To characterize the lipidation states of Aβ peptides and apolipoprotein E in the cerebrospinal fluid in adults with respect to cognitive diagnosis and APOE ε4 allele carrier status and after a dietary intervention. (nih.gov)
The ε4 allele of apolipoprotein E (APOE4) is the main genetic risk factor for Alzheimer's disease 4. (cress-umr1153.fr)
Apolipoprotein E4 allele frequency was highest in dementia with comorbid diabetes mellitus type 2 (0.26). (telomerescience.com)
Apolipoprotein E4 allele was not significantly associated with telomere attrition in both dementia and cognitively normal group irrespective of comorbid diabetes mellitus type 2 (P>0.05). (telomerescience.com)
RESULTS:We confirmed that, compared with those with APOE e3/3 genotype, APOE e4 allele carriers scored lower by 0.55 units on the average TICS score (95%CI:-0.67,-0.43). (ox.ac.uk)
The e4 allele of the apolipoprotein E ( APOE ) gene has been shown to be a risk factor for late-onset Alzheimer disease. (nature.com)
The 𝜀3 and 𝜀3/𝜀3 were the most frequent allele and genotype, respectively, followed by 𝜀4 allele and 𝜀3/𝜀4 genotype. (chewbook.com)
Apolipoprotein E gene allele 4 (APOE4) is a major genetic risk factor for late-onset Alzheimer's disease (AD). (j-alz.com)
It is thought that the apolipoprotein E produced from the e4 allele of the APOE gene may disrupt the transport of a protein called alpha-synuclein into and out of cells. (medlineplus.gov)
Alzheimer's4
Scholars@Duke publication: Clinical application of apolipoprotein E genotyping to Alzheimer's disease. (duke.edu)
Indeed, the apolipoprotein ε4 isoform is more protective against cognitive decline than other isoforms in some cases, so caution is advised before making determinant statements about the influence of APOE polymorphisms on cognition, development of Alzheimer's disease, cardiovascular disease, telomere shortening, etc. (wikipedia.org)
Apolipoprotein E (APOE) genotype has dissociable effects on memory and attentional-executive network function in Alzheimer's disease. (pennmedicine.org)
APOE in the bullseye of neurodegenerative diseases: impact of the APOE genotype in Alzheimer's disease pathology and brain diseases. (lu.se)
Apolipoprotein E4 gene is associated with increased risk of dementia with comorbid diabetes mellitus. (telomerescience.com)
We assessed relative telomere length and apolipoprotein E genotype in subjects with dementia (n=70) and cognitively normal control groups (n=55) with and without comorbid diabetes mellitus type 2. (telomerescience.com)
Apolipoprotein E e4 genotype and the temporal relationship between depression and dementia. (usc.edu)
Apolipoprotein (APOE) genotypes (a risk factor for dementia) were determined using TaqMan PCR Assays. (nutraingredients.com)
Association of Brain Amyloid-β With Slow Gait in Elderly Individuals Without Dementia: Influence of Cognition and Apolipoprotein E ε4 Genotype. (humanconnectome.org)
Alzheimer Disease1
With the increasing interest in apolipoprotein E ( APOE ) genetic testing to estimate the risk of developing late-onset Alzheimer disease, new educational tools are needed to help people make the best decision for themselves about whether to undergo this test. (nature.com)
ApoE genotype9
In other words, knowing a patient's apoE genotype helps a doctor predict whether or not the patient would be better off on statins versus a low-fat diet, for example. (news-medical.net)
Some patients might respond well to a low fat diet, some patients might respond better to statin medications, depending on their apoE genotype,' states Dr. Jonathan Stein, PhD and Director of Science and Research at SpectraCell Laboratories. (news-medical.net)
The aim of this investigation was to assess the effect of galantamine, an acetylcholinesterase inhibitor and allosteric modulator of nicotinic receptors, on brain atrophy in individuals with mild cognitive impairment (MCI), and to assess effect modification by apolipoprotein E (APOE) genotype. (biomedcentral.com)
Future research would benefit from understanding the relationship between APOE genotype and how we could use micronutrients to accumulate in brain to help relive oxidative stress. (j-alz.com)
Consumption of alcohol, Aβ aggregation in the brain, and apolipoprotein E (APOE) genotype were assessed. (newswise.com)
