Apoptosis and cell proliferation dramatically cell cycle. Medical search. Frequent questions

Erikson, Raymond L. / Polo-like kinase (Plk)1 depletion induces apoptosis in cancer cells . (uky.edu)
Restoration of miR-29b in AML cell lines and primary samples induces apoptosis and dramatically reduces tumorigenicity in a xenograft leukemia model. (ashpublications.org)
It further induces apoptosis, inhibition of colony formation and tumorigenesis of breast cancer cells in vivo. (wikipedia.org)
Meanwhile, the overexpression of miR-26a in the A549 human lung cancer cell line dramatically inhibits cell proliferation, blocks G1/S phase transition, induces apoptosis, and inhibits cell metastasis and invasion in vitro. (wikipedia.org)
Our study demonstrates that survivin and APE1/Ref-1 are significantly higher in human prostate cancer specimens compared to noncancerous controls and that APE1/Ref-1 redox-specific inhibition with small molecule inhibitor, APX3330 and a second-generation inhibitor, APX2009, decreases prostate cancer cell proliferation and induces cell cycle arrest. (oncotarget.com)
We predict that HBx/miR-221-mediated CXCL12/CXCR4 signaling induces NKT cells to promote HBV-related HCC. (techscience.com)
Pre-gastrulation exposure of 2-4% alcohol induces apoptosis in Xenopus embryo whereas 1% alcohol specifically impairs neural crest migration without observing discernible apoptosis. (biomedcentral.com)
We found that pre-gastrulation exposure of 2-4% alcohol induces developmentally non-specific apoptosis, whereas 1% alcohol specifically impairs neural crest migration without significant apoptosis, which consequently lead to neurocristopathies-like abnormalities. (biomedcentral.com)

Additionally, GEM or GEM+CDDP at low concentrations dramatically facilitated the proliferation, migration, and invasion of tumor cells in vitro . (researchsquare.com)
Cell-cycle arrest, activation of associated apoptotic proteins, and inhibition of apoptosis were also observed in tumor cells. (researchsquare.com)
CRC cells secreted extracellular miR-224-5p mainly in an exosome-dependent manner, and then miR-224-5p could be transferred to surrounding tumor cells to regulate cell proliferation in the form of autocrine or paracrine. (besjournal.com)
Knockdown of Rad9 in prostate tumor cells correlates with reduction of tumorigenicity in nude mice [ 16 ]. (biomedcentral.com)
It is likely that increased Rad9 expression is needed for proliferation of tumor cells by mechanisms such as getting beyond (tolerating) oncogene-induced replicative stress and enhancing DNA repair capability. (biomedcentral.com)
This innovative approach enhances the patient's immune system to target and eliminate tumor cells. (biomedcentral.com)
however, restoration of CBY1 expression in tumor cells reduces BCSC and its enrichment, thus lnc408 plays an essential role in maintenance of BCSC stemness. (nature.com)
GEP analyses were performed on highly purified, flow-cytometry sorted tumor-cells from eight subgroups of BCLs. (lu.se)
This enabled identification of TFs that can be uniquely associated to the tumor cells of chronic lymphocytic leukemia (CLL), diffuse large B-cell lymphoma (DLBCL), follicular lymphoma (FL), hairy cell leukemia (HCL), and mantle cell lymphoma (MCL). (lu.se)

It directly represses expression of the oncogene EZH2 (enhancer of zeste homolog 2), which in turn causes inhibition of cell growth and cell-cycle progression. (wikipedia.org)
The results demonstrated that JIB extract combined with cisplatin enhanced the inhibition of cell growth, proliferation, and survival through the obstruction of cell cycle progression and AKT/mTOR and MAPK signaling as well as the induction of cell apoptosis. (medsci.org)
Cetuximab-bound EGF receptor inhibits activation of receptor-associated kinases, resulting in inhibition of cell growth, induction of apoptosis, and decreased production of matrix metalloproteinase and vascular endothelial growth factor. (medscape.com)

We further revealed that chaetocin triggered the activation of Hippo pathway in ESCC cells, which is characterized by elevated phosphorylation levels of almost all core proteins in Hippo pathway, such as MST1 (Thr183), MST2 (Thr180), MOB1 (Thr35), LAST1 (Thr1079 and Ser909) and YAP (Ser127), ultimately leading to decreased nuclear translocation of YAP. (aging-us.com)
It is believed that this complex is important for the function of these three proteins in DNA repair as well as activation of cell cycle checkpoints. (biomedcentral.com)
A key feature of prostate cancer progression is the induction and activation of survival proteins, including the Inhibitor of Apoptosis (IAP) family member survivin. (oncotarget.com)
They were nanoscale membrane vesicles that were generated by most types of cells, which can convey information in the tumor microenvironment by transferring cargos such as DNA, RNA, proteins and lipids, therefore they are critical to tumor progression [ 5 ]. (biomedcentral.com)
Mechanistically, both peptides caused a significant reduction at G0/G1 phase, in correlation with an augmented expression of the cell cycle inhibitory proteins p53, p27, p21, necrosis, exacerbated generation of reactive oxygen species and diminished mitochondrial membrane potential, all hallmarks of cellular stress. (nature.com)
Targeted therapy drugs are used to target specific genes and proteins of cancer cells to precisely identify and attack specific types of cancer cells. (medsci.org)
In fruit flies, apoptosis is activated by proteins known as Grim, Hid and Reaper. (elifesciences.org)
created 'undead' cells in which one of these proteins was turned on, but other downstream proteins (that are responsible for the cellular execution phase of apoptosis) had been turned off: these cells were undergoing apoptosis, but could not complete the process and die. (elifesciences.org)
The Wnt signaling pathway creates a complex network of proteins that have different effects on cells, so they can be involved in many cancers, including gliomas. (researchsquare.com)
The Wnt signaling pathway creates a complex network of proteins that have different effects on cells. (researchsquare.com)
Cuproptosis is a newly discovered type of cell death in tumor, which is characterized by accumulation of intracellular copper leading to the aggregation of mitochondrial lipoproteins and destabilization of proteins. (biomedcentral.com)

