APOEPolymorphismsProteinGeneticApoE4LipoproteinAlzheimer'sAlzheimer DiseaseMutationsVariantsRegulationLipoproteinsSerumGeneticsHypercholesterolemiaAntibodyAPOA1ELISAChromosomeDifferentially expressedAllele FrequenciesAtheroscleroticMiceAtherosclerosisMyocardial infarctionIsoformsRiskCholesterolDetectsSeveral genesSusceptibilityDiseasesVariantSingle geneInducesAmyloid2017AbnormalMembraneGenotypePathwaysHumanProteins
APOE36
- Apolipoprotein E (APOE) gene variants have been reported to influence psoriasis risk. (hindawi.com)
- Saudi subjects (294) were genotyped for APOE gene using APOE StripAssay kit. (hindawi.com)
- Lipid metabolism in the epidermis may be regulated by the expression of apolipoprotein E (APOE), a glycoprotein which is synthesized in a wide variety of extrahepatic tissues including skin [ 27 - 29 ]. (hindawi.com)
- The APOE gene encodes 3 isoforms Ɛ4, Ɛ3 and Ɛ2 with APOE Ɛ4 associated with higher plasma cholesterol levels and increased pathogenesis in several infectious diseases (HIV, HSV). (edu.au)
- Results suggest an epistatic interaction between APOE and HbS genes such that sickle cell trait only had an effect on parasite density in APOE Ɛ4 children. (edu.au)
- This study examines the distribution of apolipoprotein E (APOE) alleles in a population of healthy male and female Norwegians (n = 798) below the age of 40. (wayne.edu)
- The -491A/T polymorphism of the promoter region of the APOE gene was also examined. (wayne.edu)
- Genome-wide gene expression profiling was employed to study the effects of apoE genotype on hippocampal gene expression in LPS-treated mice, transgenic for either apoE4 or the AD benign allele, apoE3. (nih.gov)
- Earlier studies were associated with Apolipoprotein E ( ApoE ) in variable diseases. (edu.pl)
- The current study aims to investigate the genetic association between FH disease and ApoE gene (rs429358 and rs7412) in the Saudi population. (edu.pl)
- Common polymorphisms (rs429358 and rs7412) were selected from the ApoE gene and we then performed the genotyping as the TaqMan assay. (edu.pl)
- ApoE gene polymorphism and its relationship with coronary artery disease in ethnic Kashmiri population. (edu.pl)
- Apolipoprotein E (APOE) genotype is the single most important determinant to the common form of Alzheimer disease (AD) yet identified. (ox.ac.uk)
- Apolipoprotein E (ApoE) a protein component of bloodstream lipid particles has an important function in lipid transportation. (careersfromscience.org)
- This study shows that direct intracerebral gene delivery of APOE2 via an AAV vector significantly reduces brain Abeta and amyloid deposition in these transgenic mouse models of AD and rescues the detrimental effects of both APOE4 as well as murine Apoe on brain amyloid pathology. (nih.gov)
- Using DNA microarrays, hepatic gene expression was analysed in apoE-deficient mice fed one of two isoenergetic, isonitrogenous diets containing either 10 % (w/w) olive oil or unsaponifiable fraction-enriched olive oil. (ox.ac.uk)
- The eleven genes fulfilling these prerequisites were confirmed by quantitative RT-PCR, and then analysed in apoE-deficient mice with a C57BL/6J genetic background. (ox.ac.uk)
- eg, apolipoprotein E (ApoE) subtypes confer different risk profiles. (medscape.com)
- lt;p>The apolipoprotein E (ApoE) gene makes a protein which, when combined with fat, becomes a lipoprotein. (feedburner.com)
- Apolipoprotein E (APOE) is a lipid-transport protein abundantly expressed in most neurons in the central nervous system. (dovepress.com)
- The apolipoprotein E (APOE) gene is located on chromosome 19 and encodes a glycoprotein that is 299 amino acids long. (dovepress.com)
- There are three different alleles for the APOE gene: ε2, ε3, and ε4. (nature.com)
- vi) APP transgenic mice with apolipoprotein E (ApoE) deficiency had increased atherosclerosis and vascular inflammation ( 16 ). (spandidos-publications.com)
- The human ApoE gene has 3 allelic variants (ε2, ε3, and ε4). (spandidos-publications.com)
- The so-called human apolipoprotein E (APOE) gene encodes instructions for creating the homonymous protein. (medicalnewstoday.com)
