• Ernst AM (1967) Mode of action of apomorphine and dexamphetamine in gnawing compulsion in rats. (springer.com)
  • Enhanced antinociception with repeated microinjections of apomorphine into the periaqueductal gray of male and female rats. (nih.gov)
  • Microinjection of the dopamine receptor agonist apomorphine into the PAG produced a dose-dependent increase in hot plate latency and a decrease in open field activity that was greater in male than in female rats. (nih.gov)
  • Surprisingly, the antinociceptive potency of apomorphine was enhanced following systemic administration of the opioid receptor antagonist naloxone in male, but not in female rats. (nih.gov)
  • Apomorphine was injected into or adjacent to the ventrolateral PAG in male (left) and female (right) rats. (nih.gov)
  • Microinjection of apomorphine into the ventrolateral PAG produced a dose-dependent decrease in open field activity in both male (n = 16) and female (n = 20) rats. (nih.gov)
  • Apomorphine, an unselective dopamine Dl and D2 receptor agonist, induces in laboratory animals (mice and rats), several behavioural phenomena such as stereotyped behaviour, hyperlocomotion, aggressiveness, etc 1-3 . (springer.com)
  • This hypothesis is evidenced by the fact that most of the psychotropic drugs used in clinical practice for the treatment of psychosis attenuate or completely block the apomorphine-induced aggression in adult male Wistar rats. (springer.com)
  • Apomorphine is the only agent approved for the acute, intermittent treatment of hypomobility, "OFF" episodes ("end-of-dose wearing OFF" and unpredictable "ON/OFF" episodes) associated with advanced PD, and in Canada and the U.S. it is currently approved as a subcutaneous injection. (rdmag.com)
  • In patients with advanced disease in whom oral medication is ineffective or intolerable, intermittent subcutaneous injection of the dopamine receptor agonist, apomorphine can be very effective. (bmj.com)
  • Treatment with APO-go(R)/MOVAPO(R) (apomorphine) subcutaneous infusion for 12 weeks gave significantly greater reductions in OFF time (periods when PD medications don't work) from baseline compared with placebo: -2.47 h/day versus -0.58 h/day, respectively - a treatment difference of almost 2 hours (p=0.0025) and double the change in OFF time recognised as meaningful to PD patients. (thailand4.com)
  • Apomorphine injection is in a class of medications called dopamine agonists. (medlineplus.gov)
  • Use apomorphine injection exactly as directed. (medlineplus.gov)
  • Do not use a second dose of apomorphine injection for treatment of the same "off" episode. (medlineplus.gov)
  • Your doctor will give you another medication called trimethobenzamide (Tigan) to take when you begin to use apomorphine injection. (medlineplus.gov)
  • This medication will help decrease your chance of developing nausea and vomiting while you are using apomorphine injection, especially during the beginning of treatment. (medlineplus.gov)
  • Your doctor will probably tell you to begin taking trimethobenzamide a few days before you begin to use apomorphine injection, and to continue taking it for up to 2 months. (medlineplus.gov)
  • You should know that taking trimethobenzamide along with apomorphine injection may increase your risk of drowsiness, dizziness, and falls. (medlineplus.gov)
  • Your doctor will probably start you on a low dose of apomorphine injection and gradually increase your dose, not more than once every few days. (medlineplus.gov)
  • Ask your doctor what to do if you do not use apomorphine injection for longer than 1 week. (medlineplus.gov)
  • You will receive your first dose of apomorphine injection in a medical office where your doctor can closely monitor your condition. (medlineplus.gov)
  • Before you use apomorphine injection yourself the first time, read the written instructions that come with it. (medlineplus.gov)
  • Be careful not to get apomorphine injection on your skin or in your eyes. (medlineplus.gov)
  • If apomorphine injection does get on your skin or in your eyes, immediately wash your skin or flush your eyes with cold water. (medlineplus.gov)
  • Keep a record of how much apomorphine injection you use each time you receive an injection so that you will know when to replace the medication cartridge. (medlineplus.gov)
  • When you use an injection pen with apomorphine, the medicine is measured in milliliters (mL) marked on the pen. (wellspan.org)
  • One milligram, or 1 mg, of apomorphine is equal to 0.1 mL marked on the injection pen. (wellspan.org)
  • When you dial in your dose on the injection pen, make sure there is enough medicine inside the apomorphine cartridge to make up the full dose. (wellspan.org)
  • Measuring your apomorphine dose correctly is extremely important. (wellspan.org)
  • Microinjection of apomorphine into the anterior or posterior ventrolateral PAG produced a dose-dependent antinociception. (nih.gov)
  • The present findings show that there is a functional predominance of the alpha(1D)-AR subtype in the rat erectile tissue, and that blockade of this receptor facilitates rat penile erection induced by a suboptimal dose of apomorphine. (lu.se)
  • The effects of the non-competitive NMDA receptor antagonist, MK-801 (dizocilpine), on the development of sensitization to the mixed dopamine receptor agonist, apomorphine were examined. (semanticscholar.org)
  • Sensitization to apomorphine, effects of dizocilpine NMDA receptor blockades. (semanticscholar.org)
  • Apomorphine can cause severe nausea and vomiting. (wellspan.org)
  • The TOLEDO study is sponsored by Britannia Pharmaceuticals Ltd., part of the STADA Arzneimittel AG group of companies and manufacturer of apomorphine products. (thailand4.com)
  • Historically, apomorphine has been tried for a variety of uses including as a way to relieve anxiety and craving in alcoholics, an emetic (to induce vomiting), for treating stereotypies (repeated behaviour) in farmyard animals and more recently in treating erectile dysfunction. (wikipedia.org)
  • A-119637 (0.3 micromol kg(-1), i.p.) tripled the number of erections, and produced a 6 fold increase in the duration of apomorphine-induced erectile responses. (lu.se)
  • The apomorphine-induced (0.5-1.0 mg/kg, once or twice daily during 10-15 days) aggression has been considered to be an animal model of human psychotic behaviour 4,5 . (springer.com)
  • Ten hours later they were injected with amphetamine or apomorphine and their behaviour was observed for a further 2 h at which time they were overdosed with anaesthetic and their brains were removed, frozen and processed for Fos and Jun B immunohistochemistry. (semanticscholar.org)
  • The development of behavioral sensitization to apomorphine is blocked by MK-801. (semanticscholar.org)
  • Apomorphine may also be used for purposes not listed in this medication guide. (wellspan.org)
  • To prevent these symptoms, you may be given anti-nausea medication to start taking a few days before you start using apomorphine. (wellspan.org)
  • If you stop using apomorphine for 7 days or longer , ask your doctor before restarting the medication. (wellspan.org)
  • However, there is a paucity of information on long-term benefits of apomorphine, including no large-scale phase III trial. (springer.com)
  • The emetic properties of apomorphine are exploited in veterinary medicine to induce therapeutic emesis in canines that have recently ingested toxic or foreign substances. (wikipedia.org)
  • You should not use apomorphine if you also taking alosetron (Lotronex), dolasetron (Anzemet), granisetron (Kytril), ondansetron (Zofran), or palonosetron (Aloxi). (wellspan.org)
  • Some anti-nausea medicines can increase certain side effects of apomorphine, or can make your Parkinson's symptoms worse. (wellspan.org)
  • Serious drug interactions can occur when certain medicines are used together with apomorphine. (wellspan.org)
  • Apomorphine solution comes in a glass cartridge to use with an injector pen. (medlineplus.gov)
  • If you have an allergy to apomorphine or any other part of this drug. (mskcc.org)