• The fourth and perhaps the most important recently discovered gene linked to AAlzheimers disease is the Apolipoprotein E (ApoE) gene on chromosome 19, which has been associated with many lateonset familial cases of Alzheimers disease as well as sporadic cases in the over-60 age group. (slideshare.net)
  • Apolipoprotein E (apoE) plays an important role in the transport and uptake of cholesterol by way of its high affinity interaction with lipoprotein receptors, including the low-density lipoprotein (LDL) receptor. (wikipedia.org)
  • Recent findings with apoA1 and apoE suggest that the tertiary structures of these two members of the human exchangeable apolipoprotein gene family are related. (wikipedia.org)
  • Exchangeable apolipoproteins (apoA, apoC and apoE) have the same genomic structure and are members of a multi-gene family that probably evolved from a common ancestral gene. (ebi.ac.uk)
  • APOE is primarily located in HDL and VLDL Apolipoproteins act as lipid transfer carrier enzymes, cofactors and receptor ligands which control lipoprotein metabolism. (prospecbio.com)
  • Human apolipoprotein E (apoE) consists of a single polypeptide chain with 299 amino acids and is best known for its role in the transport of cholesterol and other lipids between peripheral tissues and the liver. (ingentaconnect.com)
  • Apolipoprotein E (ApoE) is a protein associated with cardiovascular disease (CVD) and Alzheimer's disease. (genomebc.ca)
  • Apolipoprotein E ( ApoE ) is a class of proteins involved in the metabolism of fats in the body. (wikidoc.org)
  • The gene, APOE , is mapped to chromosome 19 in a cluster with apolipoprotein C1 (APOC-I) and the apolipoprotein C2 . (wikidoc.org)
  • The lipid transport protein, apolipoprotein E (apoE), is expressed in many peripheral tissues in vivo including the adrenal gland and testes. (pnas.org)
  • Several studies in mice indicate a role for apolipoprotein E (APOE) in lipid accumulation and adipogenic differentiation in adipose tissue. (osti.gov)
  • They examined the correlation of high-density lipoprotein cholesterol (HDL-C), apoA1, apoCIII, apoD, and apoE and the ratios of apolipoproteins with apoA1 with T2D risk. (medicalxpress.com)
  • The apolipoprotein (APOE) epsilon4 allele is a genetic risk factor for the development of Alzheimer's disease (AD). (unboundmedicine.com)
  • VL - 483 IS - 1 N2 - The apolipoprotein (APOE) epsilon4 allele is a genetic risk factor for the development of Alzheimer's disease (AD). (unboundmedicine.com)
  • Objectives: To evaluate the frequency of apolipoprotein (APOE) alleles and determine whether APOE type 4 allele (e4) was associated with edentulousness even when certain factors were controlled.Background: The APOE are important in lipid homeostasis, and APOE e4 has been found in many diseases and to have a negative impact on longevity. (diva-portal.org)
  • METHODS AND RESULTS: Apolipoprotein E (Apoe) null mice that had knockout of a single allele of the insulin receptor (Insr) gene were compared with littermate Apoe null mice with intact insulin receptors. (biomedsearch.com)
  • In addition to stabilizing lipoprotein structure and solubilizing the lipid component, apolipoproteins interact with lipoprotein receptors and lipid transport proteins, thereby participating in lipoprotein uptake and clearance. (wikipedia.org)
  • In lipid transport, apolipoproteins function as structural components of lipoprotein particles, ligands for cell-surface receptors and lipid transport proteins, and cofactors for enzymes (e.g. apolipoprotein C-II for lipoprotein lipase and apolipoprotein A-I (apoA1) for lecithin-cholesterol acyltransferase). (wikipedia.org)
  • APOL1 is a member of a family of apolipoproteins which also includes six other proteins and it is a member of bcl2 genes which are involved in autophagic cell death. (wikipedia.org)
  • Using the models of two long anti-atherogenic and anti-inflammatory proteins (apolipoprotein A-I and apolipoprotein E with 243 and 299 amino acids, respectively) short mimetic peptides of 18 to 28 amino acid residues in length, which can be produced either synthetically or genetically in edible fruits and vegetables, have been shown to exert profound biological effects in a large number of animal models of diseases. (springer.com)
