• KYNMOBI (apomorphine hydrochloride) sublingual film, a novel formulation of apomorphine, a dopamine agonist, is the first and only sublingual therapy for the fast-acting, on-demand treatment of OFF episodes associated with Parkinson's disease. (pipelinereview.com)
  • KYNMOBI TM (apomorphine hydrochloride) sublingual film is a prescription medicine used to treat short-term (acute), intermittent "off" episodes in people with Parkinson's disease (PD). (pipelinereview.com)
  • Apomorphine Hydrochloride Hemihydrate is a powerful emetic and has been used for that effect in acute poisoning. (pharmaffiliates.com)
  • Apomorphine hydrochloride is a potent dopamine-receptor agonist. (guidetomalariapharmacology.org)
  • The increases in the growth hormone (GH) level following intravenous infusion of the 5-hydroxytryptamine precursor tryptophan, the alpha 2-adrenoceptor agonist clonidine hydrochloride, and subcutaneous injection of the dopamine agonist apomorphine hydrochloride were determined in volunteers before and in the third week of a weight-reducing diet (1200 kcal/d). (ox.ac.uk)
  • The patients were treated for a period of 14 days and received either capsules containing lactose (placebo) or 20 mg apomorphine hydrochloride in lactose. (inter-zone.org)
  • MARLBOROUGH, MA, USA I May 21, 2020 I Sunovion Pharmaceuticals Inc. (Sunovion) announced today that the U.S. Food and Drug Administration (FDA) has approved KYNMOBI™ (apomorphine HCI) sublingual film (APL-130277) for the acute, intermittent treatment of OFF episodes in patients with Parkinson's disease (PD). (pipelinereview.com)
  • Apomorphine is used in advanced Parkinson's disease intermittent hypomobility ("off" episodes), where a decreased response to an anti-Parkinson drug such as L-DOPA causes muscle stiffness and loss of muscle control. (wikipedia.org)
  • Continuous subcutaneous apomorphine infusion (CSAI) is a safe and effective way of reducing off time in patients with Parkinson's disease (PD) whose motor complications are suboptimally controlled by oral medication [ 1 ] and treating severe insomnia in patients with fluctuating PD [ 2 ]. (e-jmd.org)
  • A: Titration of continuous subcutaneous apomorphine infusion dose over 12 years. (e-jmd.org)
  • Continuous subcutaneous apomorphine infusion (CSAI) is increasingly used in Parkinson's disease (PD), notably in patients contraindicated for subthalamic deep brain stimulation. (konexionsnc.com)
  • After 3 months, she was no longer taking oral medication, and the daily dose of apomorphine was 168 mg. (e-jmd.org)
  • Currently, apomorphine is used in the treatment of Parkinson's disease. (wikipedia.org)
  • P enile erections were regularly induced by intermittent subcutaneous injections of apomorphine in five patients with Parkinson's disease (PD) complicated by motor fluctuations. (biopsychiatry.com)
  • Apomorphine therapy offers an effective treatment option for various stages of Parkinson's Disease. (bangalorenewsnetwork.com)
  • Discover how apomorphine cured alcoholics, evolved as a treatment for Parkinson's Disease, and why it's being re-investigated as an addiction remedy. (apomorphine.info)
  • While apomorphine is more commonly used in treatment of Parkinson's disease, it was found that low doses were enough to stimulate erection with minimal unintentional effects. (brandeismd.com)
  • Apomorphine Monotherapy for Parkinson's Disease: A Neglected Option? (e-jmd.org)
  • The effects of CSAI on motor complications (Unified Parkinson's Disease Rating Scale [UPDRS]) and quality of life (Parkinson's Disease Questionnaire-39 [PDQ-39]) were evaluated at 1 year, 5 years and 12 years ( Figure 1B and C ). After a few weeks, she could manage the pump device without the help of a caregiver, and she has never complained of major side effects related to apomorphine. (e-jmd.org)
  • Apomorphine is the most potent dopamine agonist that provides anti-Parkinson's effect comparable to levodopa, and potentially improves dyskinesia. (mdsabstracts.org)
  • Can Anyone take apomorphine (Uprima) and Tadalafil (cialis) together, or the interaction of apomorphine and tadalafil together. (doctorspring.com)