Here, we demonstrated that chaetocin dramatically inhibited the proliferation in ESCC cells by causing cycle arrest in the M phase and activating the caspase-dependent apoptosis signaling pathway in vitro , and we also found that chaetocin induced the accumulation cellular reactive oxygen species (ROS). (aging-us.com)
Tumor and endothelial cell functions, apoptosis, cell cycle analysis, as well as bone marrow derived cells (BMDCs) mobilization, were evaluated with transwell, MTT or flow cytometry analysis in vitro , respectively. (researchsquare.com)
This study observes a previously neglected pharmacological phenomenon and investigates its mechanism of that the continuous low-dose administration of some antineoplastic agents in certain dose ranges can promote tumorigenesis and tumor progression in vitro and in vivo , through stimulation of tumor cell functions directly as well as enhancement of tumor angiogenesis by BMDCs recruitment indirectly. (researchsquare.com)
Functional roles of MSI2 and miR-143 on AML cell proliferation and migration were determined by CCK-8 assay, colony formation, and transwell assays in vitro and in mouse subcutaneous xenograft and orthotopic transplantation models in vivo. (biomedcentral.com)
In pediatric solid tumors and brain tumors, PLK1 inhibition leads to apoptosis in vitro and in tumor xenografts. (childrenscolorado.org)
Because APE1/Ref-1 is expressed and elevated in prostate cancer, we sought to characterize APE1/Ref-1 expression and activity in human prostate cancer cell lines and determine the effect of selective reduction-oxidation (redox) function inhibition on prostate cancer cells in vitro and in vivo . (oncotarget.com)
We subsequently confirmed that PAK3 was overexpressed in HCC clinical samples and HCC cell lines and that PAK3 promoted the proliferation, migration and invasion of HCC cells in vitro . (jcancer.org)
Both inhibition of WDR5 by siRNA and OICR-9429 could reduce proliferation, and increase apoptosis and chemosensitivity to cisplatin in vitro and in vivo . (thno.org)

Downregulation of Herg1 suppresses osteosarcoma proliferation and invasion by targeting Hippo signaling pathway]. (cancerindex.org)
P21-activated kinase 3 (PAK3) is a serine/threonine protein kinase, and PAK3 affects the EMT, proliferation, metastasis and invasion of HCC. (jcancer.org)
In addition, after the overexpression or knockdown of PAK3 in cells, the proliferation, migration and invasion abilities of these cells were assessed by Cell Counting Kit-8 (CCK-8), wound healing and Transwell assays, and the results were confirmed in vivo experiments in mice. (jcancer.org)
Furthermore, small interfering RNA (siRNA)-mediated silencing of SPC24 was employed in SMMC7721 and HepG2 human HCC cells to investigate cell proliferation, invasion and apoptosis. (oncotarget.com)
Finally, we determined that knockdown of LIPT1 gene expression inhibited proliferation and invasion of hepatoma cells. (biomedcentral.com)
In addition, we verified that LIPT1 may promote proliferation, invasion and migration of LIHC cells. (biomedcentral.com)
We found that 4HPR impairs DU145 and PC3 prostate cancer cells migration and invasion by down-regulating FAK and AKT activation and by enhancing β-catenin degradation, causing the downregulation of target genes like cyclin D1, survivin and VEGF. (biomedcentral.com)
In addition, we found that BMP-2, a 4HPR target with antiangiogenic activity, decreased prostate cancer cell proliferation, migration and invasion by down-regulating the pathway described involving AKT phosphorylation, β-catenin stability and cyclin D1 expression. (biomedcentral.com)
These data point to 4HPR as a negative regulator of AKT phosphorylation, effectively targeting the β-catenin pathway and inducing a relatively benign phenotype in prostate cancer cells, limiting neoangiogenesis and cell invasion. (biomedcentral.com)
Since angiogenesis and metastatic spread are strictly related, in this study we analyzed the regulation of multiple signaling pathways responsible for cancer cell invasion. (biomedcentral.com)
We found that 4HPR-induced inhibition of PC cell migration and invasion correlates with decreased FAK and AKT phosphorylation, activation of the glycogen synthase kinase 3β(GSK3β) and β-catenin destabilization. (biomedcentral.com)