  • 1995). "Site-specific detection and structural characterization of the glycosylation of human plasma proteins lecithin:cholesterol acyltransferase and apolipoprotein D using HPLC/electrospray mass spectrometry and sequential glycosidase digestion" . (wikidoc.org)
  • Additionally we are shipping Apolipoprotein D Kits (32) and Apolipoprotein D Proteins (24) and many more products for this protein. (antibodies-online.com)
  • Apolipoprotein J Antibody functions as a secreted chaperone that prevents aggregation of nonnative proteins. (rockland-inc.com)
  • Apolipoprotein J does not require ATP or refold proteins by itself. (rockland-inc.com)
  • This product has been prepared by immunoaffinity chromatography using immobilized antigens followed by extensive cross-adsorption against other apoLipoproteins and human serum proteins to remove any unwanted specificities. (rockland-inc.com)
  • Non-specific cross reaction of anti-apoLipoprotein antibodies with other human serum proteins is negligible. (rockland-inc.com)
  • These proteins, known as apolipoproteins, are the major identifying characteristics of a lipoprotein. (labce.com)
  • One role is to increase the overall solubility of the lipid particle, helping it to dissolve in the aqueous environment of the blood (apolipoproteins are amphipathic, or detergent-like proteins). (labce.com)
  • Apolipoprotein C-IV , also known as apolipoprotein C4 , is a protein that in humans is encoded by the APOC4 gene . (wikipedia.org)
  • Apolipoprotein (apo)C4 gene is a member of the apolipoprotein C gene family. (wikipedia.org)
  • 2002). "Regulated expression of the apolipoprotein E/C-I/C-IV/C-II gene cluster in murine and human macrophages. (wikipedia.org)
  • 2009). "Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip" . (wikipedia.org)
  • Apolipoprotein C2 or apolipoprotein C-II is a protein that in humans is encoded by the APOC2 gene . (wikipedia.org)
  • 1986). "The structure of the human apolipoprotein C-II gene. (wikipedia.org)
  • 1989). "A nonsense mutation in the apolipoprotein C-IIPadova gene in a patient with apolipoprotein C-II deficiency" . (wikipedia.org)
  • 1988). "Donor splice site mutation in the apolipoprotein (Apo) C-II gene (Apo C-IIHamburg) of a patient with Apo C-II deficiency" . (wikipedia.org)
  • Apolipoprotein AI amyloidosis (apoAI) is an autosomal dominant amyloidosis caused by point mutations in the apoAI gene. (medscape.com)
  • Apolipoprotein L1 is a protein that in humans is encoded by the APOL1 gene. (wikipedia.org)
  • This gene encodes apolipoprotein A-I, which is the major protein component of high density lipoprotein (HDL) in plasma. (nih.gov)
  • This gene is closely linked with two other apolipoprotein genes on chromosome 11. (nih.gov)
  • Two novel APOA1 gene mutations in a Japanese renal transplant recipient with recurrent apolipoprotein A-I related amyloidosis. (nih.gov)
  • The objective of this study was to evaluate whether apolipoprotein gene polymorphisms confer susceptibility to osteonecrosis of the femoral head. (nih.gov)
  • We have generated transgenic mice over-expressing human apolipoprotein CI (apo CI) using the native gene joined to the downstream 154-bp liver-specific enhancer that we defined for apo E. Human apo CI (HuCI)-transgenic mice showed elevation of plasma triglycerides (mg/dl) compared to controls in both the fasted (211 +/- 81 vs 123 +/- 52, P = 0.0001) and fed (265 +/- 105 vs 146 +/- 68, P (jci.org)
  • Apolipoprotein E genotype and the association between C-reactive protein and postoperative delirium: Importance of gene-protein interactions. (harvard.edu)
  • There are two forms, apolipoprotein B-100 and apolipoprotein B-48, both derived from a single gene. (harvard.edu)
  • Apolipoprotein All (ApoAII) amyloidosis, first reported in 2001 in a family with renal amyloidosis, is associated with mutations in the stop codon of the apolipoprotein AII gene resulting in a carboxyl terminal peptide extension of 21 amino acid residues in the protein. (highbeam.com)