  • Thanks for your reply sir, kindly tell me the Indication in which we can take Apomorphine and tadalafil, and can anyone take Apomorphine and Tadalafil with Flurezepam (Fluraz)or other sleep disorder drugs? (doctorspring.com)
  • How do I take apomorphine? (brandeismd.com)
  • How long before intercourse should I take apomorphine and how long does it last? (brandeismd.com)
  • Historically, apomorphine has been tried for a variety of uses, including as a way to relieve anxiety and craving in alcoholics, an emetic (to induce vomiting), for treating stereotypies (repeated behaviour) in farmyard animals, and more recently in treating erectile dysfunction. (wikipedia.org)
  • Four of the patients reported erectile dysfunction before beginning apomorphine and two of these report a significant improvement in their sexual function resulting from apomorphine use. (biopsychiatry.com)
  • Apomorphine is not a popular drug in any of the classes but it is indicated in certain diseases such as parkinsons disease, alcoholism, alzheimers disease and one indication which is common with Tadalafil is erectile dysfunction. (doctorspring.com)
  • Methods: Ten patients with psychogenic erectile dysfunction and six potent controls underwent functional magnetic resonance of the brain during video sexual stimulation after the administration of either apomorphine sublingual 4 mg or placebo following a randomized, double blind design. (uninsubria.it)
  • In patients with psychogenic erectile dysfunction apomorphine sublingual caused an increase in the extension of the activated networks, plus additional activation foci in subcortical and deep structures, namely in the nucleus accumbens, hypothalamus and mesencephalon: this activation was greater than that seen with placebo. (uninsubria.it)
  • Erectile function in rats was assessed by apomorphine. (bvsalud.org)
  • For refractory, disabling symptoms in patients without dementia, stereotactic deep brain stimulation or lesional surgery and levodopa and an apomorphine pump may help. (msdmanuals.com)
  • Dopamine antagonists, by their nature of competing for sites at dopamine receptors, reduce the effectiveness of the agonistic apomorphine. (wikipedia.org)
  • Apomorphine improves motor function by activating dopamine receptors in the nigrostriatal pathway, the limbic system, the hypothalamus, and the pituitary gland. (wikipedia.org)
  • To characterize the local safety and PK of a novel apomorphine formulation, ND0701, in comparison to a commercially available apomorphine-HCl solution. (mdsabstracts.org)
  • Steady state plasma concentrations of apomorphine were attained after ∼2.5 hours and were similar (5.4 ±1.8 ng/ml) among all 4 tested formulations, demonstrating that 1% and 2.5% ND0701 formulations are bioequivalent to the commercially available Apomorphine-HCl formulation. (mdsabstracts.org)
  • Conclusion: This was the first study of a new sublingual apomorphine formulation in PD patients. (barrowneuro.org)
  • For the evaluation of local site reactions, four drug formulations, 1% ND0701, 2.5% ND0701, 0.5% apomorphine-HCl or 1% apomorphine-HCl, were administered by subcutaneous continuous infusion of 50 mg apomorphine during 24h, at a volume of 5, 2, 10 and 5 ml, respectively. (mdsabstracts.org)
  • For the determination of steady state plasma concentration of apomorphine, the drug formulations were administered by subcutaneous continuous infusion of 14 mg apomorphine during 7h, at a rate of 0.2, 0.08, 0.4 and 0.2 ml/h, respectively. (mdsabstracts.org)
  • Objectives: To evaluate the in vivo effect of apomorphine sublingual versus placebo on cortical and subcortical brain activation during video sexual stimulation. (uninsubria.it)
  • Conclusions: Apomorphine significantly enhances the activation of cortical and subcortical brain function during video sexual stimulation. (uninsubria.it)
  • Some people use portable mini-pumps that continuously infuse them with apomorphine, allowing them to stay in the "on" state and using apomorphine as an effective monotherapy. (wikipedia.org)
