Cell AgingApoptosisTumor Suppressor Protein p53Cyclin-Dependent Kinase Inhibitor p16Apoptosis Regulatory ProteinsCaspasesCaspase 3FibroblastsCell Line, TumorProto-Oncogene Proteins c-bcl-2AgingCells, CulturedTelomereCyclin-Dependent Kinase Inhibitor p21Signal TransductionInhibitor of Apoptosis ProteinsCell ProliferationPlant LeavesDNA DamageTelomeraseDNA FragmentationCell CycleCell Survivalbeta-GalactosidaseAging, PrematureIn Situ Nick-End Labelingbcl-2-Associated X ProteinCell LineReactive Oxygen SpeciesX-Linked Inhibitor of Apoptosis ProteinMitochondriaCell DivisionOxidative StressBlotting, WesternEnzyme ActivationDown-RegulationRNA, Small InterferingApoptosis Inducing FactorCASP8 and FADD-Like Apoptosis Regulating ProteinTumor Cells, CulturedCaspase 9Caspase InhibitorsRetinoblastoma ProteinCell Cycle CheckpointsUp-RegulationTelomere ShorteningFlow CytometryCaspase 8Tumor Suppressor ProteinsRNA InterferenceGene Expression RegulationFas Ligand ProteinCytochromes cCell Transformation, Neoplasticbcl-X ProteinProto-Oncogene ProteinsTime FactorsAnnexin A5Reverse Transcriptase Polymerase Chain ReactionTransfectionAntineoplastic AgentsRNA, MessengerDNA-Binding ProteinsPhenotypeModels, BiologicalChlorophyllGene Expression Regulation, PlantCell DeathMutationEthylenesPhosphorylationProtein-Serine-Threonine KinasesHydrogen PeroxideNuclear ProteinsGene Expression Regulation, NeoplasticEnzyme InhibitorsMice, KnockoutCysteine Proteinase InhibitorsMice, Inbred C57BLLongevityTumor Suppressor Protein p14ARFNeoplasmsCell Cycle ProteinsPoly(ADP-ribose) PolymerasesTranscription FactorsCell Line, TransformedAmino Acid Chloromethyl KetonesArabidopsisGene ExpressionSirtuin 1Dose-Response Relationship, DrugGene Knockdown TechniquesProto-Oncogene Proteins c-aktEpithelial CellsGenes, p53Autophagyras ProteinsPlant Growth RegulatorsHCT116 CellsImmunohistochemistry