  • Apolipoprotein D is a protein that in humans is encoded by the APOD gene . (wikidoc.org)
  • Expression of the human apolipoprotein E gene suppresses steroidogenesis in mouse Y1 adrenal cells. (pnas.org)
  • The data show that a single dose of the gene therapy carrying a short hairpin RNA to silence Apolipoprotein B100 (ApoB100) resulted in a reduction of serum cholesterol of approximately 80% without any signs of toxicity. (thefreedictionary.com)
  • Mammalian apolipoprotein B (apo B) exists in two forms, each the product of a single gene. (sciencemag.org)
  • The apolipoprotein E gene ε4 all. (bio-medicine.org)
  • The apolipoprotein E gene ε4 allele is considered a negative fact. (bio-medicine.org)
  • The apolipoprotein E gene ε4 allele is considered a negative factor for neural regeneration in late-onset Alzheimer's disease cases. (bio-medicine.org)
  • A research team from Department of Neurology, Peking University Shenzhen Hospital in China pointed out a non-invasive and fast method to genotype large samples to help to elucidate the role of apolipoprotein E gene ε4 allele in neural regeneration in the cases with late-onset Alzheimer's disease. (bio-medicine.org)
  • Chen CH, Albers JJ (1985) Activation of lecithin:cholesterol acyltransferase by apolipoproteins E-2, E-3, and AIV isolated from human plasma. (springer.com)
  • LDL-cholesterol (LDL- C), apolipoproteins (apo) B, CIII, and E, and by decreased levels of HDL-cholesterol (HDL-C), apoA-I, and lecithin:cholesterol acyltransferase (LCAT) activity. (tudelft.nl)
  • It forms a complex, known as a trypanosome lytic factor (TLF), with high-density lipoprotein 3 (HDL3) particles that also contain apolipoprotein A1 (APOA1) and the hemoglobin-binding, haptoglobin-related protein (HPR). (wikipedia.org)
  • Case Report: recurrence of non-familial hereditary apolipoprotein A-I amyloidosis in Japanese transplant recipient with two novel APOA1 mutations. (nih.gov)
  • An example of non-exchangeable apolipoprotein is APOAB which is attached to the lipoprotein particle while examples of Lipoprotein exchangeable are APOM, APOD, APOJ, APOH and APOA1 which are transported between different lipoprotein molecules. (prospecbio.com)
  • HDL begins to develop when two copies of the protein apolipoprotein A-I (APOA1) mediate the removal of excess lipids from peripheral cells and form a nanodisc. (pnas.org)
  • Understanding the function of high-density lipoprotein (HDL) requires detailed knowledge of the structure of its primary protein, apolipoprotein A-I (APOA1). (pnas.org)
  • HealthDay)-Apolipoprotein (apo) CIII and apoCIII-to-apoA1 ratio are correlated with incident type 2 diabetes (T2D), according to a study published online Dec. 28 in Diabetes Care . (medicalxpress.com)
  • Apolipoprotein A I (APOA1) - Pipeline Review, H2 2016', provides in depth analysis on Apolipoprotein A I (APOA1) targeted pipeline therapeutics. (researchandmarkets.com)
  • The report provides comprehensive information on the Apolipoprotein A I (APOA1) , targeted therapeutics, complete with analysis by indications, stage of development, mechanism of action (MoA), route of administration (RoA) and molecule type. (researchandmarkets.com)
  • Additionally, the report provides an overview of key players involved in Apolipoprotein A I (APOA1) targeted therapeutics development and features dormant and discontinued projects. (researchandmarkets.com)
  • Apolipoprotein A-I/ApoA1 Polyclonal antibody specifically detects Apolipoprotein A-I/ApoA1 in Human, Mouse samples. (fishersci.com)
  • Verghese, P. B., Castellano, J. M. & Holtzman, D. M. Apolipoprotein E in Alzheimer's disease and other neurological disorders. (nature.com)
  • Elevated IgM against Nε-(Carboxyethyl)lysine-modified Apolipoprotein A1 peptide 141-147 in Taiwanese with Alzheimer's disease. (nih.gov)
  • To determine the association between the e4 allele of apolipoprotein E and Alzheimer's disease in a randomly selected population sample. (bmj.com)
  • The prevalence of Alzheimer's disease was 2.9% in subjects with no e4 alleles, 7.6% in subjects with one e4 allele, and 21.4% in subjects with two e4 alleles of apolipoprotein E. (bmj.com)
