol are examples of CDK inhibitors (CDKIs) designed and investigated for their apoptotic potential on cancer cells ( 3 ). (spandidos-publications.com)
  • We identified a novel mode of communication by which apoptotic cells induce additional apoptosis in the same tissue. (elifesciences.org)
  • Strong induction of apoptosis in one compartment of the Drosophila wing disc causes apoptosis of cells in the other compartment, indicating that dying cells can release long-range death factors. (elifesciences.org)
  • Apoptosis has been thought to resemble a form of silent suicide by cells, but more recent work suggests that apoptotic cells can also transmit signals. (elifesciences.org)
  • Strikingly, undead cells in the posterior (back) region of the wing imaginal disc-the tissue in the larva that gives rise to the wing in the adult fruit fly-could trigger apoptosis in cells in the anterior (front) half. (elifesciences.org)
  • found that the JNK pathway activated apoptosis in anterior cells. (elifesciences.org)
  • when Eiger was absent from posterior cells in the wing imaginal disc, apoptosis in anterior cells ceased, indicating that Eiger might signal at long range. (elifesciences.org)
  • Apoptosis is a distinct form of programmed cell death in which cells activate an intrinsic suicide program to self-destruct. (elifesciences.org)
  • Similarly studies with Emodin and Aloe emodin derivatives have also revealed greater therapeutic potential, DNA intercalation property, and reactive oxygen species generation and thereby induction of apoptosis in cancer cells [ 12 ]. (longdom.org)
  • In cancer patients, fasting with or without activation of autophagy may play a role in the immune response to cancer cells, especially in the context of chemotherapy. (diabetes.co.uk)
  • For example, it has been shown that cancer patients fasting up to 72 hours before chemo lowered damage to immune cells and reduced biomarkers of cancer. (diabetes.co.uk)
  • His work is relevant for many diseases, such as neurodegenerative diseases and cancer, in which cells take the wrong decision in this choice between life and death. (ki.se)
  • During apoptosis, cells shrink, their DNA breaks down, and they are eventually dismantled and removed by immune cells. (studymoose.com)
  • We suggest that apoptosis in yeast confers a selective advantage for this unicellular organism, and demonstrate that old yeast cells release substances into the medium that stimulate survival of the clone. (scienceopen.com)
  • The basic machinery to carry out apoptosis appears to be present in essentially all mammalian cells at all times, but the activation of the suicide program is regulated by many different signals that originate from both the intracellular and the extracellular milieu. (scienceopen.com)
  • The GQDs have further been used to image human breast adenocarcinoma cell line (MCF-7 cells), human cervical cancer cell line (HeLa cells), and normal human mammary epithelial cell line (MCF-10A). (nycu.edu.tw)
  • Stress-induced cyclin C cytoplasmic translocalization and mitochondrial hyperfragmentation insures timely activation of apoptosis in stressed cells. (rowan.edu)
  • The Company's state-of-the-art and patented Todos Biochemical Infrared Analyses (TBIA) is a proprietary cancer-screening technology using peripheral blood analysis that examines cancer's influence on the immune system, looking for biochemical changes in blood mononuclear cells and plasma. (yahoo.com)
  • On the other hand, the infiltration of organs by a monoclonal population of aberrant cells, the possibility of lethal evolution, and the cancer-based modalities of successful treatment are all consistent with a neoplastic process. (medscape.com)
  • His laboratory recently identified more than 15 genes that act downstream of the C. elegans cell death protease CED-3 to execute programmed cell death and at least eight new genes that control sexually dimorphic apoptosis, which is an ancient developmental process crucial for the reproduction of animal species. (colorado.edu)
  • miRNA in cancer: apoptosis which is also known as programmed cell death is very important in animal's development and disease. (studymoose.com)
  • Apoptosis (programmed cell death) is linked to many incurable neurodegenerative, cardiovascular and cancer causing diseases. (nycu.edu.tw)
  • High ROS levels induce lipid oxidation, protein aggregation, mitochondrial hyperfragmentation, DNA damage and programmed cell death (PCD), also called apoptosis. (rowan.edu)
  • These differences were found in genes involved in cell cycle regulation, apoptosis, cell signaling, metastasis, and myeloid differentiation. (medscape.com)
  • Therefore, the abnormal regulation of PCD is associated with numerous human diseases, including cancers and neurodegenerative diseases. (nature.com)
  • This process plays a major role in development and tissue homeostasis, and abnormal regulation of apoptosis is associated with a variety of human diseases ( Fuchs and Steller, 2011 ). (elifesciences.org)
  • Recent studies reported a mitochondrial translocation of n-cofilin during apoptosis. (nature.com)
  • Mitochondrial dysfunction has been associated with many diseases, including neurogegeneration, diabetes and cancer, although its exact role in the development of these diseases remains controversial. (nih.gov)
  • To elucidate the general importance of ADF/cofilin activity for apoptosis, we exposed mouse embryonic fibroblasts deficient for n-cofilin, ADF (actin depolymerizing factor), or all ADF/cofilin isoforms to well-characterized apoptosis inducers. (nature.com)
  • We offer caspase related apoptosis products that include: apoptosis inducers, Casapase activity and inhibitor assays and high quality human recombinant active caspases to study enzyme regulation and kinetics, screen caspase inhibitors, determine target substrates, etc. (cephamls.com)