The genetic expression of APOE4 constitutes one of the highest genetic risk factors for developing AD, yet, new mutations are being discovered potentially influencing AD's pathology, hence evidencing the profound impact of the APOE genotype in AD pathophysiology [2]. (lu.se)
Alleles3
In this context, apolipoprotein E gene ( APOE ) is a key element with a well-established association among their alleles and the neurodegenerative consequences of mercury intoxication. (chewbook.com)
Moreover, apolipoprotein genotype analysis revealed that AD subjects with the E3/E4 alleles had the highest content of mitochondrial APP. (jneurosci.org)
The proportion of APOE genotypes and alleles differ between populations of different ethnic groups and gender [1]. (j-alz.com)
Mild cognitive2
Depression, apolipoprotein E genotype, and the incidence of mild cognitive impairment: a prospective cohort study. (qxmd.com)
It remains unknown whether depression and apolipoprotein E genotype are risk factors for incident mild cognitive impairment (MCI). (qxmd.com)
Lipid4
However, apoE genotyping is best when used in conjunction with additional lipid profile testing. (news-medical.net)
Lipid-depleted (LD) apolipoproteins are less effective at binding and clearing Aβ, and LD Aβ peptides are more toxic to neurons. (nih.gov)
Lipid-depleted Aβ42 and Aβ40 and apolipoprotein E in cerebrospinal fluid. (nih.gov)
The gene, APOE, is mapped to chromosome 19 in a cluster with apolipoprotein C1 (APOC1) and the apolipoprotein C2 (APOC2). (wikipedia.org)
The APOE gene provides instructions for making a protein called apolipoprotein E. This protein combines with fats (lipids) in the body to form molecules called lipoproteins. (medlineplus.gov)
Profile and regulation of apolipoprotein E (ApoE) expression in the CNS in mice with targeting of green fluorescent protein gene to the ApoE locus. (lu.se)
Interaction4
We found a synergistic interaction between depression and apolipoprotein E genotype. (qxmd.com)
Interaction between apolipoprotein E genotype and hypertension on cognitive function in older women in the Nurses' Health Study. (ox.ac.uk)
OBJECTIVE:To examine the interaction between APOE genotypes and both treated and untreated hypertension on cognitive function in an updated analysis of Nurses' Health Study (NHS) data. (ox.ac.uk)
APOE e4-genotype and lifestyle interaction on cognitive performance: Results of the LIFE-adult-study. (mpg.de)
Chronic1
Objective: To measure LVP in patients with chronic hepatitis C genotype 1 (CHC-G1) and examine metabolic determinants of LVP load. (ncl.ac.uk)
Fats1
Apolipoprotein E (Apo-E) is a protein involved in the metabolism of fats in the body of mammals. (wikipedia.org)
Populations2
However, no studies have addressed APOE genotyping in Amazonian exposed populations. (chewbook.com)
Additionally, epidemiological studies with APOE genotyping in Amazon have been restricted to indigenous populations. (chewbook.com)
Clinical1
The MolDX Team has determined Apolipoprotein (Apo) E genotype testing, developed to assess the risk of cardiovascular disease, has insufficient evidence to support the required clinical utility for the established Medicare benefit category. (cms.gov)
Findings1
These findings may provide insight into the mechanisms through which apolipoprotein E4 and unhealthy diets impart risk for developing AD. (nih.gov)
Test1
As reviewed, the developers described the indication to perform an Apolipoprotein (Apo) E genotype test as a risk assessment for developing a disease or condition. (cms.gov)
Found2
Two out of three male patients tested had the rare ϵ2/ϵ2 genotype, which was not found in any of the females. (ox.ac.uk)
Only 𝜀2/𝜀2 genotype was not found, suggesting that the absence of this genotype is a generalized phenomenon in Amazon. (chewbook.com)
Suggest1
Evidence from animal models and cell culture suggest that low-density apolipoprotein B (apoB)-associated HCV lipoviral particles (LVP) are more infectious than high-density HCV. (ncl.ac.uk)
Patients2
Twenty‐three patients with late paraphrenia were genotyped for ApoE. (ox.ac.uk)
ATP1A3 mutations and genotype-phenotype correlation of alternating hemiplegia of childhood in Chinese patients. (cdc.gov)
Unique1
Apolipoproteins are not unique to mammals. (wikipedia.org)