  • Allele e4 of apolipoprotein is associated with Alzheimer's disease in a dose-response fashion in a randomly selected elderly population. (bmj.com)
  • RF 1-2* Evidence is accumulating that apolipoprotein E is important in late onset Alzheimer's disease. (bmj.com)
  • The first evidence that e4 allele of apolipoprotein E could be associated with Alzheimer's disease was published by Pericak-Vance et al. (bmj.com)
  • All the studies that have investigated the relation between apolipoprotein E polymorphism and Alzheimer's disease have included highly selected patients and corresponding controls. (bmj.com)
  • Several recently published studies showed the existence of an association between the allele ε4 of the apolipoprotein E and Alzheimer's disease (AD) in developed countries. (scielo.br)
  • TY - JOUR T1 - Apolipoprotein epsilon4 and neuropsychological performance in Alzheimer's disease and vascular dementia. (unboundmedicine.com)
  • The method developed for apolipoprotein E genotyping is accurate and reliable, and also suitable for genotyping large samples, which may help determine the role of the apolipoprotein E ε4 allele in neural regeneration in late-onset Alzheimer's disease cases. (bio-medicine.org)
  • Apolipoprotein M (apoM) participates in the lipid metabolism and exhibit anti‑atherosclerotic functions and it is presented in high-density lipoprotein (HDL), low-density lipoprotein (LDL) and very low-density lipoprotein (VLDL). (wikipedia.org)
  • Apolipoproteins regulate lipid metabolism, adipose tissue, and energy production and serve major regulatory roles in both pre- and pro-atherosclerotic mechanisms. (springer.com)
  • Lipoprotein (a) and Low-density lipoprotein apolipoprotein B metabolism following apheresis in patients with elevated lipoprotein(a) and coronary artery disease. (harvard.edu)
  • Kei AA, Filippatos TD, Tsimihodimos V, Elisaf MS. A review of the role of apolipoprotein C-II in lipoprotein metabolism and cardiovascular disease. (randox.com)
  • Apolipoprotein B100 metabolism in autosomal-dominant hypercholesterolemia related to mutations in PCSK9. (thefreedictionary.com)
  • Fidge NH (1980) The redistribution and metabolism of iodinated apolipoprotein AIV in rats. (springer.com)
  • The apolipoproteins dictate where the particles will dock and where they can bind, and in so doing the apolipoproteins regulate lipid metabolism in the body. (labce.com)
  • Apolipoprotein B100 (apoB100) is a protein that plays a role in moving cholesterol around your body. (medlineplus.gov)
  • Apolipoprotein L1 (apoL1) is a minor apoprotein component of HDL (High-density lipoprotein) or 'good cholesterol' which is synthesized in the liver and also in many other tissues, including pancreas, kidney, and brain. (wikipedia.org)
  • First, plasma apolipoprotein E maintains overall plasma cholesterol homeostasis by facilitating efficient hepatic uptake of lipoprotein remnants. (nih.gov)
  • Second, lesion apolipoprotein E in concert with apolipoprotein A-I facilitates cellular cholesterol efflux from macrophage foam cells within the intima of the lesion. (nih.gov)
  • Apolipoprotein levels and ratios are more significant than LDL cholesterol levels in the prediction of fatal myocardial infarction. (greenmedinfo.com)
  • The Ratio of High-Density Lipoprotein Cholesterol to Apolipoprotein A-I Predicts Myocardial Injury Following Elective Percutaneous Coronary Intervention. (medscape.com)
  • The proband, a 65-year-old woman, had greatly diminished concentrations of serum HDL cholesterol (0.19 mmol/L) and apolipoprotein (apo) A-I (21.9 mg/dL). (ahajournals.org)
  • Plasma apolipoprotein E phenotypes modulate lipoprotein concentrations, particularly that of low density lipoprotein cholesterol. (bmj.com)
  • These complex molecules have a "shell" composed of cholesterol, phospholipids, and apolipoproteins, and a core with the transport material: cholesterol esters and triglycerides (see Figure 1). (taconic.com)
  • Apolipoproteins are protein-lipid complexes that bind oil-soluble substances such as fat and cholesterol. (taconic.com)
