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  • protein
  • The study by Harvard School of Public Health (HSPH) researchers is the first research to show that a small protein, apolipoprotein C-III (apoC-III), that sometimes resides on the surface of HDL cholesterol may increase the risk of heart disease and that HDL cholesterol without this protein may be especially heart protective. (thefreedictionary.com)
  • 7 December 2011 - US drug discovery and development company ISIS Pharmaceuticals Inc (NASDAQ:ISIS) reported on Tuesday positive data from a Phase I clinical trial with ISIS-APOCIIIRx, demonstrating that ISIS-APOCIIIRx treatment led to fast, dose-dependent reductions of up to 78% in apolipoprotein C-III (apoC-III) protein and up to 44% in blood triglyceride levels. (thefreedictionary.com)
  • The mature 79-amino-acid ApoC-III protein is synthesized predominantly in the liver but also to a lesser extent in the intestine. (biomedcentral.com)
  • In this study we examined whether three type III HLP predisposing apoE3 variants, namely R136S, R145C and K146E affect the biophysical properties of the protein. (nih.gov)
  • Spectra shown are the average of three separate measurements on different days with different protein batches. (nih.gov)
  • To identify the mechanisms by which cocoa induces HDL levels and since apolipoprotein AI (ApoAI) is the major protein in HDLs, we analyzed, upon incubation with cocoa metabolites, ApoAI mRNA levels, its transcriptional regulation, and the levels of the transcription factors involved in this process. (wiley.com)
  • Incubation with 3-methyl-epicatechin led to an increase in HNF-3β mRNA, HNF-3β, ER-α, Sp1, and NFY protein levels and the activation of ApoAI transcription mediated by NFY, Sp1, and ER-α. (wiley.com)
  • Provided herein are methods and compositions for limiting development of and/or treating diabetes, involving compounds of formula A-B, wherein A is a pancreatic β cell targeting moiety, and B is an inhibitor of expression and/or activity of Apolipoprotein CIII (apoCIII), protein kinase A (PKA), Src kinase, and/or β1 integrin. (freepatentsonline.com)
  • 1. A method for treating or limiting development of diabetes, comprising administering to a subject in need thereof an amount effective of a composition comprising a compound of formula A-B, wherein A is a pancreatic β cell targeting moiety, and B is an inhibitor of expression and/or activity of Apolipoprotein CIII (apoCIII), protein kinase A (PKA), Src kinase, and/or β1 integrin. (freepatentsonline.com)
  • 11. A composition of formula A-B, wherein A is a pancreatic β cell targeting moiety, and B is an inhibitor of Apolipoprotein CIII (apoCIII), protein kinase A (PKA), Src kinase, or β1 integrin. (freepatentsonline.com)
  • atherosclerosis
  • Cross-sectional and longitudinal associations between plasma apoC-III proteoforms (by mass spectrometric immunoassay) and plasma lipids were tested in two randomized clinical trials: ACT NOW, a study of pioglitazone in subjects with impaired glucose tolerance (n = 531), and RACED (n = 296), a study of intensive glycemic control and atherosclerosis in type 2 diabetes patients. (univ-lorraine.fr)
  • novel
  • Materials: The EVOLVE trial evaluated 2, 3, and 4 g/d of a novel omega-3 free-fatty acid (FFA) formulation containing both EPA + DHA compared with 4 g/d of olive oil. (ahajournals.org)