  • Studies have investigated apomorphine for treatment of low arousal and sexual dysfunction in women, with results of increased sexual satisfaction scores. (brandeismd.com)
  • Apomorphine, sold under the brand name Apokyn among others, is a type of aporphine having activity as a non-selective dopamine agonist which activates both D2-like and, to a much lesser extent, D1-like receptors. (wikipedia.org)
  • Heat pain threshold and intensity, cold pain threshold, and the response to tonic cold pain (latency, intensity, and tolerance) were evaluated before and for up to 120 min after the administration of 1.5 mg apomorphine/placebo. (haifa.ac.il)
  • 1] found in a double-blind study that a group of alcoholics were statistically significantly more sober the day after apomorphine administration than a similar group receiving chlordiazepoxide or placebo. (inter-zone.org)
  • during the second and about equal for apomorphine and placebo groups. (inter-zone.org)
  • There is, however, no clinical evidence that apomorphine is an effective and safe treatment regimen for opiate addiction. (wikipedia.org)
  • While apomorphine is derived from dehydration of the morphine molecule, there are no opiate activities. (brandeismd.com)
  • This means that in a urine drug test, apomorphine will not show up as an opiate. (brandeismd.com)
  • When an episode sets in, the apomorphine is injected subcutaneously or applied sublingually, and signs subside. (wikipedia.org)
  • In contrast, sedative responses to the dopamine agonist apomorphine (5 micrograms/kg subcutaneously) were decreased when subjects were taking the contraceptive pill. (ox.ac.uk)
  • The benefit of apomorphine on sexual function in some patients suggests a possible role in the treatment of impotence in PD. (biopsychiatry.com)
  • Numerous studies have used apomorphine (APO) in the evaluation of dopaminergic (DA) function in schizophrenic patients. (mdpi.com)
  • Lal and Schlatter [4] reported that apomorphine decreased the craving for alcohol when administered to hospitalized patients and recently Buus et al. (inter-zone.org)
  • I have gone through your question.I would like to let you know that tadalafil and apomorphine do not have any major interaction and can be taken together. (doctorspring.com)
  • Apomorphine, Tadalafil and Flurazepam are all different drugs of different category and do not point out to a single diagnosis. (doctorspring.com)
  • MRI analysis showed that local site reactions following continuous subcutaneous administration of ND0701, at concentrations as high as ×2.5-5 than those of Apomorphine-HCl, were significantly smaller and exhibited better recovery. (mdsabstracts.org)
  • Histopathological evaluation supported these findings showing only a minimal, chronic inflammatory reaction following continuous subcutaneous administration of 1% and 2.5% ND0701, while mild, chronic, granulomatous inflammation and necrosis of the subcutis were observed following Apomorphine-HCl administration. (mdsabstracts.org)
  • Background: APL-130277 is a sublingually administered apomorphine oral strip. (barrowneuro.org)
  • Effects of the contraceptive pill on sedative responses to clonidine and apomorphine in normal women. (ox.ac.uk)
  • The effects of dieting and weight loss on neuroendocrine responses to tryptophan, clonidine, and apomorphine in volunteers. (ox.ac.uk)
  • These activated neural systems were modulated by apomorphine administration which produced a picture that was similar to the one seen in potent controls. (uninsubria.it)
  • The possible involvement of the dopaminergic system in the actions of T. catigua extract was substantiated by data showing the potentiation of apomorphine-induced hypothermia and by the prevention of haloperidol-induced catalepsy. (hindawi.com)
  • The priapism is caused by apomorphine increasing arterial blood supply to the penis. (wikipedia.org)
  • Apomorphine-induced erections in PD are probably more common than previously thought. (biopsychiatry.com)
  • In a double-blind study in chronic alcoholics apomorphine was shown to have a significant effect on alcoholic crax g and on tension. (inter-zone.org)