  • Apolipoprotein A is a protein carried in HDL ("good") cholesterol. (ahealthyme.com)
  • Although apolipoprotein A levels can be measured, it's more common to measure the HDL and LDL ("bad") cholesterol when looking at cardiovascular risk. (ahealthyme.com)
  • At the end of 12 weeks, total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), very-low-density lipoprotein cholesterol (VLDL-C), and apolipoprotein B100 (Apo B100) were significantly lower in the soy nut group compared with the control group. (thefreedictionary.com)
  • Association of high-density lipoprotein cholesterol with incident cardiovascular events in women, by low-density lipoprotein cholesterol and apolipoprotein B100 Levels: a cohort study. (thefreedictionary.com)
  • Birmingham, AL), developer of the VAP Cholesterol Test, announced it has received a patent on its method to derive and report apolipoprotein B100 (apoB) using the Vertical Auto Profile (VAP) technology. (thefreedictionary.com)
  • Recently, we have reported that serum apolipoprotein (apo)AI and apoB levels were strongly associated with the presence and severity of diabetic retinopathy ( 1 ), and these associations were more prominent than those of traditional lipids (e.g., total cholesterol). (diabetesjournals.org)
  • Cholesterol-loaded macrophages secrete cholesterol and apolipoprotein E. The current studies show that this secretion occurs by two independent pathways. (sciencemag.org)
  • In the absence of serum, the cells secrete apolipoprotein E, but not cholesterol. (sciencemag.org)
  • In the presence of monensin (an inhibitor of protein secretion), the cells secrete cholesterol, but little apolipoprotein E. After secretion, apolipoprotein E and cholesterol associate with high-density lipoprotein to form a particle that can deliver cholesterol to the liver by receptor-mediated endocytosis. (sciencemag.org)
  • We conclude that apolipoprotein E does not function to remove cholesterol from macrophages but rather to participate in "reverse cholesterol transport. (sciencemag.org)
  • Hazard ratios (HRs), adjusted for several conventional factors, were calculated for 1-SD higher values: 0.52 loge triglyceride, 15 mg/dL high-density lipoprotein cholesterol (HDL-C), 43 mg/dL non-HDL-C, 29 mg/dL apolipoprotein AI, 29 mg/dL apolipoprotein B, and 33 mg/dL directly measured low-density lipoprotein cholesterol (LDL-C). Within-study regression analyses were adjusted for within-person variation and combined using meta-analysis. (pubmedcentralcanada.ca)
  • Lipid assessment in vascular disease can be simplified by measurement of either total and HDL cholesterol levels or apolipoproteins without the need to fast and without regard to triglyceride. (pubmedcentralcanada.ca)
  • 1 , 2 Expert opinion is divided about whether assessment of apolipoprotein AI (apo AI) and apolipoprotein B (apo B) should replace assessment of high-density lipoprotein cholesterol (HDL-C) and total cholesterol levels in assessment of vascular risk. (pubmedcentralcanada.ca)
  • Xu, Nilsson-Ehle, Ahrén: Correlation of apolipoprotein M with leptin and cholesterol in normal and obese subjects. (antikoerper-online.de)
  • Despite the hyperinsulinemia, atherosclerotic lesion size was not different between the 2 groups at time points up to 52 weeks of age when measured as en face lesion area in the aorta, cross-sectional plaque area in the aortic sinus, and cholesterol abundance in the brachiocephalic artery. (biomedsearch.com)
  • Ajeganova S, Ehrnfelt C, Alizadeh R, Rohani M, Jogestrand T, Hafström I et al (2011) Longitudinal levels of apolipoproteins and antibodies against phosphorylcholine are independently associated with carotid artery atherosclerosis 5 years after rheumatoid arthritis onset-a prospective cohort study. (springer.com)
  • Eo HS, Lee KB, Kim AK, Kim MH, Kim DH, Kim DI (2011) Association with inflammatory cells and apolipoproteins to the progression of atherosclerosis. (springer.com)
  • Garber DW, Handattu SP, Datta G, Mishra VK, Gupta H, White CR et al (2006) Atherosclerosis and vascular disease: effects of peptide mimetics of apolipoproteins. (springer.com)
  • Horejsi B, Ceska R (2000) Apolipoproteins and atherosclerosis. (springer.com)