Overexpression of miR-26a brings about negative regulation of both cell proliferation and of the cell cycle. (wikipedia.org)
Mnt overexpression suppressed cell cycle entry and cell proliferation, suggesting that the ratio of Mnt-Max to c-Myc-Max is critical for cell cycle entry. (silverchair.com)
In this study, the authors used DNA microarray to compare and identify genes induced by HER2 in mammary epithelial cell line with ectopic HER2 overexpression and breast cancer cell lines derived from patients with different level of HER2 expression. (biomedcentral.com)
Additionally, DNMT1, the DNA methyltransferase that maintains methylation patterns, is aberrantly upregulated in HCC cell lines, and its overexpression is responsible for hypermethylation of the miR-148a promoter. (spandidos-publications.com)
Importantly, we demonstrate that the overexpression of miR-148a significantly inhibits HCC cell proliferation and cell cycle progression. (spandidos-publications.com)

A downregulation of FASN effectively inhibits the activity of "HER2-PI3K/Akt axis" and alters the malignant phenotype in colorectal cancer cells. (biomedcentral.com)
found that TNF is produced by apoptotic cells in hair follicles, and that blocking TNF inhibits the death of other cells in the same cohort: this suggests that a common mechanism could regulate the communal death of cells in flies and mammals. (elifesciences.org)

Accumulating data have confirmed that high expression of Msi2 mRNA is associated with poor prognosis in AML, as patients with as low as 1% of total bone marrow cells expressing elevated MSI2 levels still have a short survival [ 14 , 15 ]. (biomedcentral.com)
Due to the role of oncogenic transcriptional activators NFĸB and STAT3 in survivin protein expression, and APE1/Ref-1 redox activity regulating their transcriptional activity, we assessed selective inhibition of APE1/Ref-1's redox function as a novel method to halt prostate cancer cell growth and survival. (oncotarget.com)
Increasing evidence has shown that KSHV infection can alter central carbon metabolic pathways to produce biomass for viral replication, as well as the survival and proliferation of infected cells. (frontiersin.org)
Therefore, we investigated the combined effect of Temozolomide (TMZ) and KC7F2 on cell survival and changes in gene expression in the Wnt signal pathway. (researchsquare.com)
The protein kinase Akt also known as PKB, regulates multiple cellular functions including proliferation, survival, and growth during embryonic development and adult tissue homeostasis [ 1 - 5 ]. (biomedcentral.com)

Furthermore, exosome-derived miR-224-5p partially reversed the proliferation regulation of ULK2 on CRC cells. (besjournal.com)
Given the strong link between the regulation of some of these genes and the growth and dissemination of gastrointestinal cancers, we believe their aberrant expression in UC may provide a mechanism for epithelial hyper-proliferation and, in the context of malignant transformation, for tumour growth. (bmj.com)
This process plays a major role in development and tissue homeostasis, and abnormal regulation of apoptosis is associated with a variety of human diseases ( Fuchs and Steller, 2011 ). (elifesciences.org)
Herein, we describe the epigenetic regulation of miR-148a and its impact on HCC cells. (spandidos-publications.com)
Copper plays an important role in cells as a catalytic cofactor for essential enzymes involved in energy conversion, oxygen transport, and regulation of oxidative metabolism in cells [ 7 ]. (biomedcentral.com)
As a consequence, 4HPR led to the regulation of genes controlling cell proliferation, angiogenesis and metastasis. (biomedcentral.com)
In mammals, Akt is ubiquitously expressed and is associated with regulation of cellular proliferation, metabolism, cell growth and cell death. (biomedcentral.com)

We found that PIk1 depletion dramatically inhibited cell proliferation, decreased viability, and resulted in cell-cycle arrest with 4 N DNA content. (uky.edu)
In addition, we designed and screened a panel of gomesin analogues with amino acid modifications that were predicted to influence cell viability. (nature.com)
The effects of TMZ and KC7F2 on cancer cell viability and proliferation were investigated by WST-1 method. (researchsquare.com)
Path alone didn't inhibit cell success (significantly less than 10%) whereas mixed treatment with PT exhibited a will dependent decrease in cell viability (Fig. 1B). (researchensemble.com)

