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  • Ldlr
  • LDLR -/- /APOBEC1 -/- /FG -/- (L -/- /A -/- /FG -/- ) triple-deficient mice presented more advanced plaque in their aortic trees and aortic sinuses at 24, 36, and 48 weeks of age compared to L -/- /A -/- mice, a feature that may result from enhanced platelet activation in these former mice. (bloodjournal.org)
  • 1 Thus, most of the LDL in mice is apoB-48 positive and is not dependent on the Ldlr for its clearance. (bloodjournal.org)
  • mechanisms
  • There is accumulating evidence reporting that FH patients have increased fasting apoB-48 levels [ 13 - 17 ], but data on the underlying mechanisms in cause are mixed. (beds.ac.uk)
  • fatty
  • Rather, the suppressed production of apo B-48 by n-3 fatty acids was associated with intracellular proteasome-mediated posttranslational downregulation in insulin-resistant and diabetic animals. (ovid.com)
  • levels
  • Skoog M, Xu N, Berggren-Soderlund M, Lovegrove JA , Nilsson-Ehle P ACTH reduces rise in ApoB-48 levels after fat intake. (reading.ac.uk)
  • There were no correlations between apoB-48 and PCSK9 plasma levels in both controls (ρ = 0.06, P = 0.5) and HeFH subjects (ρ = 0.07, P = 0.4). (beds.ac.uk)
  • These data indicate that the elevation in plasma apoB-48 levels associated with FH is independent of PCSK9 levels. (beds.ac.uk)
  • baseline
  • 0.0001) and similar median decreases in TG (-33.0%, -27.6%), RemL-C (-58.7%, -61.5%), and apoB-48 (-37.5%, -32.1%) as compared to baseline. (usda.gov)
  • subjects
  • Kinetic analysis of plasma apolipoprotein enrichment curves demonstrated that mature plasma apoA-I production rates (PRs) were similar in patients and control subjects (7.9 and 9.1 versus 10.5±1.7 mg · kg −1 · d −1 ). (ahajournals.org)