  • Apolipoprotein E and apolipoprotein(a) as candidate genes of premature development of atherosclerosis. (springer.com)
  • Seishima M (2016) Physiological function of apolipoproteins and atherosclerosis. (springer.com)
  • Zivanovic Z, Divjak I, Jovicevic M, Rabi-Zikic T, Radovanovic B, Ruzicka-Kaloci S et al (2018) Association between apolipoproteins AI and B and ultrasound indicators of carotid atherosclerosis. (springer.com)
  • Apolipoprotein E plays a key protective role in atherosclerosis. (nih.gov)
  • Avogaro P, Bittolo-Bon G, Cazzolato G, Quinci GB (1979) Are apolipoproteins better discriminators than lipids for atherosclerosis? (springer.com)
  • Human apolipoprotein A-I-derived amyloid: its association with atherosclerosis. (sigmaaldrich.com)
  • Hyperinsulinemia does not change atherosclerosis development in apolipoprotein E null mice. (biomedsearch.com)
  • The analyst should use the special sampling weights in this file to analyze Apolipoprotein B (ApoB). (cdc.gov)
  • Here we show that increased hepatic sortilin not only reduced hepatic apolipoprotein B (APOB) secretion, but also increased LDL catabolism, and that both effects were dependent on intact lysosomal targeting. (jci.org)
  • However, Cox proportional hazards models with quartiles of each variable adjusted for confounders and hs-CRP or IL-6 identified apolipoprotein (apo)B-to-apoA-I ratio (apoB/apoA-I) and oxidized HDL, but not apoA-I or apoA-II, as independent risk factors for composite CVD events. (unboundmedicine.com)
  • Aldehyde-modified peptide sequences in apolipoprotein B-100 (apoB-100) are major targets for these immune responses. (ahajournals.org)
  • 2,3 The LDL protein apolipoprotein B-100 (apoB-100) is degraded, and aldehydes bind to free amino groups on the peptide fragments. (ahajournals.org)
  • Apolipoprotein D (Apo-D) is a component of high-density lipoprotein that has no marked similarity to other apolipoprotein sequences. (wikidoc.org)
  • Apolipoproteins are associated with survival among patients on hemodialysis (HD), but these associations might be influenced by dysfunctional (oxidized) high-density lipoprotein (HDL). (unboundmedicine.com)
  • Apolipoprotein D (apoD) is a soluble carrier protein of lipophilic molecules in neurons and glial cells within the central and peripheral nervous system and apoD can also modulate the stability and oxidation status of these molecules. (wikipedia.org)
  • On www.antibodies-online.com are 116 Apolipoprotein D (APOD) Antibodies from 22 different suppliers available. (antibodies-online.com)
  • The association of the apolipoprotein (Apo E) -epsilon4 allele to neurodegenerative diseases such as Parkinson's disease (PD) has been analyzed in several studies. (hindawi.com)
  • Apolipoprotein CII (apoCII) is a protein found in large fat particles that the gastrointestinal tract absorbs. (medlineplus.gov)
  • Apolipoproteins function in lipid transport as structural components of lipoprotein particles, cofactors for enzymes and ligands for cell-surface receptors. (ebi.ac.uk)
  • Apolipoproteins have important structural and functional roles in several lipoprotein particles. (springer.com)
  • The apolipoproteins act as stabilizers of the intact lipoprotein particles. (abcam.com)
  • In addition, quantitative immunological measurements of certain apolipoproteins (especially A-1 and B) have been suggested to be more accurate estimators of coronary heart disease than measurements of lipoprotein particles (especially HDL and LDL). (abcam.com)
  • It does not interchange between lipoprotein particles, as do the other apolipoproteins, and it is found in IDL and LDL after the removal of the Apo-A, E, and C. Apo-B48 is present in chylomicrons and their remnants. (sigmaaldrich.com)
  • Apolipoprotein B100 (Apo B) molecule is present in all major atherogenic particles (VLDL, IDL, LDL). (thefreedictionary.com)
  • Serum apolipoprotein A1 (APO-A1), apolipoprotein B100 (APO-B100) and lipoprotein-(a) (LPA) were measured in the Pathology Laboratories of Postgraduate Lady Reading Hospital, Peshawar using turbiditrimetric kits of Roche Diagnostics, on chemistry auto analyzer, modular P-800 by Roche, Cobas (Japan). (thefreedictionary.com)