Hepatocellular carcinoma miR-26a has been found to induce cell cycle arrest at the G1 phase in human hepatocellular carcinoma cells, in part through direct downregulation of cyclin D2 and cyclin E2. (wikipedia.org)
JIB extract induced cell cycle arrest at the G 0 /G 1 phase and decreased cyclin and cdk protein expressions. (medsci.org)

miR-26 expression is induced in response to hypoxia and upregulated during smooth muscle cell (SMC) differentiation and neurogenesis. (wikipedia.org)
Smooth muscle cell (SMC) differentiation miRNA-26a is found to be significantly upregulated during SMC differentiation and downregulated in abdominal aortic aneurysm (AAA) formation. (wikipedia.org)
Inhibition of miRNA-26a accelerates SMC differentiation, and also promotes apoptosis, while inhibiting proliferation and migration. (wikipedia.org)
Acute myeloid leukemia (AML) is a heterogenous hematological malignancy characterized by inhibited differentiation and uncontrolled proliferation of hematopoietic stem/progenitor cells (HSPC). (biomedcentral.com)
Since their discovery in 1993, miRNAs have been described in all multicellular organisms and are associated with a vast breadth of biological functions, including cellular proliferation, cellular differentiation and immunity, as well as tissue remodeling and various human diseases, including cancer ( 4 ). (spandidos-publications.com)
Transcription factors (TFs) are critical for B-cell differentiation, affecting gene expression both by repres- sion and transcriptional activation. (lu.se)
In this study, highly purified, flow-cytometry sorted, classified in relation to normal B-cell differentiation [1]. (lu.se)

A leading contributing factor to metastasis and treatment resistance is the heterogeneity and plasticity of the cells within tumors 6 . (nature.com)
PC cells usually remain confined in the organ, while a small proportion of carcinomas acquire the ability to metastasize and approximately 80% of patients who have died of advanced hormone refractory PC have clinical evidence of bone metastasis. (biomedcentral.com)

These findings indicate that, the continuous low-dose administration of GEM and GEM+CDDP can promote tumorigenesis and tumor progression in vivo by inhibiting apoptosis, mobilizing BMDCs, and promoting angiogenesis in certain dose ranges. (researchsquare.com)
Therapeutic miR-26a delivery using adeno-associated virus (AAV) is able to inhibit cancer cell formation while also inducing tumour-specific apoptosis and providing dramatic protection from disease progression without toxicity. (wikipedia.org)
Ectopic expression of miR-26a influences cell cycle progression by targeting the bona fide oncogene EZH2 which is a polycomb protein and global regulator of gene expression. (wikipedia.org)
Eukaryotic cells have developed exquisite mechanisms that monitor and coordinate cell cycle progression with repair of DNA damage to maintain genome integrity. (biomedcentral.com)
The progression of hepatocellular carcinogenesis is thought to involve the deregulation of genes that are critical to cellular processes, such as cell cycle control, cell growth, apoptosis, cell migration and spreading. (spandidos-publications.com)

Twenty-nine of these genes were significantly regulated in UC-in-remission subjects compared with non-IBD controls, including a large number of epithelial cell-expressed genes such as REG4, S100P, SERPINB5, SLC16A1, DEFB1, AQP3 and AQP8, which modulate epithelial cell growth, sensitivity to apoptosis and immune function. (bmj.com)
We found that MSI2 was significantly overexpressed in AML and exerted its role of promoting AML cell growth by targeting DLL1 and thereby activating Notch signaling pathway. (biomedcentral.com)
The oncogenic kinase PLK1 controls cell cycle and growth and is a cancer therapeutic target. (childrenscolorado.org)
The novel PLK1 inhibitor, onvansertib, is the first available for oral administration and has shown tumor growth inhibition in hematologic tumors, osteosarcoma, ovarian carcinoma, breast cancer and colon adenocarcinoma cells. (childrenscolorado.org)
Cell cycle and DNA replication are top signaling hubs for medulloblastoma cell growth. (childrenscolorado.org)
Curcumin can help protect against cancer initiation, slow its growth when it occurs, and even sensitize cancer cells to treatment. (beatcancer.org)
Normalize Cell Growth - Curcumin restores normal growth controls, reverses uncontrolled reproduction of malignant cells, blocks access of cancer cells to growth factors, turns on genes that prevent cell growth and turns off genes that promote cancer growth. (beatcancer.org)
The aim of this study was to assess the effects of brief, intense exposure to tobacco smoke on granulosa cell number, oocyte growth, and follicle size during puberty in female Swiss mice. (biomedcentral.com)
In addition, AKT/mTOR signaling and MAPK signaling were inhibited by JIB extract to suppress melanoma cell growth and proliferation. (medsci.org)
It has been shown that the growth factors, hormones and activation of their receptors increased FASN transcription in cancer cells. (biomedcentral.com)
Dysregulation of various cells in the tumor microenvironment (TME) causes immunosuppressive functions and aggressive tumor growth. (biomedcentral.com)

Transcriptome analysis after ectopic transfection of synthetic miR-29b into leukemia cells indicates that miR-29b target apoptosis, cell cycle, and proliferation pathways. (ashpublications.org)
The term "oncotarget" encompasses all molecules, pathways, cellular functions, cell types, and even tissues that can be viewed as targets relevant to cancer as well as other diseases. (oncotarget.com)
Cancer cell energy metabolism is mainly dominated by three pathways of central carbon metabolism, including aerobic glycolysis, glutaminolysis, and fatty acid synthesis. (frontiersin.org)
Cancer cells often rewire metabolic pathways to balance ATP production for supporting rapidly tumor proliferation. (frontiersin.org)

This non-migratory phenotype was similarly produced in both cell lines by stable silencing of β-catenin. (biomedcentral.com)

