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  • PMID
  • PMID 28488322 ] The amount of GLCCI1 protein induced by glucocorticoids was significantly lower in the bronchial epithelial cells of rs37973 (G;G) patients as compared to wild type homozygotes possibly resulting in inferior response. (snpedia.com)
  • apoptotic
  • Protein S can bind to the negatively charged phospholipids and function as a bridging molecule between the apoptotic cell and the phagocyte. (wikipedia.org)
  • The bridging property of Protein S enhances the phagocytosis of the apoptotic cell, allowing it to be removed 'cleanly' without any symptoms of tissue damage such as inflammation occurring. (wikipedia.org)
  • The p53 upregulated modulator of apoptosis (PUMA) also known as Bcl-2-binding component 3 (BBC3), is a pro-apoptotic protein, member of the Bcl-2 protein family. (wikipedia.org)
  • However, when the cell is apoptotic nuclear export of cIAP1 is induced provoking an increase in the cytosolic concentration of the protein. (wikipedia.org)
  • showed that the Xk-family protein Xkr8 mediates PtdSer exposure in response to apoptotic stimuli. (wikipedia.org)
  • transport binding
  • In the circulation, CSF, and brain interstitial fluid (ISF), soluble Aβ may exist as a free peptide or be associated with different transport binding proteins such as apolipoproteins J (apoJ) ( 17 - 18 ) and E (apoE) ( 19 ), transthyretin ( 20 ), lipoproteins ( 21 ), albumin ( 22 ), and α 2 -macroglobulin (α 2 M) ( 23 ). (pubmedcentralcanada.ca)
  • coagulation
  • The blood coagulation cascade. (britannica.com)
  • This protein is the only one in the coagulation pathway for which a congenital deficiency has not been described. (wikipedia.org)
  • The best known function of tissue factor is its role in blood coagulation. (wikipedia.org)
  • Protein S is partly homologous to other vitamin K-dependent plasma coagulation proteins, such as protein C and factors VII, IX, and X. Similar to them, it has a Gla domain and several EGF-like domains (four rather than two), but no serine protease domain. (wikipedia.org)
  • The best characterized function of Protein S is its role in the anti coagulation pathway, where it functions as a cofactor to Protein C in the inactivation of Factors Va and VIIIa. (wikipedia.org)
  • inflammation
  • The absence of oxygen and nutrients from blood during the ischemic period creates a condition in which the restoration of circulation results in inflammation and oxidative damage through the induction of oxidative stress rather than (or along with) restoration of normal function. (wikipedia.org)
  • Continuous pressure limits blood supply and causes ischemia, and the inflammation occurs during reperfusion. (wikipedia.org)
  • inhibitors
  • Other agents that induce p53 dependent apoptosis are neurotoxins, proteasome inhibitors, microtubule poisons, and transcription inhibitors. (wikipedia.org)
  • phosphorylation
  • PUMA protein is degraded in a proteasome dependent manner and its degradation is regulated by phosphorylation at a conserved serine residue at position 10. (wikipedia.org)
  • These include receptor antagonists, neurotransmitters, neurotransmitter reuptake, G protein-coupled receptors, G proteins, second messengers, the enzymes that trigger protein phosphorylation in response to cAMP, and consequent metabolic processes such as glycogenolysis. (wikipedia.org)
  • These transcription factors share the ability to be inhibited and translocated out of the nucleus on phosphorylation by proteins such as Akt/PKB in the PI3K signaling pathway (aside from FOXO6, which may be constitutively nuclear). (wikipedia.org)
  • trigger
  • Both ubiquitination and SUMOylation of PML protein can trigger its degradation in the proteasome, thus providing a means of modulating PML protein lability within the cell. (wikipedia.org)
  • antibodies
  • Aβ 1-40 clearance was substantially inhibited by the receptor-associated protein, and by antibodies against LDL receptor-related protein-1 (LRP-1) and α 2 -macroglobulin (α 2 M). As compared to adult wild-type mice, clearance was significantly reduced in young and old apolipoprotein E (apoE) knockout mice, and in old wild-type mice. (pubmedcentralcanada.ca)
  • glucose
  • Therefore, we examined the rat ovary for the presence of Glut1-4 and blood glucose level after eCG (equine chorionic gonadotropin) and anti-eCG antiserum treatment. (jove.com)
  • plasma
  • Protein S (also known as S-Protein) is a vitamin K-dependent plasma glycoprotein synthesized in the liver. (wikipedia.org)
  • Instead, there is a large C-terminus domain that is homologous to plasma steroid hormone-binding proteins such as sex hormone-binding globulin and corticosteroid-binding globulin. (wikipedia.org)
  • Absolute bioavailability is 58%, and highest blood plasma concentrations of ixazomib are reached after one hour. (wikipedia.org)
  • lymphocytes
  • As a result, apoptosis is enabled again, the lymphocytes die and the equilibrium in the immune system is restored. (eurekalert.org)
  • Whereas the apoptosis inhibitor caused no anomalies in young mice, the scenario in older mice was quite different: "The composition of the lymphocytes was changed significantly," says Schmitz. (eurekalert.org)
  • bind
  • Protein S can bind to negatively charged phospholipids via the carboxylated Gla domain. (wikipedia.org)
  • Signaling molecules bind to a domain of the GPCR located outside the cell, and an intracellular GPCR domain then in turn activates a particular G protein. (wikipedia.org)