  • This could explain reduced capacity of the liver to synthesize apolipoprotein B100 (ApoB100). (thefreedictionary.com)
  • Is vitellogenin an ancestor of apolipoprotein B100 of human low-density lipoprotein and human lipoprotein lipase? (thefreedictionary.com)
  • Apolipoprotein E genotyping is crucial to apolipoprotein E polymorphism analysis. (bio-medicine.org)
  • Peripheral venous blood is the conventional tissue source for apolipoprotein E genotyping polymorphism analysis. (bio-medicine.org)
  • Apolipoprotein F (apoF) is one of the minor apolipoprotein in blood plasma and it is a lipid transfer inhibit protein to inhibit cholesteryl ester transfer protein-mediated transfers of cholesteryl esters and triglycerides. (wikipedia.org)
  • Familial apolipoprotein CII deficiency is a very rare (rarer than LPL deficiency) autosomal recessive disorder in which apolipoprotein CII (apoC-II), a cofactor for LPL, is absent, the clearance of chylomicrons from the blood is greatly impaired and triglycerides (TG) accumulate in the plasma. (renalandurologynews.com)
  • The present invention relates to methods of use of phosphonate-phosphates and diphosphonates to modulate apolipoprotein E levels and the use of such compounds in therapy, including cardiovascular and neurological disease states. (freepatentsonline.com)
  • Alzheimers Is Genetic Protect Your Future www.alzheimer-herbs.com/ Apolipoprotein alzheimers disease connection The scientific enthusiasm about the possible role of amyloid protein in the pathology of Alzheimers disease has been further fueled by the results of molecular genetics studies that have identified genes associated with familial (inherited) Alzheimers disease on chromosomes 21, 14, 1, and 19. (slideshare.net)
  • Title: The relationship between apolipoprotein genes polymorphisms and susceptibility to osteonecrosis of the femoral head: a meta-analysis. (nih.gov)
  • In this study a series of Sicilian neonates was studied in order to investigate about the distribution of serum lipid and apolipoprotein at birth and the differences with adults. (springer.com)
  • In conclusion lipid and apolipoprotein distributions in Sicilian newborns are not different from that of other population and there are no differences between males and females. (springer.com)
  • The determination of the circulating levels of apolipoproteins has become common practice in clinical laboratories, in view of the apparent correlation between levels of specific apolipoproteins and increased or decreased cardiovascular risk [1, 2]. (springer.com)
  • Hundreds of genetic polymorphisms of the apolipoproteins have been described, and many of them alter their structure and function. (wikipedia.org)
  • However, most apolipoproteins cannot be detected using standard clinical immunoassays, and multiplexing is not available for some species of apolipoproteins. (springer.com)
  • Our Apolipoprotein L2 Lysates can be used in a variety of model species. (novusbio.com)
  • Our Apolipoprotein C1 ELISA Kits can be used in a variety of model species: Human. (novusbio.com)
  • Specific cross reaction of anti-apoLipoprotein antibodies with antigens from other species has not been determined. (rockland-inc.com)
  • Contributions of domain structure and lipid interaction to the functionality of exchangeable human apolipoproteins. (ebi.ac.uk)
  • Structure of a biologically active fragment of human serum apolipoprotein C-II in the presence of sodium dodecyl sulfate and dodecylphosphocholine. (randox.com)
  • Kukita M, Hiwada K, Kokubu T (1984) Serum apolipoprotein A-I, A-II and B levels and their discriminative values in relatives of patients with coronary artery disease. (springer.com)
  • Serum apolipoprotein (apo)AI and -B have been shown to be associated with diabetic retinopathy, but the underlying mechanisms are unclear. (diabetesjournals.org)
  • OBJECTIVE To determine plasma apolipoprotein A-IV (apoA-IV) levels and phenotype distribution in non-insulin-dependent diabetes mellitus (NIDDM) patients and to analyze the influence of apoA-IV phenotype on lipid profiles in NIDDM. (diabetesjournals.org)