Additionally, JIB extract induced B16/F10 cell apoptosis via the caspase cascade. (medsci.org)

Enhance Immune Surveillance - Curcumin prevents cancer cells from evading normal immune system detection and improves the body's ability to detect and destroy malignant cells. (beatcancer.org)
This process is also termed as anaplerosis, and is a dominant metabolism mode in rapidly growing malignant cells besides Warburg effect. (frontiersin.org)
Background/Aims Combination therapy utilizing tumor necrosis element (TNF)-related apoptosis-inducing ligand (TRAIL) together with other anticancer real estate agents is a promising technique to overcome TRAIL level of resistance in malignant cells. (researchensemble.com)

Recently, we described that the genome of S. mediterranea contains a single Akt ortholog termed Smed-Akt , which affects cell division and impairs planarian locomotion [ 22 ]. (biomedcentral.com)

Cells are constantly exposed to stresses from cellular metabolites as well as environmental genotoxins. (biomedcentral.com)
Cytotoxic T lymphocytes were determined as the cellular effectors of GVHD, and the key role of antigen-presenting cells (APCs) in T-lymphocyte activation was established during the following years [ 11 , 12 ]. (hindawi.com)
The current understanding of aGVHD pathogenesis can be summarized as (1) initial tissue damage induced by the conditioning regimen followed by the denudation of auto- and alloantigens accompanied by massive inflammatory cytokine secretion ("cytokine storm") activating APCs, (2) auto- and alloantigen presentation mediated by APCs together with the costimulatory signaling prime donor's cytotoxic T lymphocytes and their proliferation, and (3) the migration of activated cellular effectors toward GVHD target tissues. (hindawi.com)
The TME consists of various cellular components, including immune cells, stromal cells, and extracellular matrix, along with soluble factors and signaling molecules. (biomedcentral.com)
Nonetheless, there is limited understanding of how Akt signaling controls the response of stem cells during cellular turnover and tissue injury in the complexity of the whole organism. (biomedcentral.com)
The neoblasts are the only dividing cells in planarians and constantly proliferate to repair tissues and support systemic cellular turnover [ 21 ]. (biomedcentral.com)

Collectively, our results indicate that JIB extract showed anti-tumor effects and synergized with cisplatin against B16/F10 cells, indicating the possibility of JIB extract to be developed as adjuvant therapy for melanoma. (medsci.org)
These data revealed that targeting WDR5 suppressed proliferation, enhanced apoptosis, chemosensitivity to cisplatin and immunotherapy in PCa. (thno.org)

Kaposi's sarcoma-associated herpesvirus (KSHV), a human oncogenic herpesvirus, is tightly associated with several human malignancies by infecting B-lymphocyte or endothelial cells. (frontiersin.org)

Methods The miR-224-5p expression in CRC patient tissues and cell-derived exosomes was measured by laser capture microdissection and qRT-PCR, respectively. (besjournal.com)
The tissues of developing organisms can be shaped by apoptosis, a form of regulated cell killing. (elifesciences.org)
However, apoptosis has been traditionally regarded as a silent process that does not affect surrounding tissues. (elifesciences.org)
These checkpoints act as molecular brakes on immune cells, preventing excessive activation and potential damage to healthy tissues. (biomedcentral.com)
Several inflammatory cytokines and adipokines were dramatically dysregulated in the metabolic tissues of aged MTMR14 KO mice compared to control mice. (biomedcentral.com)
Processes involved in later stage disease, like development of androgen independence as a consequence of androgen depletion therapy, neoangiogenesis and homing of metastatic cells in lymphatic or bone tissues are generally undetectable at early stages. (biomedcentral.com)

Keratinocytes isolated from Mrad1 +/- mice had significantly more spontaneous DNA double strand breaks, proliferated slower and had slightly enhanced spontaneous apoptosis than Mrad1 +/+ control cells. (biomedcentral.com)
The effects of heterozygous deletion of Mrad1 on proliferation and apoptosis of keratinocytes is different from those resulted from Mrad9 heterozygous deletion (from our previous study), suggesting that Mrad1 also functions independent of Mrad9 besides its role in the Mrad9-Mrad1-Mhus1 complex in mouse cells. (biomedcentral.com)

Conclusion Our findings demonstrate that exosome-transmitted miR-224-5p promotes p53-dependent cell proliferation by targeting ULK2 in CRC, which may offer promising targets for CRC prevention and therapy. (besjournal.com)
Co-treatment with TRAIL and 3-Butylidenephthalide PT caused a 3-fold increase in the proportion of annexin V-positive cells (41.86%) indicating that PT promotes TRAIL-induced apoptosis in TRAIL-resistant cells. (researchensemble.com)
The present study demonstrates that HBx promotes HCC cell proliferation via the C-X-C motif chemokine ligand 12-C-X-C chemokine receptor type 4 (CXCL12-CXCR4) axis. (techscience.com)

