• Apolipoprotein E (APOE) is a lipid-transport protein abundantly expressed in most neurons in the central nervous system. (dovepress.com)
  • This review will summarize the updated research progress on APOE functions and its role in Alzheimer's disease, Parkinson's disease, cardiovascular diseases, multiple sclerosis, type 2 diabetes mellitus, Type III hyperlipoproteinemia, vascular dementia, and ischemic stroke. (dovepress.com)
  • The apolipoprotein E (APOE) gene is located on chromosome 19 and encodes a glycoprotein that is 299 amino acids long. (dovepress.com)
  • 3 In this review, we discuss the biological functions of human APOE and its role in Alzheimer's disease (AD), Parkinson's disease (PD), cardiovascular diseases (CVD), multiple sclerosis (MS), type 2 diabetes mellitus (T2DM), vascular dementia (VD), and ischemic (occlusive) stroke (IS). (dovepress.com)
  • Previously published data have shown an allele-specific variation in the in vitro binding of apolipoprotein E (apoE) to tau, which prompted the hypothesis that apoE binding may protect tau from phosphorylation, apoE3 being more efficient than apoE4. (ox.ac.uk)
  • We have, therefore, investigated the effects of apoE on tau phosphorylation in vitro by the proline-directed kinase, glycogen synthase kinase (GSK)-3 beta. (ox.ac.uk)
  • Apolipoprotein C-III also known as apo-CIII, and apolipoprotein C3, is a protein that in humans is encoded by the APOC3 gene. (wikipedia.org)
  • The impact of common variants in the apolipoprotein gene cluster (APOC3-A4-A5) on prospective coronary heart disease (CHD) risk was examined in healthy UK men. (nih.gov)
  • The apolipoprotein A-I gene is actively expressed in the rapidly myelinating avian peripheral nerve. (rupress.org)
  • The expression of the apolipoprotein A-I (apo A-I) gene was investigated in the myelinating sciatic nerve. (rupress.org)
  • Apolipoprotein E4 (apoE4), the major genetic risk factor of Alzheimer's disease (AD), is associated with enhanced brain inflammation. (nih.gov)
  • In order to determine the effects of percutaneous coronary intervention (PCI) on symptoms in patients with a grey-zone FFR, Hennigan and colleagues 3 randomised 104 symptomatic patients with a 30%-80% coronary stenosis and an FFR of 0.75-0.80 to optimal medical therapy (OMT) alone or PCI plus OMT ( figure 2 ). (bmj.com)
  • Select up to three search categories and corresponding keywords using the fields to the right. (cdc.gov)
  • Apolipoprotein CIII is also found on HDL particles. (wikipedia.org)
  • It was observed that there was no difference in the plasma clearance of [125 I]Aβ and that of the 3 H-cholesteryl ester, a marker of the emulsion particles, demonstrating that Aβ remains associated with these particles throughout both their lipolysis and tissue uptake. (iospress.com)
  • Apolipoprotein C-III also known as apo-CIII, and apolipoprotein C3, is a protein that in humans is encoded by the APOC3 gene. (wikipedia.org)
  • Apolipoprotein CIII is also found on HDL particles. (wikipedia.org)
  • This multiplex assay kit manufactured by Linco Research is to be used for the simultaneous quantification of the following six apolipoproteins in any combinations: Apo AI, Apo AII, Apo B, Apo CII, Apo CIII, and Apo E. This kit may be used for the analysis of the above apolipoproteins in serum, plasma, tissue extract, other biological fluids, or tissue culture supernatant samples. (lincoresearch.com)
  • Each lipoprotein is characterized by its lipid composition and by the type and number of apolipoproteins it possesses. (medscape.com)
  • these apolipoproteins have lipid-soluble segments, the beta apolipoproteins, which remain part of the lipoprotein throughout its metabolism. (medscape.com)
  • Dietary alpha-lipoic acid supplementation inhibits atherosclerotic lesion development in apolipoprotein E-deficient and apolipoprotein E/low-density lipoprotein receptor-deficient mice. (oregonstate.edu)
  • Gemfibrozil increases levels of high density lipoprotein (HDL) subfractions HDL 2 and HDL 3 , as well as apolipoproteins AI and AII. (nih.gov)
  • E1/E2 heterodimer binds host apolipoproteins such as APOB and APOE thereby forming a lipo-viro-particle (LVP) (PubMed:25122793, PubMed:29695434, PubMed:24838241). (proteopedia.org)
  • The interaction between E2 and host apolipoprotein E/APOE allows the proper assembly, maturation and infectivity of the viral particles (PubMed:25122793, PubMed:29695434). (proteopedia.org)
  • Omega-3 fatty acids had no significant effect on serum lipid levels, ApoA-I, glucose, insulin and HbA1c. (who.int)
  • So, LDL-P may play a useful role in patient management by helping judge the adequacy of LDL-lowering therapy, particularly among those with elevated triglycerides and reduced HDL-C. Such a role also has been proposed for apolipoprotein B (apo B). Indeed, both non-HDL-C and apo B have been proposed as secondary treatment targets after LDL-C goals have been achieved. (medscape.com)
  • In order to test whether hyperlipidaemia and glycaemic control can be improved among diabetes patients by dietary supplementation with purified omega-3 fatty acids, we carried out a double-blind, placebo-controlled trial on 50 type 2 diabetes patients randomized to 2 g/day purified omega-3 fatty acids or placebo for 10 weeks. (who.int)
  • Using gene expression (microarray) analysis of human hippocampus from APOE3/3 AD and APOE4/4 AD cases, we found different gene transcription patterns between APOE4/4 and APOE3/3 AD cases. (niagads.org)
  • Differences in apolipoprotein E3/3 and E4/4 allele-specific gene expression in hippocampus in Alzheimer disease. (niagads.org)
  • Nous avons réalisé un essai en double aveugle contre placebo sur 50 patients atteints de diabète de type 2 randomisés pour recevoir 2 g/jour d'acides gras oméga 3 purifiés ou un placebo pendant 10 semaines. (who.int)
  • Deficiency or defects in Apo E are causes of HYPERLIPOPROTEINEMIA TYPE III. (curehunter.com)
  • Apolipoprotein E4 (APOE4) allele is a major risk factor for late-onset familial and sporadic Alzheimer disease (AD). (niagads.org)
  • A few months after the 2007 JACC study was published, many of the same investigators - this time led by Wim A. van der Steeg, MD - published a paper looking at the role of the apo B-apolipoprotein A-I (apo B-apo A-I) ratio in cardiovascular risk assessment. (medscape.com)
  • This study aimed to investigate the relationship between apolipoprotein B (apo B) and bone mineral density (BMD) at different skeletal sites (lumbar spine, femoral neck, and total femur) and to compare the influence of apo B with other traditional lipid markers. (biomedcentral.com)
  • The study included participants from the National Health and Nutrition Examination Survey (NHANES) between 2011 and 2016 who had complete data for apo B and BMD at the three skeletal sites. (biomedcentral.com)
  • 9.5 nm) were associated with increased risk of CAD (Figure 3 and Figure 4). (medscape.com)
  • ApoC-III is a relatively small protein containing 79 amino acids that can be glycosylated at threonine-74. (wikipedia.org)