- Typically, the APOE gene combines with fats to create lipoproteins - proteins that, in turn, carry cholesterol and other liquids through the bloodstream. (medicalnewstoday.com)
- The variant E4 of the APOE gene significantly raises a person's risk of developing Alzheimer's disease . (medicalnewstoday.com)
- In the new study, the scientists used mouse models of Alzheimer's disease with an activated version of the E4 or E3 variant of the APOE gene. (medicalnewstoday.com)
- Like other apolipoproteins, APOE is involved in lipid binding, and it is the predominant cholesterol transporter in the brain. (j-alz.com)
- The involvement of chromosome 19 in AD has been associated with apoliprotein E (ApoE) and the epsi4 gene frequency has been related to increased risk and early onset of AD. (lu.se)
- Apolipoprotein Gene Polymorphisms (APOB, APOC111, APOE) in the Development of Coronary Heart Disease in Ethnic Groups of Kazakhstan. (cdc.gov)
- APOE gene polymorphism analysis in Barranquilla, Colombia. (cdc.gov)
- Data on plasma levels of apolipoprotein E, correlations with lipids and lipoproteins stratified by APOE genotype, and risk of ischemic heart disease. (cdc.gov)
- Recent findings have highlighted an increase of the Gal3 gene (lgal3) in apoE4-microglia and upregulated APOE levels, particularly in aged microglia [6]. (lu.se)
- Moreover, our group has recently evidenced that early-life infection in 5xFAD mice induces a subpopulation of microglial cells with a monocyte-like profile presenting as potential markers genes corresponding to Gal3, and APOE. (lu.se)
- Profile and regulation of apolipoprotein E (ApoE) expression in the CNS in mice with targeting of green fluorescent protein gene to the ApoE locus. (lu.se)
Polymorphisms7
- Previous studies suggested that Apolipoprotein AI (ApoAI) and apolipoprotein B (ApoB) gene polymorphisms may result in lipid metabolism disorders. (biomedcentral.com)
- Genetic polymorphisms in these genes may be associated with the occurrence of osteonecrosis. (biomedcentral.com)
- The eNOS gene has several single nucleotide polymorphisms reported, one of which is G894T. (scirp.org)
- 2008) Proc Natl Acad Sci USA 105:13987-13992] and 1,762 German centenarians/nonagenarians and younger controls provided evidence that polymorphisms in this gene were indeed associated with the ability to attain exceptional old age. (feedburner.com)
- Benn M, Nordestgaard BG, Jensen JS, Tybjaerg-Hansen A. Polymorphisms in apolipoprotein B and risk of ischemic stroke. (prosci-inc.com)
- Using data from the second phase (1991-1994) of the Third National Health and Nutrition Examination Survey (NHANES III), we examined associations between 22 polymorphisms in 13 candidate genes and four serum lipids: high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), total cholesterol (TC), and triglycerides (TG). (cdc.gov)
- Recent candidate gene studies [ 13 - 16 ], as well as genome-wide association studies [ 17 - 25 ], have identified polymorphisms that account for a portion of the variation in blood lipid levels. (cdc.gov)
Protein17
- Apolipoprotein E is a monomeric protein secreted by the liver and responsible for the transport of plasma cholesterol and triglycerides. (edu.au)
- Streamlining Regulon Identification in Bacteria Regulons are a group of genes that can be turned on or off by the same regulatory protein. (doe.gov)
- Apolipoprotein B (ApoB) is a protein that in humans is encoded by the APOB gene. (wikipedia.org)
- Apolipoprotein B100 (apoB100) is a protein that plays a role in moving cholesterol around your body. (medlineplus.gov)
- This gene encodes a member of the subtilisin-like proprotein convertase family, which includes proteases that process protein and peptide precursors trafficking through regulated or constitutive branches of the secretory pathway. (nih.gov)
- Apolipoprotein B (apo B) in human plasma is a major protein of low density lipoproteins (LDL) with a molecular mass of approximately 260-500 kDa. (thermofisher.com)
- Deposited amyloid protein in these patients is identical to the amyloid protein seen in sporadic cases, and the likely genetic defect is in the amyloid protein precursor protein ( APP ) gene on chromosome 21. (medscape.com)