KSHV is tightly associated with Kaposi's sarcoma (KS) and two B-cell lymphomas including primary effusion lymphoma (PEL) and multicentric Castleman disease (MCD) by infecting B-lymphocyte and endothelial cells, respectively. (frontiersin.org)
The hemostatic system consists of platelets, coagulation factors, and the endothelial cells lining the blood vessels. (medscape.com)
Under physiological circumstances, the resistance of the endothelial cell lining to interactions with platelets and coagulation factors prevents thrombosis. (medscape.com)

The MTT and colony formation assays were used to assess the proliferation potential. (biomedcentral.com)

The migration was investigated by the transwell, and the apoptosis and cell cycle were assayed by the flow cytometry. (biomedcentral.com)

This paucity is likely due to the ubiquitous nature of this signaling pathway and the difficulty of analyzing stem cells in their natural environment during physiological cell turnover and regeneration in conventional animal models [ 15 - 17 ]. (biomedcentral.com)
This study defined the role of Smed-Akt in abnormal cell proliferation triggered by the abrogation of the phosphatase PTEN, an upstream component of the Akt signaling pathway, which is highly mutated in human cancers. (biomedcentral.com)

Among the genes that remain deregulated during remission, we identify several that are expressed by epithelial cells and are involved in epithelial cell proliferation, resistance to apoptosis and response to stress. (bmj.com)
Other particles may be engulfed by epithelial cells, primarily in the vicinity of the bronchial-alveolar duct junctions, and retained for much longer periods, with gradual removal to lymph nodes. (cdc.gov)
In HHV-1 and HHV-2 oral infections, viral replication within the oral epithelium may cause lysis of epithelial cells, with vesicle formation. (medscape.com)

A decrease in MTDH and EZH2 expression has been shown to be accompanied by an increase in apoptosis, whilst re-expression of MTDH partially reverses miR-26a's pro-apoptotic effect. (wikipedia.org)
Apoptotic cells can produce signals to instruct cells in their local environment, including ones that stimulate engulfment and proliferation. (elifesciences.org)
We identified a novel mode of communication by which apoptotic cells induce additional apoptosis in the same tissue. (elifesciences.org)
Eiger is produced in apoptotic cells and, through activation of the c-Jun N-terminal kinase (JNK) pathway, is able to propagate the initial apoptotic stimulus. (elifesciences.org)
We also show that during coordinated cell death of hair follicle cells in mice, TNF-α is expressed in apoptotic cells and is required for normal cell death. (elifesciences.org)
Although this process can occur in individual cells, apoptotic signals may also dictate the 'communal death' of many cells simultaneously. (elifesciences.org)
Apoptosis has been thought to resemble a form of silent suicide by cells, but more recent work suggests that apoptotic cells can also transmit signals. (elifesciences.org)
To explore whether apoptotic cells could communicate with other cells, Pérez-Garijo et al. (elifesciences.org)
Only more recently has it become clear that apoptotic cells are the source of signals that can have profound effects on their neighbors. (elifesciences.org)
2 PT Enhances TRAIL - induced Apoptotic Cell Death To support the earlier observations annexin-V analysis was performed using FACScan. (researchensemble.com)
Fig. 2 The apoptotic effect of combined parthenolide (PT) and tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) treatment. (researchensemble.com)
A) Apoptotic cell death induced by combination treatment. (researchensemble.com)
Treating cells with PT and/or TRAIL resulted in the presence of a sub-G1 population indicating apoptotic cell death. (researchensemble.com)
Up coming cells had been stained with Hoechst 33258 and visualized by confocal microscopy to look for the existence apoptotic nuclear morphology. (researchensemble.com)
On the other hand upon treatment with both agencies HT-29 cells exhibited apoptotic features including cell shrinkage nuclear condensation and nuclear fragmentation. (researchensemble.com)

A significant enrichment for apoptosis genes, including MCL-1 , was found among the mRNAs inversely correlated with miR-29b expression in 45 primary AML samples. (ashpublications.org)
miR-26a again suppresses tumorigenesis in nasopharyngeal cells in vivo, with suppressed expression of c-myc, cyclins D3 and E2, and cyclin-dependent kinases CDK4 and CDK6. (wikipedia.org)
An investigation of PLK1 expression in DepMap found PLK1 is a critical mediator in 55 central nervous system cell lines, including eight medulloblastoma cell lines. (childrenscolorado.org)
Caco-2 cells with a high expression of both HER2 and FASN were selected for functional characterization. (biomedcentral.com)
Caco-2 cells were transfected with either the FASN specific RNAi plasmid or the negative control RNAi plasmid, followed by the RT-qPCR and western blot to examine the expression of FASN, HER2, PI3K and Akt. (biomedcentral.com)
However, in cancer cells and pre-neoplastic lesions, FASN expression has been frequently found to be upregulated. (biomedcentral.com)
PI3K activity was thought to be the mediator of the HER2 control on FASN expression because LY294002, a known PI3K inhibitor, abrogated HER2 induced FASN protein production in the HER2 overexpressing normal mammary epithelial and breast cancer cells. (biomedcentral.com)
Also, Quantitative RT-PCR was used to evaluate the mRNA expression level of genes related to the Wnt signal pathway in treated cancer cells and control groups. (researchsquare.com)
Subsequently, the expression of PAK3 was further confirmed in HCC cells. (jcancer.org)
Interestingly, targeting WDR5 by siRNA and OICR-9429 could block IFN-γ-induced PD-L1 expression in PCa cells. (thno.org)
Intriguingly, the expression of DNMT1, which is a target of miR-148a, is inversely correlated with the expression of miR-148a in HCC cells. (spandidos-publications.com)
Besides the secretion of pro-inflammatory cytokines (TNF-alpha, IL-1beta, and IL-6), the increased expression of receptor repertoire (pattern recognition receptors, PRR) on APCs, mostly macrophages and dendritic cells, occurs as a result of the release of endogenous and exogenous antigens (damage-associated molecular patterns, DAMPs, and pathogen-associated molecular patterns, PAMPs). (hindawi.com)
After miR-221 mimic, miR-221 mimic negative control, miR-221 inhibitor, miR-221 inhibitor negative control were transfected into cells, the expression of CXCL12 and miR-221 was detected by qPCR and western blot. (techscience.com)
Conversely, the expression of constitutively active AKT (myr-AKT) overcame the effects of 4HPR and β-catenin-silencing on cell migration. (biomedcentral.com)