  • Parkinson's disease (PD) is a common neurodegenerative disease. (amegroups.org)
  • BACKGROUND: Antioxidant, antiproliferative and apoptosis inducing activities of a natural polyphenolic compound, ellagic acid, were studied. (nutrimedical.com)
  • Apples offer cancer protection - Apples may offer antimutagenic activity, antioxidant activity, anti-inflammatory mechanisms, antiproliferative and apoptosis-inducing activity. (rebootwithjoe.com)
  • Apoptosis is essential for many fundamental processes, such as embryogenesis and tissue homeostasis. (nature.com)
  • This study aimed to elucidate the potential molecular mechanisms by which ACSL1 is involved in lipid metabolism in endometrial cancer, providing valuable insights for targeted therapeutic strategies. (bvsalud.org)
  • In Apoptosis in Health and Disease: Clinical and Therapeutic Aspects (pp. 96-155). (johnshopkins.edu)
  • She has participated in and led several proteomic and multi-omic studies, which were primarily aimed at understanding the complex biological processes underlying development and heterogeneity of various diseases, such as Alzheimer´s disease and various cancers, as well as exploring possible new diagnostic and therapeutic options. (lu.se)
  • Patients in the high-risk group had worse overall survival, lower immune score and ESTIMATE score, higher TMB, higher cancer stem cell index, and higher sensitivity to conventional chemotherapeutic agents. (biomedcentral.com)
  • Now we see that enzymes linked to apoptosis are also involved in the survival signalling. (ki.se)
  • Disruption of apoptosis through deletion of yeast caspase YCA1 initially results in better survival of aged cultures. (scienceopen.com)
  • In addition to basic science investigations in such areas as tumor cell invasion, oncogenes, immunotherapy and genetic inheritance, our scientists and physicians participate in national cancer trials. (upstate.edu)
  • As these studies also revealed impaired cytochrome c release and a block in apoptosis upon small interfering RNA-mediated n-cofilin knockdown, n-cofilin was postulated to be essential for apoptosis induction. (nature.com)
  • Effect of stainless steel manual metal arc welding fume on free radical production, DNA damage, and apoptosis induction. (cdc.gov)
  • She is now focusing on improving companion diagnostic biomarker testings for solid cancers in immuno-oncology using computer vision. (upstate.edu)
  • INTRODUCTION Cisplatin is one of the best and first metal-based chemotherapeutic drugs, used for wide range of solid cancers such as testicular, ovarian, bladder, lung, head and neck, gastric cancers[1]. (studymoose.com)
  • We have found that apoptosis can be induced in the yeast Saccharomyces cerevisiae by depletion of glutathione or by low external doses of H2O2. (scienceopen.com)
  • Multiple preclinical studies in vitro and in vivo have proven curcumin to be effective against various cancers. (hindawi.com)
  • These potent effects are driven by curcumin's ability to induce G2/M cell cycle arrest, induce autophagy, activate apoptosis, disrupt molecular signaling, inhibit invasion and metastasis, and increase the efficacy of current chemotherapeutics. (hindawi.com)
  • It doesn't get any lower in amplitude because every step of the way it's generating its own impetus by converting more inactive molecules to active molecules, until apoptosis has spread to every nook and cranny of the cell. (livescience.com)
  • There is no smaller amplitude because at each step it generates swoj own impulse, transforming inactive molecules into active ones, until apoptosis spreads to every nook and cranny of the comorki - explained Ferrell. (samurai-mag.com)
  • These data support a model that Med13p plays an important role in protecting the cell from aberrant ROS-induced apoptosis by retaining cyclin C in the nucleus. (rowan.edu)
  • Increased Acyl-CoA synthetase long-chain family member 1 (ACSL1) activity may contribute to aberrant lipid metabolism, which is a potential factor that contributes to the pathogenesis of endometrial cancer. (bvsalud.org)
  • Dr Peter Czabotar , Professor Peter Colman and colleagues in the institute's Structural Biology division , together with Dr Dana Westphal from the institute's Molecular Genetics of Cancer division , made the discovery which is published in the latest edition of the journal Cell . (edu.au)
  • In the following 128 years, HD has inspired thousands of research papers in which elucidation of this unrelenting neurodegenerative disorder has been attempted. (medscape.com)
  • As one of the most prevalent types of malignant tumors, lung cancer has been ranked among the highest incidence and mortality rates in many parts of the world [ 1 ]. (biomedcentral.com)
  • At this stage, research on the use of specific biomarkers to construct prognostic models for lung cancer is emerging, and bioinformatics plays an important role during the process. (biomedcentral.com)
  • Risk of lung cancer and leukemia from exposure to ionizing radiation and potential confounders among workers at the Portsmouth Naval Shipyard. (cdc.gov)
  • In both cases, we show oxygen radicals to accumulate in the cell, whereas radical depletion or hypoxia prevents apoptosis. (scienceopen.com)
  • They have also documented hereditary damage, conceptive imperfections, cancer, neurological degeneration and problem with nervous system, weakened immune system, and numerous other harmful impacts of EMF radiation exposure. (vortexbioshield.com)
  • Here, we demonstrate that chronologically aged yeast cultures die exhibiting typical markers of apoptosis, accumulate oxygen radicals, and show caspase activation. (scienceopen.com)
  • The relationship between risk scores and tumor mutation burden (TMB), cancer stem cell index, and drug sensitivity was explored. (biomedcentral.com)