- lt;p>Forkhead box O3 protein (FOXO3) is a transcription factor involved in the regulation of genes involved in many cellular processes, including DNA repair, tumor suppression, immune function, and resistance to oxidative stress. (feedburner.com)
- The code for making this protein is found in the ACTN3 gene. (shortform.com)
- The "R variant" of the gene results in normal production of the protein, but the "X" variant prevents the protein from being synthesized. (shortform.com)
- The protein encoded by this gene is a component of high-density lipoprotein (HDL), but is unique in that it shares greater structural similarity to lipocalin than to other members of the apolipoprotein family, and has a wider tissue expression pattern. (genscript.com)
- The encoded protein is involved in lipid metabolism, and ablation of this gene results in defects in triglyceride metabolism. (genscript.com)
- Recent studies have demonstrated that ATP-binding cassette protein A1 (ABCA1) is highly regulated in macrophages and mediates the efflux of cholesterol and phospholipids to apolipoproteins, a process necessary for HDL formation. (jci.org)
- Familial hypobetalipoproteinaemia (FHBL) is a codominant disorder characterised by fatty liver and reduced plasma levels of low-density lipoprotein (LDL) and its protein constituent apolipoprotein B (apoB). (bmj.com)
- Methods: Mice were exposed by pharyngeal aspiration to 40-microg CNT and harvested 24 hours, 7 days, and 28 days postexposure for measurements of whole blood, lung and extrapulmonary tissue gene expression, blood and bronchoalveolar lavage (BAL) differentials, and serum protein profiling. (cdc.gov)
- Apolipoprotein B (apoB) is a structural protein that constitutes a major component of the very-low-density lipoprotein (VLDL), the intermediate-density lipoprotein (IDL), and the low-density lipoprotein (LDL). (medscape.com)
- One gene abnormality affects apolipoprotein E (apo E)-the protein part of certain lipoproteins, which transport cholesterol through the bloodstream. (msdmanuals.com)
Genetic15
- Inheritance being multifactorial, genetic variants in multiple genes interact both with each other and with the environment [ 13 - 20 ]. (hindawi.com)
- Hypobetalipoproteinemia is a genetic disorder that can be caused by a mutation in the ApoB gene, APOB. (wikipedia.org)
- Apolipoprotein E4 (apoE4), the major genetic risk factor of Alzheimer's disease (AD), is associated with enhanced brain inflammation. (nih.gov)
- Association of apolipoprotein E genetic variation in Alzheimer's disease in Indian population: a meta-analysis. (edu.pl)
- Moreover, single gene inheritance best explained clustering of the disorder in families of probands lacking epsilon 4, but a more complex genetic model or multiple genetic models may ultimately account for risk in this group of families. (ox.ac.uk)
- In this work we proposed to study the role of genetic polymorphism of the eNOS G894T gene in the development of diabetes on the one hand and of these degenerative complications other. (scirp.org)
- Epstein explains that it took a study of nearly 4,000 people and nearly 300,000 gene variants to determine just 45% of the genetic basis for height! (shortform.com)
- The lack of a scientific explanation for why the XX variant is virtually absent in elite sprinters has not stopped for-profit genetic testing companies from selling genetic tests for ACTN3 gene variants to interested athletes and parents. (shortform.com)
- Genetic deficiency of apolipoprotein D in the mouse is associated with nonfasting hypertriglyceridemia and hyperinsulinemia. (genscript.com)
- Our study provides direct evidence for an interaction between this Alzheimer's genetic risk gene and environmental exposures on accelerated cognitive impairment. (medicalnewstoday.com)
- Apolipoprotein E gene allele 4 (APOE4) is a major genetic risk factor for late-onset Alzheimer's disease (AD). (j-alz.com)
- Low apoB levels may indicate Bassen-Kornzweig syndrome (abetalipoproteinemia), a very rare genetic condition characterized by apolipoprotein B deficiency. (medscape.com)
- Journal of genetic syndromes & gene therapy 2014 Jan 5 (2): 216. (cdc.gov)