Breast cancer There is downregulation of miR-26a in breast cancer specimens and cell lines, and it has been shown to functionally antagonise human breast carcinogenesis. (wikipedia.org)
A transcriptome analysis of HER2 in breast cancer cells has revealed a molecular connection between FASN and HER2 through the PI3K/Akt pathway [ 10 ]. (biomedcentral.com)

Prevent DNA Damage - Curcumin protects against DNA damage to genes regulating cell replication by toxins, radiation, and other environmental factors. (beatcancer.org)

We identified Eiger, the Drosophila tumor necrosis factor (TNF) homolog, as the signal responsible for apoptosis-induced apoptosis (AiA). (elifesciences.org)
Fig. 1 The inhibitory aftereffect of mixed parthenolide (PT) and tumor necrosis element (TNF)-related apoptosis-inducing ligand (Path) treatment on cell proliferation. (researchensemble.com)

Here, we show that c-Myc induction during cell cycle entry leads to a transient decrease in Mnt-Max complexes and a transient switch in the ratio of Mnt-Max to c-Myc-Max on shared target genes. (silverchair.com)
Strong induction of apoptosis in one compartment of the Drosophila wing disc causes apoptosis of cells in the other compartment, indicating that dying cells can release long-range death factors. (elifesciences.org)
Once NC induction is accomplished NC cells undergo the epithelial-mesenchymal transition (EMT) and eventually migrate along predetermined trajectories. (biomedcentral.com)
Alcohol appears to be able to affect NC development via either interfering NC cell migration or prompting cell apoptosis [ 12 ] that is indistinguishable from induction defects. (biomedcentral.com)

The protein encoded by this gene is a putative serine/threonine kinase that localizes to the mitotic apparatus and complexes with cell cycle controller CDC2 kinase in early mitosis. (cancerindex.org)
The protein expressions of p53 and unc-51 like kinase 2 (ULK2) in CRC cells were detected by western blot. (besjournal.com)
Polo-like kinase-1 (PLK1) is highly expressed in rapidly dividing normal cells and is overexpressed in many types of cancer, including Group 3 medulloblastoma, and is associated with poor prognosis. (childrenscolorado.org)

Unrepaired DNA lesions can lead to cell death, gene mutation and cancer. (biomedcentral.com)

Flow cytometry was used to detect cell cycle and apoptosis. (besjournal.com)

Although immune checkpoint inhibitors (ICIs), in particular blockade of PD-1/PD-L1, show promising therapy response in some cancers, they are less effective in PCa which may be poor infiltration of cytotoxic T-cells [ 7 - 9 ]. (thno.org)
However, cancer cells exploit these checkpoints to evade immune surveillance and suppress antitumor immune responses. (biomedcentral.com)

Summary Mixture therapy using PT and Path might present an effetive technique to conquer Path level of resistance using CRC cells. (researchensemble.com)

Moreover, the MST1/2 inhibitor XMU-MP-1 not only partially rescued the inhibitory effect chaetocin-induced proliferation, but also rescued the chaetocin-induced apoptosis in ESCC cells. (aging-us.com)
PIk1-depletion-induced apoptosis was partially reversed by cotransfection of nondegradable mouse PIk1 constructs. (uky.edu)

PIk1 depletion induced apoptosis, as indicated by the appearance of subgenomic DNA in fluorescence-activated cell-sorter (FACS) profiles, the activation of caspase 3, and the formation of fragmented nuclei. (uky.edu)

In this review, we summarize recent studies exploring how KSHV manipulates host cell metabolism to promote viral pathogenesis, which provides the potential therapeutic targets and strategies for KSHV-associated cancers. (frontiersin.org)

HPV infections have received particular attention in recent years, as high-risk strains have been linked to some cases of oral squamous cell carcinoma. (medscape.com)

