BACKGROUND: Little is known regarding the differential effects of the apolipoprotein E (APOE) É 4 on the regional topography of amyloid and tau in patients with both early-onset (EOAD) and late-onset Alzheimer's disease (LOAD). (bvsalud.org)
24 É 4+), and 66 age-matched controls underwent 3T MRI, 18F-THK5351 (THK) and 18F-flutemetamol (FLUTE) PET scans, APOE genotyping, and neuropsychological tests. (bvsalud.org)
The gene, APOE, is mapped to chromosome 19 in a cluster with apolipoprotein C1 (APOC1) and the apolipoprotein C2 (APOC2). (wikipedia.org)
Indeed, the apolipoprotein ε4 isoform is more protective against cognitive decline than other isoforms in some cases, so caution is advised before making determinant statements about the influence of APOE polymorphisms on cognition, development of Alzheimer's disease, cardiovascular disease, telomere shortening, etc. (wikipedia.org)
The APOE gene encodes Apolipoprotein E, a protein involved in injury repair and transporting fats between brain cells. (dnaaccesslab.com)
The characteristic components of the syndrome are mostly determined by apolipoprotein E (ApoE) modulation of atherogenic plasma Apo-B containing lipoproteins. (biomedcentral.com)
Allele3
Finally, 80,000 years ago, another arginine to cysteine substitution at amino acid 158 (Arg158Cys) of the APOE3 gene created the E2 allele. (wikipedia.org)
The presence of the e4 allele is linked to an increased risk of Alzheimer's disease, whereas the e2 allele has a protective affect. (dnaaccesslab.com)
Individuals that have one copy of the e4 allele have a 3-fold increased risk of developing Alzheimer's, while e4 homozygotes (two copies of e4 ) have up to a 15-fold increased risk. (dnaaccesslab.com)
Alzheimer's Disease1
LX1001 is an AAV-based investigational gene therapy designed to deliver the apolipoprotein E2 (APOE2) gene into the CNS of APOE4 homozygous Alzheimer's disease patients to halt or slow disease progression. (lexeotx.com)
APOE41
Apolipoprotein E4 (APOE4), the most prevalent genetic risk factor of AD, is expressed in more than half of AD patients and is thus an important possible AD therapeutic target³. (genomadix.com)
Prevalent1
LOAD É 4- manifested with prevalent small vessel disease markers and the lowest correlation between THK retention and cognition. (bvsalud.org)
Protein involved1
Apolipoprotein E (Apo-E) is a protein involved in the metabolism of fats in the body of mammals. (wikipedia.org)
Underwent1
This cross-sectional study included 1683 cognitively unimpaired middle/late-middle-aged adults from the ALFA (ALzheimer and FAmilies) study who underwent neuropsychological assessment, T1-weighted structural imaging ( n = 366), and diffusion-weighted imaging ( n = 334). (biomedcentral.com)
Complex1
Apo E has three different alleles (E2, E3 and E4) determining different and complex associations with clinical phenotype expressions. (biomedcentral.com)
ApoE14
The purpose of this FOA is to conduct basic and translational studies on ApoE2 and other variants to improve understanding of physiologic and cellular differences attributable to the ApoE e2 allele (vs. other ApoE alleles), and how they mediate ApoE e2's differential effects on longevity and risk for age-related conditions. (nih.gov)
This will aid in the identification of potential therapeutic targets for interventions that prevent or ameliorate aging-related diseases by mimicking favorable differential effects of the ApoE e2 variant, while avoiding adverse effects. (nih.gov)
The human apolipoprotein E (ApoE) gene has been found to have a strong association with exceptional longevity. (nih.gov)
Common isoforms of the ApoE protein include E4, E3 and E2 which are encoded by the e4, e3 and e2 alleles, respectively. (nih.gov)
BACKGROUND: Little is known regarding the differential effects of the apolipoprotein E (APOE) É 4 on the regional topography of amyloid and tau in patients with both early-onset (EOAD) and late-onset Alzheimer's disease (LOAD). (bvsalud.org)
24 É 4+), and 66 age-matched controls underwent 3T MRI, 18F-THK5351 (THK) and 18F-flutemetamol (FLUTE) PET scans, APOE genotyping, and neuropsychological tests. (bvsalud.org)
The gene, APOE, is mapped to chromosome 19 in a cluster with apolipoprotein C1 (APOC1) and the apolipoprotein C2 (APOC2). (wikipedia.org)
Indeed, the apolipoprotein ε4 isoform is more protective against cognitive decline than other isoforms in some cases, so caution is advised before making determinant statements about the influence of APOE polymorphisms on cognition, development of Alzheimer's disease, cardiovascular disease, telomere shortening, etc. (wikipedia.org)
APOE is a gene involved in making apolipoprotein E, a protein that helps carry cholesterol and other fats in the bloodstream. (nih.gov)
To study the association of apolipoprotein E ( APOE ) polymorphisms and primary open-angle glaucoma (POAG). (molvis.org)
The human APOE gene is located on chromosome 19q13.2, with three common alleles ( ε2, ε3 , and ε4 ) encoding 3 protein isoforms (E2, E3, and E4). (molvis.org)
Apolipoprotein E (APOE) ε4 genotype is associated with increased risk of dementia in Parkinson's disease (PD), but the mechanism is not clear, because patients often have a mixture of α-synuclein (αSyn), amyloid-β (Aβ), and tau pathologies. (niagads.org)
In this study, we generated A53T αSyn transgenic mice (A53T) on Apoe knockout (A53T/EKO) or human APOE knockin backgrounds (A53T/E2, E3, and E4). (niagads.org)
A53T/E2 mice exhibited increased survival and improved motor performance compared to other APOE genotypes. (niagads.org)
Alleles1
The three major human alleles (E4, E3, E2) arose after the primate-human split around 7.5 million years ago. (wikipedia.org)
Genotypes1
Apolipoprotein E genotypes were not associated with intracranial atherosclerosis: a population-based autopsy study. (cdc.gov)
Protein1
Apolipoprotein E (Apo-E) is a protein involved in the metabolism of fats in the body of mammals. (wikipedia.org)
Disease3
The purpose of this overview is to increase the awareness of clinicians regarding Alzheimer disease (AD) and its genetic causes and management. (nih.gov)
Alzheimer disease (AD) is characterized by dementia that typically begins with subtle and poorly recognized failure of memory (often called mild cognitive impairment or MCI) and slowly becomes more severe and, eventually, incapacitating. (nih.gov)
Establishing the diagnosis of Alzheimer disease relies on clinical-neuropathologic assessment. (nih.gov)
Patients1
RESULTS: EOAD É 4- patients showed greater THK retention in the association cortices, whereas their EOAD É 4+ counterparts had more retention in medial temporal areas. (bvsalud.org)