- For example, one of the top results in any genetic analysis for heart attack is LDL cholesterol and several genes related to LDL cholesterol. (medscape.com)
- Univariate and multivariable linear regression and within-gene haplotype trend regression were used to test for genetic associations assuming an additive mode of inheritance for each of the three major race/ethnic groups in the United States (non-Hispanic white, non-Hispanic black, and Mexican American). (cdc.gov)
ApoE410
- This revealed that the expression of inflammation-related genes following intracerebroventricular injection of LPS was significantly higher and more prolonged in apoE4 than in apoE3 transgenic mice. (nih.gov)
- Clustering analysis revealed gene clusters which responded differently in apoE4 and apoE3 mice and were significantly enriched in NF-kappaB response elements. (nih.gov)
- Direct measurement of NF-kappaB-regulated genes revealed that their extent of activation was greater in the apoE4 mice. (nih.gov)
- New research in mice suggests that people who already have a copy of the APOE4 gene and are thus at risk of Alzheimer's may experience cognitive decline as a result of exposure to cadmium - a neurotoxic heavy metal. (medicalnewstoday.com)
- These symptoms occurred earlier in mice with the APOE4 gene than those with APOE3 . (medicalnewstoday.com)
- Later in life, mice with the APOE4 gene performed worse in the T-maze test than those with APOE3 . (medicalnewstoday.com)
- The authors conclude that exposure to cadmium "impaired neuronal differentiation of adult-born neurons" in the hippocampus of male mice with the APOE4 gene. (medicalnewstoday.com)
- If you have the APOE4 gene, the risk is significantly higher. (medicalnewstoday.com)
- The risk of developing AD is increased by 8-15-fold if an individual is carrying two copies of the APOE4 gene. (j-alz.com)
- Should we test for the APOE4 gene? (j-alz.com)
Lipoprotein4
- Considering the vital role of Apo genes in high-density lipoprotein formation and cholesterol transport, the present data suggest that the circadian clock system regulates testosterone production by orchestrating the rhythmic expression of Apo genes. (tmu.edu.tw)
- Apolipoprotein B binds to specific receptors on cell membranes and is involved in removal of LDL and very low density lipoprotein (VLDL) cholesterol from circulation. (thermofisher.com)
- Apolipoprotein B is mostly synthesized in the liver, and is a major apolipoprotein of very low density, intermediate density and low density lipoproteins (LDL) as well as being a major component of lipoprotein (a). (thermofisher.com)
- Apo E (Apolipoprotein E) plays an important role in the metabolism of lipids in the plasma, and is also is a constituent of various plasma lipoprotein-lipid particles. (thermofisher.com)
Alzheimer's2
- Researchers have identified 11 new genes which offer important new insights into the disease pathways associated with Alzheimer's disease. (neurosciencenews.com)
- Title: Apolipoprotein D modulates amyloid pathology in APP/PS1 Alzheimer's disease mice. (genscript.com)
Alzheimer Disease2
- Evidence for major gene inheritance of Alzheimer disease in families of patients with and without apolipoprotein E epsilon 4. (ox.ac.uk)
- Instead, other genes affect the risk of getting Alzheimer disease. (msdmanuals.com)
Mutations7
- Mutations in gene APOB100 can also cause familial hypercholesterolemia, a hereditary (autosomal dominant) form of metabolic disorder hypercholesterolemia. (wikipedia.org)
- Mutations (changes) in the gene that directs the body's production of apoB100 can cause a condition called familial hypercholesterolemia . (medlineplus.gov)
- Mutations in this gene have been associated with autosomal dominant familial hypercholesterolemia. (nih.gov)
- Hereditary forms of CAA are due to specific gene mutations. (medscape.com)
- AD can be caused by mutations in genes involved in the processing of Aβ, including APP , PSEN1 , and PSEN2 [ 5 ]. (nature.com)
- In a group of 59 patients with FHBL genotyped for APOB gene mutations, we found three novel splice-site mutations: c.904+4A→G in intron 8, c.3843−2A→G in intron 24 and c.4217−1G→T in intron 25. (bmj.com)