  • In broad clinical experience we have found that capsules of 20 mg apomorphine in lactose seem to be a good sedative for chronic alcoholics. (inter-zone.org)
  • The emetic properties of apomorphine are exploited in veterinary medicine to induce therapeutic emesis in canines that have recently ingested toxic or foreign substances. (wikipedia.org)
  • Growth hormone responses to graded doses of apomorphine HCl in schizophrenia. (mcmaster.ca)
  • These latest European drug-delivery devices are miles ahead of current apomorphine pumps available in India, which are unreliable and patient-unfriendly. (bangalorenewsnetwork.com)
  • Apomorphine is used very occasionally for certain indications and it is not generally considered as the first line drug. (doctorspring.com)
  • Apomorphine is a difficult drug to study. (inter-zone.org)
  • IV administration of apomorphine is highly discouraged, as it can crystallize in the veins and create a blood clot (thrombus) and block a pulmonary artery (pulmonary embolism). (wikipedia.org)
  • Subjects were evaluated in the pre-dose morning Off state and at 15, 30, 45, 60 and 90 minutes after administration of sublingual apomorphine. (neuro-sens.com)
  • An association was found between the enhancing effect of apomorphine on pain tolerance (120 min after its administration) and the DAT-1 polymorphism. (haifa.ac.il)
  • In conclusion, apomorphine administration produced a decrease followed by a genetically associated increase in cold pain tolerance. (haifa.ac.il)
  • I am interested in what apomorphine could do to help re-wire my brain to feel more at ease with the world without the need for liquour and manage the utter urge and desire to drink. (apomorphine.info)
  • Apomorphine is a dopamine receptor activator in the brain. (brandeismd.com)
  • Apomorphine acts directly at the brain to stimulate nerves that innervate oxytocin-activated nerves in the spinal cord. (brandeismd.com)
  • Apomorphine was also used as a private treatment of heroin addiction, a purpose for which it was championed by the author William S. Burroughs. (wikipedia.org)
  • The Foundation supported early clinical development of sublingual apomorphine, and this approval brings an important new treatment option for people with PD who experience OFF. (pipelinereview.com)
  • Read first-hand accounts by addicts who received the apomorphine treatment. (apomorphine.info)
  • Report from the 1st Congress of the European Academy of Neurology, Berlin, Germany, June 20-23, 2015 - Subcutaneous apomorphine is clinically available in many countries for the acute treatment of Off periods in PD. (neuro-sens.com)
  • Apomorphine , a dopamine agonist, has been used for 75 years in small non-emetic doses to treat the acute alcohol intoxication phase of chronic alcoholism. (inter-zone.org)
  • Find out about the doctors who used apomorphine to treat addiction. (apomorphine.info)
  • Sublingual Apomorphine (APL-130277) for the Acute Conversion of off to" by Robert A. Hauser, C. Warren Olanow et al. (barrowneuro.org)
  • The effects typically last for hours, with plasma levels of apomorphine returning to normal after 8 hours. (brandeismd.com)
  • Viagra affects the blood vessels directly, apomorphine exerts its effects through the nervous system. (brandeismd.com)
  • The aims of this study were to assess the effects of the dopamine agonist apomorphine on experimental pain models in healthy subjects and to explore the possible association between these effects and a common polymorphism within the dopamine transporter gene. (haifa.ac.il)
  • Apomorphine had an effect only on tolerance to cold pain, which consisted of an initial decrease and a subsequent increase in tolerance. (haifa.ac.il)
  • A recent study indicates that apomorphine might be a suitable marker for assessing central dopamine system alterations associated with chronic heroin consumption. (wikipedia.org)
  • After the study a representative sample of apomorphine capsules were analyzed. (inter-zone.org)
  • On the other hand variations of apomorphine may prove extremely effective in controlling the withdrawal syndrome. (erowid.org)
  • Also, unlike opiates, apomorphine is not a scheduled medication. (brandeismd.com)