  • Vlad C, Burlacu A, Florea L, Artene B, Badarau S, Covic A et al (2019) A comprehensive review on apolipoproteins as nontraditional cardiovascular risk factors in end-stage renal disease: current evidence and perspectives. (springer.com)
  • Apolipoprotein A-I Increases Insulin Secretion and Production From Pancreatic ß-Cells via a G-Protein-cAMP-PKA-FoxO1-Dependent Mechanism. (medscape.com)
  • However, because of their detergent-like (amphipathic) properties, apolipoproteins and other amphipathic molecules (such as phospholipids) can surround the lipids, creating a lipoprotein particle that is itself water-soluble, and can thus be carried through water-based circulation (i.e., blood, lymph). (wikipedia.org)
  • Nevertheless, due to of their amphipathic/detergent like characteristics, Apolipoproteins fence in the lipids, forming a lipoprotein particle which is soluble in water, hence travel in blood. (prospecbio.com)
  • The role of HDL and its main protein component the apolipoprotein A-I as being antiatherogenic is well established. (nih.gov)
  • Apolipoprotein B is the main protein component of LDL and accounts for approximately 95% of the total protein content of LDL. (cdc.gov)
  • 1990). "Apolipoprotein D is the major protein component in cyst fluid from women with human breast gross cystic disease" . (wikidoc.org)
  • Anti-Apolipoprotein J Antibody is useful for researchers interested in the immune system, Ubiquitin pathways, and cardiovascular research. (rockland-inc.com)
  • We have discovered that natural variant versions of Apolipoprotein L1 (APOL1) that protect humans against infection by the parasite Trypanosoma rhodesiense (responsible for sleeping sickness) also cause kidney disease. (europa.eu)
  • The protein encoded by APOM is an apolipoprotein and member of the lipocalin protein family. (antikoerper-online.de)
  • Duan, Dahlbäck, Villoutreix: Proposed lipocalin fold for apolipoprotein M based on bioinformatics and site-directed mutagenesis. (antikoerper-online.de)
  • encoded search term (How are specimens collected and prepared for apolipoprotein A-I (Apo-A1) testing? (medscape.com)
  • Your search returned 60 Apolipoprotein A-IV ELISA ELISA Kit across 1 supplier. (biocompare.com)
  • Your search returned 1 apolipoprotein B mRNA editing enzyme catalytic subunit 2 ELISA ELISA Kit across 1 supplier. (biocompare.com)
  • Pechlaner R, Tsimikas S, Yin X, Willeit P, Baig F, Santer P et al (2017) Very-low-density lipoprotein-associated apolipoproteins predict cardiovascular events and are lowered by inhibition of APOC-III. (springer.com)
  • Association Between ApoA-I (Apolipoprotein A-I) Immune Complexes and Adverse Cardiovascular Events. (medscape.com)
  • Minor apolipoprotein mainly associated with HDL and to a lesser extent with VLDL. (abcam.com)
  • Apolipoprotein E2 (apoE2)-associated hyperlipidemia is characterized by a disturbed clearance of apoE2-enriched VLDL remnants. (tudelft.nl)
  • The agent blocks the function of the mRNA of apolipoprotein C3 and successfully treats severe hypertriglyceridaemia in phase 3 trials (Ionis Pharmaceuticals). (ovid.com)
  • Fibrinogen alpha chain precursor and apolipoprotein a-I in urine as biomarkers for noninvasive diagnosis of calcium oxalate nephrolithiasis: a proteomics study. (medscape.com)
  • In an immunochemical reaction, Apolipoprotein B in the human serum sample form immune complexes with specific antibodies. (cdc.gov)
  • Anti-apolipoprotein antibodies have been used for indirect trapping ELISA for quantitation of antigen in serum using a standard curve, for immunoprecipitation and for western blotting for highly sensitive qualitative analysis. (rockland-inc.com)
  • The defective binding of apolipoprotein (apo) E2 to lipoprotein receptors, an underlying cause of type III hyperlipoproteinemia, results from replacement of Arg 158 with Cys, disrupting the naturally occurring salt bridge between Asp 154 and Arg 158. (rcsb.org)
  • Apolipoprotein E is a fat-binding protein ( apolipoprotein ) that is part of the chylomicron and intermediate-density lipoprotein (IDLs) . (wikidoc.org)