- These findings demonstrate the pathogenic effect of rare splice-site mutations of the APOB gene found in FHBL. (bmj.com)
Variants3
- The impact of common variants in the apolipoprotein gene cluster (APOC3-A4-A5) on prospective coronary heart disease (CHD) risk was examined in healthy UK men. (nih.gov)
- They were able to identify six gene variants that affected individual heft. (shortform.com)
- There are three variants, or alleles, of this gene. (medicalnewstoday.com)
Regulation4
- Epistatic Interactions between apolipoprotein E and hemoglobin S Genes in regulation of malaria para. (edu.au)
- This suggests a linked pathway of regulation of parasite density involving expression of these genes. (edu.au)
- Regulation and clearance of apolipoprotein B-containing lipoproteins. (medlineplus.gov)
- Differential regulation of the human versus the mouse apolipoprotein AV gene by PPARalpha. (bvsalud.org)
Lipoproteins1
- Very low-density lipoproteins and low-density lipoproteins interfere with the quorum sensing system that upregulates genes required for invasive Staphylococcus aureus infection. (wikipedia.org)
Serum4
- Male Bmal1−/− mice are infertile with low serum testosterone levels and decreased expression of testicular steroidogenic genes, suggesting that circadian clock genes regulate testosterone biosynthesis by activating steroidogenic gene transcription. (tmu.edu.tw)
- PCR results confirmed the trypanosomes positive for the T. b. rhodesiense -specific serum resistance-associated gene ( 1 ). (cdc.gov)
- Results: Early effects included increased inflammatory blood gene expression and serum cytokines followed by an acute phase response (eg, CRP, SAA-1, SAP). (cdc.gov)
- At 28 day, serum acute phase proteins with immune function including complement C3, apolipoproteins A-I and A-II, and a2-macroglobulin were increased. (cdc.gov)
Genetics1
- Therefore, I primarily study genetics and how certain genes are linked to the disease, but I also look at lifestyle and exposure to various environmental factors such as tobacco use. (lu.se)
Hypercholesterolemia5
- Mice containing only one functional copy of the mApoB gene show the opposite effect, being resistant to hypercholesterolemia. (wikipedia.org)
- D445*) in the LDLR gene that causes familial hypercholesterolemia. (edu.pl)
- These diseases share common risk factors, which are exhibited in old age, including hypertension, diabetes, hypercholesterolemia and apolipoprotein (Apo) ε4 allele. (spandidos-publications.com)
- Several findings suggest that atherosclerosis and AD are linked: i) Atherosclerotic vascular disease and AD share common risk factors, such as hypertension, diabetes, hypercholesterolemia, and apolipoprotein ε4 allele ( 5 ). (spandidos-publications.com)
- Familial hypercholesterolemia is a rare disease caused by a mutation in the apoB gene code. (medscape.com)
Antibody3
- The following product was used in this experiment: Apolipoprotein B Monoclonal Antibody (F2C9) from Thermo Fisher Scientific, catalog # MIA1609, RRID AB_11152638. (thermofisher.com)
- PVDF membrane was probed with 0.25 µg/mL of Sheep Anti-Mouse/Rat Apolipoprotein H/ApoH Antigen Affinity-purified Polyclonal Antibody (Catalog # AF6575) followed by HRP-conjugated Anti-Sheep IgG Secondary Antibody (Catalog # HAF016 ). (rndsystems.com)
- The following product was used in this experiment: Apolipoprotein E Polyclonal Antibody from Thermo Fisher Scientific, catalog # BS-4892R. (thermofisher.com)
APOA15
- Members of the apolipoprotein gene cluster (APOA1/C3/A4/A5) on human chromosome 11q23 play an important role in lipid metabolism. (doe.gov)
- The cholesterol metabolism pathway was significantly enriched in the KEGG pathway analysis, and there was lower expression of three apolipoprotein genes (Apoa1, Apoa2, and Apoc3) at CT2 in the testes of Bmal1−/− mice than in those of WT mice. (tmu.edu.tw)
- These decreases in Apoa1, Apoa2, and Apoc3 expression were verified by quantitative polymerase chain reaction analysis, which also revealed downregulation of the expression of the circadian clock (Per2, Dbp, and Nr1d1) and steroidogenic (StAR, Cyp11a1, and Hsd17b3) genes. (tmu.edu.tw)