The proliferation was decreased after a downregulation of FASN, which was consistent with an increased apoptosis rate. (biomedcentral.com)
Downregulation of Smed-Akt function also resulted in an increase of cell death throughout the animal. (biomedcentral.com)

This is supported by studies in knockout mice showing development of soft-tissue sarcomas, ovarian stromal cell tumors and a high sensitivity to carcinogenic treatments. (cancerindex.org)
Cell adhesion molecule-1 (CADM1) is a member of the immunoglobulin superfamily that functions as a tumor suppressor of lung tumors. (cancerindex.org)
Both laboratory and live animal studies demonstrate that the compound can dramatically reduce the occurrence and severity of malignant tumors. (beatcancer.org)
B-cell lymphomas (BCLs) constitute a diverse set of tially identify new functional, diagnostic, and therapeutic tumors, both morphologically and clinically, that are mainly targets. (lu.se)

However, the mechanisms by which Akt signaling regulates stem cell behavior in the complexity of the whole body are poorly understood. (biomedcentral.com)
Thus, Akt signaling regulates neoblast biology and mediates in the distribution of injury-mediated cell death during tissue repair in planarians. (biomedcentral.com)

Strikingly, undead cells in the posterior (back) region of the wing imaginal disc-the tissue in the larva that gives rise to the wing in the adult fruit fly-could trigger apoptosis in cells in the anterior (front) half. (elifesciences.org)

Reduce Production of Adhesion Molecules - Curcumin keeps malignant tissue from sticking to vessel walls and reduces cancer cells' ability to form distant metastases. (beatcancer.org)

We used the recently developed vector-based small interfering RNA technique to specifically deplete PIk1 in cancer cells. (uky.edu)
In this study, by comparing the activity of normal cell lines and cancer cell lines after treating with resveratrol, it was found that resveratrol has more significant cytotoxicity in cancer cell lines. (mdpi.com)
Resveratrol could play a toxic role through inducing apoptosis of the cancer cell in a time- and concentration-dependent manner. (mdpi.com)
In this study, the anti-cancer effects of pentadecanoic acid were evaluated in human breast carcinoma MCF-7/stem-like cells (SC), a cell line with greater mobility, invasiveness, and cancer stem cell properties compared to the parental MCF-7 cells. (mdpi.com)
It also stops proliferation of cancer cells by arresting them at different phases of the cell cycle and/or by inducing their apoptosis (programmed cell death). (beatcancer.org)
Stimulate Apoptosis - Curcumin encourages programmed cancer cell death. (beatcancer.org)
Inhibit Cancer Stem Cells - Curcumin makes cancer stem cells (normally resistant to chemotherapy and radiation) more sensitive to treatment and thereby less likely to allow cancer to regrow. (beatcancer.org)
For producing energy sufficient to maintain cancer cell proliferation, glutaminolysis is also often elevated in most of cancer cells. (frontiersin.org)
Thus, the metabolic plasticity of cancer cells is essential to generate energy required for cell proliferation. (frontiersin.org)
Hence, in this study, we analyzed the potential link between FASN and the activity of "HER2-PI3K/Akt axis" in colorectal cancer cells. (biomedcentral.com)
And the influence of FASN on proliferation and migration of colorectal cancer cells was also explored. (biomedcentral.com)
This review examines how LSD1 modulates different cell behavior in TME and emphasizes the potential use of LSD1 inhibitors in combination with ICB therapy for future cancer research studies. (biomedcentral.com)
Tumor initiation, development, and relapse may be closely associated with cancer stem cells (CSCs). (nature.com)

Li L , Jiang H , Li Y , Xiang X , Chu Y , Tang J , Liu K , Huo D , Zhang X , . Chaetocin exhibits anticancer effects in esophageal squamous cell carcinoma via activation of Hippo pathway. (aging-us.com)
Besides, 12% of patients have second- or third-degree skin reactions that are sensitive to light, and about 18% of patients develop cutaneous squamous-cell carcinoma and keratoacanthoma or occurred at the same time [ 6 ]. (medsci.org)

Anatomy27

Organisms10

Diseases14

Chemicals and Drugs112

Analytical, Diagnostic and Therapeutic Techniques and Equipment27

Phenomena and Processes66

Disciplines and Occupations1

Information Science3

Induces8

Tumor cells9

Inhibition of cell growth3

Proteins11

Vitro8

Invasion11

Overexpression5

Inhibits2

Survival5

Regulation7

Viability4

Arrest2

Differentiation7

Metastasis2

Progression5

Growth11

Pathways4

Phenotype1

Additionally1

Malignant cells3

Impairs1

Cellular6

Cisplatin2

Oncogenic1

Tissues6

Keratinocytes2

Promotes3

Endothelial3

Colony formation1

Transwell1

Signaling pathway2

Epithelial cells3

Apoptotic15

Expression14

Breast Cancer2

Genes regu1

Necrosis2

Induction4

Kinase3

Gene1

Flow cytometry1

Immune2

Resistance1

Partially2

Caspase1

Summarize1

Oral squamous cell carc1

Downregulation2

Tumors4

Regulates2

Wing in th1

Reduces1

Cancer13

Squamous2