- The expression of circadian clock genes was relatively stable in WT mice over a 20-h period, whereas there was clear circadian rhythmic expression of Apoa1, Apoa2, Apoc3, StAR, Cyp11a1, Hsd3b2, and Hsd17b3. (tmu.edu.tw)
- Bmal1−/− mice showed severely reduced expression of testicular circadian clock genes at three time points (CT4, CT12, and CT20), and a reduction in mRNA expression levels of Apo (Apoa1, Apoa2, and Apoc3) and steroidogenic (StAR, Cyp11a1, Hsd3b2, and Hsd17b3) genes. (tmu.edu.tw)
ELISA1
- MIA1609 targets Apolipoprotein B in ELISA, IP and RIA applications and shows reactivity with Human samples. (thermofisher.com)
Chromosome1
- The Apo E gene is located on chromosome 19 at position 19q13. (thermofisher.com)
Differentially expressed2
- RNA sequencing identified 37 and 48 genes that were differentially expressed between WT and Bmal1−/− mouse testes at circadian time (CT2 and CT14), respectively. (tmu.edu.tw)
- Microarray analysis of hepatic genes differentially expressed in the presence of the unsaponifiable fraction of olive oil in apolipoprotein E-deficient mice. (ox.ac.uk)
Allele Frequencies1
- Inconsistencies might be caused by differences in study design, study populations (geographic and ethnic background), statistical methods and power, allele frequencies, and gene-environment interactions. (cdc.gov)
Atherosclerotic1
- Title: Identification of apolipoprotein D as a cardioprotective gene using a mouse model of lethal atherosclerotic coronary artery disease. (genscript.com)
Mice3
- Mice containing no functional copies of the gene are not viable. (wikipedia.org)
- Using Bmal1−/− mice and their wild-type (WT) siblings, we aimed to identify additional genes by which the circadian clock regulates testosterone synthesis. (tmu.edu.tw)
- The hypothesis that the unsaponifiable fraction of olive oil dramatically influences hepatic gene expression was tested in mice. (ox.ac.uk)
Atherosclerosis1
- Apolipoprotein B is a ligand for the LDL receptor and elevated levels are associated with premature atherosclerosis. (thermofisher.com)
Myocardial infarction4
- Association between apolipoprotein E gene polymorphism and myocardial infarction. (cdc.gov)
- Meta-analysis of apolipoprotein E gene polymorphism and susceptibility of myocardial infarction. (cdc.gov)
- Relation between Apolipoprotein E Gene Polymorphism and Severity of Coronary Artery Disease in Acute Myocardial Infarction. (cdc.gov)
- Association between Apolipoprotein E polymorphism and myocardial infarction risk: A systematic review and meta-analysis. (cdc.gov)
Isoforms1
- Normal plasma apolipoprotein B levels are around 800mg/L. Apolipoprotein B occurs in plasma as two main isoforms, apoB-48 and apoB-100. (thermofisher.com)
Risk9
- Apolipoprotein measurements may provide more detail about your risk for heart disease, but the added value of this test beyond a lipid panel is unknown. (medlineplus.gov)
- Conclusion: The G894T polymorphism of eNOS gene appears to be a risk factor of T2DM. (scirp.org)
- The main objective of the study was to determine the G894T SNP in the eNOS gene such as risk factor for T2DM in Tunisian population. (scirp.org)
- For most people, the biggest risk factors for dementia are ageing and genes . (alzheimers.org.uk)
- Some risk factors for dementia can't be avoided - for example ageing and genes. (alzheimers.org.uk)
- Apolipoprotein B (apoB) levels are used to evaluate the risk for cardiovascular disease. (medscape.com)
- Some evidence has shown that the capacity of the apoB/apoA-I ratio in assessing cardiovascular risk is strong and may be better than the use of apolipoprotein B alone. (medscape.com)
- Plasma levels of apolipoprotein E and risk of ischemic heart disease in the general population. (cdc.gov)
- Kajsa Brolin explores how our genes and environment affect the risk of developing Parkinson's disease. (lu.se)
Cholesterol2
- Apolipoprotein B is the primary apolipoprotein of chylomicrons, VLDL, Lp(a), IDL, and LDL particles (LDL-commonly known as "bad cholesterol" when in reference to both heart disease and vascular disease in general), which is responsible for carrying fat molecules (lipids), including cholesterol, around the body to all cells within all tissues. (wikipedia.org)
- ABCA1 is expressed in many organs and is thought to mediate HDL maturation by facilitating the efflux of cellular phospholipids and cholesterol onto apolipoproteins. (jci.org)
Detects2
- MIA1609 detects Apolipoprotein B which has a predicted molecular weight of approximately 502 kDa. (thermofisher.com)
- Detects mouse and rat Apolipoprotein H/ApoH in Western blots and detects recombinant mouse Apolipoprotein H/ApoH in direct ELISAs. (rndsystems.com)
Several genes1
- While there's no single sports gene, science has unraveled several genes that contribute to athletic ability. (shortform.com)
Susceptibility2
- These observations, taken together with epidemiologic data, are consistent with the hypothesis of an interaction between genes and other biological factors affecting disease susceptibility. (ox.ac.uk)
- A of ApoAI gene had higher susceptibility to osteonecrosis than G allele carriers. (biomedcentral.com)
Diseases1
- As in many other diseases, there is considerable clinical heterogeneity in these syndromes, which may be caused by environmental interactions as well as the background of other genes and other diseases in the patient. (medscape.com)
Variant1
- Mus musculus apolipoprotein D (Apod), transcript variant 3, mRNA. (genscript.com)
Single gene4
- The intestinal and the hepatic forms of Apolipoprotein B are encoded by a single gene from a single, very long mRNA. (thermofisher.com)
- There's no single gene that can account for an athlete's success. (shortform.com)
- According to David Epstein, the author of The Sports Gene , at our current level of understanding, investigating the effects of a single gene can tell us more about why someone is not an elite athlete than about why they are. (shortform.com)
- In most other cases, a single gene is not dominant. (msdmanuals.com)
Induces1
- Title: Amyloid-?25-35 induces apolipoprotein D Synthesis and growth arrest in HT22 hippocampal cells. (genscript.com)
Amyloid1
- The data also demonstrate that the "efficacy" of AAV-APOE2 gene delivery to decrease amyloid pathology in these mouse models strongly depends on the level of APOE2 expression and pre-existing amyloid pathology at the time of vector administration, rather than the cellular source of APOE2 or the route of administration. (nih.gov)
20171
- Apolipoprotein L1 nephropathies: 2017 in review. (nih.gov)
Abnormal3
- Some of these abnormalities can be inherited when only one parent has the abnormal gene. (msdmanuals.com)
- That is, the abnormal gene is dominant. (msdmanuals.com)
- An affected parent has a 50% chance of passing on the abnormal gene to each child. (msdmanuals.com)
Membrane1
- Myelin extracellular leaflet compaction requires apolipoprotein D membrane management to optimize lysosomal-dependent recycling and glycocalyx removal. (genscript.com)
Genotype2
- The genotype and allele frequency distributions showed no significant difference in EcoR I, Xba Iand 3′-VNTR loci of ApoB gene between the osteonecrosis group and control group. (biomedcentral.com)
- Apolipoprotein E2 Genotype Is Associated with a 2-Fold Increase in the Incidence of Type 2 Diabetes Mellitus: Results from a Long-Term Observational Study. (cdc.gov)
Pathways1
- Many genes involved in metabolic pathways have been found to contribute to lipid level variability [ 14 , 26 , 27 ]. (cdc.gov)
Human3
- The close genomic locations of these two genes as well as their functional similarity have hindered efforts to define whether each gene independently influences human triglyceride concentrations. (doe.gov)
- In direct ELISAs, approximately 40% cross-reactivity with recombinant human Apolipoprotein H/ApoH is observed. (rndsystems.com)
- Title: Cerebral Apolipoprotein-D Is Hypoglycosylated Compared to Peripheral Tissues and Is Variably Expressed in Mouse and Human Brain Regions. (genscript.com)
Proteins1
- Apolipoprotein H (ApoH), also known as beta 2‑Glycoprotein I/ beta 2-GPI, is a variably glycosylated member of the complement control superfamily of proteins with a molecular weight of aproximately 50 kDa (1, 2). (rndsystems.com)